| CHES1 modulated tumorigenesis and senescence of pancreas cancer cells through repressing AKR1B10. | CHES1 modulated tumorigenesis and senescence of pancreas cancer cells through repressing AKR1B10.
Kong D, Wu Y, Tong B, Liang Y, Xu F, Chi X, Ni L, Tian G, Zhang G, Xu Z. | 06/28/2024 |
| FOXN3 inhibits the progression of ovarian cancer through negatively regulating the expression of RPS15A. | FOXN3 inhibits the progression of ovarian cancer through negatively regulating the expression of RPS15A.
Yang H, Li M, Qi Y. | 05/5/2023 |
| FOXN3 inhibits cell proliferation and invasion via modulating the AKT/MDM2/p53 axis in human glioma. | FOXN3 inhibits cell proliferation and invasion via modulating the AKT/MDM2/p53 axis in human glioma.
Wang C, Tu H, Yang L, Ma C, Hu J, Luo J, Wang H., Free PMC Article | 01/15/2022 |
| miR-574-5p Targets FOXN3 to Regulate the Invasion of Nasopharyngeal Carcinoma Cells via Wnt/beta-Catenin Pathway. | miR-574-5p Targets FOXN3 to Regulate the Invasion of Nasopharyngeal Carcinoma Cells via Wnt/β-Catenin Pathway.
Lin Z, Chen M, Wan Y, Lei L, Ruan H., Free PMC Article | 11/6/2021 |
| FOXN3 suppresses the growth and invasion of papillary thyroid cancer through the inactivation of Wnt/beta-catenin pathway. | FOXN3 suppresses the growth and invasion of papillary thyroid cancer through the inactivation of Wnt/β-catenin pathway.
Zhao C, Mo L, Li C, Han S, Zhao W, Liu L. | 06/12/2021 |
| MicroRNA-574-5p directly targets FOXN3 to mediate thyroid cancer progression via Wnt/beta-catenin signaling pathway. | MicroRNA-574-5p directly targets FOXN3 to mediate thyroid cancer progression via Wnt/β-catenin signaling pathway.
Zhang ZJ, Xiao Q, Li XY. | 04/3/2021 |
| The clinical and prognostic significance of FOXN3 downregulation in acute myeloid leukaemia. | The clinical and prognostic significance of FOXN3 downregulation in acute myeloid leukaemia.
Zhang J, Wang Y, Mo W, Zhang R, Li Y., Free PMC Article | 01/2/2021 |
| FOXN3 was notably downregulated in osteosarcoma (OS) tissues and the expression of FOXN3 was negatively correlated with tumor size, metastasis and TNM stage. Also, FOXN3 suppressed the proliferation, migration and invasion of osteosarcoma cells. Furthermore, FOXN3 was demonstrated to transcriptionally suppress SIRT6 expression, thereby inhibiting MMP9 secretion. | FOXN3 is downregulated in osteosarcoma and transcriptionally regulates SIRT6, and suppresses migration and invasion in osteosarcoma.
Xue W, Ma L, Wang Z, Zhang W, Zhang X. | 09/12/2020 |
| liver FOXN3 and glucagon control fasting glucose. | A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose.
Karanth S, Adams JD, Serrano MLA, Quittner-Strom EB, Simcox J, Villanueva CJ, Ozcan L, Holland WL, Yost HJ, Vella A, Schlegel A., Free PMC Article | 11/9/2019 |
| these results identified a negative cross-regulatory loop between ERalpha and CHES1 that was required for growth of breast cancer cells, it might uncover novel insight into molecular mechanism of CHES1 involved in breast cancer and provide new avenues for molecular-targeted therapy in hormone-regulated breast cancer. | Checkpoint suppressor 1 suppresses transcriptional activity of ERα and breast cancer cell proliferation via deacetylase SIRT1.
Xu Z, Yang Y, Li B, Li Y, Xia K, Yang Y, Li X, Wang M, Li S, Wu H., Free PMC Article | 11/9/2019 |
| We present co-crystal structures of the FoxN3 DNA binding domain bound to the FKH and FHL sites, respectively. FoxN3 adopts a similar conformation to recognize both motifs, making contacts with different DNA bases using the same amino acids. However, the DNA structure is different in the two complexes | Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes.
Rogers JM, Waters CT, Seegar TCM, Jarrett SM, Hallworth AN, Blacklow SC, Bulyk ML., Free PMC Article | 10/19/2019 |
| FOXN3 bind to beta-catenin and inhibited beta-catenin/TCF signaling by blocking the interaction between beta-catenin and TCF4. Loss of FOXN3 in colon cancer activates beta-catenin/TCF signaling and promotes the growth and migration of cancer cells. | Loss of FOXN3 in colon cancer activates beta-catenin/TCF signaling and promotes the growth and migration of cancer cells.
Dai Y, Wang M, Wu H, Xiao M, Liu H, Zhang D., Free PMC Article | 02/24/2018 |
| FOXN3 functions as a tumor suppressor in hepatocellular carcinoma by downregulating the expression of E2F5. | The transcription factor FOXN3 inhibits cell proliferation by downregulating E2F5 expression in hepatocellular carcinoma cells.
Sun J, Li H, Huo Q, Cui M, Ge C, Zhao F, Tian H, Chen T, Yao M, Li J., Free PMC Article | 12/30/2017 |
| the FOXN3-NEAT1-SIN3A complex promotes epithelial-to-mesenchymal transition and invasion of breast cancer cells in vitro as well as dissemination and metastasis of breast cancer in vivo | The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer.
Li W, Zhang Z, Liu X, Cheng X, Zhang Y, Han X, Zhang Y, Liu S, Yang J, Xu B, He L, Sun L, Liang J, Shang Y., Free PMC Article | 10/28/2017 |
| the rs8004664 risk allele drives excessive expression of FOXN3 during fasting and that FOXN3 regulates fasting blood glucose. | FOXN3 Regulates Hepatic Glucose Utilization.
Karanth S, Zinkhan EK, Hill JT, Yost HJ, Schlegel A., Free PMC Article | 10/14/2017 |
| Foxn3 is a direct transcriptional suppressor of N-cadherin in colorectal metastasis. | A Systematic Approach to Defining the microRNA Landscape in Metastasis.
Mudduluru G, Abba M, Batliner J, Patil N, Scharp M, Lunavat TR, Leupold JH, Oleksiuk O, Juraeva D, Thiele W, Rothley M, Benner A, Ben-Neriah Y, Sleeman J, Allgayer H. | 10/31/2015 |
| MEN1 patients with MEN1 mutations leading to CHES1-loss of interaction have a higher risk of malignant pancreatic neuroendocrine tumors with an aggressive course of disease and disease-related death. | Higher risk of aggressive pancreatic neuroendocrine tumors in MEN1 patients with MEN1 mutations affecting the CHES1 interacting MENIN domain.
Bartsch DK, Slater EP, Albers M, Knoop R, Chaloupka B, Lopez CL, Fendrich V, Kann PH, Waldmann J. | 01/17/2015 |
| CHES1 decreases protein synthesis and cell proliferation in tumor cell lines but not in normal fibroblasts. | CHES1/FOXN3 regulates cell proliferation by repressing PIM2 and protein biosynthesis.
Huot G, Vernier M, Bourdeau V, Doucet L, Saint-Germain E, Gaumont-Leclerc MF, Moro A, Ferbeyre G., Free PMC Article | 11/29/2014 |
| MicroRNA-574-5p has a critical role in TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 | MicroRNA-574-5p was pivotal for TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 in human lung cancer.
Li Q, Li X, Guo Z, Xu F, Xia J, Liu Z, Ren T., Free PMC Article | 05/11/2013 |
| the Foxn3 mutation leads to partial embryonic and postnatal lethality, growth retardation, eye formation defects, dental anomalies and craniofacial defects. | Foxn3 is essential for craniofacial development in mice and a putative candidate involved in human congenital craniofacial defects.
Samaan G, Yugo D, Rajagopalan S, Wall J, Donnell R, Goldowitz D, Gopalakrishnan R, Venkatachalam S. | 10/23/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Four genes previously not examined in that respect in laryngeal carcinoma, occurred to be good markers of the neoplasm. They are: metal-proteinase ADAM12, cyclin-dependent kinase 2-CDK2, kinesin 14-KIF14, suppressor 1 of checkpoint-CHES1. | Metal-proteinase ADAM12, kinesin 14 and checkpoint suppressor 1 as new molecular markers of laryngeal carcinoma.
Markowski J, Tyszkiewicz T, Jarzab M, Oczko-Wojciechowska M, Gierek T, Witkowska M, Paluch J, Kowalska M, Wygoda Z, Lange D, Jarzab B. | 01/21/2010 |
| FOXN3 might contribute to the observed phenotype. | A child with deletion (14)(q24.3q32.13) and auditory neuropathy.
Schlade-Bartusiak K, Macintyre G, Zunich J, Cox DW. | 01/21/2010 |
| Two novel homozygously deleted genes in hepatocellular carcinomas are caspase 3 and CHES1. | Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets.
Katoh H, Ojima H, Kokubu A, Saito S, Kondo T, Kosuge T, Hosoda F, Imoto I, Inazawa J, Hirohashi S, Shibata T. | 01/21/2010 |