| This study is the first showing that CHRNB3/A6 are highly associated with nicotine dependence in a large Chinese Han sample. | Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population.
Wen L, Han H, Liu Q, Su K, Yang Z, Cui W, Yuan W, Ma Y, Fan R, Chen J, Jiang K, Jiang X, Payne TJ, Wang J, Li MD., Free PMC Article | 04/20/2019 |
| To gain a better understanding of the pathological processes underlying ND and ND-related behaviors and to promote the development of effective smoking cessation therapies, we here present the most recent studies concerning the genetic effects of the CHRNB3-CHRNA6 gene cluster in ND. | Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research.
Wen L, Yang Z, Cui W, Li MD., Free PMC Article | 11/18/2017 |
| This study shows that unorthodox acetylcholine binding sites can form at the alpha5/alpha4 and beta3/alpha4 interfaces in (alpha4beta2)2alpha5 and (alpha4beta2)2beta3 nicotinic acetylcholine receptors (nAChRs) and at the alpha4/alpha5 in (beta2alpha4)2alpha5 nAChRs. | Unorthodox Acetylcholine Binding Sites Formed by α5 and β3 Accessory Subunits in α4β2* Nicotinic Acetylcholine Receptors.
Jain A, Kuryatov A, Wang J, Kamenecka TM, Lindstrom J., Free PMC Article | 06/3/2017 |
| More low frequency variants in the CHRNA6/CHRNB3 gene region were observed in cases compared to controls. | Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence.
Kamens HM, Corley RP, Richmond PA, Darlington TM, Dowell R, Hopfer CJ, Stallings MC, Hewitt JK, Brown SA, Ehringer MA., Free PMC Article | 05/13/2017 |
| Data provide evidence that the protective genetic variant at rs6474413 identified in human genetic studies reduces gene expression and that decreased beta3 gene expression in mice reduces nicotine intake | The β3 subunit of the nicotinic acetylcholine receptor: Modulation of gene expression and nicotine consumption.
Kamens HM, Miyamoto J, Powers MS, Ro K, Soto M, Cox R, Stitzel JA, Ehringer MA., Free PMC Article | 09/3/2016 |
| This patient's chromosomal abnormality affected only one gene that is highly expressed in the brainstem and brain, involved in neurotransmission, and could be related to her Duane retraction syndrome. | Nicotinic Receptor Mutation in a Mildly Dysmorphic Girl with Duane Retraction Syndrome.
Abu-Amero KK, Kondkar A, Hellani AM, Oystreck DT, Khan AO, Bosley TM. | 02/27/2016 |
| Data show efficient expression of (alpha6beta2)2beta3 nicotinic acetylcholine receptors (AChRs) in Xenopus oocytes using free subunits with only small changes in alpha6 subunits, while not altering AChR pharmacology or channel structure. | Efficient expression of functional (α6β2)2β3 AChRs in Xenopus oocytes from free subunits using slightly modified α6 subunits.
Ley CK, Kuryatov A, Wang J, Lindstrom JM., Free PMC Article | 12/5/2015 |
| the CHRNB3-A6 locus contains multiple variants affecting risk for vulnerability to cocaine and nicotine dependence as well as bipolar disorder, suggesting that they have pleiotropic effects. | Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: evidence for pleiotropy.
Sadler B, Haller G, Agrawal A, Culverhouse R, Bucholz K, Brooks A, Tischfield J, Johnson EO, Edenberg H, Schuckit M, Saccone N, Bierut L, Goate A., Free PMC Article | 10/24/2015 |
| Polymorphism in CHRNB3 gene is associated with esophageal adenocarcinoma. | A genetic variant in CHRNB3-CHRNA6 increases risk of esophageal squamous cell carcinoma in Chinese populations.
Song Y, Wang Y, Xu L, Ma J, Chen E, Zang R, Jia W, Tao X, Hu L. | 07/25/2015 |
| The common variant rs13273442 in the CHRNB3-CHNRA6 region is associated significantly with nicotine dependence in European Americans and African Americans. | Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans.
