| CSF1R and HCST: Novel Candidate Biomarkers Predicting the Response to Immunotherapy in Non-Small Cell Lung Cancer. | CSF1R and HCST: Novel Candidate Biomarkers Predicting the Response to Immunotherapy in Non-Small Cell Lung Cancer.
Qi X, Qi C, Wu T, Hu Y., Free PMC Article | 11/6/2021 |
| NKG2D-DAP10 signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity. | NKG2D-DAP10 signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity.
Wilton KM, Overlee BL, Billadeau DD., Free PMC Article | 09/26/2020 |
| These results suggest that NKG2D-DAP10 endocytosis represents a means to decrease cell surface receptor abundance, as well as to control signaling outcome in cytotoxic lymphocytes. | Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells.
Quatrini L, Molfetta R, Zitti B, Peruzzi G, Fionda C, Capuano C, Galandrini R, Cippitelli M, Santoni A, Paolini R. | 09/10/2016 |
| findings indicate that the functional interaction between RAGE and DAP10 coordinately regulates S100A8/A9-mediated survival and/or apoptotic response of keratinocytes | DNAX-activating protein 10 (DAP10) membrane adaptor associates with receptor for advanced glycation end products (RAGE) and modulates the RAGE-triggered signaling pathway in human keratinocytes.
Sakaguchi M, Murata H, Aoyama Y, Hibino T, Putranto EW, Ruma IM, Inoue Y, Sakaguchi Y, Yamamoto K, Kinoshita R, Futami J, Kataoka K, Iwatsuki K, Huh NH., Free PMC Article | 12/20/2014 |
| TGF-beta1 may reduce the expression of NKG2D/DAP10 and 2B4/SAPin patients with hepatitis B. | TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence.
Sun C, Fu B, Gao Y, Liao X, Sun R, Tian Z, Wei H., Free PMC Article | 07/14/2012 |
| HMBOX1 negatively regulates the expression of NKG2D and the activation of the NKG2D/DAP10 signaling pathway in NK cells. | HMBOX1 negatively regulates NK cell functions by suppressing the NKG2D/DAP10 signaling pathway.
Wu L, Zhang C, Zhang J., Free PMC Article | 01/14/2012 |
| Other gamma(c) cytokines act similarly to IL-2 in up-regulating DAP10 expression and NKG2D-DAP10 surface expression. | Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the γc cytokines and TGF-β1.
Park YP, Choi SC, Kiesler P, Gil-Krzewska A, Borrego F, Weck J, Krzewski K, Coligan JE., Free PMC Article | 11/26/2011 |
| TGF-BETA1 down-modulates surface NKG2D expression by controlling the transcriptional and translational levels of DAP10. | A possible mechanism of impaired NK cytotoxicity in cancer patients: down-regulation of DAP10 by TGF-beta1.
Lee JC, Lee KM, Ahn YO, Suh B, Heo DS. | 08/27/2011 |
| A transgenic mouse model demonstrates that induction of tolerance in Ly49H-positive natural killer (NK) cells by chronic exposure to virus-encoded ligand m157 requires signaling through the Ly49H adaptor protein DAP12, not the DAP10 adaptor protein. | Activation receptor-induced tolerance of mature NK cells in vivo requires signaling through the receptor and is reversible.
Bolanos FD, Tripathy SK., Free PMC Article | 05/21/2011 |
| the rapid degradation of NKG2D/DAP10 observed coincident with recruitment of the receptor to the cytotoxic immune synapse may explain the loss of NKG2D receptor expression after chronic exposure to NKG2D ligands | The traffic of the NKG2D/Dap10 receptor complex during natural killer (NK) cell activation.
Roda-Navarro P, Reyburn HT., Free PMC Article | 01/21/2010 |
| Downstream targets of DAP10 and DAP12 are constitutively activated in large granular lymphocyte leukemia cells, and expression of dominant-negative DAP10 and DAP12 dramatically reduces their lytic capacity. | A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia.
Chen X, Bai F, Sokol L, Zhou J, Ren A, Painter JS, Liu J, Sallman DA, Chen YA, Yoder JA, Djeu JY, Loughran TP, Epling-Burnette PK, Wei S., Free PMC Article | 01/21/2010 |
| NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway. | NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway.
Billadeau DD, Upshaw JL, Schoon RA, Dick CJ, Leibson PJ. | 01/21/2010 |
| both activated and expanded CD8+ T cells and NK cells use DAP10 for cytolysis | Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells.
Karimi M, Cao TM, Baker JA, Verneris MR, Soares L, Negrin RS. | 01/21/2010 |