Prohibitin 2: A key regulator of cell function. | Prohibitin 2: A key regulator of cell function. Zhang B, Li W, Cao J, Zhou Y, Yuan X. | 01/28/2024 |
PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer. | PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer. Xu L, Xiang W, Yang J, Gao J, Wang X, Meng L, Ye K, Zhao XH, Zhang XD, Jin L, Ye Y., Free PMC Article | 01/16/2024 |
Prohibitin2/PHB2, Transcriptionally Regulated by GABPA, Inhibits Cell Growth via PRKN/Parkin-dependent Mitophagy in Endometriosis. | Prohibitin2/PHB2, Transcriptionally Regulated by GABPA, Inhibits Cell Growth via PRKN/Parkin-dependent Mitophagy in Endometriosis. Deng Y, Lou T, Kong L, Liu C. | 12/5/2023 |
The Role of Prohibitin-2 in Diseases. | The Role of Prohibitin-2 in Diseases. Liu F, Zhang Y, Guo Z, Ren AJ. | 11/1/2023 |
LINC00478-derived novel cytoplasmic lncRNA LacRNA stabilizes PHB2 and suppresses breast cancer metastasis via repressing MYC targets. | LINC00478-derived novel cytoplasmic lncRNA LacRNA stabilizes PHB2 and suppresses breast cancer metastasis via repressing MYC targets. Guo R, Su Y, Zhang Q, Xiu B, Huang S, Chi W, Zhang L, Li L, Hou J, Wang J, Chen J, Chi Y, Xue J, Wu J., Free PMC Article | 02/16/2023 |
PHB2 promotes colorectal cancer cell proliferation and tumorigenesis through NDUFS1-mediated oxidative phosphorylation. | PHB2 promotes colorectal cancer cell proliferation and tumorigenesis through NDUFS1-mediated oxidative phosphorylation. Ren L, Meng L, Gao J, Lu M, Guo C, Li Y, Rong Z, Ye Y., Free PMC Article | 01/28/2023 |
Identification of PHB2 as a Potential Biomarker of Luminal A Breast Cancer Cells Using a Cell-Specific Aptamer. | Identification of PHB2 as a Potential Biomarker of Luminal A Breast Cancer Cells Using a Cell-Specific Aptamer. Liu M, Wang Z, Li S, Deng Y, He N. | 12/3/2022 |
GALNT14-mediated O-glycosylation on PHB2 serine-161 enhances cell growth, migration and drug resistance by activating IGF1R cascade in hepatoma cells. | GALNT14-mediated O-glycosylation on PHB2 serine-161 enhances cell growth, migration and drug resistance by activating IGF1R cascade in hepatoma cells. Chu YD, Fan TC, Lai MW, Yeh CT., Free PMC Article | 11/19/2022 |
Overexpression of Prohibitin 2 Protein is Associated with Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia. | Overexpression of Prohibitin 2 Protein is Associated with Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia. Lee YE, Lim HJ, Park JH, Kim HR, Kang MG, Cho YK, Shin JH, Shin MG., Free PMC Article | 04/30/2022 |
The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer. | The Mitochondrial PHB2/OMA1/DELE1 Pathway Cooperates with Endoplasmic Reticulum Stress to Facilitate the Response to Chemotherapeutics in Ovarian Cancer. Cheng M, Yu H, Kong Q, Wang B, Shen L, Dong D, Sun L., Free PMC Article | 03/12/2022 |
Folate receptor alpha increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer. | Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer. Sakai H, Kawakami H, Teramura T, Onodera Y, Somers E, Furuuchi K, Uenaka T, Kato R, Nakagawa K., Free PMC Article | 02/12/2022 |
The survival and proliferation of osteosarcoma cells are dependent on the mitochondrial BIG3-PHB2 complex formation. | The survival and proliferation of osteosarcoma cells are dependent on the mitochondrial BIG3-PHB2 complex formation. Toki S, Yoshimaru T, Matsushita Y, Aihara H, Ono M, Tsuneyama K, Sairyo K, Katagiri T., Free PMC Article | 10/16/2021 |
RSU-1 interaction with prohibitin-2 links cell-extracellular matrix detachment to downregulation of ERK signaling. | RSU-1 interaction with prohibitin-2 links cell-extracellular matrix detachment to downregulation of ERK signaling. Wang M, Liu J, Tu Y, Zhao Z, Qu J, Chen K, Chen Y, Sun Y, Zhao H, Deng Y, Wu C., Free PMC Article | 08/7/2021 |
