| Chondromodulin-1 and vascular endothelial growth factor-A expression in esophageal squamous cell carcinoma: accelerator and brake theory for angiogenesis at the early stage of cancer progression. | Chondromodulin-1 and vascular endothelial growth factor-A expression in esophageal squamous cell carcinoma: accelerator and brake theory for angiogenesis at the early stage of cancer progression.
Kumagai Y, Tachikawa T, Higashi M, Sobajima J, Takahashi A, Amano K, Ishibashi KI, Mochiki E, Yakabi K, Tamaru JI, Ishida H. | 07/17/2021 |
| ChMI directly suppressed the proliferation and growth of osteosarcoma cells. | Chondromodulin‑I suppresses tumorigenesis of human osteosarcoma cells.
Lin X, Wang L, Wang F. | 07/21/2018 |
| CHM1 seems to have pleiotropic functions in Ewing sarcoma. | The endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype, promoting lung metastasis in Ewing sarcoma.
von Heyking K, Calzada-Wack J, Göllner S, Neff F, Schmidt O, Hensel T, Schirmer D, Fasan A, Esposito I, Müller-Tidow C, Sorensen PH, Burdach S, Richter GHS., Free PMC Article | 06/2/2018 |
| The results of the present study indicated that ChMI was able to inhibit the growth of breast cancer cells; thus suggesting that ChM-I may have potential clinical applications in the treatment of breast cancer. | Transfection of chondromodulin I into human breast cancer cells and its effect on the inhibition of cancer cell growth.
Shao J, Gan L, Wang J. | 02/25/2017 |
| Data suggest ChM1 as potential tumor suppressor in gastric cancer and useful biomarker for the treatment and prognosis. Its expression was downregulated in cancer tissue, and correlated with advanced stages, lymph node metastasis, and poorer prognosis. | Chondromodulin-1 functions as a tumor suppressor in gastric adenocarcinoma.
Zhang P, Wang Y, Xu P, Song S, Zhu X, Shi Z, Gao S, Feng X. | 05/21/2016 |
| intact 20-25 kDa ChM-I is stored as a component of extracellular matrix in the avascular cartilage zones, but it is inactivated by a single N-terminal proteolytic cleavage in the hypertrophic zone of growth-plate cartilage | The N-terminal cleavage of chondromodulin-I in growth-plate cartilage at the hypertrophic and calcified zones during bone development.
Miura S, Kondo J, Takimoto A, Sano-Takai H, Guo L, Shukunami C, Tanaka H, Hiraki Y., Free PMC Article | 12/6/2014 |
| the inner meniscus contained larger amounts of ChM-I, and that the inner meniscus-derived ChM-I inhibited endothelial cell proliferation. | Chondromodulin-I derived from the inner meniscus prevents endothelial cell proliferation.
Fujii M, Furumatsu T, Yokoyama Y, Kanazawa T, Kajiki Y, Abe N, Ozaki T. | 04/20/2013 |
| Degenerative intervertebral disc cells express ChM-I. Administration of bFGF down-regulates the expression of ChM-I. Expression is correlated with the degree of degeneration. | [Expression of chondromodulin-1 in the adult degenerative intervertebral disc].
Li X, Wang YP, Qiu GX, Shen JX, Zhang JG, Zhao H, Tian Y, Hu JH, Zhao Y, Li SG. | 03/23/2013 |
| Inhibition of YY1 in combination with forced expression of p300 and Sp3 restored the expression of ChM-I in cells with a hypomethylated promoter region, but not in cells with hypermethylation. | Histone modifiers, YY1 and p300, regulate the expression of cartilage-specific gene, chondromodulin-I, in mesenchymal stem cells.
Aoyama T, Okamoto T, Fukiage K, Otsuka S, Furu M, Ito K, Jin Y, Ueda M, Nagayama S, Nakayama T, Nakamura T, Toguchida J., Free PMC Article | 10/23/2010 |
| Data suggest that chondromodulin-I impairs the VEGF-A-stimulated motility of endothelial cells by destabilizing lamellipodial extensions. | Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by chondromodulin-I, a cartilage-derived angiogenesis inhibitor.
Miura S, Mitsui K, Heishi T, Shukunami C, Sekiguchi K, Kondo J, Sato Y, Hiraki Y. | 03/29/2010 |
| new hypoxia-inducible and SOX9-regulated genes, Gdf10 and Chm-I. In addition, Mig6 and InhbA were induced by hypoxia, predominantly via HIF-2alpha | Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways.
Lafont JE, Talma S, Hopfgarten C, Murphy CL. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Association of chondromodulin-II Val58Ile polymorphism with radiographic joint destruction in rheumatoid arthritis.
Graessler J, Verlohren M, Graessler A, Zeissig A, Kuhlisch E, Kopprasch S, Schroeder HE. | 03/13/2008 |
| Cell-specific epigenetic regulation of ChM-I gene expression | Cell-specific epigenetic regulation of ChM-I gene expression: crosstalk between DNA methylation and histone acetylation.
Aoyama T, Okamoto T, Kohno Y, Fukiage K, Otsuka S, Furu M, Ito K, Jin Y, Nagayama S, Nakayama T, Nakamura T, Toguchida J. | 01/21/2010 |
| Methylation in the core-promoter region of the chondromodulin-I gene determines the cell-specific expression by regulating the binding of transcriptional activator Sp3 | Methylation in the core-promoter region of the chondromodulin-I gene determines the cell-specific expression by regulating the binding of transcriptional activator Sp3.
Aoyama T, Okamoto T, Nagayama S, Nishijo K, Ishibe T, Yasura K, Nakayama T, Nakamura T, Toguchida J. | 01/21/2010 |
| chondromodulin-I has a pivotal role in maintaining valvular normal function by preventing angiogenesis that may lead to valvular heart diseases | Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis.
Yoshioka M, Yuasa S, Matsumura K, Kimura K, Shiomi T, Kimura N, Shukunami C, Okada Y, Mukai M, Shin H, Yozu R, Sata M, Ogawa S, Hiraki Y, Fukuda K. | 01/21/2010 |