| METTL3/IGF2BP2 axis affects the progression of colorectal cancer by regulating m6A modification of STAG3. | METTL3/IGF2BP2 axis affects the progression of colorectal cancer by regulating m6A modification of STAG3.
Yi J, Peng F, Zhao J, Gong X., Free PMC Article | 11/7/2023 |
| The upregulation of stromal antigen 3 expression suppresses the phenotypic hallmarks of hepatocellular carcinoma through the Smad3-CDK4/CDK6-cyclin D1 and CXCR4/RhoA pathways. | The upregulation of stromal antigen 3 expression suppresses the phenotypic hallmarks of hepatocellular carcinoma through the Smad3-CDK4/CDK6-cyclin D1 and CXCR4/RhoA pathways.
Zhao M, Wang Y, Zhang Y, Li X, Mi J, Wang Q, Geng Z, Zuo L, Song X, Ge S, Zhang Z, Tang M, Li H, Wang Z, Jiang C, Su F., Free PMC Article | 08/20/2022 |
| New STAG3 gene variant as a cause of premature ovarian insufficiency", trans "Nueva variante del gen STAG3 causante de insuficiencia ovarica prematura | New STAG3 gene variant as a cause of premature ovarian insufficiency.
Gómez-Rojas S, Aristizábal-Duque JE, Muñoz-Fernández LF, Sarmiento-Ramón MP, Pereira-Gómez MDP., Free PMC Article | 05/14/2022 |
| Biallelic loss of function variants in STAG3 result in primary ovarian insufficiency. | Biallelic loss of function variants in STAG3 result in primary ovarian insufficiency.
Demain LAM, Boetje E, Edgerley JJ, Miles E, Fitzgerald CT, Busby G, Beaman GM, O'Sullivan J, O'Keefe RT, Newman WG. | 02/26/2022 |
| A Long Contiguous Stretch of Homozygosity Disclosed a Novel STAG3 Biallelic Pathogenic Variant Causing Primary Ovarian Insufficiency: A Case Report and Review of the Literature. | A Long Contiguous Stretch of Homozygosity Disclosed a Novel STAG3 Biallelic Pathogenic Variant Causing Primary Ovarian Insufficiency: A Case Report and Review of the Literature.
Mellone S, Zavattaro M, Vurchio D, Ronzani S, Caputo M, Leone I, Prodam F, Giordano M., Free PMC Article | 02/19/2022 |
| Analysis of STAG3 variants in Chinese non-obstructive azoospermia patients with germ cell maturation arrest. | Analysis of STAG3 variants in Chinese non-obstructive azoospermia patients with germ cell maturation arrest.
Liu W, Gao X, Zhang H, Liu R, Cao Y, Yu R, Fang G, Ma J, Zhao S., Free PMC Article | 11/6/2021 |
| STAG3 homozygous missense variant causes primary ovarian insufficiency and male non-obstructive azoospermia. | STAG3 homozygous missense variant causes primary ovarian insufficiency and male non-obstructive azoospermia.
Jaillard S, McElreavy K, Robevska G, Akloul L, Ghieh F, Sreenivasan R, Beaumont M, Bashamboo A, Bignon-Topalovic J, Neyroud AS, Bell K, Veron-Gastard E, Launay E, van den Bergen J, Nouyou B, Vialard F, Belaud-Rotureau MA, Ayers KL, Odent S, Ravel C, Tucker EJ, Sinclair AH. | 08/28/2021 |
| The meiosis-specific cohesin component stromal antigen 3 promotes cell migration and chemotherapeutic resistance in colorectal cancer. | The meiosis-specific cohesin component stromal antigen 3 promotes cell migration and chemotherapeutic resistance in colorectal cancer.
Sasaki M, Miyoshi N, Fujino S, Saso K, Ogino T, Takahashi H, Uemura M, Yamamoto H, Matsuda C, Yasui M, Ohue M, Mizushima T, Doki Y, Eguchi H. | 05/8/2021 |
| The association of stromal antigen 3 (STAG3) sequence variations with spermatogenic impairment in the male Korean population. | The association of stromal antigen 3 (STAG3) sequence variations with spermatogenic impairment in the male Korean population.
