| Enhanced anti-tumor activity of arginine decarboxylase through the incorporation of aromatic amino acids at the multimer-forming interface. | Enhanced anti-tumor activity of arginine decarboxylase through the incorporation of aromatic amino acids at the multimer-forming interface.
Park MY, Kim S, Kwon NH, Moon G, Cha J, Kwon I. | 01/31/2024 |
| Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology. | Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.
Sandusky-Beltran LA, Kovalenko A, Placides DS, Ratnasamy K, Ma C, Hunt JB Jr, Liang H, Calahatian JIT, Michalski C, Fahnestock M, Blair LJ, Darling AL, Baker JD, Fontaine SN, Dickey CA, Gamsby JJ, Nash KR, Abner E, Selenica MB, Lee DC., Free PMC Article | 09/25/2021 |
| Antizyme inhibitor 2 (AZIN2) associates with better prognosis of head and neck minor salivary gland adenoid cystic carcinoma. | Antizyme inhibitor 2 (AZIN2) associates with better prognosis of head and neck minor salivary gland adenoid cystic carcinoma.
Hämetoja H, Andersson LC, Mäkitie A, Bäck L, Hagström J, Haglund C. | 08/28/2021 |
| AZIN2 splice variant suppressed endogenous cardiac regeneration by targeting the PTEN/Akt pathway. | Loss of AZIN2 splice variant facilitates endogenous cardiac regeneration.
Li X, He X, Wang H, Li M, Huang S, Chen G, Jing Y, Wang S, Chen Y, Liao W, Liao Y, Bin J., Free PMC Article | 11/16/2019 |
| The morphological change induced by hADC gene delivery was the expression levels of adhesion molecules, N-CAM and integrin and showed modulation of brain-derived neurotrophic factor (BDNF), phosphoinositide 3-kinase (PI3K) and ERK1/2 expressions. | Transfection of arginine decarboxylase gene increases the neuronal differentiation of neural progenitor cells.
Bokara KK, Kim JH, Kim JY, Lee JE. | 11/25/2017 |
| The high expression of AZIN2 in various cells with secretory or vesicle transport activity indicates that the polyamine metabolism regulated by AZIN2 | Expression of ODC Antizyme Inhibitor 2 (AZIN2) in Human Secretory Cells and Tissues.
Rasila T, Lehtonen A, Kanerva K, Mäkitie LT, Haglund C, Andersson LC., Free PMC Article | 11/12/2016 |
| ODC activity is mostly linked to cell proliferation, whereas its regulation by AZIN2 in post-mitotically differentiated neurons of the brain apparently serves different purposes. | Brain neurons express ornithine decarboxylase-activating antizyme inhibitor 2 with accumulation in Alzheimer's disease.
Mäkitie LT, Kanerva K, Polvikoski T, Paetau A, Andersson LC., Free PMC Article | 01/8/2011 |
| Both endogenous and FLAG-tagged AZIN2 localize to post-Golgi vesicles of the secretory pathway. Immuno-electron microscopy revealed that the vesicles associate mainly with the trans-Golgi network. | Ornithine decarboxylase antizyme inhibitor 2 regulates intracellular vesicle trafficking.
Kanerva K, Mäkitie LT, Bäck N, Andersson LC. | 06/28/2010 |
| AZIN2 expression appears to be restricted to brain and testis and it is a labile protein degraded by a ubiquitin-dependent mechanism. | Antizyme inhibitor 2: molecular, cellular and physiological aspects.
López-Contreras AJ, Ramos-Molina B, Cremades A, Peñafiel R. | 06/14/2010 |
| localization of AZIN2 implies possible involvement in the gonadal synthesis and/or release of steroid hormones. | High expression of antizyme inhibitor 2, an activator of ornithine decarboxylase in steroidogenic cells of human gonads.
Mäkitie LT, Kanerva K, Sankila A, Andersson LC. | 04/19/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Non-synonymous single-nucleotide polymorphisms associated with blood pressure and hypertension.
Hong KW, Jin HS, Lim JE, Cho YS, Go MJ, Jung J, Lee JE, Choi J, Shin C, Hwang SY, Lee SH, Park HK, Oh B. | 04/7/2010 |