| CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression via YAP1 Activation. | CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression via YAP1 Activation.
Li K, Zhang J, Lyu H, Yang J, Wei W, Wang Y, Luo H, Zhang Y, Jiang X, Yi H, Wang M, Zhang C, Wu K, Xiao L, Wen W, Xu H, Li G, Wan Y, Yang F, Yang R, Fu X, Qin B, Zhou Z, Zhang H, Lee MH., Free PMC Article | 04/17/2024 |
| CSN6 Mediates Nucleotide Metabolism to Promote Tumor Development and Chemoresistance in Colorectal Cancer. | CSN6 Mediates Nucleotide Metabolism to Promote Tumor Development and Chemoresistance in Colorectal Cancer.
Zou S, Qin B, Yang Z, Wang W, Zhang J, Zhang Y, Meng M, Feng J, Xie Y, Fang L, Xiao L, Zhang P, Meng X, Choi HH, Wen W, Pan Q, Ghesquière B, Lan P, Lee MH, Fang L. | 02/10/2023 |
| CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9. | CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9.
Zhang Y, Hou J, Shi S, Du J, Liu Y, Huang P, Li Q, Liu L, Hu H, Ji Y, Guo L, Shi Y, Liu Y, Cui H., Free PMC Article | 10/9/2021 |
| Overexpression of CSN6 promotes the epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma. | Overexpression of CSN6 promotes the epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma.
Xu M, Zhen L, Lin L, Wu K, Wang Y, Cai X. | 09/11/2021 |
| CSN6 promotes the cell migration of breast cancer cells by positively regulating Snail1 stability. | CSN6 promotes the cell migration of breast cancer cells by positively regulating Snail1 stability.
Mou J, Wei L, Liang J, Du W, Pei D., Free PMC Article | 08/7/2021 |
| CUL4A regulates endometrial cancer cell proliferation, invasion and migration by interacting with CSN6. | CUL4A regulates endometrial cancer cell proliferation, invasion and migration by interacting with CSN6.
Wang X, Chen T., Free PMC Article | 05/22/2021 |
| CSN6 promotes malignant progression of oral squamous cell carcinoma by down-regulating TIMP-2. | CSN6 promotes malignant progression of oral squamous cell carcinoma by down-regulating TIMP-2.
Gao WY, Yang G, Wang J, He JM, Wang P. | 04/3/2021 |
| CSN6-TRIM21 axis instigates cancer stemness during tumorigenesis. | CSN6-TRIM21 axis instigates cancer stemness during tumorigenesis.
Qin B, Zou S, Li K, Wang H, Wei W, Zhang B, Xiao L, Choi HH, Tang Q, Huang D, Liu Q, Pan Q, Meng M, Fang L, Lee MH., Free PMC Article | 03/20/2021 |
| CSN6 inhibition suppresses pancreatic adenocarcinoma metastasis via destabilizing the c-Fos protein. | CSN6 inhibition suppresses pancreatic adenocarcinoma metastasis via destabilizing the c-Fos protein.
Ma F, Wang H, Liu K, Wang Z, Chen S. | 12/12/2020 |
| High CSN6 expression is associated with glioblastoma. | EGFR-ERK pathway regulates CSN6 to contribute to PD-L1 expression in glioblastoma.
Su L, Guo W, Lou L, Nie S, Zhang Q, Liu Y, Chang Y, Zhang X, Li Y, Shen H. | 07/11/2020 |
| CSN6 expression is a potential biomarker for predicting cancer recurrence and clinical survival in upper tract urothelial carcinoma. | The prognostic value of CSN6 expression in upper tract urothelial carcinomas.
Jhan JH, Lee YC, Li WM, Chang LL, Hsu WC, Lin HH, Liang PI, Hsu YL, Wu WJ, Lee HY, Li CC, Yeh HC, Ke HL. | 02/15/2020 |
| Study shows that Cullin-RING Ligase-2 (CRL2) activates CSN5/CSN6 in a neddylation-independent manner. The presence of NEDD8 is required to activate the CSN5 active site. Synergising cryo-electron microscopy with mass spectrometry, study identified sensory regions of the COP9 signalosome that mediate its stepwise activation and provide a framework for understanding the regulatory mechanism of other Cullin family members. | Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A., Free PMC Article | 12/28/2019 |
| High CSN6 expression is associated with metastasis of glioblastoma. | CSN6 controls the proliferation and metastasis of glioblastoma by CHIP-mediated degradation of EGFR.
Hou J, Deng Q, Zhou J, Zou J, Zhang Y, Tan P, Zhang W, Cui H. | 09/16/2017 |
| The overexpression of CSN6 reduced the effect of quercetin treatment on HT29 cells, suggesting that quercetininduced apoptosis may involve the AktCSN6Myc signaling axis in HT29 cells. | Quercetin-induced apoptosis of HT-29Â colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis.
Yang L, Liu Y, Wang M, Qian Y, Dong X, Gu H, Wang H, Guo S, Hisamitsu T., Free PMC Article | 04/22/2017 |
| CSN6 positively regulates c-Jun in a MEKK1-dependent manner | CSN6 positively regulates c-Jun in a MEKK1-dependent manner.
Shin J, Phan L, Chen J, Lu Z, Lee MH., Free PMC Article | 09/3/2016 |
| our results indicate that CSN6 is a positive regulator of E6AP and is important for cervical cancer development. | COP9 signalosome subunit 6 (CSN6) regulates E6AP/UBE3A in cervical cancer.
Gao S, Fang L, Phan LM, Qdaisat A, Yeung SC, Lee MH., Free PMC Article | 08/20/2016 |
| CSN6 interacts with p27(Kip1) and facilitates ubiquitin-mediated degradation of p27(Kip1). | Regulating the stability and localization of CDK inhibitor p27(Kip1) via CSN6-COP1 axis.
Choi HH, Guma S, Fang L, Phan L, Ivan C, Baggerly K, Sood A, Lee MH., Free PMC Article | 04/23/2016 |
| Findings indicate that the deregulation of beta-catenin by extracellular signal-regulated kinase 2 (ERK2)-activated CSN6 protein is important for colorectal cancer (CRC) development. | ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development.
Fang L, Lu W, Choi HH, Yeung SC, Tung JY, Hsiao CD, Fuentes-Mattei E, Menter D, Chen C, Wang L, Wang J, Lee MH., Free PMC Article | 11/28/2015 |
| Analyses of the pseudo metal-binding motif in CSN6 suggest that the loss of two key histidine residues may contribute to the lack of catalytic activity in CSN6. | Crystal structure of the human CSN6 MPN domain.
Ma XL, Xu M, Jiang T. | 02/14/2015 |
| Data suggest that CSN6 is an important negative regulator of p57 (Kip2) , and that overexpression of CSN6 in many types of cancer could lead to decreased expression of p57 (Kip2) and result in promoted cancer cell growth. | CDK inhibitor p57 (Kip2) is negatively regulated by COP9 signalosome subunit 6.
Chen B, Zhao R, Su CH, Linan M, Tseng C, Phan L, Fang L, Yang HY, Yang H, Wang W, Xu X, Jiang N, Cai S, Jin F, Yeung SC, Lee MH., Free PMC Article | 06/8/2013 |
| COPS6 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. | The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Warnatz HJ, Schmidt D, Manke T, Piccini I, Sultan M, Borodina T, Balzereit D, Wruck W, Soldatov A, Vingron M, Lehrach H, Yaspo ML., Free PMC Article | 09/14/2011 |
| loss of CSN6 enhances p53-mediated tumor suppression in vivo and CSN6 plays an important role in regulating DNA damage-associated apoptosis and tumorigenesis through control of the MDM2-p53 signaling pathway | Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.
Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, Lee DF, Jin F, Zhu R, Shaikenov T, Sarbassov D, Sahin A, Wang H, Wang H, Lai CC, Tsai FJ, Lozano G, Lee MH., Free PMC Article | 04/30/2011 |
| For the first time our data demonstrate that CSN-mediated deneddylation can be regulated by active Casp3 and that the CSN executes a specific function during the apoptotic process. | The COP9 signalosome-mediated deneddylation is stimulated by caspases during apoptosis.
Hetfeld BK, Peth A, Sun XM, Henklein P, Cohen GM, Dubiel W. | 01/21/2010 |
| critical role of caspase 8 in the processing of CSN6. | The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis.
da Silva Correia J, Miranda Y, Leonard N, Ulevitch RJ. | 01/21/2010 |