Nam Y, Kang KM, Sung SR, Park JE, Shin YJ, Song SH, Seo JT, Yoon TK, Shim SH., Free PMC Article | 12/5/2020 |
| Mutations in the stromal antigen 3 (STAG3) gene cause male infertility due to meiotic arrest. | Mutations in the stromal antigen 3 (STAG3) gene cause male infertility due to meiotic arrest.
van der Bijl N, Röpke A, Biswas U, Wöste M, Jessberger R, Kliesch S, Friedrich C, Tüttelmann F. | 10/3/2020 |
| For the first time, study reports biallelic variants in STAG3, in one sporadic patient, and a homozygous RNF212 variant, in the two brothers, as the genetic cause of non-obstructive azoospermia. Meiotic studies allowed the detection of the functional consequences of the mutations and provided information on the role of STAG3 and RNF212 in human male meiosis. | Sequencing of a 'mouse azoospermia' gene panel in azoospermic men: identification of RNF212 and STAG3 mutations as novel genetic causes of meiotic arrest.
Riera-Escamilla A, Enguita-Marruedo A, Moreno-Mendoza D, Chianese C, Sleddens-Linkels E, Contini E, Benelli M, Natali A, Colpi GM, Ruiz-Castañé E, Maggi M, Baarends WM, Krausz C. | 07/18/2020 |
| Rec8-Stag3 cohesin is shown to be susceptible to Wapl-dependent ring opening and sororin-mediated protection. | Studying meiotic cohesin in somatic cells reveals that Rec8-containing cohesin requires Stag3 to function and is regulated by Wapl and sororin.
Wolf PG, Cuba Ramos A, Kenzel J, Neumann B, Stemmann O. | 12/7/2019 |
| This is the first report of STAG3 mutations in a Caucasian family with primary ovarian insufficiency. | Novel STAG3 mutations in a Caucasian family with primary ovarian insufficiency.
Heddar A, Dessen P, Flatters D, Misrahi M. | 11/16/2019 |
| RT-PCR revealed that the mutation causes loss of wild-type donor splice-site which leads to aberrant splicing of STAG3 mRNA and consecutive formation of STAG3 alternative transcript (p.Leu490Thrfs*10) . This is the first report of splice-site mutation of STAG3 gene causes POI in 2 Han Chinese patients. | Whole-exome sequencing identifies a homozygous donor splice-site mutation in STAG3 that causes primary ovarian insufficiency.
He WB, Banerjee S, Meng LL, Du J, Gong F, Huang H, Zhang XX, Wang YY, Lu GX, Lin G, Tan YQ. | 08/3/2019 |
| c.677C > G associated with primary ovarian insufficiency | A STAG3 missense mutation in two sisters with primary ovarian insufficiency.
Colombo R, Pontoglio A, Bini M. | 09/29/2018 |
| Loss of STAG2 or STAG3, which encode subunits of the cohesin complex, in melanoma cells results in resistance to BRAF inhibitors (BRAFi). Loss-of-function mutations in STAG2, as well as decreased expression of STAG2 or STAG3 proteins were found in several tumor samples from patients with acquired resistance to BRAFi and in BRAFi-resistant melanoma cell lines. | Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma.
Shen CH, Kim SH, Trousil S, Frederick DT, Piris A, Yuan P, Cai L, Gu L, Li M, Lee JH, Mitra D, Fisher DE, Sullivan RJ, Flaherty KT, Zheng B., Free PMC Article | 08/12/2017 |
| STAG3 truncating variant as the cause of primary ovarian insufficiency has been found in two sisters in a consanguineous Lebanese family. | STAG3 truncating variant as the cause of primary ovarian insufficiency.
Le Quesne Stabej P, Williams HJ, James C, Tekman M, Stanescu HC, Kleta R, Ocaka L, Lescai F, Storr HL, Bitner-Glindzicz M, Bacchelli C, Conway GS, GOSgene., Free PMC Article | 09/24/2016 |
| We identified a homozygous 1-bp deletion inducing a frameshift mutation in STAG3 on chromosome 7. Female mice devoid of Stag3 are sterile. | Mutant cohesin in premature ovarian failure.
Caburet S, Arboleda VA, Llano E, Overbeek PA, Barbero JL, Oka K, Harrison W, Vaiman D, Ben-Neriah Z, García-Tuñón I, Fellous M, Pendás AM, Veitia RA, Vilain E., Free PMC Article | 03/22/2014 |
| we show evidence for the involvement of a common allele of STAG3 in the development of epithelial ovarian cancer | Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer.