Culverhouse RC, Johnson EO, Breslau N, Hatsukami DK, Sadler B, Brooks AI, Hesselbrock VM, Schuckit MA, Tischfield JA, Goate AM, Saccone NL, Bierut LJ., Free PMC Article | 06/20/2015 |
| CHRNB3 c.-57A>G alteration affects the promoter activity and is associated with Parkinson's disease (PD), and smoking in PD patients. | CHRNB3 c.-57A>G functional promoter change affects Parkinson's disease and smoking.
Bar-Shira A, Gana-Weisz M, Gan-Or Z, Giladi E, Giladi N, Orr-Urtreger A. | 02/14/2015 |
| Level of cigarettes per day during adolescence and young adulthood is associated with CHRNB3A6, CHRNA5A3B4, and CHRNA2 | Effect of neuronal nicotinic acetylcholine receptor genes (CHRN) on longitudinal cigarettes per day in adolescents and young adults.
Cannon DS, Mermelstein RJ, Hedeker D, Coon H, Cook EH, McMahon WM, Hamil C, Dunn D, Weiss RB., Free PMC Article | 12/6/2014 |
| Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence. | Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence.
Haller G, Kapoor M, Budde J, Xuei X, Edenberg H, Nurnberger J, Kramer J, Brooks A, Tischfield J, Almasy L, Agrawal A, Bucholz K, Rice J, Saccone N, Bierut L, Goate A., Free PMC Article | 11/8/2014 |
| this study provides convincing evidence for a role of CHRNB3 in Nicotine Dependence. | Significant association of CHRNB3 variants with nicotine dependence in multiple ethnic populations.
Cui WY, Wang S, Yang J, Yi SG, Yoon D, Kim YJ, Payne TJ, Ma JZ, Park T, Li MD. | 11/8/2014 |
| these results demonstrate that the combined effect of rs6474412-C/T polymorphism in smoking-related CHRNB3-CHRNA6 region gene and smoking behavior may not confer risk to psoriasis vulgaris (PV), but may have impact on PV severity in Chinese Han population. | Combined effect between CHRNB3-CHRNA6 region gene variant (rs6474412) and smoking in psoriasis vulgaris severity.
Zhu KJ, Quan C, Zhang C, Liu Z, Liu H, Li M, Li SJ, Zhu CY, Shi G, Li KS, Fan YM. | 07/12/2014 |
| Results demonstrate the association between SNPs in CHRNB3 nicotinic acetylcholine receptor genes and the risk of smoking in ADHD | Nicotinic receptor gene variants interact with attention deficient hyperactive disorder symptoms to predict smoking trajectories from early adolescence to adulthood.
Lee CT, Fuemmeler BF, McClernon FJ, Ashley-Koch A, Kollins SH., Free PMC Article | 03/22/2014 |
| The results indicate the genetic locus for the CHRNB3 gene is strongly associated with nicotine dependence. | CHRNB3 is more strongly associated with Fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results.
Rice JP, Hartz SM, Agrawal A, Almasy L, Bennett S, Breslau N, Bucholz KK, Doheny KF, Edenberg HJ, Goate AM, Hesselbrock V, Howells WB, Johnson EO, Kramer J, Krueger RF, Kuperman S, Laurie C, Manolio TA, Neuman RJ, Nurnberger JI, Porjesz B, Pugh E, Ramos EM, Saccone N, Saccone S, Schuckit M, Bierut LJ, GENEVA Consortium., Free PMC Article | 03/16/2013 |
| beta3 subunit coexpression promotes function of alpha6*-nAChR | Modulation of gain-of-function α6*-nicotinic acetylcholine receptor by β3 subunits.
Dash B, Lukas RJ., Free PMC Article | 07/21/2012 |
| Variants in CHRNB3/CHRNA6 are independently associated with bipolar disorder. | Genetic association of bipolar disorder with the β(3) nicotinic receptor subunit gene.
