| Pacsin 2-dependent N-cadherin internalization regulates the migration behaviour of malignant cancer cells. | Pacsin 2-dependent N-cadherin internalization regulates the migration behaviour of malignant cancer cells.
Wint H, Li J, Abe T, Yamada H, Higaki T, Nasu Y, Watanabe M, Takei K, Takeda T., Free PMC Article | 06/13/2023 |
| PACSIN2 as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cells. | PACSIN2 as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cells.
Zudeh G, Franca R, Lucafò M, Bonten EJ, Bramuzzo M, Sgarra R, Lagatolla C, Franzin M, Evans WE, Decorti G, Stocco G., Free PMC Article | 01/14/2023 |
| Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemia. | Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemia.
Park K, Yoo HS, Oh CK, Lee JR, Chung HJ, Kim HN, Kim SH, Kee KM, Kim TY, Kim M, Kim BG, Ra JS, Myung K, Kim H, Han SH, Seo MD, Lee Y, Kim DW., Free PMC Article | 11/12/2022 |
| Dynamin 2 and BAR domain protein pacsin 2 cooperatively regulate formation and maturation of podosomes. | Dynamin 2 and BAR domain protein pacsin 2 cooperatively regulate formation and maturation of podosomes.
Li J, Fujise K, Wint H, Senju Y, Suetsugu S, Yamada H, Takei K, Takeda T. | 11/22/2021 |
| A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis. | A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis.
Malinova TS, Angulo-Urarte A, Nüchel J, Tauber M, van der Stoel MM, Janssen V, de Haan A, Groenen AG, Tebbens M, Graupera M, Plomann M, Huveneers S., Free PMC Article | 06/5/2021 |
| PACSIN2 rs2413739 influence on thiopurine pharmacokinetics: validation studies in pediatric patients. | PACSIN2 rs2413739 influence on thiopurine pharmacokinetics: validation studies in pediatric patients.
Franca R, Stocco G, Favretto D, Giurici N, Del Rizzo I, Locatelli F, Vinti L, Biondi A, Colombini A, Fagioli F, Barisone E, Pelin M, Martellossi S, Ventura A, Decorti G, Rabusin M. | 05/8/2021 |
| PACSIN2 Interacts with Nonstructural Protein 5A and Regulates Hepatitis C Virus Assembly. | PACSIN2 Interacts with Nonstructural Protein 5A and Regulates Hepatitis C Virus Assembly.
Nguyen LP, Tran SC, Suetsugu S, Lim YS, Hwang SB., Free PMC Article | 08/22/2020 |
| Authors found that caveolins (CAV1 and CAV2) and the membrane sculpting F-BAR protein PACSIN2 promote L. monocytogenes protrusion engulfment during spread, and that PACSIN2 specifically localizes to protrusions. | RNAi screen reveals a role for PACSIN2 and caveolins during bacterial cell-to-cell spread.
Sanderlin AG, Vondrak C, Scricco AJ, Fedrigo I, Ahyong V, Lamason RL., Free PMC Article | 06/13/2020 |
| Pacsin2 recruitment is important for maintenance of cell-cell adhesion by stabilizing the VE-cadherin complex within focal adherens junctions and inhibition of its internalization. | The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions.
Dorland YL, Malinova TS, van Stalborch AM, Grieve AG, van Geemen D, Jansen NS, de Kreuk BJ, Nawaz K, Kole J, Geerts D, Musters RJ, de Rooij J, Hordijk PL, Huveneers S., Free PMC Article | 09/15/2018 |
| observations indicate that PACSIN2 promotes the cell-to-cell spreading of HIV-1 by connecting Gag to the actin cytoskeleton. | HIV-1 gag recruits PACSIN2 to promote virus spreading.
Popov S, Popova E, Inoue M, Wu Y, Göttlinger H., Free PMC Article | 09/8/2018 |
| To our knowledge, this is the first study showing PACSIN2 genotype association with hematological toxicity in ALL patients undergoing maintenance therapy. | PACSIN2 polymorphism is associated with thiopurine-induced hematological toxicity in children with acute lymphoblastic leukaemia undergoing maintenance therapy.
Smid A, Karas-Kuzelicki N, Jazbec J, Mlinaric-Rascan I., Free PMC Article | 04/28/2018 |
| FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets. | FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets.
