| LACTB suppresses liver cancer progression through regulation of ferroptosis. | LACTB suppresses liver cancer progression through regulation of ferroptosis.
Zeng K, Huang N, Liu N, Deng X, Mu Y, Zhang X, Zhang J, Zhang C, Li Y, Li Z., Free PMC Article | 08/30/2024 |
| OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB. | OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB.
Ma W, Sun Y, Yan R, Zhang P, Shen S, Lu H, Zhou Z, Jiang Z, Ye L, Mao Q, Xiong N, Jia W, Sun L, Gao P, Zhang H. | 02/6/2024 |
| PCBP1 protects bladder cancer cells from mitochondria injury and ferroptosis by inducing LACTB mRNA degradation. | PCBP1 protects bladder cancer cells from mitochondria injury and ferroptosis by inducing LACTB mRNA degradation.
Luo Y, Zhang Y, Pang S, Min J, Wang T, Wu D, Lin C, Xiao Z, Xiang Q, Li Q, Ma L. | 06/18/2023 |
| LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer. | LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer.
Gonzalez-Morena JM, Escudeiro-Lopes S, Ferreira-Mendes JM, Jakoube P, Cutano V, Vinaixa-Forner J, Kralova Viziova P, Hartmanova A, Sedlacek R, Machado S, Malcekova B, Keckesova Z., Free PMC Article | 02/28/2023 |
| The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding. | The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding.
Bennett JA, Steward LR, Rudolph J, Voss AP, Aydin H., Free PMC Article | 01/14/2023 |
| Clinical Significance of beta-Lactamase Expression in Colorectal Cancer. | Clinical Significance of β-Lactamase Expression in Colorectal Cancer.
Zhou S, Miao L, Li T, Liu P, Zhou H. | 12/24/2022 |
| LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug. | LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug.
Cutano V, Ferreira Mendes JM, Escudeiro-Lopes S, Machado S, Vinaixa Forner J, Gonzales-Morena JM, Prevorovsky M, Zemlianski V, Feng Y, Kralova Viziova P, Hartmanova A, Malcekova B, Jakoube P, Iyer S, Keckesova Z., Free PMC Article | 11/19/2022 |
| LACTB suppresses migration and invasion of glioblastoma via downregulating RHOC/Cofilin signaling pathway. | LACTB suppresses migration and invasion of glioblastoma via downregulating RHOC/Cofilin signaling pathway.
Hu Y, Liu H, Zhu Z, Qi X, Yuan W, Tian M, Wang D, Xu J. | 10/8/2022 |
| Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB. | Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB.
Zhang M, Zhang L, Guo R, Xiao C, Yin J, Zhang S, Yang M. | 05/14/2022 |
| LACTB suppresses melanoma progression by attenuating PP1A and YAP interaction. | LACTB suppresses melanoma progression by attenuating PP1A and YAP interaction.
Ma Y, Wang L, He F, Yang J, Ding Y, Ge S, Fan X, Zhou Y, Xu X, Jia R. | 09/18/2021 |
| [Alternative Splicing Analysis of LACTB Gene and Expression Characteristics of Different Transcripts in Leukemia Cell Lines]. | [Alternative Splicing Analysis of LACTB Gene and Expression Characteristics of Different Transcripts in Leukemia Cell Lines].
Liu ZY, Yang F, Nie W, Yan ZQ, Shi QY, Yuan B, Liu LR. | 08/14/2021 |
| LACTB mRNA expression is increased in pancreatic adenocarcinoma and high expression indicates a poor prognosis. | LACTB mRNA expression is increased in pancreatic adenocarcinoma and high expression indicates a poor prognosis.
Xie J, Peng Y, Chen X, Li Q, Jian B, Wen Z, Liu S., Free PMC Article | 06/26/2021 |
| LACTB promotes metastasis of nasopharyngeal carcinoma via activation of ERBB3/EGFR-ERK signaling resulting in unfavorable patient survival. | LACTB promotes metastasis of nasopharyngeal carcinoma via activation of ERBB3/EGFR-ERK signaling resulting in unfavorable patient survival.
Peng LX, Wang MD, Xie P, Yang JP, Sun R, Zheng LS, Mei Y, Meng DF, Peng XS, Lang YH, Qiang YY, Li CZ, Xu L, Liu ZJ, Guo LL, Xie DH, Shu DT, Lin ST, Luo FF, Huang BJ, Qian CN. | 05/1/2021 |
| LACTB was downexpressed in gliomas. Downregulation of LACTB predicted poor survival of glioma and promoted cell proliferation, invasion, and angiogenesis of gliomas | Overexpression of LACTB, a Mitochondrial Protein That Inhibits Proliferation and Invasion in Glioma Cells.
Li HT, Dong DY, Liu Q, Xu YQ, Chen L., Free PMC Article | 04/27/2019 |
| our findings successfully demonstrate for the first time that LACTB is a novel epigenetic silenced tumor suppressor through modulating the stability of p53, supporting the pursuit of LACTB as a potential therapeutic target for colorectal cancer | LACTB, a novel epigenetic silenced tumor suppressor, inhibits colorectal cancer progression by attenuating MDM2-mediated p53 ubiquitination and degradation.
Zeng K, Chen X, Hu X, Liu X, Xu T, Sun H, Pan Y, He B, Wang S. | 03/2/2019 |
| observations uncover a novel mitochondrial tumour suppressor, LACTB--and demonstrate a connection between mitochondrial lipid metabolism and the differentiation program of breast cancer cells, thereby revealing a previously undescribed mechanism of tumour suppression | LACTB is a tumour suppressor that modulates lipid metabolism and cell state.
Keckesova Z, Donaher JL, De Cock J, Freinkman E, Lingrell S, Bachovchin DA, Bierie B, Tischler V, Noske A, Okondo MC, Reinhardt F, Thiru P, Golub TR, Vance JE, Weinberg RA., Free PMC Article | 08/12/2017 |
| MiR-125b-5p attenuates the secretion of MCP-1 by directly targeting inhibiting LACTB in LPS-stimulated THP-1 macrophages. | MicroRNA-125b-5p attenuates lipopolysaccharide-induced monocyte chemoattractant protein-1 production by targeting inhibiting LACTB in THP-1 macrophages.
Lu JB, Yao XX, Xiu JC, Hu YW. | 06/4/2016 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. Clinical and genetic risk factors of self-reported penicillin allergy.
Apter AJ, Schelleman H, Walker A, Addya K, Rebbeck T. | 06/29/2008 |
| Differential expression of a novel gene, G24, in response to hsp27 and cell differentiation in human keratinocytes.(G24 PROTEIN) | Differential expression of a novel gene in response to hsp27 and cell differentiation in human keratinocytes.
Hell-Pourmojib M, Neuner P, Fischer H, Rezaie S, Kindås-Mügge I, Knobler R, Trautinger F. | 01/21/2010 |