| Targeting the mitochondrial protein YME1L to inhibit osteosarcoma cell growth in vitro and in vivo. | Targeting the mitochondrial protein YME1L to inhibit osteosarcoma cell growth in vitro and in vivo.
Sun X, Shi C, Dai J, Zhang MQ, Pei DS, Yang L., Free PMC Article | 05/28/2024 |
| The mitochondrial protein YME1 Like 1 is important for non-small cell lung cancer cell growth. | The mitochondrial protein YME1 Like 1 is important for non-small cell lung cancer cell growth.
Xia Y, He C, Hu Z, Wu Z, Hui Y, Liu YY, Mu C, Zha J., Free PMC Article | 08/10/2023 |
| Regulation of mitochondrial plasticity by the i-AAA protease YME1L. | Regulation of mitochondrial plasticity by the i-AAA protease YME1L.
Ohba Y, MacVicar T, Langer T. | 06/19/2021 |
| Examination of the Role of Mg(2+) in the Mechanism of Nucleotide Binding to the Monomeric YME1L AAA+ Domain. | Examination of the Role of Mg(2+) in the Mechanism of Nucleotide Binding to the Monomeric YME1L AAA+ Domain.
Miller JM, Brambley CA, Marsee JD. | 04/3/2021 |
| identify the mTORC1-LIPIN1-YME1L axis as a post-translational regulator of mitochondrial proteostasis at the interface between metabolism and mitochondrial dynamics | Lipid signalling drives proteolytic rewiring of mitochondria by YME1L.
MacVicar T, Ohba Y, Nolte H, Mayer FC, Tatsuta T, Sprenger HG, Lindner B, Zhao Y, Li J, Bruns C, Krüger M, Habich M, Riemer J, Schwarzer R, Pasparakis M, Henschke S, Brüning JC, Zamboni N, Langer T. | 04/11/2020 |
| in the absence of ROMO1, mitochondria lose the inner membrane YME1L protease, which participates in OPA1 processing and ROMO1 turnover. While ROMO1 is dispensable for general protein import along the presequence pathway, we show that it participates in the dynamics of TIM21 during respiratory chain biogenesis and is specifically required for import of YME1L. | ROMO1 is a constituent of the human presequence translocase required for YME1L protease import.
Richter F, Dennerlein S, Nikolov M, Jans DC, Naumenko N, Aich A, MacVicar T, Linden A, Jakobs S, Urlaub H, Langer T, Rehling P., Free PMC Article | 12/14/2019 |
| Data show that engineered YME1L protease discriminates between degradation signals by amino acid composition, implying the use of sequence-specific signals in mitochondrial proteostasis. | Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane.
Shi H, Rampello AJ, Glynn SE., Free PMC Article | 09/1/2018 |
| These results identify mutations in YME1L1 as a cause of a mitochondriopathy with optic nerve atrophy highlighting the importance of YME1L1 for mitochondrial functionality in humans. | Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation.
Hartmann B, Wai T, Hu H, MacVicar T, Musante L, Fischer-Zirnsak B, Stenzel W, Gräf R, van den Heuvel L, Ropers HH, Wienker TF, Hübner C, Langer T, Kaindl AM., Free PMC Article | 10/7/2017 |
| YME1L1 was identified as the first NUMT (nuclear mtDNA) suppressor gene in human and demonstrate that inactivation of YME1L1 induces migration of mtDNA to the nuclear genome. | Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma.
Srinivasainagendra V, Sandel MW, Singh B, Sundaresan A, Mooga VP, Bajpai P, Tiwari HK, Singh KK., Free PMC Article | 08/5/2017 |
| differential stress-induced degradation of YME1L and OMA1 as a mechanism for sensitively adapting mitochondrial inner membrane protease activity and function in response to distinct types of cellular insults. | Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress.
Rainbolt TK, Lebeau J, Puchades C, Wiseman RL., Free PMC Article | 01/14/2017 |
| YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress.Loss of YME1L compromises the regulation of mitochondrial inner membrane proteostasis. | YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress.
Rainbolt TK, Saunders JM, Wiseman RL., Free PMC Article | 08/1/2015 |
| Results reveal a crucial role for YME1L in the maintenance of mitochondrial inner-membrane proteostasis and in the proteolytic regulation of respiratory chain biogenesis. | YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation.
Stiburek L, Cesnekova J, Kostkova O, Fornuskova D, Vinsova K, Wenchich L, Houstek J, Zeman J., Free PMC Article | 08/4/2012 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A. | 12/2/2009 |