| POLD3 deficiency is associated with severe combined immunodeficiency, neurodevelopmental delay, and hearing impairment. | POLD3 deficiency is associated with severe combined immunodeficiency, neurodevelopmental delay, and hearing impairment.
Mehawej C, Chouery E, Azar-Atallah S, Shebaby W, Delague V, Mansour I, Mustapha M, Lefranc G, Megarbane A. | 05/23/2023 |
| Interaction of human HelQ with DNA polymerase delta halts DNA synthesis and stimulates DNA single-strand annealing. | Interaction of human HelQ with DNA polymerase delta halts DNA synthesis and stimulates DNA single-strand annealing.
He L, Lever R, Cubbon A, Tehseen M, Jenkins T, Nottingham AO, Horton A, Betts H, Fisher M, Hamdan SM, Soultanas P, Bolt EL., Free PMC Article | 03/7/2023 |
| Interaction of CCND2, CDKN1A, and POLD3 Variants in Mexican Patients with Colorectal Cancer. | Interaction of CCND2, CDKN1A, and POLD3 Variants in Mexican Patients with Colorectal Cancer.
Alvizo-Rodríguez CR, Flores-López BA, Ayala-Madrigal ML, Partida-Pérez M, Macías-Gómez NM, Peregrina-Sandoval J, Suárez-Villanueva AS, Moreno-Ortiz JM, Cervantes-Ortiz S, Maciel-Gutiérre VM, Gutiérrez-Angulo M., Free PMC Article | 07/16/2022 |
| Polymerase delta promotes chromosomal rearrangements and imprecise double-strand break repair. | Polymerase δ promotes chromosomal rearrangements and imprecise double-strand break repair.
Layer JV, Debaize L, Van Scoyk A, House NC, Brown AJ, Liu Y, Stevenson KE, Hemann M, Roberts SA, Price BD, Weinstock DM, Day TA., Free PMC Article | 01/9/2021 |
| ROS-induced telomeric R-loops promote repair of telomeric DSBs through CSB-RAD52-POLD3-mediated BIR, a previously unknown pathway protecting telomeres from ROS. ROS-induced telomeric SSBs may not only give rise to DSBs indirectly, but also promote DSB repair by inducing R-loops, revealing an unexpected interplay between distinct ROS-induced DNA lesions. | An R-loop-initiated CSB-RAD52-POLD3 pathway suppresses ROS-induced telomeric DNA breaks.
Tan J, Duan M, Yadav T, Phoon L, Wang X, Zhang JM, Zou L, Lan L., Free PMC Article | 03/21/2020 |
| findings demonstrate a key role of POLD1 and POLD3 in genome stability and S-phase progression revealing RNA-DNA hybrids-dependent effects for POLD3 that might be partly due to its Pol zeta interaction. | Roles of human POLD1 and POLD3 in genome stability.
Tumini E, Barroso S, -Calero CP, Aguilera A., Free PMC Article | 06/16/2018 |
| The proofreading activity of DNA polymerase delta plays a role in shunting DNA mismatch repair to an EXO1-dependent excision pathway as opposed to directly participating in gap formation via its 3'-5' exonuclease activity. | Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro.
Liu D, Frederiksen JH, Liberti SE, Lützen A, Keijzers G, Pena-Diaz J, Rasmussen LJ., Free PMC Article | 10/28/2017 |
| The mitotic DNA synthesis is RAD52 dependent, and RAD52 is required for the timely recruitment of MUS81 and POLD3 to common fragile sites in early mitosis. | RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress.
Bhowmick R, Minocherhomji S, Hickson ID. | 09/9/2017 |
| data support Poldelta contributing to translesion synthesis in vivo and suggest that the mutagenesis resulting from loss of Poldelta proofreading activity may in part be explained by enhanced lesion bypass | In vivo evidence for translesion synthesis by the replicative DNA polymerase δ.
Hirota K, Tsuda M, Mohiuddin, Tsurimoto T, Cohen IS, Livneh Z, Kobayashi K, Narita T, Nishihara K, Murai J, Iwai S, Guilbaud G, Sale JE, Takeda S., Free PMC Article | 06/24/2017 |
| Studies indicate that DNA polymerase delta 3 (Pol delta3) exhibits significant differences in properties with a major impact on cellular processes in genomic surveillance, DNA replication and DNA repair. | Multiple Forms of Human DNA Polymerase Delta Sub-Assembling in Cellular DNA Transactions.
Zhang Q, Zhang Q, Chen H, Chen Y, Zhou Y. | 02/18/2017 |
| Data suggest that relatively high affinity binding of PolD3-RIR motif to Rev1-C-terminal domain displaces subunits from PolN, Pol-iota, or PolK from Rev1 complex and promotes formation of Rev1/PolZ4 assembly with PCNA for translesion DNA replication. | Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis.
Pustovalova Y, Magalhães MT, D'Souza S, Rizzo AA, Korza G, Walker GC, Korzhnev DM., Free PMC Article | 08/27/2016 |
| POLD3 is SUMOylated by SUMO2 in response to replication stress and could play an important role in the regulation of cellular response to DNA replication stress. | Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells.