Hartz SM, Lin P, Edenberg HJ, Xuei X, Rochberg N, Saccone S, Berrettini W, Nelson E, Nurnberger J, Bierut LJ, Rice JP, NIMH Genetics Initiative Bipolar Disorder Consortium., Free PMC Article | 01/21/2012 |
| The GG genotype of SNP rs13261190 in the CHRNB3 was associated with increased novelty seeking in alcohol-dependent individuals. | Reward-related genes and personality traits in alcohol-dependent individuals: a pilot case control study.
Landgren S, Berglund K, Jerlhag E, Fahlke C, Balldin J, Berggren U, Zetterberg H, Blennow K, Engel JA. | 11/5/2011 |
| CHRNB3 and CHRNA6 polymorphisms are associated with smoking behavior and lung cancer susceptibility in Chinese Han population. | [Human chromosome 8p11 (CHRNB3-CHRNA6) region gene polymorphisms and susceptibility to lung cancer in Chinese Han population].
Zhang XB, Zhao ZH, Chen HY, Wang JC, Qian J, Yang YJ, Wei QY, Huang J, Lu DR. | 10/1/2011 |
| Concatameric pentamers and pentamers formed from combinations of trimers, dimers, and monomers of alpha6beta2beta3* acetylcholine receptors exhibit similar properties, indicating that the linkers between subunits do not alter their functional properties. | Expression of functional human α6β2β3* acetylcholine receptors in Xenopus laevis oocytes achieved through subunit chimeras and concatamers.
Kuryatov A, Lindstrom J., Free PMC Article | 01/15/2011 |
| Three single nucleotide polymorphisms (SNPs) in CHRNA6 and one SNP in CHRNB3 are associated with a composite of alcohol phenotypes. | SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample.
Hoft NR, Corley RP, McQueen MB, Huizinga D, Menard S, Ehringer MA., Free PMC Article | 01/15/2011 |
| Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) | Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
Thorgeirsson TE, Gudbjartsson DF, Surakka I, Vink JM, Amin N, Geller F, Sulem P, Rafnar T, Esko T, Walter S, Gieger C, Rawal R, Mangino M, Prokopenko I, Mägi R, Keskitalo K, Gudjonsdottir IH, Gretarsdottir S, Stefansson H, Thompson JR, Aulchenko YS, Nelis M, Aben KK, den Heijer M, Dirksen A, Ashraf H, Soranzo N, Valdes AM, Steves C, Uitterlinden AG, Hofman A, Tönjes A, Kovacs P, Hottenga JJ, Willemsen G, Vogelzangs N, Döring A, Dahmen N, Nitz B, Pergadia ML, Saez B, De Diego V, Lezcano V, Garcia-Prats MD, Ripatti S, Perola M, Kettunen J, Hartikainen AL, Pouta A, Laitinen J, Isohanni M, Huei-Yi S, Allen M, Krestyaninova M, Hall AS, Jones GT, van Rij AM, Mueller T, Dieplinger B, Haltmayer M, Jonsson S, Matthiasson SE, Oskarsson H, Tyrfingsson T, Kiemeney LA, Mayordomo JI, Lindholt JS, Pedersen JH, Franklin WA, Wolf H, Montgomery GW, Heath AC, Martin NG, Madden PA, Giegling I, Rujescu D, Järvelin MR, Salomaa V, Stumvoll M, Spector TD, Wichmann HE, Metspalu A, Samani NJ, Penninx BW, Oostra BA, Boomsma DI, Tiemeier H, van Duijn CM, Kaprio J, Gulcher JR, ENGAGE Consortium, McCarthy MI, Peltonen L, Thorsteinsdottir U, Stefansson K., Free PMC Article | 06/30/2010 |
| There was no evidence of association of any of the SNPs in CHRNAB2 (rs2072661, rs4845378) or CHRNAB3 (rs4953, rs6474413) with smoking status (p=0.30) or, among daily smokers, of association with cotinine levels (p=0.08). | Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence.
Etter JF, Hoda JC, Perroud N, Munafò M, Buresi C, Duret C, Neidhart E, Malafosse A, Bertrand D. | 05/31/2010 |