| WBSCR22 and TRMT112 synergistically suppress cell proliferation, invasion and tumorigenesis in pancreatic cancer via transcriptional regulation of ISG15. | WBSCR22 and TRMT112 synergistically suppress cell proliferation, invasion and tumorigenesis in pancreatic cancer via transcriptional regulation of ISG15.
Khan AA, Huang H, Zhao Y, Li H, Pan R, Wang S, Liu X., Free PMC Article | 03/26/2022 |
| WBSCR22 confers cell survival and predicts poor prognosis in glioma. | WBSCR22 confers cell survival and predicts poor prognosis in glioma.
Chi Y, Liang Z, Guo Y, Chen D, Lu L, Lin J, Qiu S, Wang X, Qiu E, Lin F, Chen J, Luo S, Zheng D, Xu X. | 10/2/2021 |
| Cardiac mitochondrial function depends on BUD23 mediated ribosome programming. | Cardiac mitochondrial function depends on BUD23 mediated ribosome programming.
Baxter M, Voronkov M, Poolman T, Galli G, Pinali C, Goosey L, Knight A, Krakowiak K, Maidstone R, Iqbal M, Zi M, Prehar S, Cartwright EJ, Gibbs J, Matthews LC, Adamson AD, Humphreys NE, Rebelo-Guiomar P, Minczuk M, Bechtold DA, Loudon A, Ray D., Free PMC Article | 04/24/2021 |
| Merm1 is capable of maintaining hypomethylated rRNA gene bodies and co-localizes with RNA polymerase I in the nucleolus. Merm1 interacts with Dnmt3a and represses its methyltransferase activity with the requirement of the binding motif for S-adenosyl-L-methionine. | Metastasis-related methyltransferase 1 (Merm1) represses the methyltransferase activity of Dnmt3a and facilitates RNA polymerase I transcriptional elongation.
Lyu G, Zong L, Zhang C, Huang X, Xie W, Fang J, Guan Y, Zhang L, Ni T, Gu J, Tao W. | 06/20/2020 |
| Study results demonstrated that WBSCR22 is involved in colorectal cancer (CRC) resistance to oxaliplatin, suggesting WBSCR22 may represent a novel oxaliplatin resistance biomarker as well as a potential target for CRC therapeutics. | WBSCR22 confers oxaliplatin resistance in human colorectal cancer.
Yan D, Tu L, Yuan H, Fang J, Cheng L, Zheng X, Wang X., Free PMC Article | 07/27/2019 |
| The localization of the TRMT112 protein is determined by WBSCR22, and the WBSCR22-TRMT112 complex is localized in the cell nucleus. | The Stability of Ribosome Biogenesis Factor WBSCR22 Is Regulated by Interaction with TRMT112 via Ubiquitin-Proteasome Pathway.
Õunap K, Leetsi L, Matsoo M, Kurg R., Free PMC Article | 05/7/2016 |
| DIMT1L and WBSCR22-TRMT112 are required for distinct pre-rRNA processing reactions leading to synthesis of 18S rRNA. Ribosome biogenesis requires the presence of the modification enzyme rather than its RNA-modifying catalytic activity. | The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.
Zorbas C, Nicolas E, Wacheul L, Huvelle E, Heurgué-Hamard V, Lafontaine DL., Free PMC Article | 03/12/2016 |
| Knockdown of Merm1/Wbscr22 attenuates sensitivity of H460 non-small cell lung cancer cells to SN-38 and 5-FU without alteration to p53 expression levels. | Knockdown of Merm1/Wbscr22 attenuates sensitivity of H460 non-small cell lung cancer cells to SN-38 and 5-FU without alteration to p53 expression levels.
Yan D, Zheng X, Tu L, Jia J, Li Q, Cheng L, Wang X. | 07/25/2015 |
| The key role of WBSCR22 in 40S subunit biogenesis is independent of its function as an RNA methyltransferase. | WBSCR22/Merm1 is required for late nuclear pre-ribosomal RNA processing and mediates N7-methylation of G1639 in human 18S rRNA.
Haag S, Kretschmer J, Bohnsack MT., Free PMC Article | 03/28/2015 |
| WBSCR22 protein level is decreased in lymphoblastoid cell lines. | The human WBSCR22 protein is involved in the biogenesis of the 40S ribosomal subunits in mammalian cells.
Õunap K, Käsper L, Kurg A, Kurg R., Free PMC Article | 07/19/2014 |
| Merm1 is a novel regulator of chromatin structure affecting GR recruitment and function | The methyltransferase WBSCR22/Merm1 enhances glucocorticoid receptor function and is regulated in lung inflammation and cancer.
Jangani M, Poolman TM, Matthews L, Yang N, Farrow SN, Berry A, Hanley N, Williamson AJ, Whetton AD, Donn R, Ray DW., Free PMC Article | 05/24/2014 |
| Characterization of two novel genes, WBSCR20 and WBSCR22, deleted in Williams-Beuren syndrome | Characterization of two novel genes, WBSCR20 and WBSCR22, deleted in Williams-Beuren syndrome.
Doll A, Grzeschik KH. | 01/21/2010 |