| Abundant extrasynaptic expression of alpha3beta4-containing nicotinic acetylcholine receptors in the medial habenula-interpeduncular nucleus pathway in mice. | Abundant extrasynaptic expression of α3β4-containing nicotinic acetylcholine receptors in the medial habenula-interpeduncular nucleus pathway in mice.
Tsuzuki A, Yamasaki M, Konno K, Miyazaki T, Takei N, Tomita S, Yuzaki M, Watanabe M., Free PMC Article | 07/9/2024 |
| Differential tyrosine and serine/threonine phosphorylation/dephosphorylation pathways regulate the expression of alpha7 versus alpha3beta4 nicotinic receptor subtypes in mouse hippocampal neurons. | Differential tyrosine and serine/threonine phosphorylation/dephosphorylation pathways regulate the expression of α7 versus α3β4 nicotinic receptor subtypes in mouse hippocampal neurons.
Jiménez-Pompa A, Arribas RL, McIntosh JM, Albillos A. | 11/10/2023 |
| Bidirectional sex-dependent regulation of alpha6 and beta3 nicotinic acetylcholine receptors by protein kinase Cepsilon. | Bidirectional sex-dependent regulation of α6 and β3 nicotinic acetylcholine receptors by protein kinase Cε.
Moen JK, DeBaker MC, Myjak JE, Wickman K, Lee AM., Free PMC Article | 11/6/2021 |
| alpha3* Nicotinic Acetylcholine Receptors in the Habenula-Interpeduncular Nucleus Circuit Regulate Nicotine Intake. | α3* Nicotinic Acetylcholine Receptors in the Habenula-Interpeduncular Nucleus Circuit Regulate Nicotine Intake.
Elayouby KS, Ishikawa M, Dukes AJ, Smith ACW, Lu Q, Fowler CD, Kenny PJ., Free PMC Article | 06/19/2021 |
| Regulation of nicotinic acetylcholine receptor alpha3 subtype in adipose tissue dysfunction | Regulation of nicotinic acetylcholine receptor α3 subtype in adipose tissue dysfunction.
Bai X, Ju H, Gao L, Xiong Y, Dai R, Huang X, Yang C. | 02/1/2020 |
| Mechanoinsensitive ''silent'' nociceptors are characterized by the expression of the nicotinic acetylcholine receptor subunit alpha-3 (CHRNA3); the mechanically gated ion channel PIEZO2 mediates NGF-induced mechanosensitivity in these neurons. | Functional and Molecular Characterization of Mechanoinsensitive "Silent" Nociceptors.
Prato V, Taberner FJ, Hockley JRF, Callejo G, Arcourt A, Tazir B, Hammer L, Schad P, Heppenstall PA, Smith ES, Lechner SG., Free PMC Article | 07/28/2018 |
| neuroinflammation is sufficient to provoke the decrease of a7 and a4b2 nAChRs, Ab42 accumulation and memory impairment in mice and a7(1-208) nAChR-specific antibodies can cause inflammation of the brain with symptoms typical for Alzheimer disease | α7 Nicotinic acetylcholine receptor-specific antibody induces inflammation and amyloid β42 accumulation in the mouse brain to impair memory.
Lykhmus O, Voytenko L, Koval L, Mykhalskiy S, Kholin V, Peschana K, Zouridakis M, Tzartos S, Komisarenko S, Skok M., Free PMC Article | 02/27/2016 |
| The alpha3beta4* nicotinic ACh receptor subtype mediates physical dependence to morphine | The α3β4* nicotinic ACh receptor subtype mediates physical dependence to morphine: mouse and human studies.
Muldoon PP, Jackson KJ, Perez E, Harenza JL, Molas S, Rais B, Anwar H, Zaveri NT, Maldonado R, Maskos U, McIntosh JM, Dierssen M, Miles MF, Chen X, De Biasi M, Damaj MI., Free PMC Article | 04/11/2015 |
| The present findings suggest that its thymic production and/or release are under cholinergic control involving nAChR containing the alpha3-subunit. | Terminally differentiated epithelial cells of the thymic medulla and skin express nicotinic acetylcholine receptor subunit α 3.
Soultanova A, Panneck AR, Rafiq A, Kummer W., Free PMC Article | 04/11/2015 |
| Downregulation of nAChR subunit and PSD-93 expression after cavernous nerve injury, or even manipulation, could interrupt synaptic transmission within the MPG and thus contribute to the loss of neural control of urogenital organs after pelvic surgeries. | Decrease in neuronal nicotinic acetylcholine receptor subunit and PSD-93 transcript levels in the male mouse MPG after cavernous nerve injury or explant culture.
