| Analysis of the functional sequences in the promoter region of the human adhesion molecule close homolog of L1. | Analysis of the functional sequences in the promoter region of the human adhesion molecule close homolog of L1.
Yoo M, Kayastha N, Kwon O, Man W, Cai L, Schachner M. | 06/11/2022 |
| Expression of CHL1 in Clear Cell Renal Cell Carcinoma and its Association With Prognosis. | Expression of CHL1 in Clear Cell Renal Cell Carcinoma and its Association With Prognosis.
Qin M, Gao X, Luo W, Ou K, Lu H, Liu H, Zhuang Q. | 05/7/2022 |
| Reduced Expression of Chl1 gene Impairs Insulin Secretion by Down-Regulating the Expression of Key Molecules of beta-cell Function. | Reduced Expression of Chl1 gene Impairs Insulin Secretion by Down-Regulating the Expression of Key Molecules of β-cell Function.
Taneera J, Dhaiban S, Hachim M, Mohammed AK, Mukhopadhyay D, Bajbouj K, Hamoudi R, Salehi A, Hamad M. | 02/26/2022 |
| Exosomal miR-338-3p suppresses non-small-cell lung cancer cells metastasis by inhibiting CHL1 through the MAPK signaling pathway. | Exosomal miR-338-3p suppresses non-small-cell lung cancer cells metastasis by inhibiting CHL1 through the MAPK signaling pathway.
Tian W, Yang X, Yang H, Lv M, Sun X, Zhou B., Free PMC Article | 02/5/2022 |
| Cell adhesion molecule L1 like plays a role in the pathogenesis of idiopathic hypogonadotropic hypogonadism. | Cell adhesion molecule L1 like plays a role in the pathogenesis of idiopathic hypogonadotropic hypogonadism.
Chen Y, Sun T, Niu Y, Wang D, Liu K, Wang T, Wang S, Xu H, Liu J. | 12/25/2021 |
| Downregulation of Adhesion Molecule CHL1 in B Cells but Not T Cells of Patients with Major Depression and in the Brain of Mice with Chronic Stress. | Downregulation of Adhesion Molecule CHL1 in B Cells but Not T Cells of Patients with Major Depression and in the Brain of Mice with Chronic Stress.
Yang CR, Ning L, Zhou FH, Sun Q, Meng HP, Han Z, Liu Y, Huang W, Liu S, Li XH, Zheng B, Ming D, Zhou XF. | 08/21/2021 |
| Ezrin interacts with the tumor suppressor CHL1 and promotes neuronal differentiation of human neuroblastoma. | Ezrin interacts with the tumor suppressor CHL1 and promotes neuronal differentiation of human neuroblastoma.
Ognibene M, Pezzolo A., Free PMC Article | 03/6/2021 |
| CHL1 expression levels were significantly higher in ovarian endometriosis tissue than in eutopic endometrium. | Aberrant expression of CHL1 gene and long non-coding RNA CHL1-AS1, CHL1-AS2 in ovarian endometriosis.
Zhang C, Wu W, Ye X, Ma R, Luo J, Zhu H, Chang X. | 11/30/2019 |
| The prognostic significance of CHL1 makes it a potential prognostic and therapeutic target and underlines its role as a tumour suppressor. Further validation studies and functional analyses are needed to investigate its potential role in tumourigenesis and dissemination. | Protein expression of close homologue of L1 (CHL1) is a marker for overall survival in non-small cell lung cancer (NSCLC).
Hötzel J, Melling N, Müller J, Polonski A, Wolters-Eisfeld G, Izbicki JR, Karstens KF, Tachezy M. | 08/31/2019 |
| Results identified a new tumor suppressor, CHL1, located at 3p26 which was frequently deleted in esophageal squamous cells carcinoma (ESCC). Reduced expression of CHL1 correlated with poor differentiation, increased invasion, lymph-node metastasis, advanced tumor stage, and decreased overall survival. Further data support CHL1 as an important tumor suppressor with both anti-proliferation and anti-metastasis abilities. | Loss of cell adhesion molecule L1 like promotes tumor growth and metastasis in esophageal squamous cell carcinoma.
Tang H, Jiang L, Zhu C, Liu R, Wu Y, Yan Q, Liu M, Jia Y, Chen J, Qin Y, Lee VH, Luo S, Wang Q, Guan XY. | 05/18/2019 |
| Expression level of miR-21-5p increased in both colon adenocarcinoma (COAD) tissues and cells. The result of in vivo experiments showed that down-regulation of miR-21-5p decreased the volume and weight of tumor, while knockdown of CHLI stimulated tumor growth. The overexpression of miR-21-5p can promote propagation and invasiveness of (COAD) cells through inhibiting the expression of CHL1. | Overexpression of miR-21-5p promotes proliferation and invasion of colon adenocarcinoma cells through targeting CHL1.
Yu W, Zhu K, Wang Y, Yu H, Guo J., Free PMC Article | 01/19/2019 |
| CHL1 was found to have greater than 15-fold higher expression in fragments per kilobase million in HCC compared with benign Hurthle cell tumors. This was confirmed by qRT-PCR. Moreover, the immunoreactivity score of the CHL1 protein was significantly higher in HCC compared with benign Hurthle cell nodules. | CHL1 expression differentiates Hürthle cell carcinoma from benign Hürthle cell nodules.
