| Kindlin-2 regulates colonic cancer stem-like cells survival and self-renewal via Wnt/beta-catenin mediated pathway. | Kindlin-2 regulates colonic cancer stem-like cells survival and self-renewal via Wnt/β-catenin mediated pathway.
Yadav RP, Baranwal S. | 12/20/2023 |
| Kindlin-2 controls angiogenesis through modulating Notch1 signaling. | Kindlin-2 controls angiogenesis through modulating Notch1 signaling.
Dong Y, Ma G, Hou X, Han Y, Ding Z, Tang W, Chen L, Chen Y, Zhou B, Rao F, Lv K, Du C, Cao H., Free PMC Article | 07/27/2023 |
| Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression. | Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression.
Yeon M, Bertolini I, Agarwal E, Ghosh JC, Tang HY, Speicher DW, Keeney F, Sossey-Alaoui K, Pluskota E, Bialkowska K, Plow EF, Languino LR, Skordalakes E, Caino MC, Altieri DC., Free PMC Article | 07/3/2023 |
| Alzheimer's risk factor FERMT2 promotes the progression of colorectal carcinoma via Wnt/beta-catenin signaling pathway and contributes to the negative correlation between Alzheimer and cancer. | Alzheimer's risk factor FERMT2 promotes the progression of colorectal carcinoma via Wnt/β-catenin signaling pathway and contributes to the negative correlation between Alzheimer and cancer.
Xia W, Gao Z, Jiang X, Jiang L, Qin Y, Zhang D, Tian P, Wang W, Zhang Q, Zhang R, Zhang N, Xu S., Free PMC Article | 12/24/2022 |
| Kindlin-2 promotes Src-mediated tyrosine phosphorylation of androgen receptor and contributes to breast cancer progression. | Kindlin-2 promotes Src-mediated tyrosine phosphorylation of androgen receptor and contributes to breast cancer progression.
Ma L, Tian Y, Qian T, Li W, Liu C, Chu B, Kong Q, Cai R, Bai P, Ma L, Deng Y, Tian R, Wu C, Sun Y., Free PMC Article | 06/11/2022 |
| Kindlin-2 Promotes Chondrogenesis and Ameliorates IL-1beta-Induced Inflammation in Chondrocytes Cocultured with BMSCs in the Direct Contact Coculture System. | Kindlin-2 Promotes Chondrogenesis and Ameliorates IL-1beta-Induced Inflammation in Chondrocytes Cocultured with BMSCs in the Direct Contact Coculture System.
Chen Z, Shen K, Zheng Z, Zhou J, Zhao S, Song H, Liu J, Zhao X, Liu F, Zuo Q., Free PMC Article | 04/30/2022 |
| YBX1 knockdown induces renal cell carcinoma cell apoptosis via Kindlin-2. | YBX1 knockdown induces renal cell carcinoma cell apoptosis via Kindlin-2.
Cui Q, Wang C, Liu S, Du R, Tian S, Chen R, Geng H, Subramanian S, Niu Y, Wang Y, Yue D., Free PMC Article | 04/16/2022 |
| Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner. | Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner.
Eysert F, Coulon A, Boscher E, Vreulx AC, Flaig A, Mendes T, Hughes S, Grenier-Boley B, Hanoulle X, Demiautte F, Bauer C, Marttinen M, Takalo M, Amouyel P, Desai S, Pike I, Hiltunen M, Chécler F, Farinelli M, Delay C, Malmanche N, Hébert SS, Dumont J, Kilinc D, Lambert JC, Chapuis J., Free PMC Article | 02/5/2022 |
| Kindlin-2 promoted the progression of keloids through the Smad pathway and Fas/FasL pathway. | Kindlin-2 promoted the progression of keloids through the Smad pathway and Fas/FasL pathway.
