| ZBTB16 inhibits DNA replication and induces cell cycle arrest by targeting WDHD1 transcription in lung adenocarcinoma. | ZBTB16 inhibits DNA replication and induces cell cycle arrest by targeting WDHD1 transcription in lung adenocarcinoma.
Wang K, Guo D, Yan T, Sun S, Wang Y, Zheng H, Wang G, Du J. | 06/17/2024 |
| The clinical significance of transcription factor WD repeat and HMG-box DNA binding protein 1 in laryngeal squamous cell carcinoma and its potential molecular mechanism. | The clinical significance of transcription factor WD repeat and HMG-box DNA binding protein 1 in laryngeal squamous cell carcinoma and its potential molecular mechanism.
Wu JY, Lan XL, Yan DM, Fang YY, Peng YX, Liang FF, Jiang L, Huang SN, Mo M, Lin CX, Niu YT, Wu XW, Wei ZX. | 03/26/2022 |
| Targeted inhibition of acidic nucleoplasmic DNA-binding protein 1 enhances radiosensitivity of non-small cell lung cancer. | Targeted inhibition of acidic nucleoplasmic DNA-binding protein 1 enhances radiosensitivity of non-small cell lung cancer.
Gou W, Yu X, Wu S, Wu H, Chang H, Chen L, Wei H, Bi C, Ning H, Wu Y, Hou W, Zuo D, Li Y. | 03/12/2022 |
| WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer. | WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer.
Ertay A, Liu H, Liu D, Peng P, Hill C, Xiong H, Hancock D, Yuan X, Przewloka MR, Coldwell M, Howell M, Skipp P, Ewing RM, Downward J, Wang Y., Free PMC Article | 05/1/2021 |
| WDHD1 facilitates G1 checkpoint abrogation in HPV E7 expressing cells by modulating GCN5. | WDHD1 facilitates G1 checkpoint abrogation in HPV E7 expressing cells by modulating GCN5.
Zhou Y, Pei F, Ji M, Zhang F, Sun Y, Zhao Q, Wang X, Hong Y, Tian J, Wang Y, Chen JJ., Free PMC Article | 04/17/2021 |
| The study indicated that miR-494 overexpression suppresses epithelial-mesenchymal transition, tumor formation and lymph node metastasis while promoting cholangiocarcinoma (CCA) cell apoptosis through inhibiting WDHD1 in CCA. | MicroRNA-494-dependent WDHDI inhibition suppresses epithelial-mesenchymal transition, tumor growth and metastasis in cholangiocarcinoma.
Liu B, Hu Y, Qin L, Peng XB, Huang YX. | 09/21/2019 |
| AND-1 depletion is incompatible with proliferation, owing to cells accumulating in G2 with activated DNA damage checkpoint | AND-1 fork protection function prevents fork resection and is essential for proliferation.
Abe T, Kawasumi R, Giannattasio M, Dusi S, Yoshimoto Y, Miyata K, Umemura K, Hirota K, Branzei D., Free PMC Article | 01/12/2019 |
| important role of And-1 in homologous recombination repair by regulating CtIP-mediated DNA double-strand break end resection | And-1 is required for homologous recombination repair by regulating DNA end resection.
Li Y, Li Z, Wu R, Han Z, Zhu W., Free PMC Article | 08/12/2017 |
| And-1 interacts with CtIP and that these interactions are required for DNA damage checkpoint maintenance, thereby linking DNA processing with prolonged cell cycle arrest to allow sufficient time for DNA repair. | And-1 coordinates with CtIP for efficient homologous recombination and DNA damage checkpoint maintenance.
Chen Y, Liu H, Zhang H, Sun C, Hu Z, Tian Q, Peng C, Jiang P, Hua H, Li X, Pei H., Free PMC Article | 08/12/2017 |
| findings provide important insights into the mechanistic details of human AND-1 function, advancing our understanding of replisome formation during eukaryotic replication. | The structure and polymerase-recognition mechanism of the crucial adaptor protein AND-1 in the human replisome.