Girard BM, Merriam LA, Tompkins JD, Vizzard MA, Parsons RL., Free PMC Article | 01/18/2014 |
| findings suggest an important role for the a3b4* nAChR subtype in nicotine reward and physical aspects of the nicotine withdrawal syndrome. | The α3β4* nicotinic acetylcholine receptor subtype mediates nicotine reward and physical nicotine withdrawal signs independently of the α5 subunit in the mouse.
Jackson KJ, Sanjakdar SS, Muldoon PP, McIntosh JM, Damaj MI., Free PMC Article | 11/30/2013 |
| A mechanistic model provides sharpening of mitral cell receptive fields by activation of the alpha3beta4 subtype of nicotinic receptor, which could aid in odor discrimination and perceptual learning. | Nicotinic receptor-mediated filtering of mitral cell responses to olfactory nerve inputs involves the α3β4 subtype.
D'Souza RD, Vijayaraghavan S., Free PMC Article | 04/21/2012 |
| Greater expression of Chrna3 is found in whole brain and dissected brain regions relevant to locomotor behavior in mice that are less sensitive to ethanol-induced stimulation compared to mice that are robustly stimulated. | The alpha 3 subunit gene of the nicotinic acetylcholine receptor is a candidate gene for ethanol stimulation.
Kamens HM, McKinnon CS, Li N, Helms ML, Belknap JK, Phillips TJ., Free PMC Article | 01/15/2011 |
| Polymorphisms located within the Chrna5-Chrna3-Chrnb4 cluster on mouse chromosome 9 were found to co-segregate with alcohol preference, with high-drinking F(2) mice carrying B6 alleles and low-drinking F(2) mice carrying D2 alleles. | Delineation of the role of nicotinic acetylcholine receptor genes in alcohol preference in mice.
Symons MN, Weng J, Diehl E, Heo E, Kleiber ML, Singh SM. | 01/8/2011 |
| The results of this study demonstrated that hyperglycemia also interferes with the function of alpha3-containing nAChRs through Cys residues on the alpha3 subunit | Diabetes depresses synaptic transmission in sympathetic ganglia by inactivating nAChRs through a conserved intracellular cysteine residue.
Campanucci V, Krishnaswamy A, Cooper E. | 08/9/2010 |
| Our results suggest that PrP(C) is a member of a multiprotein membrane complex participating in the formation and function of alpha3beta4 nAChR. | Cellular prion protein co-localizes with nAChR beta4 subunit in brain and gastrointestinal tract.
Petrakis S, Irinopoulou T, Panagiotidis CH, Engelstein R, Lindstrom J, Orr-Urtreger A, Gabizon R, Grigoriadis N, Sklaviadis T. | 01/21/2010 |
| Reporter gene analysis demonstrated that this sequence, termed "alpha3 intron 5," inhibits the transcriptional activities of the alpha3 and beta4 subunit gene promoters | Transcriptional repression by a conserved intronic sequence in the nicotinic receptor alpha3 subunit gene.
Medel YF, Gardner PD. | 01/21/2010 |
| functional nicotinic ACh receptors are detected on stem and progenitor cells of fetal mouse cerebral cortex as early as embryonic day 10 | Functional nicotinic acetylcholine receptor expression on stem and progenitor cells of the early embryonic nervous system.
Schneider AS, Atluri P, Shen Q, Barnes W, Mah SJ, Stadfelt D, Goderie SK, Temple S, Fleck MW. | 01/21/2010 |
| alpha3beta2 nicotinic receptor has a role in regulating gene expression after tobacco exposure in oral epithelial cells | Receptor-mediated tobacco toxicity: regulation of gene expression through alpha3beta2 nicotinic receptor in oral epithelial cells.
Arredondo J, Chernyavsky AI, Marubio LM, Beaudet AL, Jolkovsky DL, Pinkerton KE, Grando SA., Free PMC Article | 01/21/2010 |
| Fast synaptic transmission in mammalian sympathetic ganlia requires alpha3 expression; in knockout mice, the preganglionic nerve forms synapses that appear morphologically normal and persist for several weeks. | A null mutation for the alpha3 nicotinic acetylcholine (ACh) receptor gene abolishes fast synaptic activity in sympathetic ganglia and reveals that ACh output from developing preganglionic terminals is regulated in an activity-dependent retrograde manner.
Rassadi S, Krishnaswamy A, Pié B, McConnell R, Jacob MH, Cooper E., Free PMC Article | 01/21/2010 |