| Glucocorticoid-Induced Transcript 1(GLCCI1) SNP rs37937 Is Associated With the Risk of Developing Allergic Rhinitis and the Response to Intranasal Corticosteroids in a Chinese Han Population. | Glucocorticoid-Induced Transcript 1(GLCCI1) SNP rs37937 Is Associated With the Risk of Developing Allergic Rhinitis and the Response to Intranasal Corticosteroids in a Chinese Han Population.
Liang X, Jin P, Zhan C, Zhao L, Zi X, Zhi L, Yu K. | 03/21/2024 |
| GLCCI1 gene body methylation in peripheral blood is associated with asthma and asthma severity. | GLCCI1 gene body methylation in peripheral blood is associated with asthma and asthma severity.
Jiang Y, Xun Q, Wan R, Deng S, Hu X, Luo L, Li X, Feng J. | 12/11/2021 |
| GLCCI1 and STIP1 variants are associated with asthma susceptibility and inhaled corticosteroid response in a Tunisian population. | GLCCI1 and STIP1 variants are associated with asthma susceptibility and inhaled corticosteroid response in a Tunisian population.
Salhi M, Lahmar O, Salah MO, Banić I, Binghao B, Malik W, Hamzaoui K, Turkalj M, Hamzaoui A. | 09/18/2021 |
| Effects of STIP1 and GLCCI1 polymorphisms on the risk of childhood asthma and inhaled corticosteroid response in Chinese asthmatic children. | Effects of STIP1 and GLCCI1 polymorphisms on the risk of childhood asthma and inhaled corticosteroid response in Chinese asthmatic children.
Huang J, Hu X, Zheng X, Kuang J, Liu C, Wang X, Tang Y., Free PMC Article | 07/31/2021 |
| Hsa_circ_001659 serves as a novel diagnostic and prognostic biomarker for colorectal cancer. | Hsa_circ_001659 serves as a novel diagnostic and prognostic biomarker for colorectal cancer.
He B, Chao W, Huang Z, Zeng J, Yang J, Luo D, Huang S, Pan H, Hao Y. | 07/3/2021 |
| GLCCI1 is a downstream molecule of the GC-GR cascade that acts as an antiapoptotic mediator in thymic T cells. Phosphorylated GLCCI1colocalized with microtubules in transfected cells. GR-dependent upregulation of GLCCI1 was proapoptotic in a cultured thymocyte cell line. Transgenic mice overexpressing human GLCCI1 had enlarged thymi with many thymocytes. GLCCI1 bound to both LC8 and PAK1. It reduced BIM expression. | GLCCI1 is a novel protector against glucocorticoid-induced apoptosis in T cells.
Kiuchi Z, Nishibori Y, Kutsuna S, Kotani M, Hada I, Kimura T, Fukutomi T, Fukuhara D, Ito-Nitta N, Kudo A, Takata T, Ishigaki Y, Tomosugi N, Tanaka H, Matsushima S, Ogasawara S, Hirayama Y, Takematsu H, Yan K. | 05/23/2020 |
| this study found the GG genotype of GLCCI1 to be associated with better inhaled corticosteroids treatment response in asthma patients | GLCCI1 Polymorphism rs37973 and Response to Treatment of Asthma With Inhaled Corticosteroids.
Rijavec M, Žavbi M, Lopert A, Fležar M, Korošec P. | 09/14/2019 |
| The rs37973 polymorphism of GLCCI1 is related to postoperative recovery from chronic rhinosinusitis (CRS) for individual sensitivity to glucocorticoids. Furthermore, AA genotype was associated with better treatment response in CRS. | Impact of genetic variants of GLCCI1 on operational therapy in Chinese chronic rhinosinusitis patients.
Liu S, Che N, Fan K, Xu F, Qin M, Zhang R, Ge R, Yu S. | 08/10/2019 |
| GLCCI1 variant was associated with a significant decrease of the total lung capacity at 3 years after lung transplantation | A single-nucleotide polymorphism in a gene modulating glucocorticoid sensitivity is associated with the decline in total lung capacity after lung transplantation.
Yamamoto H, Sugimoto S, Tanaka S, Kurosaki T, Otani S, Yamane M, Taira N, Oto T, Toyooka S. | 04/6/2019 |
| The GLCCI1 rs37973 variant is a risk factor for glucocorticoid resistance in Chinese patients with SAR who receive short-term intranasal corticosteroids treatment. one genotype of GLCCI1, rs37973, was significantly associated with the INCS response. The effective rate of the GG group was lower than those of the AA and AG groups (AA vs. GG: 73.7% vs. 51.6%, P=0.007; AG vs. GG: 78.8% vs. 51.6%, P=0.000). | Glucocorticoid-Induced Transcription Factor 1 (GLCCI1) Variant Impacts the Short-Term Response to Intranasal Corticosteroids in Chinese Han Patients with Seasonal Allergic Rhinitis.
Dai Y, Ni S, Wu F, Zhao X., Free PMC Article | 10/27/2018 |
| A worsening of pulmonary function caused by GLCCI1 variants could be prevented due to recently used medications based on new action mechanisms. | Impact of the genetic variants of GLCCI1 on clinical features of asthmatic patients.
Chiba S, Nakamura Y, Mizuno T, Abe K, Horii Y, Nagashima H, Sasaki N, Kanno H, Tanita T, Yamauchi K. | 10/6/2018 |
| CC/CT genotype was significantly associated with post-transplant hypertension | Association Between GLCCI1 Promoter Polymorphism (Rs37972) and Post-Transplant Hypertension in Renal Transplant Recipients.
