| An E3 Ubiquitin Ligase RNF139 Serves as a Tumor-Suppressor in Glioma. | An E3 Ubiquitin Ligase RNF139 Serves as a Tumor-Suppressor in Glioma.
Chen X, Kuang W, Zhu Y, Zhou B, Li X, Zhang X, Li B, Li L, Zou S., Free PMC Article | 01/8/2022 |
| INSIG1 coordinated with another ligase, translocation in renal carcinoma chromosome 8 (TRC8), and promoted Gag degradation through the lysosome pathway. | Insulin-induced gene 1 (INSIG1) inhibits HIV-1 production by degrading Gag via activity of the ubiquitin ligase TRC8.
Zhang Y, Lu J, Ma J, Liu X., Free PMC Article | 06/29/2019 |
| TRC8 and MARCH6 depletion altered the turnover of the tail-anchored protein heme oxygenase-1. | MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.
Stefanovic-Barrett S, Dickson AS, Burr SP, Williamson JC, Lobb IT, van den Boomen DJ, Lehner PJ, Nathan JA., Free PMC Article | 04/20/2019 |
| Low RNF139 expression is associated with progression of tongue cancer. | E3 ubiquitin ligase, RNF139, inhibits the progression of tongue cancer.
Wang L, Yin W, Shi C., Free PMC Article | 03/31/2018 |
| interaction with Bag1 then shifts hERG degradation to the membrane-anchored E3 ligase TRC8 and its E2-conjugating enzyme Ube2g2, as determined by siRNA screening | Bag1 Co-chaperone Promotes TRC8 E3 Ligase-dependent Degradation of Misfolded Human Ether a Go-Go-related Gene (hERG) Potassium Channels.
Hantouche C, Williamson B, Valinsky WC, Solomon J, Shrier A, Young JC., Free PMC Article | 07/8/2017 |
| TRC8 and TMEM129 are endoplasmic reticulum-associated degradation ubiquitin E3 ligases for viral and cellular targeting of MHC class I. (Review) | Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I.
van den Boomen DJ, Lehner PJ., Free PMC Article | 01/30/2016 |
| TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation. | TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation.
Lin PH, Lan WM, Chau LY. | 07/13/2013 |
| TRC8 function may provide a regulatory link between the lipid and protein biosynthetic pathways. | The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways.
Lee JP, Brauweiler A, Rudolph M, Hooper JE, Drabkin HA, Gemmill RM., Free PMC Article | 05/3/2010 |
| Data show that the TRC8 E3 ligase is required for MHC I dislocation from the ER and identify a new complex associated with mammalian ERAD. | The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER.
Stagg HR, Thomas M, van den Boomen D, Wiertz EJ, Drabkin HA, Gemmill RM, Lehner PJ., Free PMC Article | 01/21/2010 |
| TRC8 is a novel sterol-sensing endoplasmic reticulum membrane protein that hinders SREBP-2 processing through interaction with SREBP-2 and SCAP, regulating its own turnover rate by means of its E3 ubiquitin ligase activity | The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage.
Irisawa M, Inoue J, Ozawa N, Mori K, Sato R., Free PMC Article | 01/21/2010 |
| The presence of diploid and tetraploid tumor cells with and without TRC8 deletions on the nontranslocated chromosome suggest that loss of the remaining normal allele of TRC8 may contribute to tumor development at later stages. | A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma.
Poland KS, Azim M, Folsom M, Goldfarb R, Naeem R, Korch C, Drabkin HA, Gemmill RM, Plon SE. | 01/21/2010 |
| TRC8 modulation of sterol response element binding protein activity comprises a novel regulatory link between growth control and the cholesterol/lipid homeostasis pathway. | RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene.
Brauweiler A, Lorick KL, Lee JP, Tsai YC, Chan D, Weissman AM, Drabkin HA, Gemmill RM. | 01/21/2010 |