| Clinical and immunological relevance of SLAMF6 expression in the tumor microenvironment of breast cancer and melanoma. | Clinical and immunological relevance of SLAMF6 expression in the tumor microenvironment of breast cancer and melanoma.
Oba T, Long MD, Ito KI, Ito F., Free PMC Article | 02/8/2024 |
| SLAMF6 is associated with the susceptibility and severity of rheumatoid arthritis in the Chinese population. | SLAMF6 is associated with the susceptibility and severity of rheumatoid arthritis in the Chinese population.
Xia G, Li Y, Pan W, Qian C, Ma L, Zhou J, Xu H, Cheng C., Free PMC Article | 03/12/2022 |
| Expression and function of SLAMF6 in CD8(+) T lymphocytes of patients with severe aplastic anemia. | Expression and function of SLAMF6 in CD8(+) T lymphocytes of patients with severe aplastic anemia.
Liu B, Zeng L, Shao Y, Fu R. | 11/27/2021 |
| SLAMF6 is an important regulator of T cell activation where both its ectodomain and its endodomain contribute differentially to T cell functions. | SLAMF6 clustering is required to augment T cell activation.
Dragovich MA, Adam K, Strazza M, Tocheva AS, Peled M, Mor A., Free PMC Article | 02/29/2020 |
| Authors found that seSLAMF6 reduced activation-induced cell death and had an antiapoptotic effect on tumor-infiltrating lymphocytes. | Soluble SLAMF6 Receptor Induces Strong CD8(+) T-cell Effector Function and Improves Anti-Melanoma Activity In Vivo.
Eisenberg G, Engelstein R, Geiger-Maor A, Hajaj E, Merims S, Frankenburg S, Uzana R, Rutenberg A, Machlenkin A, Frei G, Peretz T, Lotem M. | 03/16/2019 |
| these results showed that the NTB-A/SAP pathway regulates T-cell activation and restimulation-induced cell death during human tuberculosis | Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses.
Hernández Del Pino RE, Pellegrini JM, Rovetta AI, Peña D, Álvarez GI, Rolandelli A, Musella RM, Palmero DJ, Malbran A, Pasquinelli V, García VE., Free PMC Article | 06/23/2018 |
| in addition to its established role in Invariant NKT(iNKT) cell ontogeny, Ly108 regulates iNKT cell function in mice and humans | Invariant NKT Cell Activation Is Potentiated by Homotypic trans-Ly108 Interactions.
Baglaenko Y, Cruz Tleugabulova M, Gracey E, Talaei N, Manion KP, Chang NH, Ferri DM, Mallevaey T, Wither JE. | 09/23/2017 |
| In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'. | A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education.
Wu N, Zhong MC, Roncagalli R, Pérez-Quintero LA, Guo H, Zhang Z, Lenoir C, Dong Z, Latour S, Veillette A. | 08/13/2016 |
| our data reveal how SAP nucleates a previously unknown signaling complex involving NTB-A and LCK to potentiate restimulation-induced cell death of activated human T cells. | SAP facilitates recruitment and activation of LCK at NTB-A receptors during restimulation-induced cell death.
Katz G, Krummey SM, Larsen SE, Stinson JR, Snow AL. | 06/7/2014 |
| Together, these results suggest that the reduction of NTB-A from the cell surface is associated with the Vpu-mediated effect on the glycosylation pattern of newly synthesized NTB-A molecules. | HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A.
Bolduan S, Hubel P, Reif T, Lodermeyer V, Höhne K, Fritz JV, Sauter D, Kirchhoff F, Fackler OT, Schindler M, Schubert U., Free PMC Article | 06/29/2013 |
| Data indicate that the dominance of the SLAMF3/SLAMF6 pathway in inducing IL-17A production can be attributed to an increased nuclear abundance and recruitment of RORgammat to the IL17A promoter. | CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances RORγt recruitment to the IL17A promoter in human T lymphocytes.
Chatterjee M, Hedrich CM, Rauen T, Ioannidis C, Terhorst C, Tsokos GC., Free PMC Article | 01/26/2013 |
| SLAMF3 and SLAMF6 T cell surface expression and IL-17 levels significantly correlate with disease activity in systemic lupus erythematosus patients | Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation.
Chatterjee M, Rauen T, Kis-Toth K, Kyttaris VC, Hedrich CM, Terhorst C, Tsokos GC., Free PMC Article | 06/16/2012 |
| Although the expression of SLAMF6 on the surface of T cells from patients with systemic lupus erythematosus (SLE) T cells is comparable to that on the normal T cells, engagement of SLAMF6 results in severely reduced Th1 and IL-2 cytokine production | SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells.
Chatterjee M, Kis-Toth K, Thai TH, Terhorst C, Tsokos GC., Free PMC Article | 07/23/2011 |
| Vpu downmodulation of NTB-A protects the infected cell from lysis by NK cells. | Degranulation of natural killer cells following interaction with HIV-1-infected cells is hindered by downmodulation of NTB-A by Vpu.
Shah AH, Sowrirajan B, Davis ZB, Ward JP, Campbell EM, Planelles V, Barker E., Free PMC Article | 03/5/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesNew genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 04/7/2010 |
| 2B4, NTB-A and CRACC have roles in the regulation of Natural Killer cell function [review] | Regulation of NK cell activity by 2B4, NTB-A and CRACC.
Claus M, Meinke S, Bhat R, Watzl C. | 01/21/2010 |
| HTLV-1-infected CD4+ T cells did not express ligands for NK cell activating receptors, NCR and NKG2D, although they did express ligands for NK cell coactivating receptors, NTB-A and 2B4. | Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells.
Banerjee P, Feuer G, Barker E., Free PMC Article | 01/21/2010 |
| The 3.0 A crystal structure of the complete NTB-A ectodomain revealed a rod-like monomer that self-associates to form a highly kinked dimer spanning an end-to-end distance of approximately 100 A. | NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family.
Cao E, Ramagopal UA, Fedorov A, Fedorov E, Yan Q, Lary JW, Cole JL, Nathenson SG, Almo SC. | 01/21/2010 |
| regulation of interferon-gamma secretion, and not interleukin-4 in vitro, as well as inhibition of Th1 cell-induced isotype switching and attenuation of experimental allergic encephalomyelitis identifies NTB-A as a regulator of T cell response | NTB-A, a new activating receptor in T cells that regulates autoimmune disease.
Valdez PA, Wang H, Seshasayee D, van Lookeren Campagne M, Gurney A, Lee WP, Grewal IS. | 01/21/2010 |
| blocking the engagement of 2B4, NTB-A and CRACC has no effect on the proliferation or development of the cytotoxic potential of NK cells but triggering by their physiological ligands on MHC class I-negative target cells induces potent NK cell cytotoxicity | 2B4 (CD244), NTB-A and CRACC (CS1) stimulate cytotoxicity but no proliferation in human NK cells.
Stark S, Watzl C. | 01/21/2010 |
| NTB-A is an interlymphocyte signaling molecule, which serves to orchestrate the activities of immune cells. | Cutting edge: NTB-A activates NK cells via homophilic interaction.
Flaig RM, Stark S, Watzl C. | 01/21/2010 |
| NTB-A-mediated IFN-gamma production was greatly reduced in the absence of SLAM-associated protein (SAP), demonstrating that cytokine production and cytotoxicity are differentially dependent on SAP and possibly EAT-2 | Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells.
Eissmann P, Watzl C. | 01/21/2010 |