| Dissecting CTCF site function in a tense HoxD locus. | Dissecting CTCF site function in a tense HoxD locus.
Bruneau BG., Free PMC Article | 04/9/2022 |
| Chromatin topology and the timing of enhancer function at the HoxD locus. | Chromatin topology and the timing of enhancer function at the HoxD locus.
Rodríguez-Carballo E, Lopez-Delisle L, Willemin A, Beccari L, Gitto S, Mascrez B, Duboule D., Free PMC Article | 02/2/2021 |
| these data indicate that Hox5 genes play a critical role in alveolar development by governing the proper cellular behavior of myofibroblasts during alveologenesis | Loss of Hox5 function results in myofibroblast mislocalization and distal lung matrix defects during postnatal development.
Hrycaj SM, Marty-Santos L, Rasky AJ, Lukacs NW, Wellik DM. | 07/13/2019 |
| Results reveal a novel role for Hox5 genes as developmental regulators of Th2 immune cell function that demonstrates a redeployment of mesenchyme-associated developmental genes. | Hox5 Paralogous Genes Modulate Th2 Cell Function during Chronic Allergic Inflammation via Regulation of Gata3.
Ptaschinski C, Hrycaj SM, Schaller MA, Wellik DM, Lukacs NW., Free PMC Article | 09/30/2017 |
| Hox proteins coordinate motor neuron differentiation and connectivity programs through Ret/Gfra genes. | Hox Proteins Coordinate Motor Neuron Differentiation and Connectivity Programs through Ret/Gfrα Genes.
Catela C, Shin MM, Lee DH, Liu JP, Dasen JS., Free PMC Article | 12/17/2016 |
| data show that Hox5 genes are key upstream mesenchymal regulators of the Wnt2/2b-Bmp4-signaling axis critical for proper lung patterning. | Hox5 Genes Regulate the Wnt2/2b-Bmp4-Signaling Axis during Lung Development.
Hrycaj SM, Dye BR, Baker NC, Larsen BM, Burke AC, Spence JR, Wellik DM., Free PMC Article | 05/28/2016 |
| Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb. | Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb.
Xu B, Hrycaj SM, McIntyre DC, Baker NC, Takeuchi JK, Jeannotte L, Gaber ZB, Novitch BG, Wellik DM., Free PMC Article | 02/1/2014 |
| HoxA and HoxD genes are required for proper AER-FGFs expression, independently of their function in controlling Shh expression | Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth.
Sheth R, Grégoire D, Dumouchel A, Scotti M, Pham JM, Nemec S, Bastida MF, Ros MA, Kmita M. | 06/29/2013 |
| one HocD duplication led to transcriptional down-regulation in developing digits by impairing physical interactions between the target genes and their upstream regulatory elements, phenocopying the effect obtained when these enhancer sequences are deleted | Impact of copy number variations (CNVs) on long-range gene regulation at the HoxD locus.
Montavon T, Thevenet L, Duboule D., Free PMC Article | 03/2/2013 |
| work uncovers a bimodal type of HoxD spatial collinearity in the developing spinal cord that relies on two separate 'enhancer mini-hubs' to ensure correct Hoxd gene expression levels while maintaining their appropriate anteroposterior boundaries | Bimodal control of Hoxd gene transcription in the spinal cord defines two regulatory subclusters.
Tschopp P, Christen AJ, Duboule D. | 05/12/2012 |
| Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling | Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling.
Barna M, Merghoub T, Costoya JA, Ruggero D, Branford M, Bergia A, Samori B, Pandolfi PP. | 01/21/2010 |
| Reduntant 5'Hoxd genes regulate digit pattern downstream of Shh and Gli3. | Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of Shh.
Chen Y, Knezevic V, Ervin V, Hutson R, Ward Y, Mackem S. | 01/21/2010 |