Bursomanno S, Beli P, Khan AM, Minocherhomji S, Wagner SA, Bekker-Jensen S, Mailand N, Choudhary C, Hickson ID, Liu Y. | 07/25/2015 |
| Findings provide evidence for the novel concept that Pol delta3 has a role in lagging strand synthesis, and that both forms of Pol delta3 and 4 may participate in DNA replication in higher eukaryotic cells. | Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase δ.
Lin SH, Wang X, Zhang S, Zhang Z, Lee EY, Lee MY., Free PMC Article | 06/21/2014 |
| In a cyclin E overexpression model of DNA replication stress, POLD3, the human ortholog of POL32, was required for cell cycle progression and processive DNA synthesis. | Break-induced replication repair of damaged forks induces genomic duplications in human cells.
Costantino L, Sotiriou SK, Rantala JK, Magin S, Mladenov E, Helleday T, Haber JE, Iliakis G, Kallioniemi OP, Halazonetis TD., Free PMC Article | 01/25/2014 |
| Pol delta3 is the predominant form of Pol delta at sites of UV damage as a result of p12 degradation; results show that Pol delta at the DNA damage site is the Pol delta trimer lacking p12 regardless of the cell cycle phase | Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage.
Chea J, Zhang S, Zhao H, Zhang Z, Lee EY, Darzynkiewicz Z, Lee MY., Free PMC Article | 02/2/2013 |
| We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 x 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 x 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 x 10(-10)). | Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
Dunlop MG, Dobbins SE, Farrington SM, Jones AM, Palles C, Whiffin N, Tenesa A, Spain S, Broderick P, Ooi LY, Domingo E, Smillie C, Henrion M, Frampton M, Martin L, Grimes G, Gorman M, Semple C, Ma YP, Barclay E, Prendergast J, Cazier JB, Olver B, Penegar S, Lubbe S, Chander I, Carvajal-Carmona LG, Ballereau S, Lloyd A, Vijayakrishnan J, Zgaga L, Rudan I, Theodoratou E, Colorectal Tumour Gene Identification (CORGI) Consortium, Starr JM, Deary I, Kirac I, Kovacević D, Aaltonen LA, Renkonen-Sinisalo L, Mecklin JP, Matsuda K, Nakamura Y, Okada Y, Gallinger S, Duggan DJ, Conti D, Newcomb P, Hopper J, Jenkins MA, Schumacher F, Casey G, Easton D, Shah M, Pharoah P, Lindblom A, Liu T, Swedish Low-Risk Colorectal Cancer Study Group, Smith CG, West H, Cheadle JP, COIN Collaborative Group, Midgley R, Kerr DJ, Campbell H, Tomlinson IP, Houlston RS., Free PMC Article | 11/17/2012 |
| Serine-458, located in the proliferating cell nuclear antigen (PCNA)-interacting motif of Poldelta(p68), is a phosphorylation site for protein kinase A (PKA); p68 mutation results in decreased p68 affinity for PCNA as well as processivity of Poldelta. | Phosphorylation of the p68 subunit of Pol δ acts as a molecular switch to regulate its interaction with PCNA.
Rahmeh AA, Zhou Y, Xie B, Li H, Lee EY, Lee MY. | 03/10/2012 |
| Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) | Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.
Michiels S, Laplanche A, Boulet T, Dessen P, Guillonneau B, Méjean A, Desgrandchamps F, Lathrop M, Sarasin A, Benhamou S. | 03/25/2009 |
| the crystal structure of p50*p66(N) complex featuring oligonucleotide binding and phosphodiesterase domains in winged helix-turn-helix N-terminal domain in p66 | X-ray structure of the complex of regulatory subunits of human DNA polymerase delta.
Baranovskiy AG, Babayeva ND, Liston VG, Rogozin IB, Koonin EV, Pavlov YI, Vassylyev DG, Tahirov TH., Free PMC Article | 01/21/2010 |
| As a first step towards understanding the functional importance of their regulatory subunit interactions, the three-dimensional structure of the p50-p66 heterodimer of human Pol delta has been solved using X-ray crystallography. | Crystallization and preliminary crystallographic analysis of the complex of the second and third regulatory subunits of human Pol delta.
Baranovskiy AG, Babayeva ND, Pavlov YI, Tahirov TH., Free PMC Article | 01/21/2010 |
| Taken together, the results provide evidence that concurrent phosphorylation events in p66 may positively and negatively regulate its activity and interactions with other components of the replisome during the cell cycle. | Phosphorylation of the C subunit (p66) of human DNA polymerase delta.
Lemmens L, Urbach S, Prudent R, Cochet C, Baldacci G, Hughes P. | 01/21/2010 |
| POLD3, plays a crucial role in the efficient recycling of PCNA during dissociation-association cycles of pol delta during elongation phase of DNA replication. | Dynamics of human replication factors in the elongation phase of DNA replication.
Masuda Y, Suzuki M, Piao J, Gu Y, Tsurimoto T, Kamiya K., Free PMC Article | 01/21/2010 |
| show that there is a direct interaction between p66 and PCNA in living cells during DNA replication. The dominant negative effect upon growth resulting from expression of p66 sub-domains confirms that the p66-PCNA interaction is essential in vivo. | An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit.
Pohler JR, Otterlei M, Warbrick E., Free PMC Article | 01/21/2010 |