| USP7-mediated ERbeta stabilization mitigates ROS accumulation and promotes osimertinib resistance by suppressing PRDX3 SUMOylation in non-small cell lung carcinoma. | USP7-mediated ERβ stabilization mitigates ROS accumulation and promotes osimertinib resistance by suppressing PRDX3 SUMOylation in non-small cell lung carcinoma.
Meng Y, Lin W, Wang N, Wei X, Mei P, Wang X, Zhang C, Huang Q, Liao Y. | 01/17/2024 |
| Knockdown of circSOD2 ameliorates osteoarthritis progression via the miR-224-5p/PRDX3 axis. | Knockdown of circSOD2 ameliorates osteoarthritis progression via the miR-224-5p/PRDX3 axis.
Li H, Cao Y, Chang C, Huang W, Su S, Peng Z, Zhang J., Free PMC Article | 06/22/2023 |
| PRDX3 promotes resistance to cisplatin in gastric cancer cells. | PRDX3 promotes resistance to cisplatin in gastric cancer cells.
Yan H, Cai X, Fu S, Zhang X, Zhang J. | 01/21/2023 |
| Silencing of B7-H4 induces intracellular oxidative stress and inhibits cell viability of breast cancer cells via downregulating PRDX3. | Silencing of B7-H4 induces intracellular oxidative stress and inhibits cell viability of breast cancer cells via downregulating PRDX3.
Chen HC, Long M, Gao ZW, Liu C, Wu XN, Yang L, Dong K, Zhang HZ. | 08/13/2022 |
| LncRNA LUADT1 inhibits cell apoptosis in diabetic retinopathy by regulating miR-383/peroxiredoxin 3 axis. | LncRNA LUADT1 inhibits cell apoptosis in diabetic retinopathy by regulating miR-383/peroxiredoxin 3 axis.
Dai R, Sun Z, Qian Y, Zhang B, Han Y, Deng G. | 06/11/2022 |
| Confirmation of PRDX3 c.568G>C as the Genetic Basis of Punctiform and Polychromatic Pre-Descemet Corneal Dystrophy. | Confirmation of PRDX3 c.568G>C as the Genetic Basis of Punctiform and Polychromatic Pre-Descemet Corneal Dystrophy.
Choo CH, Boto de Los Bueis A, Chung DD, Aldave AJ., Free PMC Article | 05/21/2022 |
| A quantitative proteomic analysis reveals the potential roles of PRDX3 in neurite outgrowth in N2a-APPswe cells. | A quantitative proteomic analysis reveals the potential roles of PRDX3 in neurite outgrowth in N2a-APPswe cells.
Xu B, Gao C, Zhang H, Huang X, Yang X, Yang C, Liu W, Wu D, Liu J. | 04/16/2022 |
| Biallelic loss-of-function variations in PRDX3 cause cerebellar ataxia. | Biallelic loss-of-function variations in PRDX3 cause cerebellar ataxia.
Rebelo AP, Eidhof I, Cintra VP, Guillot-Noel L, Pereira CV, Timmann D, Traschütz A, Schöls L, Coarelli G, Durr A, Anheim M, Tranchant C, van de Warrenburg B, Guissart C, Koenig M, Howell J, Moraes CT, Schenck A, Stevanin G, Züchner S, Synofzik M, PREPARE network. | 09/25/2021 |
| Hsa_circ_0032131 knockdown inhibits osteoarthritis progression via the miR-502-5p/PRDX3 axis. | Hsa_circ_0032131 knockdown inhibits osteoarthritis progression via the miR-502-5p/PRDX3 axis.
Xu J, Ma X., Free PMC Article | 07/24/2021 |
| A novel circRNA, circNUP98, a potential biomarker, acted as an oncogene via the miR-567/ PRDX3 axis in renal cell carcinoma. | A novel circRNA, circNUP98, a potential biomarker, acted as an oncogene via the miR-567/ PRDX3 axis in renal cell carcinoma.
Yu R, Yao J, Ren Y., Free PMC Article | 05/8/2021 |
| High immunohistochemical expression of PRDX3 in primary uveal melanoma (UM) tissue is associated with metastasis and poor survival. | PRDX3 is associated with metastasis and poor survival in uveal melanoma.
Ramasamy P, Larkin AM, Linge A, Tiernan D, McAree F, Horgan N, Moriarty P, Beatty S, Murphy CC, Clynes M, Kennedy S, Meleady P. | 07/11/2020 |
| the results show that PPPCD is associated with an alteration of corneal biomechanics and a novel missense variant in PRDX3. | Punctiform and Polychromatic Pre-Descemet Corneal Dystrophy: Clinical Evaluation and Identification of the Genetic Basis.
Alió Del Barrio JL, Chung DD, Al-Shymali O, Barrington A, Jatavallabhula K, Swamy VS, Yébana P, Angélica Henríquez-Recine M, Boto-de-Los-Bueis A, Alió JL, Aldave AJ., Free PMC Article | 05/9/2020 |
| Here generated are a range of peroxiredoxin 3 mutants with either a decreased or knocked out ability to stack, and used both imaging and solution studies to show that peroxiredoxin 3 stacks through electrostatic interactions that are stabilised by a hydrogen bonding network. | Engineering peroxiredoxin 3 to facilitate control over self-assembly.
Conroy F, Rossi T, Ashmead H, Crowther JM, Mitra AK, Gerrard JA. | 02/8/2020 |
| Upregulated expression of Prdx3 and Prdx5 has been reported in different cancer types involving their association with different factors, such as transcription factors, micro RNAs, tumor suppressors, response elements, and oncogenic genes. Also, increased production of Prdx3 and Prdx5 is associated with the development of chemoresistance in certain types of cancers and it leads to further complications. [review] | Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression.
Ismail T, Kim Y, Lee H, Lee DS, Lee HS., Free PMC Article | 02/1/2020 |
| human Prx3 rapidly reduces peroxynitrite; Prx3 intrinsic fluorescence presents biphasic changes upon oxidation;Peroxynitrite in excess leads to Prx3 nitration and hyperoxidation;Both Prx3 and Prx5 are predicted to be main targets for mitochondrial peroxynitrite. | Rapid peroxynitrite reduction by human peroxiredoxin 3: Implications for the fate of oxidants in mitochondria.
De Armas MI, Esteves R, Viera N, Reyes AM, Mastrogiovanni M, Alegria TGP, Netto LES, Tórtora V, Radi R, Trujillo M. | 12/14/2019 |
| The positive association of plasma PRX3 and insulin suggest PRX3 to be a potential indicator of high insulin resistance. | The association of plasma peroxiredoxin 3 with insulin in pregnant women.
Wang L, Hao JM, Yu AQ, Li TT, Liu RR, Li L, Li J, Li X. | 09/21/2019 |
| n patients, reduced mitochondrial content and size and increased expression and oxidation of peroxiredoxin 3, a mitochondrial peroxidase, were associated with reduced muscle fiber cross-sectional area | Skeletal muscle atrophy and dysfunction in breast cancer patients: role for chemotherapy-derived oxidant stress.
Guigni BA, Callahan DM, Tourville TW, Miller MS, Fiske B, Voigt T, Korwin-Mihavics B, Anathy V, Dittus K, Toth MJ., Free PMC Article | 07/6/2019 |
| These results suggest that there are distinct prognostic values of PRDX family members in patients with ovarian cancer, and that the expression of PRDX3, PRDX5, and PRDX6 mRNAs are a useful prognostic indicator in the effect of chemotherapy in ovarian cancer patients. | The prognostic values of the peroxiredoxins family in ovarian cancer.
Li S, Hu X, Ye M, Zhu X., Free PMC Article | 05/18/2019 |
| the role of Spalt like protein 4 (SALL4) in pancreatic ductal adenocarcinoma cell proliferation, mobility and its regulation in mitochondrial ROS via FoxM1/Prx III axis. | SALL4 suppresses reactive oxygen species in pancreatic ductal adenocarcinoma phenotype via FoxM1/Prx III axis.
Huynh DL, Zhang JJ, Chandimali N, Ghosh M, Gera M, Kim N, Park YH, Kwon T, Jeong DK. | 01/19/2019 |
| tubular PRX3 in combination with conventional predictors can further improve recovery prediction and may help with risk stratification in AKI patients with pre-existing CKD. | Tubular Peroxiredoxin 3 as a Predictor of Renal Recovery from Acute Tubular Necrosis in Patients with Chronic Kidney Disease.
Wu CL, Su TC, Chang CC, Kor CT, Chang CH, Yang TH, Chiu PF, Tarng DC., Free PMC Article | 11/10/2018 |
| results suggest that decreased PRDX3 by excessive bile acids in trophoblasts plays a critical role in the pathogenesis and progression of Intrahepatic cholestasis of pregnancy. | Downregulation of peroxiredoxin-3 by hydrophobic bile acid induces mitochondrial dysfunction and cellular senescence in human trophoblasts.
Wu WB, Menon R, Xu YY, Zhao JR, Wang YL, Liu Y, Zhang HJ., Free PMC Article | 06/16/2018 |
| Mutants created to investigate link between oligomerisation and peroxidase activity. Obligate dimer is less active than wildtype but still displays peroxidase activity. 2.4A structure (PDB: 5UCX) shows cysteine-stabilised protein interface. | Quaternary structure influences the peroxidase activity of peroxiredoxin 3.
Yewdall NA, Peskin AV, Hampton MB, Goldstone DC, Pearce FG, Gerrard JA. | 04/7/2018 |
| the present study identified the protein profiles of the PRDX family in LSCC and showed that down-regulation of PRDX3 in Hep-2 cells induced cell apoptosis and inhibited cell proliferation and cell migration. | Differential expression of peroxiredoxin 3 in laryngeal squamous cell carcinoma.
Zhang H, Liu X, Chen L, Cai L, Li N, Zhu P, Chen J, Song X, Li G., Free PMC Article | 03/10/2018 |
| The UNG1-PRDX3 interaction protected UNG1 from reactive oxygen species-mediated degradation and prevented mitochondrial DNA oxidation. | Hydrogen peroxide mediated mitochondrial UNG1-PRDX3 interaction and UNG1 degradation.
Liu Z, Hu Y, Gong Y, Zhang W, Liu C, Wang Q, Deng H. | 12/30/2017 |
| PRDX3 knockdown led to the down-regulation of ATP synthases and the decreased cellular ATP level, contributing to the slow-down of cell growth. Furthermore, silencing PRDX3 enhanced invasive properties of HepG2 cells via TIMP-1 down-regulation and the increased ECM degradation | Silencing PRDX3 Inhibits Growth and Promotes Invasion and Extracellular Matrix Degradation in Hepatocellular Carcinoma Cells.
Liu Z, Hu Y, Liang H, Sun Z, Feng S, Deng H. | 11/11/2017 |