| Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality. | Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality.
Wang R, Gomez Salazar M, Pruñonosa Cervera I, Coutts A, French K, Pinto MM, Gohlke S, García-Martín R, Blüher M, Schofield CJ, Kourtzelis I, Stimson RH, Bénézech C, Christian M, Schulz TJ, Gudmundsson EF, Jennings LL, Gudnason VG, Chavakis T, Morton NM, Emilsson V, Michailidou Z., Free PMC Article | 09/12/2024 |
| Endothelial specific prolyl hydroxylase domain-containing protein 2 deficiency attenuates aging-related obesity and exercise intolerance. | Endothelial specific prolyl hydroxylase domain-containing protein 2 deficiency attenuates aging-related obesity and exercise intolerance.
Pan L, He X, Xu R, Bhattarai U, Niu Z, do Carmo J, Sun Y, Zeng H, Clemmer JS, Chen JX, Chen Y., Free PMC Article | 07/31/2024 |
| Loss of prolyl hydroxylase 1 and 2 in SM22alpha-expressing cells prevents Hypoxia-Induced pulmonary hypertension. | Loss of prolyl hydroxylase 1 and 2 in SM22α-expressing cells prevents Hypoxia-Induced pulmonary hypertension.
Barnes EA, Ito R, Che X, Alvira CM, Cornfield DN., | 11/18/2023 |
| Proline hydroxylase 2 (PHD2) promotes brown adipose thermogenesis by enhancing the hydroxylation of UCP1. | Proline hydroxylase 2 (PHD2) promotes brown adipose thermogenesis by enhancing the hydroxylation of UCP1.
Li F, Zhang F, Yi X, Quan LL, Yang X, Yin C, Ma Z, Wu R, Zhao W, Ling M, Lang L, Hussein A, Feng S, Fu Y, Wang J, Liang S, Zhu C, Wang L, Zhu X, Gao P, Xi Q, Zhang Y, Zhang L, Shu G, Jiang Q, Wang S., Free PMC Article | 06/29/2023 |
| Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2. | Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2.
Feng T, Zhao X, Gu P, Yang W, Wang C, Guo Q, Long Q, Liu Q, Cheng Y, Li J, Cheung CKY, Wu D, Kong X, Xu Y, Ye D, Hua S, Loomes K, Xu A, Hui X., Free PMC Article | 09/24/2022 |
| Myeloid PHD2 deficiency accelerates neointima formation via Hif-1alpha. | Myeloid PHD2 deficiency accelerates neointima formation via Hif-1α.
Christoph M, Pfluecke C, Mensch M, Augstein A, Jellinghaus S, Ende G, Mierke J, Franke K, Wielockx B, Ibrahim K, Poitz DM. | 08/27/2022 |
| The oxygen sensor prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cells. | The oxygen sensor prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cells.
Ajouaou Y, Azouz A, Taquin A, Denanglaire S, Hussein H, Krayem M, Andris F, Moser M, Goriely S, Leo O., Free PMC Article | 07/30/2022 |
| AMP-activated protein kinase alpha1 phosphorylates PHD2 to maintain systemic iron homeostasis. | AMP-activated protein kinase α1 phosphorylates PHD2 to maintain systemic iron homeostasis.
Wang C, Zhang W, Xu W, Liu Z, Huang K., Free PMC Article | 05/14/2022 |
| Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia. | Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia.
Rosendahl AH, Monnius M, Laitala A, Railo A, Miinalainen I, Heljasvaara R, Mäki JM, Myllyharju J., Free PMC Article | 05/14/2022 |
| Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma. | Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma.
Eckardt L, Prange-Barczynska M, Hodson EJ, Fielding JW, Cheng X, Lima JDCC, Kurlekar S, Douglas G, Ratcliffe PJ, Bishop T., Free PMC Article | 04/23/2022 |
| Prolyl-4-hydroxylases 2 and 3 control erythropoietin production in renin-expressing cells of mouse kidneys. | Prolyl-4-hydroxylases 2 and 3 control erythropoietin production in renin-expressing cells of mouse kidneys.
Broeker KAE, Fuchs MAA, Schrankl J, Lehrmann C, Schley G, Todorov VT, Hugo C, Wagner C, Kurtz A. | 02/26/2022 |
| PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes. | PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes.
Angelini A, Saha PK, Jain A, Jung SY, Mynatt RL, Pi X, Xie L., Free PMC Article | 02/19/2022 |
| HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD. | HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD.
Laitakari A, Tapio J, Mäkelä KA, Herzig KH, Dengler F, Gylling H, Walkinshaw G, Myllyharju J, Dimova EY, Serpi R, Koivunen P., Free PMC Article | 06/12/2021 |
| Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice. | Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice.
Settelmeier S, Schreiber T, Mäki J, Byts N, Koivunen P, Myllyharju J, Fandrey J, Winning S., Free PMC Article | 08/15/2020 |
| Inhibition of the Oxygen Sensor PHD2 Enhances Tissue-Engineered Endochondral Bone Formation. | Inhibition of the Oxygen Sensor PHD2 Enhances Tissue-Engineered Endochondral Bone Formation.