PHB2 promotes tumorigenesis via RACK1 in non-small cell lung cancer. | PHB2 promotes tumorigenesis via RACK1 in non-small cell lung cancer. Wu B, Chang N, Xi H, Xiong J, Zhou Y, Wu Y, Wu S, Wang N, Yi H, Song Y, Chen L, Zhang J., Free PMC Article | 07/31/2021 |
Functional role and molecular mechanisms underlying prohibitin 2 in platelet mitophagy and activation. | Functional role and molecular mechanisms underlying prohibitin 2 in platelet mitophagy and activation. Hu LL, Zou K, Chen Y, Wu LJ, Cao J, Xiong XY, Wang L, Cheng XS, Xiao QZ, Yang RQ., Free PMC Article | 05/8/2021 |
SLAMF receptors negatively regulate B cell receptor signaling in chronic lymphocytic leukemia via recruitment of prohibitin-2. | SLAMF receptors negatively regulate B cell receptor signaling in chronic lymphocytic leukemia via recruitment of prohibitin-2. von Wenserski L, Schultheiß C, Bolz S, Schliffke S, Simnica D, Willscher E, Gerull H, Wolters-Eisfeld G, Riecken K, Fehse B, Altfeld M, Nollau P, Binder M., Free PMC Article | 05/1/2021 |
Prohibitin 2 deficiency impairs cardiac fatty acid oxidation and causes heart failure. | Prohibitin 2 deficiency impairs cardiac fatty acid oxidation and causes heart failure. Wu D, Jian C, Peng Q, Hou T, Wu K, Shang B, Zhao M, Wang Y, Zheng W, Ma Q, Li CY, Cheng H, Wang X, Zhao L., Free PMC Article | 04/17/2021 |
Interaction between PHB2 and Enterovirus A71 VP1 Induces Autophagy and Affects EV-A71 Infection. | Interaction between PHB2 and Enterovirus A71 VP1 Induces Autophagy and Affects EV-A71 Infection. Su W, Huang S, Zhu H, Zhang B, Wu X., Free PMC Article | 02/20/2021 |
Prohibitin 2/PHB2 in Parkin-Mediated Mitophagy: A Potential Therapeutic Target for Non-Small Cell Lung Carcinoma. | Prohibitin 2/PHB2 in Parkin-Mediated Mitophagy: A Potential Therapeutic Target for Non-Small Cell Lung Carcinoma. Zhang H, Yin C, Liu X, Bai X, Wang L, Xu H, Ju J, Zhang L., Free PMC Article | 02/6/2021 |
PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis. | PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis. Yan C, Gong L, Chen L, Xu M, Abou-Hamdan H, Tang M, Désaubry L, Song Z., Free PMC Article | 11/28/2020 |
Cytoplasmic sequestration of the RhoA effector mDiaphanous1 by Prohibitin2 promotes muscle differentiation. | Cytoplasmic sequestration of the RhoA effector mDiaphanous1 by Prohibitin2 promotes muscle differentiation. Saleh A, Subramaniam G, Raychaudhuri S, Dhawan J., Free PMC Article | 10/31/2020 |
Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3eta as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability. | Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3η as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability. Silva LE, Souza RC, Kitano ES, Monteiro LF, Iwai LK, Forti FL. | 09/5/2020 |
These results establish a model for the BIG3-PHB2 interaction and an entry for drug discovery for breast cancer. | Biophysical characterization of the breast cancer-related BIG3-PHB2 interaction: Effect of non-conserved loop region of BIG3 on the structure and the interaction. Chigira T, Nagatoishi S, Takeda H, Yoshimaru T, Katagiri T, Tsumoto K. | 06/6/2020 |
during cell stress, Bif-1 regulates mitochondrial inner membrane by interacting with prohibitin-2 to disrupt prohibitin complexes and induce OPA1 proteolysis and inactivation. | Bif-1 Interacts with Prohibitin-2 to Regulate Mitochondrial Inner Membrane during Cell Stress and Apoptosis. Cho SG, Xiao X, Wang S, Gao H, Rafikov R, Black S, Huang S, Ding HF, Yoon Y, Kirken RA, Yin XM, Wang HG, Dong Z., Free PMC Article | 04/25/2020 |
Prohibitin 2-mediated mitophagy attenuates renal tubular epithelial cells injury by regulating mitochondrial dysfunction and NLRP3 inflammasome activation. | Prohibitin 2-mediated mitophagy attenuates renal tubular epithelial cells injury by regulating mitochondrial dysfunction and NLRP3 inflammasome activation. Xu Y, Wang J, Xu W, Ding F, Ding W. | 11/30/2019 |