Notaridou M, Quaye L, Dafou D, Jones C, Song H, Høgdall E, Kjaer SK, Christensen L, Høgdall C, Blaakaer J, McGuire V, Wu AH, Van Den Berg DJ, Pike MC, Gentry-Maharaj A, Wozniak E, Sher T, Jacobs IJ, Tyrer J, Schildkraut JM, Moorman PG, Iversen ES, Jakubowska A, Mędrek K, Lubiński J, Ness RB, Moysich KB, Lurie G, Wilkens LR, Carney ME, Wang-Gohrke S, Doherty JA, Rossing MA, Beckmann MW, Thiel FC, Ekici AB, Chen X, Beesley J, Australian Ovarian Cancer Study Group/Australian Cancer Study (Ovarian Cancer), Gronwald J, Fasching PA, Chang-Claude J, Goodman MT, Chenevix-Trench G, Berchuck A, Pearce CL, Whittemore AS, Menon U, Pharoah PD, Gayther SA, Ramus SJ, Ovarian Cancer Association Consortium, Notaridou M, Quaye L, Dafou D, Jones C, Song H, Høgdall E, Kjaer SK, Christensen L, Høgdall C, Blaakaer J, McGuire V, Wu AH, Van Den Berg DJ, Pike MC, Gentry-Maharaj A, Wozniak E, Sher T, Jacobs IJ, Tyrer J, Schildkraut JM, Moorman PG, Iversen ES, Jakubowska A, Mędrek K, Lubiński J, Ness RB, Moysich KB, Lurie G, Wilkens LR, Carney ME, Wang-Gohrke S, Doherty JA, Rossing MA, Beckmann MW, Thiel FC, Ekici AB, Chen X, Beesley J, Australian Ovarian Cancer Study Group/Australian Cancer Study (Ovarian Cancer), Gronwald J, Fasching PA, Chang-Claude J, Goodman MT, Chenevix-Trench G, Berchuck A, Pearce CL, Whittemore AS, Menon U, Pharoah PD, Gayther SA, Ramus SJ, Ovarian Cancer Association Consortium., Free PMC Articles: PMC3098608, PMC3098608 | 05/14/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesCommon alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer.
Notaridou M, Quaye L, Dafou D, Jones C, Song H, Høgdall E, Kjaer SK, Christensen L, Høgdall C, Blaakaer J, McGuire V, Wu AH, Van Den Berg DJ, Pike MC, Gentry-Maharaj A, Wozniak E, Sher T, Jacobs IJ, Tyrer J, Schildkraut JM, Moorman PG, Iversen ES, Jakubowska A, Mędrek K, Lubiński J, Ness RB, Moysich KB, Lurie G, Wilkens LR, Carney ME, Wang-Gohrke S, Doherty JA, Rossing MA, Beckmann MW, Thiel FC, Ekici AB, Chen X, Beesley J, Australian Ovarian Cancer Study Group/Australian Cancer Study (Ovarian Cancer), Gronwald J, Fasching PA, Chang-Claude J, Goodman MT, Chenevix-Trench G, Berchuck A, Pearce CL, Whittemore AS, Menon U, Pharoah PD, Gayther SA, Ramus SJ, Ovarian Cancer Association Consortium, Notaridou M, Quaye L, Dafou D, Jones C, Song H, Høgdall E, Kjaer SK, Christensen L, Høgdall C, Blaakaer J, McGuire V, Wu AH, Van Den Berg DJ, Pike MC, Gentry-Maharaj A, Wozniak E, Sher T, Jacobs IJ, Tyrer J, Schildkraut JM, Moorman PG, Iversen ES, Jakubowska A, Mędrek K, Lubiński J, Ness RB, Moysich KB, Lurie G, Wilkens LR, Carney ME, Wang-Gohrke S, Doherty JA, Rossing MA, Beckmann MW, Thiel FC, Ekici AB, Chen X, Beesley J, Australian Ovarian Cancer Study Group/Australian Cancer Study (Ovarian Cancer), Gronwald J, Fasching PA, Chang-Claude J, Goodman MT, Chenevix-Trench G, Berchuck A, Pearce CL, Whittemore AS, Menon U, Pharoah PD, Gayther SA, Ramus SJ, Ovarian Cancer Association Consortium. Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival.
Quaye L, Dafou D, Ramus SJ, Song H, Gentry-Maharaj A, Notaridou M, Hogdall E, Kjaer SK, Christensen L, Hogdall C, Easton DF, Jacobs I, Menon U, Pharoah PD, Gayther SA. | 03/25/2009 |
| plays a role in regulation of transcription due to genetic imprinting, sister chromatid exchange, chromosome segregation and as an insulator element. (review) | [Function of cohesin in transcription].
Maeshima K, Yoshida K, Shirahige K. | 01/21/2010 |
| identified as one of five genes containing 11 somatic mutations in a panel that included 132 colorectal cancers, then demonstrated that down-regulation of such homologs resulted in chromosomal instability and chromatid cohesion defects in human cells | Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers.
Barber TD, McManus K, Yuen KW, Reis M, Parmigiani G, Shen D, Barrett I, Nouhi Y, Spencer F, Markowitz S, Velculescu VE, Kinzler KW, Vogelstein B, Lengauer C, Hieter P., Free PMC Article | 01/21/2010 |