| SUB1 promotes colorectal cancer metastasis by activating NF-kappaB signaling via UBR5-mediated ubiquitination of UBXN1. | SUB1 promotes colorectal cancer metastasis by activating NF-κB signaling via UBR5-mediated ubiquitination of UBXN1.
Wang H, Chen W, Wang Y, Gao Y, Zhang Z, Mi S, Wang L, Xue M. | 10/25/2024 |
| HMGB3 and SUB1 Bind to and Facilitate the Repair of N[2]-Alkylguanine Lesions in DNA. | HMGB3 and SUB1 Bind to and Facilitate the Repair of N(2)-Alkylguanine Lesions in DNA.
Zhao T, He X, Liang X, Kellum AH Jr, Tang F, Yin J, Guo S, Wang Y, Gao Z, Wang Y., | 08/15/2024 |
| PC4 promotes bladder cancer progression and stemness by directly interacting with Sp1 to transcriptionally activate the Wnt5a/beta-catenin pathway. | PC4 promotes bladder cancer progression and stemness by directly interacting with Sp1 to transcriptionally activate the Wnt5a/β-catenin pathway.
Yan B, Luo P, Qiu H, Wang J, Xiong Q, Hu W, Wang F, Liu G, Zhi Y, Fang Q, Shi C, Li W. | 06/28/2024 |
| Periodic changes of cyclin D1 mRNA stability are regulated by PC4 modifications in the cell cycle. | Periodic changes of cyclin D1 mRNA stability are regulated by PC4 modifications in the cell cycle.
Pan Q, Luo P, Hu K, Qiu Y, Liu G, Dai S, Cui B, Yin D, Shi C., Free PMC Article | 02/15/2024 |
| Phosphorylation-dependent association of human chromatin protein PC4 to linker histone H1 regulates genome organization and transcription. | Phosphorylation-dependent association of human chromatin protein PC4 to linker histone H1 regulates genome organization and transcription.
Mustafi P, Hu M, Kumari S, Das C, Li G, Kundu TK., Free PMC Article | 08/27/2022 |
| CircVCAN/SUB1 up-regulates MYC/HSP90beta to enhance the proliferation and migration of glioma cells. | CircVCAN/SUB1 up-regulates MYC/HSP90β to enhance the proliferation and migration of glioma cells.
Liu Z, Wang J, Wang J, Niu J, Wang J, Tong H. | 04/23/2022 |
| The Transcription Factor SUB1 Is a Master Regulator of the Macrophage TLR Response in Atherosclerosis. | The Transcription Factor SUB1 Is a Master Regulator of the Macrophage TLR Response in Atherosclerosis.
Huang R, Hu Z, Chen X, Cao Y, Li H, Zhang H, Li Y, Liang L, Feng Y, Wang Y, Su W, Kong Z, Melgiri ND, Jiang L, Li X, Du J, Chen Y., Free PMC Article | 02/12/2022 |
| Chromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4. | Chromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4.
Ochiai K, Yamaoka M, Swaminathan A, Shima H, Hiura H, Matsumoto M, Kurotaki D, Nakabayashi J, Funayama R, Nakayama K, Arima T, Ikawa T, Tamura T, Sciammas R, Bouvet P, Kundu TK, Igarashi K. | 12/25/2021 |
| Knockdown of PC4 increases chemosensitivity of Oxaliplatin in triple negative breast cancer by suppressing mTOR pathway. | Knockdown of PC4 increases chemosensitivity of Oxaliplatin in triple negative breast cancer by suppressing mTOR pathway.
Wang Q, Ma L, Chen L, Chen H, Luo M, Yang W, Liao F, Gong Q, Wang Y, Yang Z, Wu J, Zhang C, Zheng J, Han S, Leng Y, Luo P, Shi C. | 09/4/2021 |
| PC4 is essential for genomic integrity and autophagy regulation. | Nonhistone human chromatin protein PC4 is critical for genomic integrity and negatively regulates autophagy.
Sikder S, Kumari S, Mustafi P, Ramdas N, Padhi S, Saha A, Bhaduri U, Banerjee B, Manjithaya R, Kundu TK. | 06/20/2020 |
| PC4 emerges as a global co-regulator of p53 and a therapeutic target against pathogeneses where the p53-dependent cell death process plays a crucial role. | Multifunctional transcriptional coactivator PC4 is a global co-regulator of p53-dependent stress response and gene regulation.
Mondal P, Saleem S, Sikder S, Kundu TK, Biswas SC, Roy S. | 11/30/2019 |
| this study reveals for the first time that PC4 promotes breast cancer progression by directly regulating c-Myc transcription to promote Warburg effect, implying a novel therapeutic target for breast cancer. | Transcriptional positive cofactor 4 promotes breast cancer proliferation and metastasis through c-Myc mediated Warburg effect.
Luo P, Zhang C, Liao F, Chen L, Liu Z, Long L, Jiang Z, Wang Y, Wang Z, Liu Z, Miao H, Shi C., Free PMC Article | 08/17/2019 |
| PC4 expression correlated with radiosensitivity and was an independent prognostic factor of progression-free survival (PFS) in patients with NSCLC. | Inhibition of PC4 radiosensitizes non-small cell lung cancer by transcriptionally suppressing XLF.
Zhang T, Liu X, Chen X, Wang J, Wang Y, Qian D, Pang Q, Wang P., Free PMC Article | 08/10/2019 |
| Study shows that PC4 might repress RNA pol II recruitment and transcription of replication-dependent histone genes in order to maintain the balance between histone gene expression and DNA synthesis. Moreover, PC4 might promote the interaction of cleavage and polyadenylation complex with histone pre-mRNAs, that might impede with the recruitment of histone cleavage complex. | Positive cofactor 4 (PC4) contributes to the regulation of replication-dependent canonical histone gene expression.
Brzek A, Cichocka M, Dolata J, Juzwa W, Schümperli D, Raczynska KD., Free PMC Article | 11/17/2018 |
| REVIEW: many evidences showed that Sub1 influences processes downstream during mRNA biogenesis, such as elongation, termination, and RNAPII phosphorylation. The recent discovery that Sub1 directly interacts with the RNAPII stalk adds new insights into how it achieves all these tasks. | Sub1 and RNAPII, until termination does them part.
Calvo O., Free PMC Article | 10/20/2018 |
| Evolutionarily conserved role for Sub1 and PC4 in the maintenance of yeast and human genome stability has been summarized. (Review) | Sub1/PC4, a multifaceted factor: from transcription to genome stability.
Garavís M, Calvo O. | 06/23/2018 |
| Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA. | Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA.
Lopez CR, Singh S, Hambarde S, Griffin WC, Gao J, Chib S, Yu Y, Ira G, Raney KD, Kim N., Free PMC Article | 09/23/2017 |
| Results show elevated expression of SUB1 in aggressive prostate cancer. Knockdown of SUB1 in prostate cancer cells resulted in reduced cell proliferation, invasion and migration. | MicroRNA-101 regulated transcriptional modulator SUB1 plays a role in prostate cancer.
Chakravarthi BV, Goswami MT, Pathi SS, Robinson AD, Cieślik M, Chandrashekar DS, Agarwal S, Siddiqui J, Daignault S, Carskadon SL, Jing X, Chinnaiyan AM, Kunju LP, Palanisamy N, Varambally S., Free PMC Article | 09/16/2017 |
| these data provide a novel mode of PC4 binding to a DNA secondary structure that remains within the framework of the model for binding to ssDNA. Additionally, consideration of the PC4-G4DNA interaction could provide insight into the biological functions of PC4, which remain incompletely understood. | A biochemical and biophysical model of G-quadruplex DNA recognition by positive coactivator of transcription 4.
Griffin WC, Gao J, Byrd AK, Chib S, Raney KD., Free PMC Article | 06/24/2017 |
| PC4 associates with Aurora A and Aurora B and undergoes phosphorylation, following which PC4 activates both Aurora A and B to sustain optimal kinase activity to maintain the phosphorylation gradient for the proper functioning of the mitotic machinery. | Multifunctional human transcriptional coactivator protein PC4 is a substrate of Aurora kinases and activates the Aurora enzymes.
Dhanasekaran K, Kumari S, Boopathi R, Shima H, Swaminathan A, Bachu M, Ranga U, Igarashi K, Kundu TK. | 08/6/2016 |
| PC4 has similar functions to RPA in binding ssDNA to promote genome stability, especially at sites of replication-transcription collisions. | PC4 promotes genome stability and DNA repair through binding of ssDNA at DNA damage sites.
Mortusewicz O, Evers B, Helleday T. | 07/2/2016 |
| SMYD3 interacts with the human positive coactivator 4 (PC4) and that such interaction potentiates a group of genes whose expression is linked to cell proliferation and invasion. | Cooperation between SMYD3 and PC4 drives a distinct transcriptional program in cancer cells.
Kim JM, Kim K, Schmidt T, Punj V, Tucker H, Rice JC, Ulmer TS, An W., Free PMC Article | 05/14/2016 |
| Sub1, and its human homolog PC4, bind preferentially to G-quadruplexes | Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA.
Gao J, Zybailov BL, Byrd AK, Griffin WC, Chib S, Mackintosh SG, Tackett AJ, Raney KD., Free PMC Article | 01/2/2016 |
| expression of PC4 in astrocytoma was upregulated as assessed by western blot and immunohistochemical staining. Moreover, elevated PC4 expression was strongly correlated with the progression of astrocytoma and overall survival. | Human positive coactivator 4 (PC4) is involved in the progression and prognosis of astrocytoma.
Chen L, Du C, Wang L, Yang C, Zhang JR, Li N, Li Y, Xie XD, Gao GD. | 07/25/2015 |
| PC4 protects esophageal squamous cell carcinoma cells from IR-induced death by enhancing the nonhomologous end joining-promoting activity of XLF. | Inhibition of human positive cofactor 4 radiosensitizes human esophageal squmaous cell carcinoma cells by suppressing XLF-mediated nonhomologous end joining.
Qian D, Zhang B, Zeng XL, Le Blanc JM, Guo YH, Xue C, Jiang C, Wang HH, Zhao TS, Meng MB, Zhao LJ, Hao JH, Wang P, Xie D, Lu B, Yuan ZY., Free PMC Article | 06/20/2015 |