| Pretreatment controlling nutritional status (CONUT) score and carcinoembryonic antigen level provide tumor progression and prognostic information in gastric cancer: A retrospective study. | Pretreatment controlling nutritional status (CONUT) score and carcinoembryonic antigen level provide tumor progression and prognostic information in gastric cancer: A retrospective study.
Chen X, Chen C, Huang L, Wu P., Free PMC Article | 01/11/2024 |
| Diffusion-weighted magnetic resonance sequence and CA125/CEA ratio can be used as add-on tools to ultrasound for the differentiation of ovarian from non-ovarian pelvic masses. | Diffusion-weighted magnetic resonance sequence and CA125/CEA ratio can be used as add-on tools to ultrasound for the differentiation of ovarian from non-ovarian pelvic masses.
Nunes Pereira P, Françoise Derchain S, Yoshida A, Hoelz de Oliveira Barros R, Menezes Jales R, Sarian LO., Free PMC Article | 04/4/2023 |
| Phagocytosis mediated by the human granulocyte receptor CEACAM3 is limited by the receptor-type protein tyrosine phosphatase PTPRJ. | Phagocytosis mediated by the human granulocyte receptor CEACAM3 is limited by the receptor-type protein tyrosine phosphatase PTPRJ.
Goob G, Adrian J, Cossu C, Hauck CR., Free PMC Article | 10/22/2022 |
| Antibody ligation of CEACAM1, CEACAM3, and CEACAM6, differentially enhance the cytokine release of human neutrophils in responses to Candida albicans. | Antibody ligation of CEACAM1, CEACAM3, and CEACAM6, differentially enhance the cytokine release of human neutrophils in responses to Candida albicans.
Klaile E, Prada Salcedo JP, Klassert TE, Besemer M, Bothe AK, Durotin A, Müller MM, Schmitt V, Luther CH, Dittrich M, Singer BB, Dandekar T, Slevogt H. | 02/26/2022 |
| CEACAM3 decreases asthma exacerbations and modulates respiratory syncytial virus latent infection in children. | CEACAM3 decreases asthma exacerbations and modulates respiratory syncytial virus latent infection in children.
Tsai CH, Wu AC, Chiang BL, Yang YH, Hung SP, Su MW, Chang YJ, Lee YL. | 12/26/2020 |
| Amino acid alterations found in CEACAM3 translate into characteristic binding patterns for bacterial adhesins. One such amino acid residue is F62 in human and chimp CEACAM3, which is critical for binding the OMP P1 adhesin of Haemophilus aegyptius. Incorporation of the F62-containing motif into gorilla CEACAM3 results in a gain-of-function phenotype with regard to phagocytosis of H. aegyptius. | Adaptation to Host-Specific Bacterial Pathogens Drives Rapid Evolution of a Human Innate Immune Receptor.
Adrian J, Bonsignore P, Hammer S, Frickey T, Hauck CR. | 03/7/2020 |
| High serum CEA expression is associated with systemic recurrence in colorectal cancer. | Serum carcinoembryonic antigen to predict recurrence in the follow-up of patients with colorectal cancer.
Ramphal W, Boeding JRE, van Iwaarden M, Schreinemakers JMJ, Rutten HJT, Crolla RMPH, Gobardhan PD. | 09/14/2019 |
| the findings reveal an integration of the specific innate immune receptor CEACAM3 into the network of more conventional pattern recognition receptors, providing a mechanism by which the innate immune system can unleash its response to a relentless pathogen. | Bcl10 synergistically links CEACAM3 and TLR-dependent inflammatory signalling.
Sintsova A, Guo CX, Sarantis H, Mak TW, Glogauer M, Gray-Owen SD. | 08/4/2018 |
| Here, the authors identify members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as receptors of Helicobacter pylori and show that HopQ is the surface-exposed adhesin that specifically binds human CEACAM1, CEACAM3, CEACAM5 and CEACAM6. | Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs.
Javaheri A, Kruse T, Moonens K, Mejías-Luque R, Debraekeleer A, Asche CI, Tegtmeyer N, Kalali B, Bach NC, Sieber SA, Hill DJ, Königer V, Hauck CR, Moskalenko R, Haas R, Busch DH, Klaile E, Slevogt H, Schmidt A, Backert S, Remaut H, Singer BB, Gerhard M. | 01/27/2018 |
| Helicobacter pylori HopQ binds the amino-terminal IgV-like domain of human CEACAM1, CEACAM3, CEACAM5 or CEACAM6 proteins, thereby enabling translocation of the major pathogenicity factor CagA into host cells. | Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA.
Königer V, Holsten L, Harrison U, Busch B, Loell E, Zhao Q, Bonsor DA, Roth A, Kengmo-Tchoupa A, Smith SI, Mueller S, Sundberg EJ, Zimmermann W, Fischer W, Hauck CR, Haas R. | 01/27/2018 |
| CEACAM3 signalling in neutrophils is able to specifically modulate airway inflammation caused by infection with M. catarrhalis. | Moraxella catarrhalis induces CEACAM3-Syk-CARD9-dependent activation of human granulocytes.
Heinrich A, Heyl KA, Klaile E, Müller MM, Klassert TE, Wiessner A, Fischer K, Schumann RR, Seifert U, Riesbeck K, Moter A, Singer BB, Bachmann S, Slevogt H., Free PMC Article | 06/10/2017 |
| We demonstrate that recombinant Neisseria Opa proteins reconstituted into liposomes retain the ability to recognize and interact with CEACAM1 and 3 in vitro but do not maintain receptor specificity compared to that of Opa proteins natively expressed by Neisseria gonorrhoeae. | Neisserial Opa Protein-CEACAM Interactions: Competition for Receptors as a Means of Bacterial Invasion and Pathogenesis.
