| Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase. | Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase.
Rawat C, Ben-Salem S, Singh N, Chauhan G, Rabljenovic A, Vaghela V, Venkadakrishnan VB, Macdonald JD, Dahiya UR, Ghanem Y, Bachour S, Su Y, DePriest AD, Lee S, Muldong M, Kim HT, Kumari S, Valenzuela MM, Zhang D, Hu Q, Cortes Gomez E, Dehm SM, Zoubeidi A, Jamieson CAM, Nicolas M, McKenney J, Willard B, Klein EA, Magi-Galluzzi C, Stauffer SR, Liu S, Heemers HV., Free PMC Article | 12/20/2023 |
| Novel circRNA_0071196/miRNA19b3p/CIT axis is associated with proliferation and migration of bladder cancer. | Novel circRNA_0071196/miRNA‑19b‑3p/CIT axis is associated with proliferation and migration of bladder cancer.
Liu Z, Yang Y, Yang Z, Xia S, Lin D, Xiao B, Xiu Y., Free PMC Article | 05/29/2021 |
| Down-regulation of CIT can inhibit the growth of human bladder cancer cells. | Down-regulation of CIT can inhibit the growth of human bladder cancer cells.
Liu Z, Yan H, Yang Y, Wei L, Xia S, Xiu Y. | 11/21/2020 |
| gene expression profile data set showed that MM patients with high CIT gene expression had significantly worse overall survival compared with MM patients with low CIT gene expression. CIT silencing in MM cell lines induced cytokinesis failure and resulted in decreased MM cell proliferation in vitro and in vivo. | Citron Rho-interacting kinase silencing causes cytokinesis failure and reduces tumor growth in multiple myeloma.
Sahin I, Kawano Y, Sklavenitis-Pistofidis R, Moschetta M, Mishima Y, Manier S, Sacco A, Carrasco R, Fonseca R, Roccaro AM, Witzig T, Ghobrial IM., Free PMC Article | 07/25/2020 |
| CIT-K overexpression is associated with breast cancer. | Citron kinase (CIT-K) promotes aggressiveness and tumorigenesis of breast cancer cells in vitro and in vivo: preliminary study of the underlying mechanism.
Meng D, Yu Q, Feng L, Luo M, Shao S, Huang S, Wang G, Jing X, Tong Z, Zhao X, Liu R. | 12/7/2019 |
| CITK deletion decreased tumor growth and increased overall survival in these mice, with no apparent side effects. These results suggest that CITK can be a useful molecular target for medulloblastoma treatment. | Inactivation of Citron Kinase Inhibits Medulloblastoma Progression by Inducing Apoptosis and Cell Senescence.
Pallavicini G, Sgrò F, Garello F, Falcone M, Bitonto V, Berto GE, Bianchi FT, Gai M, Chiotto AMA, Filippi M, Cutrin JC, Ala U, Terreno E, Turco E, Cunto FD. | 09/28/2019 |
| in this study we have provided evidence that ASPM controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM for this activity. | ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.
Gai M, Bianchi FT, Vagnoni C, Vernì F, Bonaccorsi S, Pasquero S, Berto GE, Sgrò F, Chiotto AM, Annaratone L, Sapino A, Bergo A, Landsberger N, Bond J, Huttner WB, Di Cunto F., Free PMC Article | 07/29/2017 |
| Control of abscission requires Eph kinase activity, and Src and citron kinase (CitK) are downstream effectors in the Eph-induced signal transduction cascade | Eph-mediated tyrosine phosphorylation of citron kinase controls abscission.
Jungas T, Perchey RT, Fawal M, Callot C, Froment C, Burlet-Schiltz O, Besson A, Davy A., Free PMC Article | 06/3/2017 |
| The striking phenotypic overlap between CIT-mutated individuals and the knockout mice and rats that are specifically deficient in the kinase domain supports the proposed causal link between CIT mutation and primary microcephaly in humans. | Mutations in CIT, encoding citron rho-interacting serine/threonine kinase, cause severe primary microcephaly in humans.
Shaheen R, Hashem A, Abdel-Salam GM, Al-Fadhli F, Ewida N, Alkuraya FS. | 05/20/2017 |
| Splice site variant in CIT, identified in this study, is predicted to abolish splice donor site. cDNA sequence of an affected individual showed retention of an intron next to the splice donor site. The study, presented here, revealed the first variant in the CIT causing Autosomal recessive primary microcephaly in the family. | CIT, a gene involved in neurogenic cytokinesis, is mutated in human primary microcephaly.
Basit S, Al-Harbi KM, Alhijji SA, Albalawi AM, Alharby E, Eldardear A, Samman MI. | 05/20/2017 |
| identification of recessively inherited pathogenic variants in CIT as the genetic basis of severe microcephaly and neonatal death; and postmortem data showing that CIT is critical to building a normally sized human brain | Mutations in Citron Kinase Cause Recessive Microlissencephaly with Multinucleated Neurons.
Harding BN, Moccia A, Drunat S, Soukarieh O, Tubeuf H, Chitty LS, Verloes A, Gressens P, El Ghouzzi V, Joriot S, Di Cunto F, Martins A, Passemard S, Bielas SL., Free PMC Article | 05/13/2017 |
| Biallelic Mutations in Citron Kinase Link Mitotic Cytokinesis to Human Primary Microcephaly | Biallelic Mutations in Citron Kinase Link Mitotic Cytokinesis to Human Primary Microcephaly.
Li H, Bielas SL, Zaki MS, Ismail S, Farfara D, Um K, Rosti RO, Scott EC, Tu S, Chi NC, Gabriel S, Erson-Omay EZ, Ercan-Sencicek AG, Yasuno K, Çağlayan AO, Kaymakçalan H, Ekici B, Bilguvar K, Gunel M, Gleeson JG., Free PMC Article | 05/13/2017 |
| The CIT-K may promote this event by interacting with TUBB3 and by recruiting at the midbody casein kinase-2alpha (CK2alpha) that has previously been reported to phosphorylate the S444 residue. | Tissue-specific control of midbody microtubule stability by Citron kinase through modulation of TUBB3 phosphorylation.
Sgrò F, Bianchi FT, Falcone M, Pallavicini G, Gai M, Chiotto AM, Berto GE, Turco E, Chang YJ, Huttner WB, Di Cunto F., Free PMC Article | 12/31/2016 |
| Proper midbody architecture requires cross-regulation between two cell division kinases, Citron kinase (CIT-K) and Aurora B, the kinase component of the chromosomal passenger complex. | Cross-regulation between Aurora B and Citron kinase controls midbody architecture in cytokinesis.
McKenzie C, Bassi ZI, Debski J, Gottardo M, Callaini G, Dadlez M, D'Avino PP., Free PMC Article | 12/17/2016 |
| The TPC1 was shown to interact with citron kinase, with TPC1 overexpression affecting RhoA activity and myosin light chain phosphorylation levels in cytokinesis. | Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis.
Horton JS, Wakano CT, Speck M, Stokes AJ., Free PMC Article | 12/12/2015 |
| HIV-1 infection upregulates citK expression at the transcriptional level | [Mechanism Underlying Increased Expression of a Member of the Serine/Threonine Kinase Family (Citron kinase) Induced by HIV-1 Infection].
Ding J, Mi Z, Zhao J, Zhou J, Li X, Cen S. | 12/5/2015 |
| Data propose that the CC-domain-mediated translocation and actions of Citron-K ensure proper stabilization of the midbody structure during the transition from constriction to abscission. | Citron kinase mediates transition from constriction to abscission through its coiled-coil domain.
Watanabe S, De Zan T, Ishizaki T, Narumiya S. | 11/2/2013 |
| High CIT expression is associated with prostate cancer. | Identification of kinases regulating prostate cancer cell growth using an RNAi phenotypic screen.
Whitworth H, Bhadel S, Ivey M, Conaway M, Spencer A, Hernan R, Holemon H, Gioeli D., Free PMC Article | 03/30/2013 |
| p27 has a role in cytokinesis via the regulation of citron-K activity | p27(Kip1) controls cytokinesis via the regulation of citron kinase activation.
Serres MP, Kossatz U, Chi Y, Roberts JM, Malek NP, Besson A., Free PMC Article | 05/5/2012 |
| CIT-K is a crucial abscission regulator that may promote midbody stability through active RhoA and anillin. | Citron kinase controls abscission through RhoA and anillin.
Gai M, Camera P, Dema A, Bianchi F, Berto G, Scarpa E, Germena G, Di Cunto F., Free PMC Article | 02/18/2012 |
| Hrs inhibits HIV-1 production by inhibiting citron kinase-mediated exocytosis. | Hrs inhibits citron kinase-mediated HIV-1 budding via its FYVE domain.
Ding J, Su L, Gao G., Free PMC Article | 11/12/2011 |
| CITRON has a role in proliferation of hepatocellular carcinoma cells | RNA interference targeting CITRON can significantly inhibit the proliferation of hepatocellular carcinoma cells.
Fu Y, Huang J, Wang KS, Zhang X, Han ZG. | 05/28/2011 |
| Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging. | Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging.
Nicodemus KK, Callicott JH, Higier RG, Luna A, Nixon DC, Lipska BK, Vakkalanka R, Giegling I, Rujescu D, St Clair D, Muglia P, Shugart YY, Weinberger DR. | 05/7/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |