The NTE domain of PTENα/β promotes cancer progression by interacting with WDR5 via its SSSRRSS motif.
Huang X, Zhang C, Shang X, Chen Y, Xiao Q, Wei Z, Wang G, Zhen X, Xu G, Min J, Shen S, Liu Y., Free PMC Article

METTL3 orchestrates glycolysis by stabilizing the c-Myc/WDR5 complex in triple-negative breast cancer.
Yuan XN, Shao YC, Guan XQ, Liu Q, Chu MF, Yang ZL, Li H, Zhao S, Tian YH, Zhang JW, Wei L.

Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus.
Streeter SA, Williams AG, Evans JR, Wang J, Guarnaccia AD, Florian AC, Al-Tobasei R, Liu Q, Tansey WP, Weissmiller AM., Free PMC Article

WD repeat domain 5 promotes the development of late-onset preeclampsia by activating nuclear factor kappa B.
Zhao X, Su F, Kong F, Su J, Yang X, Li L, Li A, Li Q., Free PMC Article

Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5.
Chen Y, Su H, Zhao J, Na Z, Jiang K, Bacchiocchi A, Loh KH, Halaban R, Wang Z, Cao X, Slavoff SA., Free PMC Article

MLL1 inhibits the neurogenic potential of SCAPs by interacting with WDR5 and repressing HES1.
Zhang C, Ye W, Zhao M, Long L, Xia D, Fan Z., Free PMC Article

Intermittent hypoxia BMSCs-derived exosomal miR-31-5p promotes lung adenocarcinoma development via WDR5-induced epithelial mesenchymal transition.
Ren J.

A clustering of heterozygous missense variants in the crucial chromatin modifier WDR5 defines a new neurodevelopmental disorder.
Snijders Blok L, Verseput J, Rots D, Venselaar H, Innes AM, Stumpel C, Õunap K, Reinson K, Seaby EG, McKee S, Burton B, Kim K, van Hagen JM, Waisfisz Q, Joset P, Steindl K, Rauch A, Li D, Zackai EH, Sheppard SE, Keena B, Hakonarson H, Roos A, Kohlschmidt N, Cereda A, Iascone M, Rebessi E, Kernohan KD, Campeau PM, Millan F, Taylor JA, Lochmüller H, Higgs MR, Goula A, Bernhard B, Velasco DJ, Schmanski AA, Stark Z, Gallacher L, Pais L, Marcogliese PC, Yamamoto S, Raun N, Jakub TE, Kramer JM, den Hoed J, Fisher SE, Brunner HG, Kleefstra T., Free PMC Article

WDR5 is required for DUX4 expression and its pathological effects in FSHD muscular dystrophy.
Mocciaro E, Giambruno R, Micheloni S, Cernilogar FM, Andolfo A, Consonni C, Pannese M, Ferri G, Runfola V, Schotta G, Gabellini D., Free PMC Article

miR-101-3p contributes to the progression of preeclampsia by suppressing WDR5-mediated proliferation and invasion of trophoblast.
Zhao X, Su F, Kong F, Guo Q, Wang X, Cui H, Li Q, Zhang W, Li L, Li A.

Circ_0072995 drives cervical cancer development by regulating the miR-29a/WDR5 axis.
Song Z, Li H.

The SCF-FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage.
Hänle-Kreidler S, Richter KT, Hoffmann I., Free PMC Article

RhoC in association with TET2/WDR5 regulates cancer stem cells by epigenetically modifying the expression of pluripotency genes.
Thomas P, Srivastava S, Udayashankara AH, Damodaran S, Yadav L, Mathew B, Suresh SB, Mandal AK, Srikantia N., Free PMC Article

Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation.
Cai WL, Chen JF, Chen H, Wingrove E, Kurley SJ, Chan LH, Zhang M, Arnal-Estape A, Zhao M, Balabaki A, Li W, Yu X, Krop ED, Dou Y, Liu Y, Jin J, Westbrook TF, Nguyen DX, Yan Q., Free PMC Article

TM4SF19-AS1 facilitates the proliferation of lung squamous cell carcinoma by recruiting WDR5 to mediate TM4SF19.
Luo M, Xie L, Su Y, Zhang K, Liang R, Ma Z, Li Y.

Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic.
Li D, Yu X, Kottur J, Gong W, Zhang Z, Storey AJ, Tsai YH, Uryu H, Shen Y, Byrum SD, Edmondson RD, Mackintosh SG, Cai L, Liu Z, Aggarwal AK, Tackett AJ, Liu J, Jin J, Wang GG., Free PMC Article

USP7 sustains an active epigenetic program via stabilizing MLL2 and WDR5 in diffuse large B-cell lymphoma.
Wu Y, Gu H, Bao Y, Lin T, Wang Z, Gu D, Shen H, Xian H, Fan Y, Mao R.

WDR5 facilitates EMT and metastasis of CCA by increasing HIF-1α accumulation in Myc-dependent and independent pathways.
Chen T, Li K, Liu Z, Liu J, Wang Y, Sun R, Li Z, Qiu B, Zhang X, Ren G, Xu Y, Zhang Z., Free PMC Article

WDR5 promotes the proliferation of lung adenocarcinoma by inducing SOX9 expression.
Ji A, Qian L, Tian Z, Cui J.

GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Induced Cellular Transformation.
Wei S, Lu S, Liang L, Wang X, Li W, Li T, Chen L, Ju E, Zhang X, Lai Z, Huang Y, Lu X, Gao SJ., Free PMC Article

Long Noncoding RNA NEAT1 Acts as a Molecular Switch for BRD4 Transcriptional Activity and Mediates Repression of BRD4/WDR5 Target Genes.
Pistoni M, Rossi T, Donati B, Torricelli F, Polano M, Ciarrocchi A.

Impact of WIN site inhibitor on the WDR5 interactome.
Guarnaccia AD, Rose KL, Wang J, Zhao B, Popay TM, Wang CE, Guerrazzi K, Hill S, Woodley CM, Hansen TJ, Lorey SL, Shaw JG, Payne WG, Weissmiller AM, Olejniczak ET, Fesik SW, Liu Q, Tansey WP., Free PMC Article

WDR5 promotes the tumorigenesis of oral squamous cell carcinoma via CARM1/β-catenin axis.
Lyu XY, Shui YS, Wang L, Jiang QS, Meng LX, Zhan HY, Yang R.

BAG3 epigenetically regulates GALNT10 expression via WDR5 and facilitates the stem cell-like properties of platin-resistant ovarian cancer cells.
Zhao FY, Zhang Q, Wang JM, Jiang JY, Huyan LY, Liu BQ, Yan J, Li C, Wang HQ.

WD repeat domain 5 promotes chemoresistance and Programmed Death-Ligand 1 expression in prostate cancer.
Zhou Q, Chen X, He H, Peng S, Zhang Y, Zhang J, Cheng L, Liu S, Huang M, Xie R, Lin T, Huang J., Free PMC Article