Hamada AM, Yamamoto I, Nakada Y, Kobayashi A, Koike Y, Miki J, Yamada H, Tanno Y, Ohkido I, Tsuboi N, Yamamoto H, Urashima M, Yokoo T. | 09/1/2018 |
| The genetic variant rs37973 in GLCCI1 is associated with poorer clinical therapeutic response to inhaled glucocorticoids in a Chinese asthma population. | GLCCI1 rs37973: A potential genetic predictor of therapeutic response to inhaled corticosteroids in Chinese asthma patients.
Xu Y, Wu H, Wu X, Xu Y, Zhao J, Xie J, Yu J., Free PMC Article | 02/10/2018 |
| GLCCI1 variations may affect inhaled corticosteroid response by modulating GLCCI1 expression. | GLCCI1 Variation Is Associated with Asthma Susceptibility and Inhaled Corticosteroid Response in a Chinese Han Population.
Hu C, Xun Q, Li X, He R, Lu R, Zhang S, Hu X, Feng J. | 07/8/2017 |
| Carriers of the GLCCI1-C allele had lower levels of baseline rheumatoid arthritis disease activity, suggesting a role for the GLCCI1 gene in regulation of glucocorticoid sensitivity to endogenously produced cortisol. | Polymorphisms in the glucocorticoid receptor gene and in the glucocorticoid-induced transcript 1 gene are associated with disease activity and response to glucocorticoid bridging therapy in rheumatoid arthritis.
Quax RA, Koper JW, Huisman AM, Weel A, Hazes JM, Lamberts SW, Feelders RA., Free PMC Article | 03/19/2016 |
| Carriers of the rs41423247 GLCCI1 polymorphism had a higher probability of responding to glucocorticoids, whereas all other polymorphisms did not affect the likelihood of response to treatment of graft-versus-host disease patients. | GLCCI1 and Glucocorticoid Receptor Genetic Diversity and Response to Glucocorticoid-Based Treatment of Graft-versus-Host Disease.
O'Meara A, Boukouaci W, Robin M, Xhaard A, Fortier C, Marzais F, Sicre de Fontbrune F, Peffault de Latour R, Charron D, Socié G, Tamouza R. | 03/5/2016 |
| the minor alleles "T" and "G" of rs37972 and rs37973 SNPs, respectively, were not significantly associated with increased asthma risk in asthma patients from Saudi Arabia | Rs37972 and rs37973 single-nucleotide polymorphisms in the glucocorticoid-inducible 1 gene are not associated with asthma risk in a Saudi Arabian population.
Al-Muhsen S, Vazquez-Tello A, Jamhawi A, Al-Dosari MS, Mahboub B, Iqbal N, Temsah MH, Al-Eyadhy A, Alharbi N, Halwani R. | 11/21/2015 |
| GLCCI1 rs37972 T allele was not significantly associated with an increased risk of oral corticosteroid use. | Pharmacogenetic analysis of GLCCI1 in three north European pediatric asthma populations with a reported use of inhaled corticosteroids.
Vijverberg SJ, Tavendale R, Leusink M, Koenderman L, Raaijmakers JA, Postma DS, Koppelman GH, Turner SW, Mukhopadhyay S, Palmer CN, Maitland-van der Zee AH. | 01/17/2015 |
| GLCCI1 variant accelerates pulmonary function decline in patients with asthma receiving inhaled corticosteroids. | GLCCI1 variant accelerates pulmonary function decline in patients with asthma receiving inhaled corticosteroids.
Izuhara Y, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Nagasaki T, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Ono J, Ohta S, Tamari M, Hirota T, Yokoyama T, Niimi A, Mishima M. | 12/6/2014 |
| Novel association was found between intraocular pressure and a common variant at 7p21 near to GLCCI1 and ICA1. | Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus.
Blue Mountains Eye Study (BMES), Wellcome Trust Case Control Consortium 2 (WTCCC2)., Free PMC Article | 06/7/2014 |
| GLCCI1 rs37973 does not influence treatment response to inhaled corticosteroids in white subjects with asthma. | GLCCI1 rs37973 does not influence treatment response to inhaled corticosteroids in white subjects with asthma.
Hosking L, Bleecker E, Ghosh S, Yeo A, Jacques L, Mosteller M, Meyers D., Free PMC Article | 05/17/2014 |
| Studied the influence of GLCCI1 SNP rs37972 on dexamethasone efficacy in bacterial meningitis patients.Results show rs37972 in GLCCI1 is associated with death in patients with CA bacterial meningitis treated with adjunctive dexamethasone therapy. | Genetic variation in GLCCI1 and dexamethasone in bacterial meningitis.
Brouwer MC, van der Ende A, Baas F, van de Beek D. | 04/20/2013 |
| GLCCI1 nucleotide polymorphisms associated with steroid-responsiveness in asthmatic patients are unlikely to have a clinically actionable impact in pediatric nephrotic syndrome. | GLCCI1 single nucleotide polymorphisms in pediatric nephrotic syndrome.
Cheong HI, Kang HG, Schlondorff J., Free PMC Article | 12/8/2012 |
| Variation at GLCCI1 and FCER2 could lead personalized asthma treatment. | Variation at GLCCI1 and FCER2: one step closer to personalized asthma treatment.
Maitland-van der Zee AH, Raaijmakers JA. | 07/21/2012 |
| A functional GLCCI1 variant is associated with substantial decrements in the response to inhaled glucocorticoids in patients with asthma. | Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.
Tantisira KG, Lasky-Su J, Harada M, Murphy A, Litonjua AA, Himes BE, Lange C, Lazarus R, Sylvia J, Klanderman B, Duan QL, Qiu W, Hirota T, Martinez FD, Mauger D, Sorkness C, Szefler S, Lazarus SC, Lemanske RF Jr, Peters SP, Lima JJ, Nakamura Y, Tamari M, Weiss ST., Free PMC Article | 10/22/2011 |