Stiers PJ, Stegen S, van Gastel N, Van Looveren R, Torrekens S, Carmeliet G. | 05/30/2020 |
| findings have shown a new role for the PHD2/Hif2a couple in the reversible regulation of T cell and immune activity. | Systemic silencing of PHD2 causes reversible immune regulatory dysfunction.
Yamamoto A, Hester J, Macklin PS, Kawai K, Uchiyama M, Biggs D, Bishop T, Bull K, Cheng X, Cawthorne E, Coleman ML, Crockford TL, Davies B, Dow LE, Goldin R, Kranc K, Kudo H, Lawson H, McAuliffe J, Milward K, Scudamore CL, Soilleux E, Issa F, Ratcliffe PJ, Pugh CW., Free PMC Article | 05/16/2020 |
| Depletion of PHD2 and PHD3 leads to dilated cardiomyopathy and exacerbates cardiac injury. | Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction.
Fan Q, Mao H, Angelini A, Coarfa C, Robertson MJ, Lagor WR, Wehrens XHT, Martin JF, Pi X, Xie L., Free PMC Article | 04/25/2020 |
| PHD2 may itself directly mediate increases in PHD2 may itself directly mediate increases in 5-hydroxymethylcytosine in chondrocyte and osteoblast genes. | Vitamin C effects on 5-hydroxymethylcytosine and gene expression in osteoblasts and chondrocytes: Potential involvement of PHD2.
Lindsey RC, Cheng S, Mohan S., Free PMC Article | 03/21/2020 |
| exerts anti-cancer and anti-inflammatory effects in colon cancer xenografts via attenuating NF-kappaB activity | PHD2 exerts anti-cancer and anti-inflammatory effects in colon cancer xenografts mice via attenuating NF-κB activity.
Wang L, Niu Z, Wang X, Li Z, Liu Y, Luo F, Yan X. | 02/8/2020 |
| The inhibition of endothelial PHD2 activity may be a new therapeutic strategy for acute inflammatory diseases. | Prolyl Hydroxylase Domain-2 Protein Regulates Lipopolysaccharide-Induced Vascular Inflammation.
Fan Q, Mao H, Xie L, Pi X., Free PMC Article | 10/26/2019 |
| Deletion of Phd2 in combination with expression of BRaf(V600E) in melanocytes (Tyr::CreER;Phd2(lox/lox);BRaf(CA)) leads to the development of melanoma with 100% penetrance and frequent lymph node metastasis. | Loss of Phd2 cooperates with BRAF(V600E) to drive melanomagenesis.
Liu S, Zhang G, Guo J, Chen X, Lei J, Ze K, Dong L, Dai X, Gao Y, Song D, Ecker BL, Yang R, Feltcher C, Peng K, Feng C, Chen H, Lee RX, Kerestes H, Niu J, Kumar S, Xu W, Zhang J, Wei Z, Martin JS, Liu X, Mills G, Lu Y, Guo W, Sun L, Zhang L, Weeraratna A, Herlyn M, Wei W, Lee FS, Xu X., Free PMC Article | 02/23/2019 |
| Oxygen sensing by PHD2 in osteocytes negatively regulates bone mass through epigenetic regulation of sclerostin and targeting PHD2 elicits an osteo-anabolic response in osteoporotic mouse models. | Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin.
Stegen S, Stockmans I, Moermans K, Thienpont B, Maxwell PH, Carmeliet P, Carmeliet G., Free PMC Article | 01/19/2019 |
| Data show that deletion of prolyl hydroxylase 2 (PHD2) in intestinal epithelial cells (IECs) did not lead to spontaneous enteritis or colitis in mice. | Prolyl hydroxylase 2 is dispensable for homeostasis of intestinal epithelium in mice.
Xie Y, Yuan T, Qin Y, Weng Z, Fang J. | 10/13/2018 |
| PHD2 and PHD3 are essential for normal kidney development as the combined inactivation of stromal PHD2 and PHD3 resulted in renal failure that was associated with reduced kidney size, decreased numbers of glomeruli, and abnormal postnatal nephron formation. | Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development.
Kobayashi H, Liu J, Urrutia AA, Burmakin M, Ishii K, Rajan M, Davidoff O, Saifudeen Z, Haase VH., Free PMC Article | 07/7/2018 |
| aberrant hypoxic responses due to dysfunction of PHD2 caused both glomerular and tubular damages in HFD-induced obese mice. Phd2-inactivation provides a novel strategy against obesity-induced kidney injury | Obesity-induced kidney injury is attenuated by amelioration of aberrant PHD2 activation in proximal tubules.
Futatsugi K, Tokuyama H, Shibata S, Naitoh M, Kanda T, Minakuchi H, Yamaguchi S, Hayashi K, Minamishima YA, Yanagita M, Wakino S, Itoh H., Free PMC Article | 05/19/2018 |