Li W, Xia S, Aronova A, Min IM, Verma A, Scognamiglio T, Gray KD, Ullmann TM, Liang H, Moore MD, Elemento O, Zarnegar R, Fahey TJ. | 11/24/2018 |
| Results indicate that close homolog of L1 protein (CHL1) is downregulated by hypermethylation and that this epigenetic alteration is an independent prognostic factor in breast cancer (BC). | CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer.
Martín-Sánchez E, Mendaza S, Ulazia-Garmendia A, Monreal-Santesteban I, Blanco-Luquin I, Córdoba A, Vicente-García F, Pérez-Janices N, Escors D, Megías D, López-Serra P, Esteller M, Illarramendi JJ, Guerrero-Setas D., Free PMC Article | 08/26/2017 |
| CHL1 expression patient-derived lymphoblasts correlated with clinical outcome in depressive disorder patients. | CHL1, ITGB3 and SLC6A4 gene expression and antidepressant drug response: results from the Munich Antidepressant Response Signature (MARS) study.
Probst-Schendzielorz K, Scholl C, Efimkina O, Ersfeld E, Viviani R, Serretti A, Fabbri C, Gurwitz D, Lucae S, Ising M, Paul AM, Lehmann ML, Steffens M, Crisafulli C, Calabrò M, Holsboer F, Stingl J. | 03/19/2016 |
| our findings suggest that miR-590-5p acts as an oncogene by targeting the CHL1 gene and promotes cervical cancer proliferation | MicroRNA-590 promotes cervical cancer cell growth and invasion by targeting CHL1.
Chu Y, Ouyang Y, Wang F, Zheng A, Bai L, Han L, Chen Y, Wang H. | 11/8/2014 |
| There was no statistical association between polymorphisms of the CHL1 gene and idiopathic scoliosis in a Chinese population. | Lack of association between the CHL1 gene and adolescent idiopathic scoliosis susceptibility in Han Chinese: a case-control study.
Qiu XS, Lv F, Zhu ZZ, Qian BP, Wang B, Yu Y, Qiu Y., Free PMC Article | 10/4/2014 |
| Our data collectively indicate that miR-182 in PTC promotes cell proliferation and invasion through direct suppression of CHL1, supporting the potential utility of miR-182 inhibition as a novel therapeutic strategy against PTC. | miR-182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma.
Zhu H, Fang J, Zhang J, Zhao Z, Liu L, Wang J, Xi Q, Gu M. | 09/27/2014 |
| The rs2272522 polymorphism (in the CHL1 gene) was found to exhibit a highly significant association with schizophrenia in the Qatari population. | Significant association of close homologue of L1 gene polymorphism rs2272522 with schizophrenia in Qatar.
Shaltout TE, Alali KA, Bushra S, Alkaseri AM, Jose ED, Al-Khainji M, Saleh R, Salama Dahir A, Shaltout H, Al-Abdullah M, Rizk NM. | 07/5/2014 |
| In 1 of 113 Colombian children with refractory epilepsy, MLPA showed a subtelomeric duplication of exon 3 of CHL1, also present in 2 relatives. | [Detection of subtelomeric rearrangements due to MLPA in paediatric patients with refractory epilepsy in Colombia: the role of the CHL1 gene in pharmacoresistance].
Maradei-Anaya SJ, Espinosa E, Izquierdo Á, Velasco-Parra HM. | 06/28/2014 |
| CHL1 has a role in human breast tumorigenesis and progression | CHL1 is involved in human breast tumorigenesis and progression.
He LH, Ma Q, Shi YH, Ge J, Zhao HM, Li SF, Tong ZS. | 11/30/2013 |
| The miRNA miR-151-3p had 6.7-fold higher basal expression in paroxetine-sensitive LCLs. This corresponds with lower expression of CHL1, a target of miR-151-3p | Genome-wide miRNA expression profiling of human lymphoblastoid cell lines identifies tentative SSRI antidepressant response biomarkers.
Oved K, Morag A, Pasmanik-Chor M, Oron-Karni V, Shomron N, Rehavi M, Stingl JC, Gurwitz D. | 04/6/2013 |
| BACE1(-/-) axon guidance defects are likely the result of abrogated BACE1 processing of CHL1 and BACE1 deficiency produces a CHL1 loss-of-function phenotype | β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects.
Hitt B, Riordan SM, Kukreja L, Eimer WA, Rajapaksha TW, Vassar R., Free PMC Article | 02/2/2013 |
| miR-10a expression is upregulated in cervical cancer tissues, and miR-10a promotes cell growth, migration and invasion by targeting CHL1 in human cervical cancer cells. | MicroRNA-10a targets CHL1 and promotes cell growth, migration and invasion in human cervical cancer cells.
Long MJ, Wu FX, Li P, Liu M, Li X, Tang H. | 10/13/2012 |
| Overall, our study found a significant association of IL-17RC gene polymorphisms with AIS in a Chinese Han population, indicating IL-17RC gene may be as a susceptibility gene for AIS. | Association study of IL-17RC, CHL1, DSCAM and CNTNAP2 genes polymorphisms with adolescent idiopathic scoliosis susceptibility in a Chinese Han population.
Zhou S, Zhu Z, Qiu X, Wu W, Wang W, Liu Z, Lv F, Qiu Y. | 09/15/2012 |
| CHL1 is involved in the development of different human cancers. | Differential expression of CHL1 gene during development of major human cancers.
Senchenko VN, Krasnov GS, Dmitriev AA, Kudryavtseva AV, Anedchenko EA, Braga EA, Pronina IV, Kondratieva TT, Ivanov SV, Zabarovsky ER, Lerman MI., Free PMC Article | 07/9/2011 |