Martin JN, Ball LM, Solomon TL, Dewald AH, Criss AK, Columbus L., Free PMC Article | 05/13/2017 |
| Opacity protein OpaI of Neisseria gonorrhoeae in lipooligosaccharide mutants lost ability to interact with neutrophil-restricted CEACAM3. | Opacity proteins of neisseria gonorrhoeae in lipooligosaccharide mutants lost ability to interact with neutrophil-restricted CEACAM3 (CD66d).
Zhang S, Tu YT, Cai HH, Ding HH, Li Q, He YX, Liu XX, Wang X, Hu F, Chen T, Chen HX. | 04/8/2017 |
| p-CEA measurement in patients with pleural effusion of uncertain etiology is a safe and cost-effective procedure, everywhere easily available, which may help clinicians in selecting patients for further evaluations | Evaluation of predictive value of pleural CEA in patients with pleural effusions and histological findings: A prospective study and literature review.
Tozzoli R, Basso SM, D'Aurizio F, Metus P, Lumachi F. | 02/18/2017 |
| Demonstrated the CEACAM3 specificity and a perioperative trend of circulating tumor cells which is coherent with the clinical/pathological considerations in colorectal cancer. | The Trend of CEACAM3 Blood Expression as Number Index of the CTCs in the Colorectal Cancer Perioperative Course.
Taddei A, Castiglione F, Ringressi MN, Niccolai E, Tofani L, Boni L, Bechi P, Amedei A., Free PMC Article | 11/5/2016 |
| COLIV is a promising tumour marker for CLM and can possibly be used to detect postoperative CLM recurrence. The combination of COLIV and CEA is superior to either marker alone in detecting CLM | Improved tumour marker sensitivity in detecting colorectal liver metastases by combined type IV collagen and CEA measurement.
Nyström H, Tavelin B, Björklund M, Naredi P, Sund M., Free PMC Article | 04/30/2016 |
| The higher expression of CD44v6, integrin-beta1, CA199, and CEA are closely related to the progression and metastasis of pancreatic cancer.[CA199, CD44v6] | The efficacy evaluation of cryosurgery in pancreatic cancer patients with the expression of CD44v6, integrin-β1, CA199, and CEA.
Zhou G, Chiu D, Qin D, Niu L, Cai J, He L, Huang W, Xu K. | 02/26/2016 |
| A failure of CEACAM3-mediated innate immune detection might be linked to the ability of gonococci to cause disseminated infections. | Innate recognition by neutrophil granulocytes differs between Neisseria gonorrhoeae strains causing local or disseminating infections.
Roth A, Mattheis C, Muenzner P, Unemo M, Hauck CR., Free PMC Article | 08/31/2013 |
| Grb14 is the first negative regulator of CEACAM3-initiated bacterial phagocytosis and might help to focus granulocyte responses to the subcellular sites of pathogen-host cell contact | Grb14 is a negative regulator of CEACAM3-mediated phagocytosis of pathogenic bacteria.
Kopp K, Buntru A, Pils S, Zimmermann T, Frank R, Zumbusch A, Hauck CR., Free PMC Article | 02/2/2013 |
| CEACAM3 promotes opsonin-independent phagocytosis of CEACAM-binding bacteria. CEACAM3 is the main driver for this process on human granulocytes. | HemITAM signaling by CEACAM3, a human granulocyte receptor recognizing bacterial pathogens.
Buntru A, Roth A, Nyffenegger-Jann NJ, Hauck CR. | 08/25/2012 |
| The authors show that the expression of CEACAM1 and CEACAM6 potentiate CEACAM3-dependent responses of neutrophils, exposing a cooperative role for this family of proteins during neisserial infection of neutrophils. | Defining the roles of human carcinoembryonic antigen-related cellular adhesion molecules during neutrophil responses to Neisseria gonorrhoeae.
Sarantis H, Gray-Owen SD., Free PMC Article | 02/18/2012 |
| the prognostic value of preoperative serum carbohydrate antigen19-9, carcinoembryonic antigen, and carbohydrate antigen 125 for overall survival in patients with colorectal cancer was studied | Preoperative serum carbohydrate antigen 125 level is an independent negative prognostic marker for overall survival in colorectal cancer.
Yang XQ, Li Y, Chen C, Peng CW, Liu SP, Liu Y. | 01/21/2012 |
| the ability of CEACAM3 to coordinate signaling events that not only mediate bacterial uptake, but also trigger the killing of internalized pathogens. | Phosphatidylinositol 3'-kinase activity is critical for initiating the oxidative burst and bacterial destruction during CEACAM3-mediated phagocytosis.
Buntru A, Kopp K, Voges M, Frank R, Bachmann V, Hauck CR., Free PMC Article | 05/21/2011 |
| CEACAM6 and a regulatory element near the 3' end of CEACAM3 are associated with cystic fibrosis disease severity and intrapair discordance | Hierarchical fine mapping of the cystic fibrosis modifier locus on 19q13 identifies an association with two elements near the genes CEACAM3 and CEACAM6.
Stanke F, Becker T, Hedtfeld S, Tamm S, Wienker TF, Tümmler B. | 05/7/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |