| CircRAPGEF5 sponges miR-582-3p and targets KIF3A to regulate bladder cancer cell proliferation, migration and invasion. | CircRAPGEF5 sponges miR-582-3p and targets KIF3A to regulate bladder cancer cell proliferation, migration and invasion.
Wang C, Yang X. | 04/15/2024 |
| Inhibitory mechanism of KIF3A gene on nasopharyngeal carcinoma stem cells. | Inhibitory mechanism of KIF3A gene on nasopharyngeal carcinoma stem cells.
Liu R, Li T, Zhang W. | 09/25/2023 |
| Kinesin family member 3A induces related diseases via wingless-related integration site/beta-catenin signaling pathway. | Kinesin family member 3A induces related diseases via wingless-related integration site/β-catenin signaling pathway.
Liu S, He Y, Li S, Gao X, Yang F., Free PMC Article | 01/11/2023 |
| lncRNA MIR600HG induces the proliferation and invasion of colorectal cancer cells via regulating miR-144-3p/KIF3A. | lncRNA MIR600HG induces the proliferation and invasion of colorectal cancer cells via regulating miR-144-3p/KIF3A.
Huang Y, Wang L, Liu D. | 06/25/2022 |
| Skin depletion of Kif3a resembles the pediatric atopic dermatitis transcriptome profile. | Skin depletion of Kif3a resembles the pediatric atopic dermatitis transcriptome profile.
Stevens ML, Mersha TB, Zhang Z, Kothari A, Khurana Hershey GK., Free PMC Article | 06/11/2022 |
| Coordination of two kinesin superfamily motor proteins, KIF3A and KIF13A, is essential for pericellular matrix degradation by membrane-type 1 matrix metalloproteinase (MT1-MMP) in cancer cells. | Coordination of two kinesin superfamily motor proteins, KIF3A and KIF13A, is essential for pericellular matrix degradation by membrane-type 1 matrix metalloproteinase (MT1-MMP) in cancer cells.
Gifford V, Woskowicz A, Ito N, Balint S, Lagerholm BC, Dustin ML, Itoh Y., Free PMC Article | 04/2/2022 |
| Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk. | Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk.
Stevens ML, Zhang Z, Johansson E, Ray S, Jagpal A, Ruff BP, Kothari A, He H, Martin LJ, Ji H, Wikenheiser-Brokamp K, Weirauch MT, Supp DM, Biagini Myers JM, Khurana Hershey GK., Free PMC Article | 09/12/2020 |
| Silencing of KIF3A suppressed TNBC cell proliferation by repressing the Rb-E2F signaling pathway and inhibited migration and invasion by repressing epithelial-mesenchymal transition. The tumor size was smaller and the number of lung metastatic nodules was lower in KIF3A depletion MDA-MB-231 cell xenograft mice than in the negative control group. In addition, KIF3A overexpression correlated with chemoresistance. | Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb-E2F signaling and epithelial-mesenchymal transition.
Wang W, Zhang R, Wang X, Wang N, Zhao J, Wei Z, Xiang F, Wang C., Free PMC Article | 04/25/2020 |
| Study demonstrates that human ICK (intestinal cell kinase) that authors herein call CAPK (ciliopathy-associated protein kinase) interacts with human KIF3A and phosphorylates a conserved site Thr672 both in vitro and in vivo. Long, unstructured, non-catalytic carboxyl-terminal domain (CTD) of CAPK is required for this interaction with and phosphorylation of KIF3A | Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis.
Oh YS, Wang EJ, Gailey CD, Brautigan DL, Allen BL, Fu Z., Free PMC Article | 01/4/2020 |
| the association of KIF3A is with asthma + eczema. The presence of AR comorbidity did not increase the genetic association of KIF3A with asthma or even with asthma + eczema. Thus, asthma + eczema constitutes a distinct asthmatic phenotype characterized by an association with KIF3A SNPs, which is not strengthened by AR. | KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis.
Johansson E, Biagini Myers JM, Martin LJ, He H, Pilipenko V, Mersha T, Weirauch M, Salomonis N, Ryan P, LeMasters GK, Bernstein DI, Lockey J, Khurana Hershey GK., Free PMC Article | 05/25/2019 |
| KIF3A plays an important role in epithelium apoptosis and bronchial inflammation in asthma | KIF3A knockdown sensitizes bronchial epithelia to apoptosis and aggravates airway inflammation in asthma.
Geng G, Du Y, Dai J, Tian D, Xia Y, Fu Z. | 08/11/2018 |
| A correlation between KIF3A loss and a poorer NSCLC prognosis as well as beta-catenin and cyclin D1 upregulation further suggests that KIF3A suppresses Wnt/beta-catenin signalling and tumourigenesis in NSCLC | KIF3A binds to β-arrestin for suppressing Wnt/β-catenin signalling independently of primary cilia in lung cancer.
Kim M, Suh YA, Oh JH, Lee BR, Kim J, Jang SJ., Free PMC Article | 06/16/2018 |
| The rate of transport is set by an equilibrium between a faster state, where only kinesin family member 17 protein (KIF17) motors move the train, and a slower state, where at least one kinesin family member 3A/B protein (KIF3AB) motor on the train remains active in transport. | Intraflagellar transport velocity is governed by the number of active KIF17 and KIF3AB motors and their motility properties under load.
Milic B, Andreasson JOL, Hogan DW, Block SM., Free PMC Article | 06/2/2018 |
| p0071 is required for directional vesicle movement and secretion of different KIF3-transported carriers, thereby regulating the transport of intracellular membrane vesicles along microtubules. | The armadillo protein p0071 controls KIF3 motor transport.
Becher A, Eiseler T, Porzner M, Walther P, Keil R, Bobrovich S, Hatzfeld M, Seufferlein T. | 05/26/2018 |
| PLCD1 acts as a tumour suppressor, by KIF3A-mediated suppression of ERK1/2/beta-catenin/MMP7 signalling, at least in part, in breast cancer. | Phospholipase Cδ1 suppresses cell migration and invasion of breast cancer cells by modulating KIF3A-mediated ERK1/2/β- catenin/MMP7 signalling.
Shao Q, Luo X, Yang D, Wang C, Cheng Q, Xiang T, Ren G., Free PMC Article | 03/10/2018 |
| Inhibition of kif3a in the human dental follicle cells (hDFCs) and human dental pulp cells (hDPCs) is disrupted primary cilia formation and/or function, and it was shown that kif3a is important in the differentiation of hDFCs and hDPCs through the Wnt pathway. | Disruption of kif3a results in defective osteoblastic differentiation in dental mesenchymal stem/precursor cells via the Wnt signaling pathway.
Jiang S, Chen G, Feng L, Jiang Z, Yu M, Bao J, Tian W., Free PMC Article | 07/1/2017 |
| High KIF3A expression is associated with glioblastoma. | Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.
Hoang-Minh LB, Deleyrolle LP, Siebzehnrubl D, Ugartemendia G, Futch H, Griffith B, Breunig JJ, De Leon G, Mitchell DA, Semple-Rowland S, Reynolds BA, Sarkisian MR., Free PMC Article | 12/24/2016 |
| These data suggest that GLI interactions with KIF3A-KIF3B-KAP3 complexes are essential for proper GLI transcriptional activity. | The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function.
Carpenter BS, Barry RL, Verhey KJ, Allen BL., Free PMC Article | 12/26/2015 |
| KIF3A and OVOL1 are involved in the development of Atopic dermatitis in the Chinese pediatric population. | Correlation of KIF3A and OVOL1, but not ACTL9, with atopic dermatitis in Chinese pediatric patients.
Kang Z, Li Q, Fu P, Yan S, Guan M, Xu J, Xu F. | 12/12/2015 |
| Ablation of this phosphorylation abolished herpes simplex virus 1 US3-mediated downregulation of CD1d expression, suggesting that phosphorylation of KIF3A is the primary mechanism of viral suppression of CD1d expression. | Herpes Simplex Virus 1 US3 Phosphorylates Cellular KIF3A To Downregulate CD1d Expression.
Xiong R, Rao P, Kim S, Li M, Wen X, Yuan W., Free PMC Article | 08/29/2015 |
| Findings support the notion that upregulation of KIF3a is causal of aberrant activation of Wnt signaling in advanced prostate cancer through the KIF3a-DVL2-beta-catenin axis. | KIF3a promotes proliferation and invasion via Wnt signaling in advanced prostate cancer.
Liu Z, Rebowe RE, Wang Z, Li Y, Wang Z, DePaolo JS, Guo J, Qian C, Liu W., Free PMC Article | 02/21/2015 |
| POPX2 affects trafficking by determining the phosphorylation status of KIF3A at serine 690. | POPX2 phosphatase regulates the KIF3 kinesin motor complex.
Phang HQ, Hoon JL, Lai SK, Zeng Y, Chiam KH, Li HY, Koh CG. | 10/11/2014 |
| Association of KIF3A, but not OVOL1 and ACTL9, with atopic eczema in Italian patients | Association of KIF3A, but not OVOL1 and ACTL9, with atopic eczema in Italian patients.
Lepre T, Cascella R, Ragazzo M, Galli E, Novelli G, Giardina E. | 11/16/2013 |
| in addition to its ciliogenic roles, Kif3a recruits p150(Glued) to the subdistal appendages of mother centrioles, critical for centrosomes to function as microtubule-organizing centres. | Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages.
Kodani A, Salomé Sirerol-Piquer M, Seol A, Garcia-Verdugo JM, Reiter JF., Free PMC Article | 04/20/2013 |
| KIF3A is a novel candidate gene for childhood asthma | Identification of KIF3A as a novel candidate gene for childhood asthma using RNA expression and population allelic frequencies differences.
Kovacic MB, Myers JM, Wang N, Martin LJ, Lindsey M, Ericksen MB, He H, Patterson TL, Baye TM, Torgerson D, Roth LA, Gupta J, Sivaprasad U, Gibson AM, Tsoras AM, Hu D, Eng C, Chapela R, Rodríguez-Santana JR, Rodríguez-Cintrón W, Avila PC, Beckman K, Seibold MA, Gignoux C, Musaad SM, Chen W, Burchard EG, Hershey GK., Free PMC Article | 12/24/2011 |