Guan C, Li J, Sun D, Liu Y, Liang H., Free PMC Article | 06/24/2017 |
| The WDHD1 gene, one of the genes that is upregulated in human papillomavirus E7-expressing cells, was found to play an important role in E7-induced G1 checkpoint abrogation and rereplication | Role of WDHD1 in Human Papillomavirus-Mediated Oncogenesis Identified by Transcriptional Profiling of E7-Expressing Cells.
Zhou Y, Zhang Q, Gao G, Zhang X, Liu Y, Yuan S, Wang X, Chen JJ., Free PMC Article | 05/13/2017 |
| Results provide additional evidence suggesting that WDHD1 is involved in the mismatch repair pathway. | Proteomic Analysis Reveals a Novel Mutator S (MutS) Partner Involved in Mismatch Repair Pathway.
Chen Z, Tran M, Tang M, Wang W, Gong Z, Chen J., Free PMC Article | 12/17/2016 |
| RecQL4-dependent association of Mcm10 and Ctf4 with replication origins appears to be the first important step controlled by S phase promoting kinases and checkpoint pathways for the initiation of DNA replication in human cells. | RecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cells.
Im JS, Park SY, Cho WH, Bae SH, Hurwitz J, Lee JK., Free PMC Article | 01/2/2016 |
| And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress. | And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress.
Hao J, de Renty C, Li Y, Xiao H, Kemp MG, Han Z, DePamphilis ML, Zhu W., Free PMC Article | 10/31/2015 |
| The Ctf4-CMG complex contains a homodimeric Ctf4 that acts as a platform linking polymerase alpha to the monomeric hCMG complex. | Interaction between human Ctf4 and the Cdc45/Mcm2-7/GINS (CMG) replicative helicase.
Kang YH, Farina A, Bermudez VP, Tappin I, Du F, Galal WC, Hurwitz J., Free PMC Article | 02/8/2014 |
| And-1 together with HJURP regulates the assembly of new CENP-A onto centromeres. | Acidic nucleoplasmic DNA-binding protein (And-1) controls chromosome congression by regulating the assembly of centromere protein A (CENP-A) at centromeres.
Jaramillo-Lambert A, Hao J, Xiao H, Li Y, Han Z, Zhu W., Free PMC Article | 03/30/2013 |
| Human And-1 facilitates loading of the MCM2-7 helicase onto chromatin during the assembly of prereplicative complex. | The involvement of acidic nucleoplasmic DNA-binding protein (And-1) in the regulation of prereplicative complex (pre-RC) assembly in human cells.
Li Y, Xiao H, de Renty C, Jaramillo-Lambert A, Han Z, DePamphilis ML, Brown KJ, Zhu W., Free PMC Article | 02/16/2013 |
| Data show that And-1 forms a complex with both histone H3 and Gcn5. | And-1 is required for the stability of histone acetyltransferase Gcn5.
Li Y, Jaramillo-Lambert AN, Yang Y, Williams R, Lee NH, Zhu W., Free PMC Article | 03/31/2012 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Polymorphisms in innate immunity genes and risk of childhood leukemia.
Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D., Free PMC Article | 06/30/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesRisk of meningioma and common variation in genes related to innate immunity.
Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD. Common variation in genes related to innate immunity and risk of adult glioma.
Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ. | 06/30/2010 |
| in human cells, hCtf4 plays an essential role in DNA replication and its ability to stimulate the replicative DNA polymerases may contribute to this effect | Influence of the human cohesion establishment factor Ctf4/AND-1 on DNA replication.
Bermudez VP, Farina A, Tappin I, Hurwitz J., Free PMC Article | 05/3/2010 |
| Assembly of the Cdc45-Mcm2-7-GINS complex requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. | Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins.
Im JS, Ki SH, Farina A, Jung DS, Hurwitz J, Lee JK., Free PMC Article | 01/21/2010 |
| AND-1 coordinates multiple cellular events in S phase and G2 phase. | Roles of human AND-1 in chromosome transactions in S phase.
Yoshizawa-Sugata N, Masai H., Free PMC Article | 01/21/2010 |
| Mcm10 is required for chromatin loading of And-1. | Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication.
Zhu W, Ukomadu C, Jha S, Senga T, Dhar SK, Wohlschlegel JA, Nutt LK, Kornbluth S, Dutta A., Free PMC Article | 01/21/2010 |