| Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19. | Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19.
Götz MP, Skjoedt MO, Bayarri-Olmos R, Hansen CB, Pérez-Alós L, Jarlhelt I, Benfield T, Rosbjerg A, Garred P., Free PMC Article | 01/3/2024 |
| MASP2 inhibition by narsoplimab suppresses endotheliopathies characteristic of transplant-associated thrombotic microangiopathy: in vitro and ex vivo evidence. | MASP2 inhibition by narsoplimab suppresses endotheliopathies characteristic of transplant-associated thrombotic microangiopathy: in vitro and ex vivo evidence.
Elhadad S, Redmond D, Huang J, Tan A, Laurence J., Free PMC Article | 11/3/2023 |
| Mannose-binding lectin gene 2 variant DD (rs 5030737) is associated with susceptibility to COVID-19 infection in the urban population of Patna City (India). | Mannose-binding lectin gene 2 variant DD (rs 5030737) is associated with susceptibility to COVID-19 infection in the urban population of Patna City (India).
Sharma S, Kumari B, Ali A, Patel PK, Sharma AK, Nair R, Singh PK, Hajela K., Free PMC Article | 08/25/2023 |
| l-ficolin-MASP arm of the complement system in schizophrenia. | l-ficolin-MASP arm of the complement system in schizophrenia.
Mayilyan KR, Krarup A, Soghoyan AF, Jensenius JC, Sim RB. | 03/8/2023 |
| Ficolin-3 and MASP-2 gene variants in Siberian arctic populations: Summarized evidence of selective pressure for the high frequency of lectin complement pathway deficiency. | Ficolin-3 and MASP-2 gene variants in Siberian arctic populations: Summarized evidence of selective pressure for the high frequency of lectin complement pathway deficiency.
Tereshchenko SY, Smolnikova MV, Freidin MB. | 02/28/2023 |
| Mannan-binding lectin serine protease-2 (MASP-2) in human kidney and its relevance for proteolytic activation of the epithelial sodium channel. | Mannan-binding lectin serine protease-2 (MASP-2) in human kidney and its relevance for proteolytic activation of the epithelial sodium channel.
Zachar R, Thiel S, Hansen S, Henriksen ML, Skjoedt MO, Skjodt K, Hamzaei Z, Madsen K, Lund L, Hummler E, Svenningsen P, Jensen BL., Free PMC Article | 10/15/2022 |
| Mannose binding lectin-associated serine protease 2 (MASP2) gene polymorphism and susceptibility to human T-lymphotropic virus type 1 (HTLV-1) infection in blood donors from Mashhad, Iran. | Mannose binding lectin-associated serine protease 2 (MASP2) gene polymorphism and susceptibility to human T-lymphotropic virus type 1 (HTLV-1) infection in blood donors from Mashhad, Iran.
Aghamohammadi A, Rafatpanah H, Maghsoodlu M, Tohidi N, Mollahosseini F, Shahabi M. | 10/15/2022 |
| Significance of Mannan Binding Lectin-Associated Serine Protease 2 in Urinary Extracellular Vesicles in IgA Nephropathy. | Significance of Mannan Binding Lectin-Associated Serine Protease 2 in Urinary Extracellular Vesicles in IgA Nephropathy.
Wu FWB, Chen YY, Huang JX, Wang KY, Xu HS, Lin D. | 10/1/2022 |
| High Levels of Complement Activating Enzyme MASP-2 Are Associated With the Risk of Future Incident Venous Thromboembolism. | High Levels of Complement Activating Enzyme MASP-2 Are Associated With the Risk of Future Incident Venous Thromboembolism.
Damoah CE, Snir O, Hindberg K, Garred P, Ludviksen JK, Brækkan SK, Morelli VM, Mollnes TE, Hansen JB, INVENT Consortium. | 09/3/2022 |
| Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation. | Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation.
Nagy ZA, Héja D, Bencze D, Kiss B, Boros E, Szakács D, Fodor K, Wilmanns M, Kocsis A, Dobó J, Gál P, Harmat V, Pál G., Free PMC Article | 07/2/2022 |
| Impact of MASP2 gene polymorphism and gene-tea drinking interaction on susceptibility to tuberculosis. | Impact of MASP2 gene polymorphism and gene-tea drinking interaction on susceptibility to tuberculosis.
Li Z, Wang M, Zhong H, Huang X, Wu X, Zhang X, Wang J, Deng J, Chen M, Chen L, Tan H., Free PMC Article | 10/30/2021 |
| The Role of Mannose-binding Lectin in Infectious Complications of Pediatric Hemato-Oncologic Diseases. | The Role of Mannose-binding Lectin in Infectious Complications of Pediatric Hemato-Oncologic Diseases.
Dobi M, Szilágyi Á, Csuka D, Varga L, Prohászka Z, Bereczki C, Kovács G, Fekete F. | 08/28/2021 |
| MASP2 levels are elevated in thrombotic microangiopathies: association with microvascular endothelial cell injury and suppression by anti-MASP2 antibody narsoplimab. | MASP2 levels are elevated in thrombotic microangiopathies: association with microvascular endothelial cell injury and suppression by anti-MASP2 antibody narsoplimab.
Elhadad S, Chapin J, Copertino D, Van Besien K, Ahamed J, Laurence J., Free PMC Article | 07/31/2021 |
| The Clinical Significance of Serum MASP-2 and IDH1 in the Early Diagnosis of Non-Small Cell Lung Cancer. | The Clinical Significance of Serum MASP-2 and IDH1 in the Early Diagnosis of Non-Small Cell Lung Cancer.
Chen Y, Wu ED, Ma S, Bai WQ, Yin YJ, Shi GL. | 07/24/2021 |
| Association of MASP2 levels and MASP2 gene polymorphisms with systemic lupus erythematosus. | Association of MASP2 levels and MASP2 gene polymorphisms with systemic lupus erythematosus.
Xu WD, Liu XY, Su LC, Huang AF., Free PMC Article | 05/8/2021 |
| Should MASP-2 Deficiency Be Considered a Primary Immunodeficiency? Relevance of the Lectin Pathway. | Should MASP-2 Deficiency Be Considered a Primary Immunodeficiency? Relevance of the Lectin Pathway.
García-Laorden MI, Hernández-Brito E, Muñoz-Almagro C, Pavlovic-Nesic S, Rúa-Figueroa I, Briones ML, Rajas O, Borderías L, Payeras A, Lorente L, Freixinet J, Ferreres J, Obando I, González-Quevedo N, Rodríguez de Castro F, Solé-Violán J, Rodríguez-Gallego C., Free PMC Article | 02/13/2021 |
| Sporotrichosis patients had decreased levels of MBL and MASP-2 in their serum samples compared with controls. Our findings linked, for the first time, MASP-2 deficiencies with susceptibility to Sporothrix sp. | Mannose-Binding Lectin and Mannose-Binding Lectin-Associated Serine Protease-2 Genotypes and Serum Levels in Patients with Sporotrichosis.
Bao F, Fu X, Yu G, Wang Z, Liu H, Zhang F., Free PMC Article | 03/28/2020 |
| that MASP-2 deficiency can increase susceptibility to adult Herpes simplex virus encephalitis | Herpes simplex encephalitis in adult patients with MASP-2 deficiency.
Bibert S, Piret J, Quinodoz M, Collinet E, Zoete V, Michielin O, Menasria R, Meylan P, Bihl T, Erard V, Fellmann F, Rivolta C, Boivin G, Bochud PY., Free PMC Article | 03/7/2020 |
| Novel MASP-2 inhibitors developed via directed evolution of human TFPI1 are potent lectin pathway inhibitors. | Novel MASP-2 inhibitors developed via directed evolution of human TFPI1 are potent lectin pathway inhibitors.
Szakács D, Kocsis A, Szász R, Gál P, Pál G., Free PMC Article | 12/14/2019 |
| The allele rs7567833G, the genotypes rs7567833AG and rs7567833GG, and the COLEC11*GGC haplotype were related to T. cruzi infection and clinical progression towards symptomatic Chagas Disease (CD). COLEC11 and MASP2*CD risk genotypes were associated with cardiomyopathy, suggesting that both loci act synergistically in immune modulation of the disease. | Human collectin-11 (COLEC11) and its synergic genetic interaction with MASP2 are associated with the pathophysiology of Chagas Disease.
Sandri TL, Andrade FA, Lidani KCF, Einig E, Boldt ABW, Mordmüller B, Esen M, Messias-Reason IJ., Free PMC Article | 09/21/2019 |
| MASP2, but not MBL in very low birth weight infants may indicate increased risk for late-onset infection | Mannose-binding lectin and mannose-binding protein-associated serine protease 2 levels and infection in very-low-birth-weight infants.
Hartz A, Schreiter L, Pagel J, Moser K, Wieg C, Grotheer A, Rupp J, Herting E, Göpel W, Härtel C. | 09/14/2019 |
| Comparative analysis of C4 alone, C4-Tryp, and C4-MASP2 revealed the impact of Tryp on C4 was similar as MASP2. | Insight into the intermolecular recognition mechanism involved in complement component 4 activation through serine protease-trypsin.
Sinha VK, Sharma OP, Kumar MS. | 01/12/2019 |
| High MAp19 concentration is associated with microalbuminuria in newly diagnosed type 1 diabetes. | Incident microalbuminuria and complement factor mannan-binding lectin-associated protein 19 in people with newly diagnosed type 1 diabetes.
Østergaard JA, Thiel S, Hoffmann-Petersen IT, Hovind P, Parving HH, Tarnow L, Rossing P, Hansen TK. | 04/28/2018 |
| The complement lectin pathway serine proteases, MASP-1 and MASP-2, can be associated with ischaemic stroke development risk and may participate in pathological events leading to post-ischaemic brain damage. Moreover rs3203210 and rs147270785 single nucleotide polymorphisms in the MASP1 and MASP2 genes, respectively, are strongly associated with ischaemic stroke. | Serine proteases of the complement lectin pathway and their genetic variations in ischaemic stroke.
Tsakanova G, Stepanyan A, Nahapetyan K, Sim RB, Arakelyan A, Boyajyan A. | 02/3/2018 |
| The results of this study show that MASP-2 contributes to severity and outcome in pneumococcal meningitis. In patients with pneumococcal meningitis, MASP-2 concentration was elevated in the CSF and high levels were associated with poor functional outcome. | Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis.
Kasanmoentalib ES, Valls Seron M, Ferwerda B, Tanck MW, Zwinderman AH, Baas F, van der Ende A, Schwaeble WJ, Brouwer MC, van de Beek D., Free PMC Article | 10/14/2017 |