| A pan-cancer analysis of potassium channel tetramerization domain containing 12 in human cancer. | A pan-cancer analysis of potassium channel tetramerization domain containing 12 in human cancer.
Liu P, Liu Z, Luo Q, Fu Q, Zhang X, Yu P, Zhou S, Wang Y, Zhang J, Chen S, Zhang H, Zhu Q, Qin T., Free PMC Article | 08/30/2023 |
| KCTD12 promotes G1/S transition of breast cancer cell through activating the AKT/FOXO1 signaling. | KCTD12 promotes G1/S transition of breast cancer cell through activating the AKT/FOXO1 signaling.
Ye RY, Kuang XY, Zeng HJ, Shao N, Lin Y, Wang SM., Free PMC Article | 06/26/2021 |
| Bayesian Genome-wide TWAS Method to Leverage both cis- and trans-eQTL Information through Summary Statistics. | Bayesian Genome-wide TWAS Method to Leverage both cis- and trans-eQTL Information through Summary Statistics.
Luningham JM, Chen J, Tang S, De Jager PL, Bennett DA, Buchman AS, Yang J., Free PMC Article | 12/5/2020 |
| association of KCTD12 gene and miR-383-binding genes with rumination | Genome-wide association analysis reveals KCTD12 and miR-383-binding genes in the background of rumination.
Eszlari N, Millinghoffer A, Petschner P, Gonda X, Baksa D, Pulay AJ, Réthelyi JM, Breen G, Deakin JFW, Antal P, Bagdy G, Juhasz G., Free PMC Article | 01/11/2020 |
| KCTD12 may exert its inhibitory role in ESCC through the suppression of WNT /NOTCH, stem cell factors, and chromatin remodelers and can be introduced as an efficient therapeutic marker. | Contribution of KCTD12 to esophageal squamous cell carcinoma.
Abbaszadegan MR, Taghehchian N, Li L, Aarabi A, Moghbeli M., Free PMC Article | 12/22/2018 |
| our study demonstrate that KCTD12 binds to CDC25B and activates CDK1 and Aurora A to facilitate the G2/M transition and promote tumorigenesis and that Aurora A phosphorylates KCTD12 at serine 243 to trigger a positive feedback loop, thereby potentiating the effects of KCTD12. Thus, the KCTD12-CDC25B-CDK1-Aurora A axis has important implications for cancer diagnoses and prognoses. | KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition.
Zhong Y, Yang J, Xu WW, Wang Y, Zheng CC, Li B, He QY., Free PMC Article | 11/25/2017 |
| Low KCTD12 expression is associated with uveal melanoma. | Lentiviral-mediated overexpression of KCTD12 inhibits the proliferation of human uveal melanoma OCM-1 cells.
Luo L, Cui J, Feng Z, Li Y, Wang M, Cai Y, Wu Y, Jin J. | 04/15/2017 |
| Studies determined that KCTD12 plays an important role in the tumorigenesis of colorectal cancer progression via activation of the ERK signaling pathway. | KCTD12 Regulates Colorectal Cancer Cell Stemness through the ERK Pathway.
Li L, Duan T, Wang X, Zhang RH, Zhang M, Wang S, Wang F, Wu Y, Huang H, Kang T., Free PMC Article | 01/14/2017 |
| N-terminal domain of KCTD12 assumes an alpha/beta structure, whereas the C-terminal domain is predominantly characterized by a beta-structure. | A biophysical characterization of the folded domains of KCTD12: insights into interaction with the GABAB2 receptor.
Correale S, Esposito C, Pirone L, Vitagliano L, Di Gaetano S, Pedone E. | 03/15/2014 |
| KCTD12 is a useful and reliable biomarker for both the diagnosis and prognosis of gastrointestinal stromal tumor. | Use of potassium channel tetramerization domain-containing 12 as a biomarker for diagnosis and prognosis of gastrointestinal stromal tumor.
