| The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions. | The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions.
Fasciani I, Petragnano F, Wang Z, Edwards R, Telugu N, Pietrantoni I, Zabel U, Zauber H, Grieben M, Terzenidou ME, Di Gregorio J, Pellegrini C, Santini S Jr, Taddei AR, Pohl B, Aringhieri S, Carli M, Aloisi G, Marampon F, Charlesworth E, Roman A, Diecke S, Flati V, Giorgi F, Amicarelli F, Tobin AB, Scarselli M, Tokatlidis K, Rossi M, Lohse MJ, Annibale P, Maggio R., Free PMC Article | 06/3/2024 |
| M2 muscarinic receptors negatively modulate cell migration in human glioblastoma cells. | M2 muscarinic receptors negatively modulate cell migration in human glioblastoma cells.
Guerriero C, Fanfarillo R, Mancini P, Sterbini V, Guarguaglini G, Sforna L, Michelucci A, Catacuzzeno L, Tata AM. | 03/7/2024 |
| Deep learning-based classification of breast cancer cells using transmembrane receptor dynamics. | Deep learning-based classification of breast cancer cells using transmembrane receptor dynamics.
Kim M, Hong S, Yankeelov TE, Yeh HC, Liu YL., Free PMC Article | 02/17/2023 |
| Vibrational spectroscopy analysis of ligand efficacy in human M2 muscarinic acetylcholine receptor (M2R). | Vibrational spectroscopy analysis of ligand efficacy in human M(2) muscarinic acetylcholine receptor (M(2)R).
Katayama K, Suzuki K, Suno R, Kise R, Tsujimoto H, Iwata S, Inoue A, Kobayashi T, Kandori H., Free PMC Article | 12/25/2021 |
| M2 Muscarinic Receptor Activation Impairs Mitotic Progression and Bipolar Mitotic Spindle Formation in Human Glioblastoma Cell Lines. | M2 Muscarinic Receptor Activation Impairs Mitotic Progression and Bipolar Mitotic Spindle Formation in Human Glioblastoma Cell Lines.
Di Bari M, Tombolillo V, Alessandrini F, Guerriero C, Fiore M, Asteriti IA, Castigli E, Sciaccaluga M, Guarguaglini G, Degrassi F, Tata AM., Free PMC Article | 10/30/2021 |
| Cross Interaction between M2 Muscarinic Receptor and Notch1/EGFR Pathway in Human Glioblastoma Cancer Stem Cells: Effects on Cell Cycle Progression and Survival. | Cross Interaction between M2 Muscarinic Receptor and Notch1/EGFR Pathway in Human Glioblastoma Cancer Stem Cells: Effects on Cell Cycle Progression and Survival.
Cristofaro I, Alessandrini F, Spinello Z, Guerriero C, Fiore M, Caffarelli E, Laneve P, Dini L, Conti L, Tata AM., Free PMC Article | 03/20/2021 |
| Modeling the allosteric modulation on a G-Protein Coupled Receptor: the case of M2 muscarinic Acetylcholine Receptor in complex with LY211960. | Modeling the allosteric modulation on a G-Protein Coupled Receptor: the case of M2 muscarinic Acetylcholine Receptor in complex with LY211960.
Maggi L, Carloni P, Rossetti G., Free PMC Article | 11/21/2020 |
| Pharmacogenetics of tardive dyskinesia in schizophrenia: The role of CHRM1 and CHRM2 muscarinic receptors. | Pharmacogenetics of tardive dyskinesia in schizophrenia: The role of CHRM1 and CHRM2 muscarinic receptors.
Boiko AS, Ivanova SA, Pozhidaev IV, Freidin MB, Osmanova DZ, Fedorenko OY, Semke AV, Bokhan NA, Wilffert B, Loonen AJM. | 11/21/2020 |
| Group II muscarinic acetylcholine receptors attenuate hepatic injury via Nrf2/ARE pathway. | Group II muscarinic acetylcholine receptors attenuate hepatic injury via Nrf2/ARE pathway.
Luo L, Zhang G, Mao L, Wang P, Xi C, Shi G, Leavenworth JW. | 08/22/2020 |
| M2 muscarinic receptor displays conformational complexity depending on the nature of ligands. | Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy.
Xu J, Hu Y, Kaindl J, Risel P, Hübner H, Maeda S, Niu X, Li H, Gmeiner P, Jin C, Kobilka BK. | 01/18/2020 |
| CHRM2 is important to process of "prior information" needed to inform subsequent cognitive operations. | CHRM2 Genotype Affects Inhibitory Control Mechanisms During Cognitive Flexibility.
Zink N, Bensmann W, Arning L, Stock AK, Beste C. | 01/11/2020 |
| A key step in CHRM2 activation is the exchange of a Na+ ion from an extracellular binding pocket to the cytoplasm. | Intracellular Transfer of Na(+) in an Active-State G-Protein-Coupled Receptor.
Vickery ON, Carvalheda CA, Zaidi SA, Pisliakov AV, Katritch V, Zachariae U., Free PMC Article | 12/1/2018 |
| Ligation of the identical phosphopeptide onto the beta2AR, the muscarinic acetylcholine receptor 2 and the mu-opioid receptor reveals that the ability of beta-arrestin1 to enhance agonist binding relative to G protein differs substantially among receptors. | Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling.
