| MLLT11 Regulates Endometrial Stroma Cell Adhesion, Proliferation and Survival in Ectopic Lesions of Women with Advanced Endometriosis. | MLLT11 Regulates Endometrial Stroma Cell Adhesion, Proliferation and Survival in Ectopic Lesions of Women with Advanced Endometriosis.
Proestling K, Husslein H, Hudson QJ, Witzmann-Stern M, Widmar B, Bagó-Horváth Z, Sandrieser L, Perricos A, Wenzl R, Yotova I., Free PMC Article | 01/16/2024 |
| MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells. | MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells.
Liu X, Bai W, Li J, Ma J, Liu Y, Wang Z, Hu L, Li Z, Papukashvili D, Rcheulishvili N, Wang F, Lu X., Free PMC Article | 12/20/2023 |
| A Monoallelic Variant in REST Is Associated with Non-Syndromic Autosomal Dominant Hearing Impairment in a South African Family. | A Monoallelic Variant in REST Is Associated with Non-Syndromic Autosomal Dominant Hearing Impairment in a South African Family.
Manyisa N, Schrauwen I, de Souza Rios LA, Mowla S, Tekendo-Ngongang C, Popel K, Esoh K, Bharadwaj T, Nouel-Saied LM, Acharya A, Nasir A, Wonkam-Tingang E, Kock C, Dandara C, Leal SM, Wonkam A., Free PMC Article | 02/19/2022 |
| LPAR5 stimulates the malignant progression of non-small-cell lung carcinoma by upregulating MLLT11. | LPAR5 stimulates the malignant progression of non-small-cell lung carcinoma by upregulating MLLT11.
Zhang HP, Chen QK, Xu JF. | 05/22/2021 |
| AF1q Expression Associates with CD44 and STAT3 and Impairs Overall Survival in Adenoid Cystic Carcinoma of the Head and Neck. | AF1q Expression Associates with CD44 and STAT3 and Impairs Overall Survival in Adenoid Cystic Carcinoma of the Head and Neck.
Kadletz LC, Brkic FF, Jank BJ, Schneider S, Cede J, Seemann R, Gruber ES, Gurnhofer E, Heiduschka G, Kenner L., Free PMC Article | 03/27/2021 |
| High AF1q expression is associated with Esophageal Cancer. | The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer.
Gruber ES, Oberhuber G, Birner P, Schlederer M, Kenn M, Schreiner W, Jomrich G, Schoppmann SF, Gnant M, Tse W, Kenner L., Free PMC Article | 07/18/2020 |
| A positive correlation between AF1q and CD44 expression. | Novel AF1q/MLLT11 favorably affects imatinib resistance and cell survival in chronic myeloid leukemia.
Li W, Ji M, Lu F, Pang Y, Dong X, Zhang J, Li P, Ye J, Zang S, Ma D, Ji C., Free PMC Article | 11/16/2019 |
| This finding suggested statistically significant role of interaction of TXNIP and AF1q polymorphisms (TXNIP-rs2236566, TXNIP-rs7211, and AF1q-rs2769605) in schizophrenia susceptibility. | The Interaction of TXNIP and AFq1 Genes Increases the Susceptibility of Schizophrenia.
Su Y, Ding W, Xing M, Qi D, Li Z, Cui D. | 04/14/2018 |
| AF1q was up-regulated in human colorectal cancer tissues, and that this up-regulation was associated with tumor metastasis. AF1q contributes to CRC tumorigenesis through the activation of the AKT signaling pathway. | AF1q Mediates Tumor Progression in Colorectal Cancer by Regulating AKT Signaling.
Hu J, Li G, Liu L, Wang Y, Li X, Gong J., Free PMC Article | 02/10/2018 |
| Data show that MLLT11/AF1q-induced PDGFR signaling enhanced STAT3 activity through Src kinase activation. | MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling.
Park J, Kim S, Joh J, Remick SC, Miller DM, Yan J, Kanaan Z, Chao JH, Krem MM, Basu SK, Hagiwara S, Kenner L, Moriggl R, Bunting KD, Tse W., Free PMC Article | 01/13/2018 |
| AF1q was significantly lower in borderline ovarian tumors (i.e., tumors of low malignant potential without stromal invasion) than in invasive tumors, thus corroborating the association between high AF1q expression and increased migratory/invasive cell behavior and confirming its potential role in ovarian cancer progression. | Involvement of AF1q/MLLT11 in the progression of ovarian cancer.
