| p53 isoforms differentially impact on the POLiota dependent DNA damage tolerance pathway. | p53 isoforms differentially impact on the POLι dependent DNA damage tolerance pathway.
Guo Y, Rall-Scharpf M, Bourdon JC, Wiesmüller L, Biber S., Free PMC Article | 02/5/2022 |
| Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices. | Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices.
Ihle M, Biber S, Schroeder IS, Blattner C, Deniz M, Damia G, Gottifredi V, Wiesmüller L., Free PMC Article | 08/14/2021 |
| Three Human Pol iota Variants with Impaired Polymerase Activity Fail to Rescue H2O2 Sensitivity in POLI-Deficient Cells. | Three Human Pol ι Variants with Impaired Polymerase Activity Fail to Rescue H(2)O(2) Sensitivity in POLI-Deficient Cells.
Yeom M, Hong JK, Kim JK, Guengerich FP, Choi JY., Free PMC Article | 07/31/2021 |
| Mysterious and fascinating: DNA polymerase i remains enigmatic 20 years after its discovery. | Mysterious and fascinating: DNA polymerase ɩ remains enigmatic 20 years after its discovery.
Vaisman A, Woodgate R., Free PMC Article | 03/28/2021 |
| DNA polymerase iota compensates for Fanconi anemia pathway deficiency by countering DNA replication stress. | DNA polymerase ι compensates for Fanconi anemia pathway deficiency by countering DNA replication stress.
Wang R, Lenoir WF, Wang C, Su D, McLaughlin M, Hu Q, Shen X, Tian Y, Klages-Mundt N, Lynn E, Wood RD, Chen J, Hart T, Li L., Free PMC Article | 02/13/2021 |
| Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance. | Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance.
Biber S, Pospiech H, Gottifredi V, Wiesmüller L., Free PMC Article | 01/2/2021 |
| Polymerase iota - an odd sibling among Y family polymerases. | Polymerase iota - an odd sibling among Y family polymerases.
McIntyre J. | 11/21/2020 |
| These results indicated that Pol iota induced invasion and metastasis of ESCC cells is mediated by ETS-1 phosphorylation at threonine-38 through the Erk signaling pathway. | Phosphorylation of ETS-1 is a critical event in DNA polymerase iota-induced invasion and metastasis of esophageal squamous cell carcinoma.
He C, Wu S, Gao A, Su Y, Min H, Shang ZF, Wu J, Yang L, Ding WQ, Zhou J., Free PMC Article | 08/18/2020 |
| our results elucidate that elevated Pol iota iota expression enhances breast cancer migration and invasion through EGFR-ERK pathway-mediated EMT. | DNA polymerase iota (Pol ι) promotes the migration and invasion of breast cancer cell via EGFR-ERK-mediated epithelial to mesenchymal transition.
Zou S, Xu Y, Chen X, He C, Gao A, Zhou J, Chen Y. | 08/10/2019 |
| data are consistent with an important role of the N-terminal region in the dRP(5'-deoxyribose-5-phosphate)-lyase activity of Pol iota, with possible involvement of residues from the finger domain in the dRP group cleavage. | Identification of amino acid residues involved in the dRP-lyase activity of human Pol ι.
Miropolskaya N, Petushkov I, Kulbachinskiy A, Makarova AV., Free PMC Article | 06/15/2019 |
| Findings indicate that DNA polymerase iota (poli) plays a positive role in lung cancer progression via promoting the migration and invasion of lung cancer cells. | siRNA of DNA polymerase iota inhibits the migration and invasion in the lung cancer cell A549.
Li L, Tian H, Cheng C, Li S, Ming L, Qi L. | 12/22/2018 |
| Data suggest that translesion DNA synthesis mediated by (1) POLI-dependent pathway (2) REV1- and POLN-dependent pathway, or (3) POLtheta-dependent pathway occur in predominantly error-free manner in human cells. (POLI = DNA polymerase iota; REV1 = DNA repair protein-REV1; POLN = DNA polymerase nu; POLtheta = DNA polymerase theta) | Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct.
Yoon JH, Hodge RP, Hackfeld LC, Park J, Roy Choudhury J, Prakash S, Prakash L., Free PMC Article | 12/22/2018 |
| Findings indicate the function of tumor suppressor protein p53 (p53) and DNA polymerase iota (POLiota) in the DNA damage response to endogenous or exogenous replication stress. | DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression.
Hampp S, Kiessling T, Buechle K, Mansilla SF, Thomale J, Rall M, Ahn J, Pospiech H, Gottifredi V, Wiesmüller L., Free PMC Article | 02/10/2018 |
| DNA polymerase iota increased the expression of MMP-2/9 to promote invasion and metastasis of esophageal squamous cell carcinoma. | DNA polymerase iota (Pol ι) promotes invasion and metastasis of esophageal squamous cell carcinoma.