Huang S, Liao J, Luo X, Liu F, Shi G, Wen W. | 12/4/2021 |
| Kindlin-2 Mediates Mechanical Activation of Cardiac Myofibroblasts. | Kindlin-2 Mediates Mechanical Activation of Cardiac Myofibroblasts.
Godbout E, Son DO, Hume S, Boo S, Sarrazy V, Clément S, Kapus A, Wehrle-Haller B, Bruckner-Tuderman L, Has C, Hinz B., Free PMC Article | 06/26/2021 |
| miRNA-200c-3p promotes endothelial to mesenchymal transition and neointimal hyperplasia in artery bypass grafts. | miRNA-200c-3p promotes endothelial to mesenchymal transition and neointimal hyperplasia in artery bypass grafts.
Chen D, Zhang C, Chen J, Yang M, Afzal TA, An W, Maguire EM, He S, Luo J, Wang X, Zhao Y, Wu Q, Xiao Q., Free PMC Article | 06/12/2021 |
| HIF-1alpha interacts with Kindlin-2 and influences breast cancer elasticity: A study based on shear wave elastography imaging. | HIF-1α interacts with Kindlin-2 and influences breast cancer elasticity: A study based on shear wave elastography imaging.
Xue X, Xue S, Wan W, Li J, Shi H., Free PMC Article | 05/15/2021 |
| Kindlin2 suppresses cervical cancer cell migration through AKT/mTORmediated autophagy induction. | Kindlin‑2 suppresses cervical cancer cell migration through AKT/mTOR‑mediated autophagy induction.
Wu G, Long Y, Lu Y, Feng Y, Yang X, Xu X, Yao D., Free PMC Article | 03/13/2021 |
| The focal adhesion protein kindlin-2 controls mitotic spindle assembly by inhibiting histone deacetylase 6 and maintaining alpha-tubulin acetylation. | The focal adhesion protein kindlin-2 controls mitotic spindle assembly by inhibiting histone deacetylase 6 and maintaining α-tubulin acetylation.
Tan HF, Tan SM., Free PMC Article | 12/26/2020 |
| Elevated kindlin-2 promotes tumour progression and angiogenesis through the mTOR/VEGFA pathway in melanoma. | Elevated kindlin-2 promotes tumour progression and angiogenesis through the mTOR/VEGFA pathway in melanoma.
Wei CY, Zhu MX, Zhang PF, Yang X, Wang L, Ying JH, Luan WJ, Chen C, Liu JQ, Zhu M, Yang YW, Feng ZH, Qi FZ, Gu JY., Free PMC Article | 09/5/2020 |
| miR-338-5p expression is lower in esophageal squamous cell carcinoma (ESCC) cells compared with normal cells. miR-338-5p reduced cell proliferation, colony formation, migration and cisplatin resistance in an ESCC cell line, CE-81T. Luciferase assays showed the direct binding between miR-338-5p and the 3' untranslated region of FERMT2 suggesting that miR-338-5p may play an antioncogenic role in ESCC via repressing FERMT2. | miR-338-5p inhibits cell proliferation, colony formation, migration and cisplatin resistance in esophageal squamous cancer cells by targeting FERMT2.
Lin WC, Chen LH, Hsieh YC, Yang PW, Lai LC, Chuang EY, Lee JM, Tsai MH. | 05/16/2020 |
| Results found that high FERMT2 expression correlated with poor disease-free survival of melanoma patients. The stability of its mRNA is regulated by the complex p62-IGF2BP1. | p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.
Karras P, Riveiro-Falkenbach E, Cañón E, Tejedo C, Calvo TG, Martínez-Herranz R, Alonso-Curbelo D, Cifdaloz M, Perez-Guijarro E, Gómez-López G, Ximenez-Embun P, Muñoz J, Megias D, Olmeda D, Moscat J, Ortiz-Romero PL, Rodríguez-Peralto JL, Soengas MS. | 10/19/2019 |
| The expression of Kindlin-2 positively correlated with DNA methyltransferase 1(DNMT1) in breast cancer patients. Mechanistically, Kindlin-2 increased the stability of DNA methyltransferase DNMT1 through interaction with DNMT1 and methylated CpG islands in the E-cadherin promoter. | Kindlin-2 interacts with and stabilizes DNMT1 to promote breast cancer development.
