| Pharmacogenetic study of CES1 gene and enalapril efficacy. | Pharmacogenetic study of CES1 gene and enalapril efficacy.
Hussain M, Basheer S, Khalil A, Haider QUA, Saeed H, Faizan M. | 09/17/2024 |
| High-Dose Methylphenidate and Carboxylesterase 1 Genetic Variability in Patients With Attention-Deficit/Hyperactivity Disorder: A Case Series. | High-Dose Methylphenidate and Carboxylesterase 1 Genetic Variability in Patients With Attention-Deficit/Hyperactivity Disorder: A Case Series.
Westerkamp AC, Pereira RR, Huitema VR, Kouwert EAM, Matic M, van Schaik RHN, Punt N, Schoevers RA, Touw DJ. | 12/22/2023 |
| The Distribution of the Genotypes of ABCB1 and CES1 Polymorphisms in Kazakhstani Patients with Atrial Fibrillation Treated with DOAC. | The Distribution of the Genotypes of ABCB1 and CES1 Polymorphisms in Kazakhstani Patients with Atrial Fibrillation Treated with DOAC.
Abdrakhmanov A, Akilzhanova A, Shaimerdinova A, Zhalbinova M, Tuyakova G, Abildinova S, Albayev R, Ainabekova B, Chinybayeva A, Suleimen Z, Bekbossynova M., Free PMC Article | 06/30/2023 |
| The Influence of Structural Variants of the CES1 Gene on the Pharmacokinetics of Enalapril, Presumably Due to Linkage Disequilibrium with the Intronic rs2244613. | The Influence of Structural Variants of the CES1 Gene on the Pharmacokinetics of Enalapril, Presumably Due to Linkage Disequilibrium with the Intronic rs2244613.
Ikonnikova A, Kazakov R, Rodina T, Dmitriev A, Melnikov E, Zasedatelev A, Nasedkina T., Free PMC Article | 01/11/2023 |
| Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms. | Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms.
Her L, Shi J, Wang X, He B, Smith LS, Jiang H, Zhu HJ., Free PMC Article | 01/7/2023 |
| Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease. | Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease.
Elfiky AMI, Ghiboub M, Li Yim AYF, Hageman IL, Verhoeff J, de Krijger M, van Hamersveld PHP, Welting O, Admiraal I, Rahman S, Garcia-Vallejo JJ, Wildenberg ME, Tomlinson L, Gregory R, Rioja I, Prinjha RK, Furze RC, Lewis HD, Mander PK, Heinsbroek SEM, Bell MJ, de Jonge WJ., Free PMC Article | 05/21/2022 |
| Adipose tissue-specific ablation of Ces1d causes metabolic dysregulation in mice. | Adipose tissue-specific ablation of Ces1d causes metabolic dysregulation in mice.
Li G, Li X, Yang L, Wang S, Dai Y, Fekry B, Veillon L, Tan L, Berdeaux R, Eckel-Mahan K, Lorenzi PL, Zhao Z, Lehner R, Sun K., Free PMC Article | 05/14/2022 |
| Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms. | Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms.
Collins JM, Lu R, Wang X, Zhu HJ, Wang D., Free PMC Article | 04/2/2022 |
| Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1. | Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1.
Zhou L, Zhang C, Yang X, Liu L, Hu J, Hou Y, Tao H, Sugimura H, Chen Z, Wang L, Chen K., Free PMC Article | 02/12/2022 |
| Copy number variation in the CES1 gene and the risk of non-alcoholic fatty liver in a Chinese Han population. | Copy number variation in the CES1 gene and the risk of non-alcoholic fatty liver in a Chinese Han population.
Chen BB, Yan JH, Zheng J, Peng HW, Cai XL, Pan XT, Li HQ, Hong QZ, Peng XE., Free PMC Article | 11/27/2021 |
| Clock gene Bmal1 controls diurnal rhythms in expression and activity of intestinal carboxylesterase 1. | Clock gene Bmal1 controls diurnal rhythms in expression and activity of intestinal carboxylesterase 1.
Chen X, Yu F, Guo X, Su C, Li SS, Wu B. | 11/6/2021 |
| Enhanced triacylglycerol catabolism by carboxylesterase 1 promotes aggressive colorectal carcinoma. | Enhanced triacylglycerol catabolism by carboxylesterase 1 promotes aggressive colorectal carcinoma.
Capece D, D'Andrea D, Begalli F, Goracci L, Tornatore L, Alexander JL, Di Veroli A, Leow SC, Vaiyapuri TS, Ellis JK, Verzella D, Bennett J, Savino L, Ma Y, McKenzie JS, Doria ML, Mason SE, Chng KR, Keun HC, Frost G, Tergaonkar V, Broniowska K, Stunkel W, Takats Z, Kinross JM, Cruciani G, Franzoso G., Free PMC Article | 10/9/2021 |
| Potential Regulatory Role of Human-Carboxylesterase-1 Glycosylation in Liver Cancer Cell Growth. | Potential Regulatory Role of Human-Carboxylesterase-1 Glycosylation in Liver Cancer Cell Growth.
Na K, Kim M, Kim CY, Lim JS, Cho JY, Shin H, Lee HJ, Kang BJ, Han DH, Kim H, Baik JH, Swiatek-de Lange M, Karl J, Paik YK. | 06/26/2021 |
| Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators. | Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators.
