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    CGA glycoprotein hormones, alpha polypeptide [ Homo sapiens (human) ]

    Gene ID: 1081, updated on 28-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Prevalence and predictors of colonoscopic findings in patients with autoimmune gastritis.

    Prevalence and predictors of colonoscopic findings in patients with autoimmune gastritis.
    Asfuroglu Kalkan E, Kalkan C, Gumussoy M, Gucbey O, Soykan I.

    04/2/2022
    Myocardial perfusion SPECT as a potential mediator on circulating chromogranin A in patients with old myocardial infarction.

    Myocardial perfusion SPECT as a potential mediator on circulating chromogranin A in patients with old myocardial infarction.
    Xourgia X, Tsiouris S, Kolettis T, Goudevenos I, Arseniou A, Fotopoulos AD.

    01/22/2022
    Analysis of the human chorionic gonadotropin protein at the intact level by HILIC-MS and comparison with RPLC-MS.

    Analysis of the human chorionic gonadotropin protein at the intact level by HILIC-MS and comparison with RPLC-MS.
    Camperi J, Combès A, Fournier T, Pichon V, Delaunay N.

    02/6/2021
    GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer.

    GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer.
    Zhou W, Brumpton B, Kabil O, Gudmundsson J, Thorleifsson G, Weinstock J, Zawistowski M, Nielsen JB, Chaker L, Medici M, Teumer A, Naitza S, Sanna S, Schultheiss UT, Cappola A, Karjalainen J, Kurki M, Oneka M, Taylor P, Fritsche LG, Graham SE, Wolford BN, Overton W, Rasheed H, Haug EB, Gabrielsen ME, Skogholt AH, Surakka I, Davey Smith G, Pandit A, Roychowdhury T, Hornsby WE, Jonasson JG, Senter L, Liyanarachchi S, Ringel MD, Xu L, Kiemeney LA, He H, Netea-Maier RT, Mayordomo JI, Plantinga TS, Hrafnkelsson J, Hjartarson H, Sturgis EM, Palotie A, Daly M, Citterio CE, Arvan P, Brummett CM, Boehnke M, de la Chapelle A, Stefansson K, Hveem K, Willer CJ, Åsvold BO., Free PMC Article

    09/12/2020
    hCG and IL-35 induced the amplification of IL10(+) and IL-35(+) B regulatory cells which played a vital peripheral regulatory role during pregnancy.

    Human chorionic gonadotropin and IL-35 contribute to the maintenance of peripheral immune tolerance during pregnancy through mediating the generation of IL-10(+) or IL-35(+) Breg cells.
    Liu J, Chen X, Hao S, Zhao H, Pang L, Wang L, Ren H, Wang C, Mao H.

    07/4/2020
    TSH level was found to be independently correlated with both carotid plaque prevalence and intima-media thickness.

    Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques.
    Yang C, Lu M, Chen W, He Z, Hou X, Feng M, Zhang H, Bo T, Zhou X, Yu Y, Zhang H, Zhao M, Wang L, Yu C, Gao L, Jiang W, Zhang Q, Zhao J., Free PMC Article

    05/9/2020
    the present results clearly demonstrated that NF-kappaB was activated to regulate VEGF expression by increasing HIF-1alpha transcription in luteal cells treated with HCG.

    Activation of NF-κB signaling pathway during HCG-induced VEGF expression in luteal cells.
    Zhang Z, Huang Y, Zhang J, Liu Z, Lin Q, Wang Z.

    06/1/2019
    The measured hCG values are considerably different depending on the pregnancy result, which is why this value is considered a quality predictive factor of the pregnancy result.

    HCG level after embryo transfer as a prognostic indicator of pregnancy finished with delivery.
    Zbořilová B, Březinová J, Tkadlec E, Procházka M, Oborná I, Sobek A Jr, Sobek A.

    06/1/2019
    Sex, age, season, and sampling time significantly affected serum TSH concentrations.

    Effects of sex, age, sampling time, and season on thyroid-stimulating hormone concentrations: A retrospective study.
    Wang D, Li D, Guo X, Yu S, Qiu L, Cheng X, Xu T, Li H, Liu H.

    05/25/2019
    These results suggested that the melatonin receptors MTNR1A and MTNR1B are essential to repress hCG-induced endoplasmic reticulum stress and cell apoptosis.

    Melatonin receptor depletion suppressed hCG-induced testosterone expression in mouse Leydig cells.
    Gao Y, Wu X, Zhao S, Zhang Y, Ma H, Yang Z, Yang W, Zhao C, Wang L, Zhang Q., Free PMC Article

    05/18/2019
    GDF9 promoted follicle-stimulating hormone (FSH)-induced progesterone production and STAR expression.

    Growth differentiation factor 9 promotes follicle-stimulating hormone-induced progesterone production in chicken follicular granulosa cells.
    Li J, Luo W, Huang T, Gong Y.

    05/18/2019
    the hCG-hyperglycosylated is functionally similar to hCG, although it has lower potency for LHCGR activation.

    Hyperglycosylated hCG activates LH/hCG-receptor with lower activity than hCG.
    Koistinen H, Koel M, Peters M, Rinken A, Lundin K, Tuuri T, Tapanainen JS, Alfthan H, Salumets A, Stenman UH, Lavogina D.

    05/18/2019
    Serum levels of chromogranin A are not predictive of high-grade, poorly differentiated prostate cancer: results from an Italian biopsy cohort.

    Serum levels of chromogranin A are not predictive of high-grade, poorly differentiated prostate cancer: results from an Italian biopsy cohort.
    De Nunzio C, Albisinni S, Presicce F, Lombardo R, Cancrini F, Tubaro A.

    04/22/2019
    Corifollitropin alfa in combination with daily GnRH[Gonadotropin-Releasing Hormone] antagonist can be successfully used in normal-responder patients stimulated for the first time in an IVF programme

    [Corifollitropin alfa in women stimulated for the first time in in vitro fertilization programme].
    Vraná-Mardešićová N, Vobořil J, Melicharová L, Jelínková L, Vilímová Š, Mardešić T.

    04/20/2019
    This study which performed for the first time in Iran suggests that polymorphism in CGA gene can affect male infertility.

    Association of T/A polymorphism in miR-1302 binding site in CGA gene with male infertility in Isfahan population.
    Jamalvandi M, Motovali-Bashi M, Amirmahani F, Darvishi P, Jamshidi Goharrizi K.

    10/6/2018
    Our findings support a model in which CREB3L1 acts as a downstream effector of TSH to regulate the expression of cargo proteins, and simultaneously increases the synthesis of transport factors and the expansion of the Golgi to synchronize the rise in cargo load with the amplified capacity of the secretory pathway

    CREB3L1-mediated functional and structural adaptation of the secretory pathway in hormone-stimulated thyroid cells.
    García IA, Torres Demichelis V, Viale DL, Di Giusto P, Ezhova Y, Polishchuk RS, Sampieri L, Martinez H, Sztul E, Alvarez C., Free PMC Article

    07/21/2018
    men with higher and women with lower serum TSH levels are at increased risk of frailty.

    Serum Thyroid-Stimulating Hormone Levels and Frailty in the Elderly: The Progetto Veneto Anziani Study.
    Veronese N, Fernando-Watutantrige S, Maggi S, Noale M, Stubbs B, Incalzi RA, Zambon S, Corti MC, Perissinotto E, Crepaldi G, Manzato E, Sergi G.

    03/24/2018
    Inhibin-B secretion and FSH isoform distribution may play an integral part of follicular selection in the natural menstrual cycle. (Review)

    Inhibin-B secretion and FSH isoform distribution may play an integral part of follicular selection in the natural menstrual cycle.
    Yding Andersen C.

    02/10/2018
    proteomic study reveals unique protein changes in both cellular (98% unique identifications) and secreted (96% unique identifications) proteins in the transition to the progesterone-dominated secretory (receptive) phase and subsequently to pregnancy, mediated by embryo-derived human chorionic gonadotropin (hCG)

    Modulating the endometrial epithelial proteome and secretome in preparation for pregnancy: The role of ovarian steroid and pregnancy hormones.
    Greening DW, Nguyen HP, Evans J, Simpson RJ, Salamonsen LA.

    11/25/2017
    the in vivo bioactivities of FSH glycoforms in Fshb null mice using a pharmacological rescue approach, was investigated.

    Evaluation of in vivo bioactivities of recombinant hypo- (FSH(21/18)) and fully- (FSH(24)) glycosylated human FSH glycoforms in Fshb null mice.
    Wang H, May J, Butnev V, Shuai B, May JV, Bousfield GR, Kumar TR., Free PMC Article

    11/11/2017
    In girls with central precocious puberty, increased body mass index (BMI) was associated with slightly lower peak stimulated luteinizing hormone (LH) levels at early pubertal stages (Tanner stages 2 and 3).

    Luteinizing Hormone Secretion during Gonadotropin-Releasing Hormone Stimulation Tests in Obese Girls with Central Precocious Puberty.
    Lee HS, Yoon JS, Hwang JS., Free PMC Article

    04/22/2017
    the distribution of 1(st) trimester TSH and evaluate its association with perinatal outcomes and future development of maternal thyrotoxicosis, is reported.

    Maternal First Trimester TSH Concentrations: Do They Affect Perinatal and Endocrine Outcomes?
    Fraenkel M, Shafat T, Erez O, Lichtenstein Y, Awesat J, Novack V, Tsur A.

    03/11/2017
    The present results have for the first time shown protective effects exerted by hCG on vascular endothelial function.

    Human Chorionic Gonadotropin Protects Vascular Endothelial Cells from Oxidative Stress by Apoptosis Inhibition, Cell Survival Signalling Activation and Mitochondrial Function Protection.
    Surico D, Farruggio S, Marotta P, Raina G, Mary D, Surico N, Vacca G, Grossini E.

    05/28/2016
    Human chorionic gonadotropin provides a mechanism to bridge embryo to endometrium through beta1,4-GalT.

    HCG induces β1,4-GalT I expression and promotes embryo implantation.
    Chen L, Xie Y, Fan J, Sui L, Xu Y, Zhang N, Ma Y, Li Y, Kong Y., Free PMC Article

    04/23/2016
    thyroid-stimulating hormone elevations can obviously be the initial finding in pseudohypoparathyroidism type Ib patients.

    TSH elevations as the first laboratory evidence for pseudohypoparathyroidism type Ib (PHP-Ib).
    Molinaro A, Tiosano D, Takatani R, Chrysis D, Russell W, Koscielniak N, Kottler ML, Agretti P, De Marco G, Ahtiainen P, Christov M, Mäkitie O, Tonacchera M, Jüppner H., Free PMC Article

    03/19/2016
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