| TPPP-BRD9 fusion-related gallbladder carcinomas are frequently associated with intracholecystic neoplasia, neuroendocrine carcinoma, and a distinctive small tubular-type adenocarcinoma commonly accompanied with a syringomatous pattern. | TPPP-BRD9 fusion-related gallbladder carcinomas are frequently associated with intracholecystic neoplasia, neuroendocrine carcinoma, and a distinctive small tubular-type adenocarcinoma commonly accompanied with a syringomatous pattern.
Pehlivanoglu B, Araya JC, Lawrence S, Roa JC, Balci S, Andersen JB, Rashid A, Hsing AW, Zhu B, Gao YT, Koshiol J, Adsay V. | 09/3/2024 |
| Perspective Strategies for Interventions in Parkinsonism: Remedying the Neglected Role of TPPP. | Perspective Strategies for Interventions in Parkinsonism: Remedying the Neglected Role of TPPP.
Oláh J, Norris V, Lehotzky A, Ovádi J., Free PMC Article | 04/3/2024 |
| HERV-W Envelope Triggers Abnormal Dopaminergic Neuron Process through DRD2/PP2A/AKT1/GSK3 for Schizophrenia Risk. | HERV-W Envelope Triggers Abnormal Dopaminergic Neuron Process through DRD2/PP2A/AKT1/GSK3 for Schizophrenia Risk.
Yan Q, Wu X, Zhou P, Zhou Y, Li X, Liu Z, Tan H, Yao W, Xia Y, Zhu F., Free PMC Article | 03/5/2022 |
| Anti-Aggregative Effect of the Antioxidant DJ-1 on the TPPP/p25-Derived Pathological Associations of Alpha-Synuclein. | Anti-Aggregative Effect of the Antioxidant DJ-1 on the TPPP/p25-Derived Pathological Associations of Alpha-Synuclein.
Oláh J, Lehotzky A, Szénási T, Ovádi J., Free PMC Article | 01/15/2022 |
| This study revealed the low expression level of TPPP in pancreatic cancer cells. In addition, the high expression of TPPP promotes the invasion, migration and angiogenesis of pancreatic cancer cells. | YY1 targets tubulin polymerisation-promoting protein to inhibit migration, invasion and angiogenesis in pancreatic cancer via p38/MAPK and PI3K/AKT pathways.
Chen Q, Yang C, Chen L, Zhang JJ, Ge WL, Yuan H, Meng LD, Huang XM, Shen P, Miao Y, Jiang KR., Free PMC Article | 06/20/2020 |
| These results demonstrate that TPPP on Golgi outposts are important for local microtubule nucleation and myelin sheath elongation. | The Golgi Outpost Protein TPPP Nucleates Microtubules and Is Critical for Myelination.
Fu MM, McAlear TS, Nguyen H, Oses-Prieto JA, Valenzuela A, Shi RD, Perrino JJ, Huang TT, Burlingame AL, Bechstedt S, Barres BA., Free PMC Article | 06/13/2020 |
| The binding of TPPP/p25 to a new binding site of DYNLL/LC8, outside the canonical binding groove, counteracted the TPPP/p25-derived hyperacetylation of the microtubule network. | Interactions between two regulatory proteins of microtubule dynamics, HDAC6, TPPP/p25, and the hub protein, DYNLL/LC8.
Oláh J, Szunyogh S, Szénási T, Szaniszló T, Szabó A, Lehotzky A, Berki T, Nyitray L, Ovádi J. | 03/21/2020 |
| TPPP/p25 is co-enriched and co-localized with alpha-synuclein in brain inclusions of Parkinson's disease patients. Interaction of alpha-synuclein with various deletion mutants and fragments of TPPP/p25 were characterized. | Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins.
Szénási T, Oláh J, Szabó A, Szunyogh S, Láng A, Perczel A, Lehotzky A, Uversky VN, Ovádi J. | 12/22/2018 |
| The objective of this paper is to highlight a critical point of a recently published Skoufias's paper in which the crucial role of the microtubules in TPPP/p25 dimerization leading to microtubule bundling was suggested. | Further evidence for microtubule-independent dimerization of TPPP/p25.
Oláh J, Szénási T, Szunyogh S, Szabó A, Lehotzky A, Ovádi J., Free PMC Article | 10/20/2018 |
| This study demonstrated that the AAV9-mediated p25 overexpression mouse model, which is a practical model exhibiting neurodegeneration-like pathological and behavioral changes. | Neurodegeneration-Like Pathological and Behavioral Changes in an AAV9-Mediated p25 Overexpression Mouse Model.
Zhou X, Huang J, Pan S, Xu M, He R, Ji Z, Hu Y. | 01/27/2018 |
| The knowledge accumulated so far underlines the key roles of the multifunctional TPPP/p25 in both physiological and diverse pathological processes, consequently its validation as drug target sorely needs a new innovative strategy that is briefly reviewed here. | Role of the microtubule-associated TPPP/p25 in Parkinson's and related diseases and its therapeutic potential.
Oláh J, Bertrand P, Ovádi J. | 11/4/2017 |
| TPPP may have a role in poor prognosis in hepatocellular carcinoma | Correlation Between Poor Prognosis and Lower TPPP Gene Expression in Hepatocellular Carcinoma.