Staus DP, Wingler LM, Choi M, Pani B, Manglik A, Kruse AC, Lefkowitz RJ., Free PMC Article | 11/3/2018 |
| Data suggests that RBM24 binds to coding region of CHRM2 to regulate mRNA stability in cardiomyocytes; RBM24appears to drive changes in alternative splicing and in production of alternative transcript isoforms. (RBM24 = RNA binding motif protein-24; CHRM2 = cholinergic receptor muscarinic 2) | Global profiling of Rbm24 bound RNAs uncovers a multi-tasking RNA binding protein.
Lin Y, Tan KT, Liu J, Kong X, Huang Z, Xu XQ. | 10/20/2018 |
| T allele carrying status (GT and TT) [rs1824024] of muscarinic cholinergic receptor 2 (CHRM2) may be associated with delirium tremens. | An exploratory study of candidate gene(s) for Delirium Tremens: Adding the new cholinergic dimension to the conundrum.
Malhotra S, Basu D, Ghosh A, Khullar M, Chugh N, Kakkar N. | 09/15/2018 |
| Two single nucleotide polymorphisms in CHRM2 gene, rs2061174 and rs6948054, showed significant difference in genotype distribution between medical and fine arts students (p<0.05). The rs2061174 showed significant at p = 0.001, OR and 95% CI were 3.78 (2.00-7.14), whereas the rs6948054 was significant at p = 0.012, OR and 95% CI were 2.50 (1.32-4.77). | Association of Cholinergic Muscarinic 2 Receptor Gene Polymorphisms with Learning Aptitude among Medical and Fine Arts Students.
Thongket P, Pleansiri C, Thurakitwannakarn W, Sukhumsirichart W. | 07/7/2018 |
| complex between M2R and holo-Gi1 is an octamer comprising four copies of each, and that activation is accompanied by a decrease in the oligomeric size of Gi1 | Single-Molecule Analysis of the Supramolecular Organization of the M2 Muscarinic Receptor and the Gαi1 Protein.
Shivnaraine RV, Fernandes DD, Ji H, Li Y, Kelly B, Zhang Z, Han YR, Huang F, Sankar KS, Dubins DN, Rocheleau JV, Wells JW, Gradinaru CC. | 05/12/2018 |
| Graded activation and free energy landscapes of a muscarinic G-protein-coupled M2 receptor has been reported. | Graded activation and free energy landscapes of a muscarinic G-protein-coupled receptor.
Miao Y, McCammon JA., Free PMC Article | 02/3/2018 |
| With final functional experiments on six selected compounds, we confirmed four of them as new negative allosteric modulators (NAMs) and one as positive allosteric modulator of agonist-mediated response at the M2 mAChR | Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor.
Miao Y, Goldfeld DA, Moo EV, Sexton PM, Christopoulos A, McCammon JA, Valant C., Free PMC Article | 01/27/2018 |
| Results show reduced autonomic nervous system (ANS) activity in association with the CHRM2 rs8191992 polymorphism in patients with schizophrenia on high-dose antipsychotics. CHRM2 polymorphisms may play an important role in ANS activity in patients with schizophrenia. | Association of the Cholinergic Muscarinic M2 Receptor with Autonomic Nervous System Activity in Patients with Schizophrenia on High-Dose Antipsychotics.
Miyauchi M, Kishida I, Suda A, Shiraishi Y, Hattori S, Fujibayashi M, Taguri M, Ishii C, Ishii N, Moritani T, Hirayasu Y. | 02/18/2017 |
| Data suggest that levels of CHRM2 are lower in Brodmann's area 24 from subjects with mood disorders, and it is possible that signalling by that receptor is also less in this cortical region; increasing levels of CHRM2 may be involved in the mechanisms of action of mood stabilisers and tricyclic antidepressants | Changes in Muscarinic M2 Receptor Levels in the Cortex of Subjects with Bipolar Disorder and Major Depressive Disorder and in Rats after Treatment with Mood Stabilisers and Antidepressants.
Gibbons AS, Jeon WJ, Scarr E, Dean B., Free PMC Article | 12/24/2016 |
| These results suggest that the M2 receptors may represent a new interesting therapeutic tool to counteract glioblastoma cancer stem cell growth and survival. | The activation of M2 muscarinic receptor inhibits cell growth and survival in human glioblastoma cancer stem cells.
Alessandrini F, Cristofaro I, Di Bari M, Zasso J, Conti L, Tata AM. | 09/17/2016 |
| Report a significant association between CHRM2 (rs1824024) polymorphism and disease severity, lower lung function test values, frequent exacerbations, and poor response to anti-cholinergic drugs in COPD patients. | Genetic Polymorphism of CHRM2 in COPD: Clinical Significance and Therapeutic Implications.
Cherubini E, Esposito MC, Scozzi D, Terzo F, Osman GA, Mariotta S, Mancini R, Bruno P, Ricci A. | 09/3/2016 |
| Inactivation of M2 AChR/NF-kappaB signaling axis reverses epithelial-mesenchymal transition and suppresses migration and invasion in non-small cell lung cancer. | Inactivation of M2 AChR/NF-κB signaling axis reverses epithelial-mesenchymal transition (EMT) and suppresses migration and invasion in non-small cell lung cancer (NSCLC).
Zhao Q, Yue J, Zhang C, Gu X, Chen H, Xu L., Free PMC Article | 08/13/2016 |
| CHRM2 gene expression was dysregulated in the anterior cingulate of bipolar patients. | Transcriptome sequencing of the anterior cingulate in bipolar disorder: dysregulation of G protein-coupled receptors.
Cruceanu C, Tan PP, Rogic S, Lopez JP, Torres-Platas SG, Gigek CO, Alda M, Rouleau GA, Pavlidis P, Turecki G. | 03/12/2016 |