Zou S, Shang ZF, Liu B, Zhang S, Wu J, Huang M, Ding WQ, Zhou J., Free PMC Article | 12/30/2017 |
| Data suggest that error-free DNA replication through 3-deaza-3-methyladenine adduct is mediated via three different pathways dependent upon POL-iota/POL-kappa, POL-theta, and POL-zeta. | Translesion synthesis DNA polymerases promote error-free replication through the minor-groove DNA adduct 3-deaza-3-methyladenine.
Yoon JH, Roy Choudhury J, Park J, Prakash S, Prakash L., Free PMC Article | 12/23/2017 |
| The predominant isoform of DNA poliota in human cells is the shorter 715 amino acid protein and that if, or when, expressed, the longer 740 amino acid isoform has identical properties to the considerably more abundant shorter isoform. | DNA polymerase ι: The long and the short of it!
Frank EG, McLenigan MP, McDonald JP, Huston D, Mead S, Woodgate R., Free PMC Article | 10/14/2017 |
| Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota. | Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase ι.
Choi JY, Patra A, Yeom M, Lee YS, Zhang Q, Egli M, Guengerich FP., Free PMC Article | 05/20/2017 |
| Mass spectrometry analysis of monoubiquitinated poliota revealed that it is ubiquitinated at over 27 unique sites. Many of these sites are localized in different functional domains of the protein. | Posttranslational Regulation of Human DNA Polymerase ι.
McIntyre J, McLenigan MP, Frank EG, Dai X, Yang W, Wang Y, Woodgate R., Free PMC Article | 04/23/2016 |
| Germline genetic variations in human POLI gene may either hinder or promote the translesion synthesis (TLS) capability of pol iota with various DNA lesions in vitro, emphasizing the potential translational importance of these pol iota genetic variations, e.g., individual differences in TLS, mutation, and cancer susceptibility to genotoxic carcinogens. | Biochemical analysis of six genetic variants of error-prone human DNA polymerase ι involved in translesion DNA synthesis.
Kim J, Song I, Jo A, Shin JH, Cho H, Eoff RL, Guengerich FP, Choi JY., Free PMC Article | 08/1/2015 |
| a single residue in pol iota is able to discriminate between NTPs and dNTPs during DNA synthesis. | The steric gate of DNA polymerase ι regulates ribonucleotide incorporation and deoxyribonucleotide fidelity.
Donigan KA, McLenigan MP, Yang W, Goodman MF, Woodgate R., Free PMC Article | 05/24/2014 |
| Dysregulation of pol iota by JNK/c-Jun is involved in carcinogenesis and offer a novel understanding of the role of pol iota or c-Jun in mutagenesis. | Overexpressed DNA polymerase iota regulated by JNK/c-Jun contributes to hypermutagenesis in bladder cancer.
Yuan F, Xu Z, Yang M, Wei Q, Zhang Y, Yu J, Zhi Y, Liu Y, Chen Z, Yang J., Free PMC Article | 05/3/2014 |
| Human Pol iota and yeast Pol zeta complex could function efficiently in the insertion and extension steps, respectively, of ranslesion synthesis and human Pol kappa and Pol eta could also extend past these lesions, albeit much less efficiently. | Translesion synthesis of 8,5'-cyclopurine-2'-deoxynucleosides by DNA polymerases η, ι, and ζ.
You C, Swanson AL, Dai X, Yuan B, Wang J, Wang Y., Free PMC Article | 12/7/2013 |
| POLI and MC4R nearby single nucleotide polymorphisms in human chromosome 18 are associated with a moderate risk of type 2 diabetes. | Association of POL1, MALT1, MC4R, PHLPP and DSEL single nucleotide polymorphisms in chromosome 18q region with type 2 diabetes in Tunisians.
Turki A, Mahjoub T, Mtiraoui N, Abdelhedi M, Frih A, Almawi WY. | 10/26/2013 |
| Results show that the physical and functional interaction between pols eta and iota occurs between ubiquitinated forms of either polymerase via their respective ubiquitin-binding domains. | Ubiquitin mediates the physical and functional interaction between human DNA polymerases η and ι.
McIntyre J, Vidal AE, McLenigan MP, Bomar MG, Curti E, McDonald JP, Plosky BS, Ohashi E, Woodgate R., Free PMC Article | 04/20/2013 |
| this review briefly discusses the main structural features and possible functional mechanisms of the active center of Pol iota. [review] | Structure of human DNA polymerase iota and the mechanism of DNA synthesis.
Makarova AV, Kulbachinskiy AV. | 12/22/2012 |