Begonja AJ, Pluthero FG, Suphamungmee W, Giannini S, Christensen H, Leung R, Lo RW, Nakamura F, Lehman W, Plomann M, Hoffmeister KM, Kahr WH, Hartwig JH, Falet H., Free PMC Article | 06/6/2017 |
| our results provide new insights into the mechanism of cellular intoxication by TcdA and the role of PACSIN2 in endocytosis. | Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent Endocytosis.
Chandrasekaran R, Kenworthy AK, Lacy DB., Free PMC Article | 06/3/2017 |
| proposed a packing model for the assembly of PACSIN 2 on membrane, where the proteins are connected by tip-to-tip and wedge loop-mediated lateral interactions on the surface of membrane to generate various diameter tubules | Tip-to-tip interaction in the crystal packing of PACSIN 2 is important in regulating tubulation activity.
Bai X, Zheng X., Free PMC Article | 12/17/2016 |
| PACSIN2 phosphorylation decreases its membrane-binding activity, thereby decreasing its stabilizing effect on caveolae and triggering dynamin-mediated removal of caveolae. | Phosphorylation of PACSIN2 by protein kinase C triggers the removal of caveolae from the plasma membrane.
Senju Y, Rosenbaum E, Shah C, Hamada-Nakahara S, Itoh Y, Yamamoto K, Hanawa-Suetsugu K, Daumke O, Suetsugu S. | 06/28/2016 |
| PC1 modulates actin cytoskeleton rearrangements and directional cell migration through the Pacsin 2/N-Wasp complex. | Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complex.
Yao G, Su X, Nguyen V, Roberts K, Li X, Takakura A, Plomann M, Zhou J., Free PMC Article | 12/6/2014 |
| Cooperation of MICAL-L1, pacsin 2 (syndapin2), and phosphatidic acid in tubular recycling endosome biogenesis. | Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis.
Giridharan SS, Cai B, Vitale N, Naslavsky N, Caplan S., Free PMC Article | 12/21/2013 |
| These data indicate that polymorphism in PACSIN2 significantly modulates TPMT activity and influences the risk of GI toxicity associated with mercaptopurine therapy. | PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity.
Stocco G, Yang W, Crews KR, Thierfelder WE, Decorti G, Londero M, Franca R, Rabusin M, Valsecchi MG, Pei D, Cheng C, Paugh SW, Ramsey LB, Diouf B, McCorkle JR, Jones TS, Pui CH, Relling MV, Evans WE., Free PMC Article | 04/6/2013 |
| a novel role for the F-BAR-domain protein PACSIN2 in regulating EGF receptor surface levels and EGF-induced downstream signaling. | The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization.
de Kreuk BJ, Anthony EC, Geerts D, Hordijk PL., Free PMC Article | 03/2/2013 |
| important role in the formation of plasma membrane caveolae | Pacsin 2 is recruited to caveolae and functions in caveolar biogenesis.
Hansen CG, Howard G, Nichols BJ. | 12/10/2011 |
| Data identify the BAR-domain protein PACSIN2 as a Rac1 interactor that regulates Rac1-mediated cell spreading and migration. | The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration.
de Kreuk BJ, Nethe M, Fernandez-Borja M, Anthony EC, Hensbergen PJ, Deelder AM, Plomann M, Hordijk PL. | 12/3/2011 |
| PACSIN2 regulates cell spreading and cell migration, which are dependent on cyclin D1 expression. | PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b.
Meng H, Tian L, Zhou J, Li Z, Jiao X, Li WW, Plomann M, Xu Z, Lisanti MP, Wang C, Pestell RG., Free PMC Article | 11/19/2011 |
| Results indicate that PACSIN2 mediates membrane sculpting by caveolin-1 in caveola morphology and recruits dynamin-2 for caveola fission. | Essential role of PACSIN2/syndapin-II in caveolae membrane sculpting.
Senju Y, Itoh Y, Takano K, Hamada S, Suetsugu S. | 11/5/2011 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation.
Kim ST, Cheng Y, Hsu FC, Jin T, Kader AK, Zheng SL, Isaacs WB, Xu J, Sun J., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |