| Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging. | Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging.
Ogura M, Kaminishi T, Shima T, Torigata M, Bekku N, Tabata K, Minami S, Nishino K, Nezu A, Hamasaki M, Kosako H, Yoshimori T, Nakamura S., Free PMC Article | 12/16/2023 |
| Prognostic and Immunological Role of STK38 across Cancers: Friend or Foe? | Prognostic and Immunological Role of STK38 across Cancers: Friend or Foe?
Liu Y, Shi Z, Zheng Z, Li J, Yang K, Xu C, Liu Q, Gong Z, Yang Y, Zhao Y, Xuan Z, Sun H, Shao C., Free PMC Article | 10/22/2022 |
| NDR1 increases NOTCH1 signaling activity by impairing Fbw7 mediated NICD degradation to enhance breast cancer stem cell properties. | NDR1 increases NOTCH1 signaling activity by impairing Fbw7 mediated NICD degradation to enhance breast cancer stem cell properties.
Wang LL, Wan XY, Liu CQ, Zheng FM., Free PMC Article | 05/14/2022 |
| STK38 is a PPARgamma-interacting protein promoting adipogenesis. | STK38 is a PPARγ-interacting protein promoting adipogenesis.
Qian K, Yu D, Wang W, Jiang M, Yang R, Brown R, Gong DW., Free PMC Article | 01/22/2022 |
| The STK38-XPO1 axis, a new actor in physiology and cancer. | The STK38-XPO1 axis, a new actor in physiology and cancer.
Martin AP, Aushev VN, Zalcman G, Camonis JH., Free PMC Article | 04/3/2021 |
| our results reveal STK38 as an activator of XPO1, behaving as a gatekeeper of nuclear export. These observations establish a novel mechanism of XPO1-dependent cargo export regulation by phosphorylation of XPO1's C-terminal auto-inhibitory domain. | STK38 kinase acts as XPO1 gatekeeper regulating the nuclear export of autophagy proteins and other cargoes.
Martin AP, Jacquemyn M, Lipecka J, Chhuon C, Aushev VN, Meunier B, Singh MK, Carpi N, Piel M, Codogno P, Hergovich A, Parrini MC, Zalcman G, Guerrera IC, Daelemans D, Camonis JH., Free PMC Article | 05/16/2020 |
| The activation segment of NDR1 influences interaction with MST1/MST2 and Furry. | Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment.
Xiong S, Lorenzen K, Couzens AL, Templeton CM, Rajendran D, Mao DYL, Juang YC, Chiovitti D, Kurinov I, Guettler S, Gingras AC, Sicheri F., Free PMC Article | 08/10/2019 |
| Relied on its interaction with serine/threonine-protein kinase 38 (Stk38) to inhibit ubiquitination. | Kir2.1 Interaction with Stk38 Promotes Invasion and Metastasis of Human Gastric Cancer by Enhancing MEKK2-MEK1/2-ERK1/2 Signaling.
Ji CD, Wang YX, Xiang DF, Liu Q, Zhou ZH, Qian F, Yang L, Ren Y, Cui W, Xu SL, Zhao XL, Zhang X, Wang Y, Zhang P, Wang JM, Cui YH, Bian XW., Free PMC Article | 06/15/2019 |
| Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop. | Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop.
Liu Z, Qin Q, Wu C, Li H, Shou J, Yang Y, Gu M, Ma C, Lin W, Zou Y, Zhang Y, Ma F, Sun J, Wang X., Free PMC Article | 12/22/2018 |
| Study provides evidence for an inhibitory role of SOCS2 in TNFalpha induced NF-kappa B activation, identifies NDR1 as a novel substrate of SOCS2, and demonstrates that SOCS2 and TNFalpha induced NF-kappa B signaling are linked through NDR1. | The ubiquitin ligase Cullin5(SOCS2) regulates NDR1/STK38 stability and NF-κB transactivation.
Paul I, Batth TS, Iglesias-Gato D, Al-Araimi A, Al-Haddabi I, Alkharusi A, Norstedt G, Olsen JV, Zadjali F, Flores-Morales A., Free PMC Article | 11/10/2018 |
| Data show that STK38 supports Ras-driven transformation through promoting detachment-induced autophagy. | Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation.
Bettoun A, Joffre C, Zago G, Surdez D, Vallerand D, Gundogdu R, Sharif AA, Gomez M, Cascone I, Meunier B, White MA, Codogno P, Parrini MC, Camonis JH, Hergovich A., Free PMC Article | 01/13/2018 |
| a novel and intimate link between the protein kinase NDR1 and TGFbeta signaling | Identification of a Novel Link between the Protein Kinase NDR1 and TGFβ Signaling in Epithelial Cells.
Pot I, Patel S, Deng L, Chandhoke AS, Zhang C, Bonni A, Bonni S., Free PMC Article | 10/14/2017 |
| Data establish STK38 as a conserved regulator of autophagy in human cells and flies. | The Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy.
Joffre C, Dupont N, Hoa L, Gomez V, Pardo R, Gonçalves-Pimentel C, Achard P, Bettoun A, Meunier B, Bauvy C, Cascone I, Codogno P, Fanto M, Hergovich A, Camonis J., Free PMC Article | 08/27/2016 |
| PLK1-mediated phosphorylation protects the binding of Mob1 to NDR1 and subsequent NDR1 activation | Regulation of NDR1 activity by PLK1 ensures proper spindle orientation in mitosis.
Yan M, Chu L, Qin B, Wang Z, Liu X, Jin C, Zhang G, Gomez M, Hergovich A, Chen Z, He P, Gao X, Yao X., Free PMC Article | 04/2/2016 |
| STK38-mediated phosphorylation of CDC25A at Ser-76 and the subsequent degradation of CDC25A are required to promote DNA damage-induced G2/M checkpoint activation. | Serine-Threonine Kinase 38 regulates CDC25A stability and the DNA damage-induced G2/M checkpoint.
Fukasawa T, Enomoto A, Miyagawa K. | 02/27/2016 |
| STK38 regulates MYC protein stability and turnover in a kinase activity-dependent manner. STK38 kinase inactivation abrogates apoptosis following B-cell receptor activation, whereas its silencing significantly decreases MYC levels and increases apoptosis. | STK38 is a critical upstream regulator of MYC's oncogenic activity in human B-cell lymphoma.
Bisikirska BC, Adam SJ, Alvarez MJ, Rajbhandari P, Cox R, Lefebvre C, Wang K, Rieckhof GE, Felsher DW, Califano A., Free PMC Article | 01/11/2014 |
| cyclin D1 has a role in promoting cell cycle progression by enhancing NDR1/2 kinase activity independent of Cdk4 | Cyclin D1 promotes cell cycle progression through enhancing NDR1/2 kinase activity independent of cyclin-dependent kinase 4.
Du Z, Tong X, Ye X., Free PMC Article | 12/21/2013 |
| 17-allylamino-17-demethoxygeldanamycin down-regulates STK38, modulating radiosensitivity. | The HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin modulates radiosensitivity by downregulating serine/threonine kinase 38 via Sp1 inhibition.
Enomoto A, Fukasawa T, Takamatsu N, Ito M, Morita A, Hosoi Y, Miyagawa K. | 12/7/2013 |
| Findings suggest a function of NDR1, which may regulate NF-kappaB activation by its kinase activity. | NDR1/STK38 potentiates NF-κB activation by its kinase activity.
Shi DD, Shi H, Lu D, Li R, Zhang Y, Zhang J. | 05/18/2013 |
| GSK-3beta inhibits full activation of STK38, and STK38 activation is required to prevent cell death in response to oxidative stress | Serine-threonine kinase 38 is regulated by glycogen synthase kinase-3 and modulates oxidative stress-induced cell death.
Enomoto A, Kido N, Ito M, Takamatsu N, Miyagawa K. | 05/5/2012 |
| Findings show a biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling. | MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis.
Zhou Y, Adolfs Y, Pijnappel WW, Fuller SJ, Van der Schors RC, Li KW, Sugden PH, Smit AB, Hergovich A, Pasterkamp RJ., Free PMC Article | 10/15/2011 |
| These findings establish a novel MST3-NDR-p21 axis as an important regulator of G(1)/S progression of mammalian cells. | Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability.
Cornils H, Kohler RS, Hergovich A, Hemmings BA., Free PMC Article | 05/21/2011 |
| Data indicate that human MOB2 is a negative regulator of human NDR kinases in biochemical and biological settings. | Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases.
Kohler RS, Schmitz D, Cornils H, Hemmings BA, Hergovich A., Free PMC Article | 10/23/2010 |
| Results suggest that MST2-, Fry-, and MOB2-mediated activation of NDR1 is crucial for the fidelity of mitotic chromosome alignment in mammalian cells. | MST2- and Furry-mediated activation of NDR1 kinase is critical for precise alignment of mitotic chromosomes.
Chiba S, Ikeda M, Katsunuma K, Ohashi K, Mizuno K. | 01/21/2010 |
| findings identify NDR1/2 as novel proapoptotic kinases and key members of the RASSF1A/MST1 signaling cascade | NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis.
Vichalkovski A, Gresko E, Cornils H, Hergovich A, Schmitz D, Hemmings BA. | 01/21/2010 |