Hasegawa T, Asanuma H, Ogino J, Hirohashi Y, Shinomura Y, Iwaki H, Kikuchi H, Kondo T. | 08/31/2013 |
| This study provided that kctd12 are associated with Bipolar I in the Han Chinese population. | Genome-wide association study of bipolar I disorder in the Han Chinese population.
Lee MT, Chen CH, Lee CS, Chen CC, Chong MY, Ouyang WC, Chiu NY, Chuo LJ, Chen CY, Tan HK, Lane HY, Chang TJ, Lin CH, Jou SH, Hou YM, Feng J, Lai TJ, Tung CL, Chen TJ, Chang CJ, Lung FW, Chen CK, Shiah IS, Liu CY, Teng PR, Chen KH, Shen LJ, Cheng CS, Chang TP, Li CF, Chou CH, Chen CY, Wang KH, Fann CS, Wu JY, Chen YT, Cheng AT, Lee MT, Chen CH, Lee CS, Chen CC, Chong MY, Ouyang WC, Chiu NY, Chuo LJ, Chen CY, Tan HK, Lane HY, Chang TJ, Lin CH, Jou SH, Hou YM, Feng J, Lai TJ, Tung CL, Chen TJ, Chang CJ, Lung FW, Chen CK, Shiah IS, Liu CY, Teng PR, Chen KH, Shen LJ, Cheng CS, Chang TP, Li CF, Chou CH, Chen CY, Wang KH, Fann CS, Wu JY, Chen YT, Cheng AT. | 08/20/2011 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide association study of bipolar I disorder in the Han Chinese population.
Lee MT, Chen CH, Lee CS, Chen CC, Chong MY, Ouyang WC, Chiu NY, Chuo LJ, Chen CY, Tan HK, Lane HY, Chang TJ, Lin CH, Jou SH, Hou YM, Feng J, Lai TJ, Tung CL, Chen TJ, Chang CJ, Lung FW, Chen CK, Shiah IS, Liu CY, Teng PR, Chen KH, Shen LJ, Cheng CS, Chang TP, Li CF, Chou CH, Chen CY, Wang KH, Fann CS, Wu JY, Chen YT, Cheng AT, Lee MT, Chen CH, Lee CS, Chen CC, Chong MY, Ouyang WC, Chiu NY, Chuo LJ, Chen CY, Tan HK, Lane HY, Chang TJ, Lin CH, Jou SH, Hou YM, Feng J, Lai TJ, Tung CL, Chen TJ, Chang CJ, Lung FW, Chen CK, Shiah IS, Liu CY, Teng PR, Chen KH, Shen LJ, Cheng CS, Chang TP, Li CF, Chou CH, Chen CY, Wang KH, Fann CS, Wu JY, Chen YT, Cheng AT. | 06/30/2010 |
| Pfetin is a powerful prognostic marker for gastrointestinal stromal tumors. | Pfetin as a prognostic biomarker of gastrointestinal stromal tumors revealed by proteomics.
Suehara Y, Kondo T, Seki K, Shibata T, Fujii K, Gotoh M, Hasegawa T, Shimada Y, Sasako M, Shimoda T, Kurosawa H, Beppu Y, Kawai A, Hirohashi S. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesIntegrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.
Drenos F, Talmud PJ, Casas JP, Smeeth L, Palmen J, Humphries SE, Hingorani AD. Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study.
Cauchi S, Proença C, Choquet H, Gaget S, De Graeve F, Marre M, Balkau B, Tichet J, Meyre D, Vaxillaire M, Froguel P, D.E.S.I.R. Study Group. | 04/3/2008 |
| novel human gene, designated PFET1 (predominantly fetal expressed T1 domain) present in a variety of fetal organs, with highest expression levels in the cochlea and brain | Isolation from cochlea of a novel human intronless gene with predominant fetal expression.
Resendes BL, Kuo SF, Robertson NG, Giersch AB, Honrubia D, Ohara O, Adams JC, Morton CC., Free PMC Article | 01/21/2010 |