Her L, Zhu HJ., Free PMC Article | 06/5/2021 |
| In the combined cohort, CES1 rs9921399T>C was associated with prolonged overall survival (OS) (hazard ratio [HR] = 0.40) whereas ABCC1 rs17501011G>A (HR = 2.08) and UGT1 rs1113193G>A (HR = 2.12) were associated with shorter OS (p </= 0.005). | Combination of germline variations associated with survival of folinic acid, fluorouracil and irinotecan-treated metastatic colorectal cancer patients.
Labriet A, Lévesque É, De Mattia E, Cecchin E, Jonker D, Couture F, Simonyan D, Buonadonna A, D'Andrea M, Villeneuve L, Toffoli G, Guillemette C. | 07/25/2020 |
| Studied role of CYP450 Enzymes, carboxylesterase 1(CES1), paraoxonase 1(PON1), ATP binding cassette subfamily B member 1(ABCB1), and purinergic receptor P2Y12 (P2RY12) genetic polymorphisms in the response to clopidogrel treatment who had undergone neurointervention. | Influence of CYP450 Enzymes, CES1, PON1, ABCB1, and P2RY12 Polymorphisms on Clopidogrel Response in Patients Subjected to a Percutaneous Neurointervention.
Saiz-Rodríguez M, Belmonte C, Caniego JL, Koller D, Zubiaur P, Bárcena E, Romero-Palacián D, Eugene AR, Ochoa D, Abad-Santos F. | 05/23/2020 |
| Provides important insights into the metabolism of hCES1 substrates and drug designing. | Catalytic Hydrolysis Mechanism of Cocaine by Human Carboxylesterase 1: An Orthoester Intermediate Slows Down the Reaction.
Yan M, Zhang Z, Liu Z, Zhang C, Zhang J, Fan S, Yang Z., Free PMC Article | 04/11/2020 |
| A potential for clinically significant inhibition of CES1 by THC and CBD. | In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites.
Qian Y, Wang X, Markowitz JS. | 01/25/2020 |
| The study has shown the CES1 gene SNP rs2244613 frequency heterogeneity in different ethnic groups in Russia. Based on these findings and the RE-LY conclusions about rs2244613 carriage association with dabigatran concentration and the risk of bleeding we can suppose that patients taking dabigatran in ethnic groups living in Russia have a lower risk of bleeding. | Genetic determinants of dabigatran safety (CES1 gene rs2244613 polymorphism) in the Russian population: multi-ethnic analysis.
Sychev DA, Abdullaev SP, Mirzaev KB, Ryzhikova KA, Shuyev GN, Sozaeva ZA, Grishina EA, Mammaev SN, Gafurov DM, Kitaeva EY, Shprakh VV, Suleymanov SS, Bolieva LZ, Sozaeva MS, Zhuchkova SM, Gimaldinova NE, Sidukova EE, Asoskova AV, Mumladze RB. | 01/11/2020 |
| Alterations in methylation of CpG sites of specific genes (HDAC4, RAX2, APOA5 and CES1 loci) may contribute to childhood obesity. | Genome-wide analysis reveals that altered methylation in specific CpG loci is associated with childhood obesity.
Li Y, Zhou Y, Zhu L, Liu G, Wang X, Wang X, Wang J, You L, Ji C, Guo X, Zhao Y, Cui X. | 10/19/2019 |
| The results showed that there was a significant association between CES1 S75N (rs2307240) and the outcome of clopidogrel therapy. Moreover, the frequency of the T allele of rs2307240 in acute coronary syndrome patients (MAF = 0.22) was more than four times higher than that in the general public | Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients.
Xiao FY, Luo JQ, Liu M, Chen BL, Cao S, Liu ZQ, Zhou HH, Zhou G, Zhang W., Free PMC Article | 02/23/2019 |
| Study utilized humanized mouse model expressing WT (control), G143E and catalytically dead S221A variants of human CES1 in the liver in the absence of endogenous expression of the mouse orthologous gene shows that compared to wild-type CES1, expression of the CES1G143E confers resistance to development of high-fat diet induced hepatic steatosis and leads to improved metabolic profile. | Genetic variation in human carboxylesterase CES1 confers resistance to hepatic steatosis.
Lian J, Bahitham W, Panigrahi R, Nelson R, Li L, Watts R, Thiesen A, Lemieux MJ, Lehner R. | 12/22/2018 |
| Which selectively amplified CES1A1 and, if present, also CES1A2. | Novel approach for CES1 genotyping: integrating single nucleotide variants and structural variation.
Bjerre D, Berg Rasmussen H, Indices Consortium T. | 12/22/2018 |
| These results are consistent with a model in which abrogation of CES1 function attenuates the CYP27A1-LXRalpha-ABCA1 signaling axis by depleting endogenous ligands for the nuclear receptors PPARgamma, RAR, and/or RXR that regulate cholesterol homeostasis. | Silencing carboxylesterase 1 in human THP-1 macrophages perturbs genes regulated by PPARγ/RXR and RAR/RXR: down-regulation of CYP27A1-LXRα signaling.
Mangum LC, Hou X, Borazjani A, Lee JH, Ross MK, Crow JA., Free PMC Article | 09/15/2018 |
| Anordrin is predominantly catalyzed by CES1 and CES2 to generate the main active metabolite, anordiol. | Predominant contributions of carboxylesterase 1 and 2 in hydrolysis of anordrin in humans.
Jiang J, Chen X, Zhong D. | 09/1/2018 |