Inokawa Y, Sonohara F, Kanda M, Hayashi M, Nishikawa Y, Sugimoto H, Kodera Y, Nomoto S. | 02/18/2017 |
| the central folded domain of TPPP/p25 following binding to microtubules can drive s homotypic protein-protein interactions leading to bundled microtubules. | Self protein-protein interactions are involved in TPPP/p25 mediated microtubule bundling.
DeBonis S, Neumann E, Skoufias DA., Free PMC Article | 08/13/2016 |
| Results reveal a link between p25 and BACE1 in Alzheimer disease (AD) brains and suggest that upregulated Cdk5 activation by p25 accelerates AD pathogenesis by enhancing BACE1 activity via phosphorylation. | Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer's Disease.
Song WJ, Son MY, Lee HW, Seo H, Kim JH, Chung SH., Free PMC Article | 05/28/2016 |
| Epigenetic changes in TPPP, in combination with experiences of maltreatment, may confer risk for depression in children. | Child abuse, depression, and methylation in genes involved with stress, neural plasticity, and brain circuitry.
Weder N, Zhang H, Jensen K, Yang BZ, Simen A, Jackowski A, Lipschitz D, Douglas-Palumberi H, Ge M, Perepletchikova F, O'Loughlin K, Hudziak JJ, Gelernter J, Kaufman J., Free PMC Article | 04/18/2015 |
| suggest that the zinc as a specific divalent cation could be involved in the fine-tuning of the physiological TPPP/p25 level counteracting both the enrichment and the lack of this protein leading to distinct central nervous system diseases | Zinc-induced structural changes of the disordered tppp/p25 inhibits its degradation by the proteasome.
Lehotzky A, Oláh J, Szunyogh S, Szabó A, Berki T, Ovádi J. | 03/21/2015 |
| results suggest that ROCK regulates beta-catenin stability in cells via preventing TPPP1-mediated inhibition of HDAC6 activity, to reduce its acetylation and degradation via phosphorylation by CK1 and GSK3beta | Tubulin polymerization promoting protein 1 (TPPP1) increases β-catenin expression through inhibition of HDAC6 activity in U2OS osteosarcoma cells.
Schofield AV, Gamell C, Bernard O. | 10/26/2013 |
| GSK3 promotes the mitochondrial translocation of p53, enabling its interaction with Bcl2 to allow Bax oligomerization and the subsequent release of cytochrome C. | Pharmacological inhibition of GSK3 attenuates DNA damage-induced apoptosis via reduction of p53 mitochondrial translocation and Bax oligomerization in neuroblastoma SH-SY5Y cells.
Ngok-Ngam P, Watcharasit P, Thiantanawat A, Satayavivad J., Free PMC Article | 06/1/2013 |
| dual Rock and Cdk phosphorylation of Tppp1 inhibits its regulation of the cell cycle to increase cell proliferation | Tubulin polymerization promoting protein 1 (Tppp1) phosphorylation by Rho-associated coiled-coil kinase (rock) and cyclin-dependent kinase 1 (Cdk1) inhibits microtubule dynamics to increase cell proliferation.
Schofield AV, Gamell C, Suryadinata R, Sarcevic B, Bernard O., Free PMC Article | 05/18/2013 |
| The RhoA-ROCK-LIMK2-TPPP pathway controls metaphase spindle-orientation; TPPP colocalizes with LIMK2 at the mitotic spindle. | TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation.
Heng YW, Lim HH, Mina T, Utomo P, Zhong S, Lim CT, Koh CG. | 02/16/2013 |
| Although serine-129 phosphorylation of alpha-synuclein facilitates TPPP-mediated alpha-SYN oligomerization, this modification does not seem to play an inevitable role in the early step of alpha-SYN oligomer formation in a cellular model of multiple system atrophy. | Role of TPPP/p25 on α-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy.
Hasegawa T, Baba T, Kobayashi M, Konno M, Sugeno N, Kikuchi A, Itoyama Y, Takeda A. | 11/24/2012 |
| The authors conclude that the modest structural changes that p25alpha undergoes can promote weak intermolecular contacts and that polyanions such as heparin play a central role in stabilizing these aggregates. | Multiple roles of heparin in the aggregation of p25α.
Nielsen SB, Yde P, Giehm L, Sundbye S, Christiansen G, Mathiesen J, Jensen MH, Jensen PH, Otzen DE. | 10/6/2012 |
| Wnt induces the phosphorylation of LRP6 which consequently access the catalytic pocket of GSK3 as pseudo-substrates, thus directly blocking its activity against beta-catenin. | Inhibition of GSK3 by Wnt signalling--two contrasting models.
Metcalfe C, Bienz M. | 03/31/2012 |
| GSK3 has a significant role in maintaining repression of growth factor-inducible genes during quiescence. CREB, NFkB and AP-1 mediate this regulation of gene expression by GSK-3. | A GSK-3-mediated transcriptional network maintains repression of immediate early genes in quiescent cells.
Tullai JW, Graham JR, Cooper GM., Free PMC Article | 03/24/2012 |
| Data show that TPPP may work as a protective factor for cells against the damage effects of the accumulation of abnormal forms of PrPs, besides its function as an agent for dynamic stabilization of microtubular ultrastructures. | Molecular interaction of TPPP with PrP antagonized the CytoPrP-induced disruption of microtubule structures and cytotoxicity.
Zhou RM, Jing YY, Guo Y, Gao C, Zhang BY, Chen C, Shi Q, Tian C, Wang ZY, Gong HS, Han J, Xu BL, Dong XP., Free PMC Article | 02/18/2012 |