Wang P, Chu W, Zhang X, Li B, Wu J, Qi L, Yu Y, Zhang H. | 06/15/2019 |
| The detection of FERMT2 throughout extravillous trophoblast columns and the results of invasion assays demonstrated that this protein is likely an important regulator of integrin activation in extravillous cells to modulate migration and invasion. | Fermitin family homolog-2 (FERMT2) is highly expressed in human placental villi and modulates trophoblast invasion.
Kawamura E, Hamilton GB, Miskiewicz EI, MacPhee DJ., Free PMC Article | 06/15/2019 |
| The expression of Kindlin-2 is up-regulated in gallbladder cancer tissues and Kindlin-2 promoted the malignant phenotypes of gallbladder cancer cells partially by epithelial-mesenchymal transition. | [Kindlin-2 promotes gallbladder cancer metastasis and invasion by inducing epithelial-mesenchymal transition].
Lu X, Zhou C, Li RF, Ye JW, Zhai WL. | 04/6/2019 |
| Novel kindlin-2 signaling axis that senses the mechanical cues of cell microenvironment and controls mesenchymal stem cell fate decision through YAP1/TAZ. | Kindlin-2 regulates mesenchymal stem cell differentiation through control of YAP1/TAZ.
Guo L, Cai T, Chen K, Wang R, Wang J, Cui C, Yuan J, Zhang K, Liu Z, Deng Y, Xiao G, Wu C., Free PMC Article | 03/23/2019 |
| overexpression of Kindlin-2 might be a risk factor for lymph node metastasis. | Kindlin-2 could influence breast nodule elasticity and improve lymph node metastasis in invasive breast cancer.
Xue X, Li J, Wan W, Shi X, Zheng Y., Free PMC Article | 02/9/2019 |
| Data confirmed the relevance of FERMT2 for podocyte functions. Its loss resulted in pronounced formation of membrane blebbing indicating cell cortex destabilization through redistribution of actin filaments and increased actomyosin tension. These indicate a competition between ECM-adhesion and the cortical cytoskeleton for the coupling and transmission of actomyosin tension influencing podocyte morphology and function. | FERMT2 links cortical actin structures, plasma membrane tension and focal adhesion function to stabilize podocyte morphology.
Yasuda-Yamahara M, Rogg M, Frimmel J, Trachte P, Helmstaedter M, Schroder P, Schiffer M, Schell C, Huber TB. | 02/2/2019 |
| Using molecular modeling and molecular dynamics simulations, we show that Asp344, Asp352, and Thr356 in kindlin-2 and Arg243 and Arg334 in ILK kinase domain (KD) are important in kindlin-2/ILK complex formation. Mutations that disrupt these interactions abrogate kindlin-2 and ILK colocalization in HeLa cells. | The binding interface of kindlin-2 and ILK involves Asp344/Asp352/Thr356 in kindlin-2 and Arg243/Arg334 in ILK.
Guan SY, Chng CP, Ong LT, Tan HF, Alex Law SK, Tan SM. | 12/1/2018 |
| Results found Kindlin-2 expression upregulated in hepatocellular carcinoma (HCC) tissues and cell lines and it correlates with aggressive clinicopathological features and poor prognosis. Mechanistically, Kindlin-2 promotes HCC invasion, metastasis and epithelial-mesenchymal transition through Wnt/beta-catenin signaling. | Kindlin-2 promotes hepatocellular carcinoma invasion and metastasis by increasing Wnt/β-catenin signaling.
Lin J, Lin W, Ye Y, Wang L, Chen X, Zang S, Huang A., Free PMC Article | 07/14/2018 |