| Upregulation of IQGAP2 by EBV transactivator Rta and its influence on EBV life cycle. | Upregulation of IQGAP2 by EBV transactivator Rta and its influence on EBV life cycle.
Lin KM, Weng LF, Chen SJ, Lin SJ, Tsai CH., Free PMC Article | 09/6/2023 |
| IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL. | IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL.
Tang T, Wang J, Zhang L, Cheng Y, Saleh L, Gu Y, Zhang H., Free PMC Article | 10/23/2021 |
| Reduced IQGAP2 expression promotes EMT and inhibits apoptosis by modulating the MEK-ERK and p38 signaling in breast cancer irrespective of ER status. | Reduced IQGAP2 expression promotes EMT and inhibits apoptosis by modulating the MEK-ERK and p38 signaling in breast cancer irrespective of ER status.
Kumar D, Patel SA, Hassan MK, Mohapatra N, Pattanaik N, Dixit M., Free PMC Article | 10/16/2021 |
| Circular RNA sequencing indicates circ-IQGAP2 and circ-ZC3H6 as noninvasive biomarkers of primary Sjogren's syndrome. | Circular RNA sequencing indicates circ-IQGAP2 and circ-ZC3H6 as noninvasive biomarkers of primary Sjögren's syndrome.
Li F, Liu Z, Zhang B, Jiang S, Wang Q, Du L, Xue H, Zhang Y, Jin M, Zhu X, Brown MA, Wu J, Wang X. | 02/2/2021 |
| IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity. | IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity.
Xu L, Shao Y, Ren L, Liu X, Li Y, Xu J, Ye Y., Free PMC Article | 12/5/2020 |
| Data suggest that CDC42 binding to Ex-domain of IQGAP2 releases Ex-domain at C-terminal region of GRD2 domain, facilitating IQGAP2 dimerization; this promotes allosteric changes in ras GTPase-activating protein binding site providing binding site for second CDC42; RAC1 binds only to apo-IQGAP2. (IQGAP2 = IQ motif containing GTPase activating protein-2; CDC42 = GTP-binding protein CDC42; RAC1 = Rac family small GTPase-1) | Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2.
Ozdemir ES, Jang H, Gursoy A, Keskin O, Li Z, Sacks DB, Nussinov R., Free PMC Article | 01/12/2019 |
| IQGAP2 expression correlated positively with survivability, on the contrary, IQGAP3 expression levels correlated inversely with survivability | Reduced expression of IQGAP2 and higher expression of IQGAP3 correlates with poor prognosis in cancers.
Kumar D, Hassan MK, Pattnaik N, Mohapatra N, Dixit M., Free PMC Article | 11/11/2017 |
| The structural basis for Cdc42-induced dimerization of IQGAP1 and IQGAP2 has been uncovered. | The Structural Basis for Cdc42-Induced Dimerization of IQGAPs.
LeCour L Jr, Boyapati VK, Liu J, Li Z, Sacks DB, Worthylake DK., Free PMC Article | 10/7/2017 |
| The most frequently identified and connected to preterm birth genes in the exome library were IGF1, ATM and IQGAP2. | Targeted Sequencing and Meta-Analysis of Preterm Birth.
Uzun A, Schuster J, McGonnigal B, Schorl C, Dewan A, Padbury J., Free PMC Article | 07/8/2017 |
| IQGAP2 TagSNP rs457717 (A/G) was not associated with Age-Related Hearing impairment in Han male Chinese population. | The European GWAS-identified risk SNP rs457717 within IQGAP2 is not associated with age-related hearing impairment in Han male Chinese population.
Luo H, Wu H, Shen H, Chen H, Yang T, Huang Z, Jin X, Pang X, Li L, Hu X, Jiang X, Fan Z, Li J. | 03/4/2017 |
| Thus, these data identified IQGAP2 as a novel tumor suppressor for ovarian cancer to inhibit cell invasion through regulating Wnt/b-catenin signaling, and provided a new biomarker and potential therapeutic strategy for this disease. | Epigenetic regulation of IQGAP2 promotes ovarian cancer progression via activating Wnt/β-catenin signaling.
Deng Z, Wang L, Hou H, Zhou J, Li X. | 09/24/2016 |
| we identified IQGAP2 as a human and zebrafish podocyte gene product that is downregulated in microarray data sets from kidney biopsies of human patients with focal segmental glomerulosclerosis and minimal change nephrotic syndrome. | The Rho-GTPase binding protein IQGAP2 is required for the glomerular filtration barrier.
Sugano Y, Lindenmeyer MT, Auberger I, Ziegler U, Segerer S, Cohen CD, Neuhauss SC, Loffing J. | 09/10/2016 |
| Data show that IQ motif-containing GTPase-activating protein 2 (IQGAP2) expression is altered in colitis. | IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice.
Ghaleb AM, Bialkowska AB, Snider AJ, Gnatenko DV, Hannun YA, Yang VW, Schmidt VA., Free PMC Article | 04/9/2016 |
| IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardiovascular system, pancreas, and lung. (Review) | The biology of IQGAP proteins: beyond the cytoskeleton.
Hedman AC, Smith JM, Sacks DB., Free PMC Article | 12/26/2015 |
| Mammalian IQGAP proteins may play a role in cytokinesis by regulating the localization of key cytokinesis regulatory proteins to the contractile apparatus during mitosis. | Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis.
Adachi M, Kawasaki A, Nojima H, Nishida E, Tsukita S. | 05/16/2015 |
| Low IQGAP2 expression was associated with hepatocellular carcinoma. | Differential expression of IQGAP1/2 in Hepatocellular carcinoma and its relationship with clinical outcomes.
Xia FD, Wang ZL, Chen HX, Huang Y, Li JD, Wang ZM, Li XY. | 03/7/2015 |
| The first IQ-motifs from IQGAP2 and IQGAP3 form transient interactions with calmodulin in the absence of calcium. | IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain.
Atcheson E, Hamilton E, Pathmanathan S, Greer B, Harriott P, Timson DJ., Free PMC Article | 01/17/2015 |
| observations strongly indicate that IQGAP2 is a surveillance type of tumour suppressor for prostate cancer | IQGAP2, A candidate tumour suppressor of prostate tumorigenesis.
Xie Y, Yan J, Cutz JC, Rybak AP, He L, Wei F, Kapoor A, Schmidt VA, Tao L, Tang D. | 09/29/2012 |
| increased IQGAP1 and/or decreased IQGAP2 contribute to the pathogenesis of human HCC. | IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma.
White CD, Khurana H, Gnatenko DV, Li Z, Odze RD, Sacks DB, Schmidt VA., Free PMC Article | 02/5/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesInvestigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 09/15/2010 |
| The top-ranked SNP, rs457717 for association with age-related hearing impairment(P-value 3.55 x 10(-7)), was localised in an intron of the IQ motif-containing GTPase-activating-like protein (IQGAP2). | A genome-wide association study for age-related hearing impairment in the Saami.
Van Laer L, Huyghe JR, Hannula S, Van Eyken E, Stephan DA, Mäki-Torkko E, Aikio P, Fransen E, Lysholm-Bernacchi A, Sorri M, Huentelman MJ, Van Camp G, Van Laer L, Huyghe JR, Hannula S, Van Eyken E, Stephan DA, Mäki-Torkko E, Aikio P, Fransen E, Lysholm-Bernacchi A, Sorri M, Huentelman MJ, Van Camp G., Free PMC Articles: PMC2987344, PMC2987344 | 09/13/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | A genome-wide association study for age-related hearing impairment in the Saami.
Van Laer L, Huyghe JR, Hannula S, Van Eyken E, Stephan DA, Mäki-Torkko E, Aikio P, Fransen E, Lysholm-Bernacchi A, Sorri M, Huentelman MJ, Van Camp G, Van Laer L, Huyghe JR, Hannula S, Van Eyken E, Stephan DA, Mäki-Torkko E, Aikio P, Fransen E, Lysholm-Bernacchi A, Sorri M, Huentelman MJ, Van Camp G., Free PMC Articles: PMC2987344, PMC2987344 | 04/7/2010 |
| silencing of IQGAP2 by promoter methylation may contribute to gastric cancer development. | IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells.
Jin SH, Akiyama Y, Fukamachi H, Yanagihara K, Akashi T, Yuasa Y. | 01/21/2010 |