Tiberio P, Lozneanu L, Angeloni V, Cavadini E, Pinciroli P, Callari M, Carcangiu ML, Lorusso D, Raspagliesi F, Pala V, Daidone MG, Appierto V., Free PMC Article | 12/2/2017 |
| These results suggest that AF1q would have a role as an enhancer in generation of stem-like population through activation of Wnt signaling pathway. | Activation of Wnt signaling pathway by AF1q enriches stem-like population and enhance mammosphere formation of breast cells.
Tse CO, Kim S, Park J. | 06/10/2017 |
| Findings indicate that breast cancer cells with a hyperactive AF1q/TCF7/CD44 regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties. | AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis.
Park J, Schlederer M, Schreiber M, Ice R, Merkel O, Bilban M, Hofbauer S, Kim S, Addison J, Zou J, Ji C, Bunting ST, Wang Z, Shoham M, Huang G, Bago-Horvath Z, Gibson LF, Rojanasakul Y, Remick S, Ivanov A, Pugacheva E, Bunting KD, Moriggl R, Kenner L, Tse W., Free PMC Article | 07/16/2016 |
| Results demonstrate that AF1q gene transcription is regulated by REST through direct binding at -383 to -363 bp of AF1q promoter. | RE1 silencing transcription factor (REST) negatively regulates ALL1-fused from chromosome 1q (AF1q) gene transcription.
Hu Y, Sun Q, Zhang C, Sha Q, Sun X., Free PMC Article | 01/16/2016 |
| AF1Q had a KFERQ-like motif. | Degradation of AF1Q by chaperone-mediated autophagy.
Li P, Ji M, Lu F, Zhang J, Li H, Cui T, Li Wang X, Tang D, Ji C. | 10/25/2014 |
| AF1q plays a role in the onset of basal apoptosis in ovarian cancer cells, thus providing new information about the activity of this protein whose biologic functions are mostly unknown | AF1q: a novel mediator of basal and 4-HPR-induced apoptosis in ovarian cancer cells.
Tiberio P, Cavadini E, Callari M, Daidone MG, Appierto V., Free PMC Article | 01/5/2013 |
| Using in vitro assays based on either forced expression or shRNA-mediated silencing of AF1q, the study provides evidence that the protein promotes T- over B-cell differentiation in multipotent hematopoietic progenitors. | AF1q/MLLT11 regulates the emergence of human prothymocytes through cooperative interaction with the Notch signaling pathway.
Parcelier A, Maharzi N, Delord M, Robledo-Sarmiento M, Nelson E, Belakhdar-Mekid H, Pla M, Kuranda K, Parietti V, Goodhardt M, Legrand N, Bernstein ID, Gluckman JC, Sigaux F, Canque B., Free PMC Article | 10/15/2011 |
| AF1q up-regulation of BAD is through its effect on NF-kappaB and this may hint of its oncogenic mechanism in cancer. | AF1q enhancement of gamma irradiation-induced apoptosis by up-regulation of BAD expression via NF-kappaB in human squamous carcinoma A431 cells.
Co NN, Tsang WP, Tsang TY, Yeung CL, Yau PL, Kong SK, Kwok TT. | 11/13/2010 |
| high AF1q expression is a poor prognostic marker for adult patients with normal cytogenetics acute myeloid leukemia | Elevated AF1q expression is a poor prognostic marker for adult acute myeloid leukemia patients with normal cytogenetics.
Strunk CJ, Platzbecker U, Thiede C, Schaich M, Illmer T, Kang Z, Leahy P, Li C, Xie X, Laughlin MJ, Lazarus HM, Gerson SL, Bunting KD, Ehninger G, Tse W. | 01/21/2010 |
| The study provides the first evidence that AF1q plays a critical role in the regulation of apoptosis and drug resistance. | Oncogene AF1q enhances doxorubicin-induced apoptosis through BAD-mediated mitochondrial apoptotic pathway.
Co NN, Tsang WP, Wong TW, Cheung HH, Tsang TY, Kong SK, Kwok TT. | 01/21/2010 |
| overexpression of AF1Q leads to more progression in human breast cancer | Identification of the functional role of AF1Q in the progression of breast cancer.
Chang XZ, Li DQ, Hou YF, Wu J, Lu JS, Di GH, Jin W, Ou ZL, Shen ZZ, Shao ZM. | 01/21/2010 |
| The ectopic expression of human AF1q triggered the expression of the neuronal marker TuJ1 in non-neuronal human embryonic kidney (HEK) cells. | AF1q, a differentially expressed gene during neuronal differentiation, transforms HEK cells into neuron-like cells.
Lin HJ, Shaffer KM, Sun Z, Jay G, He WW, Ma W. | 01/21/2010 |