| CIS deletion by CRISPR/Cas9 enhances human primary natural killer cell functions against allogeneic glioblastoma. | CIS deletion by CRISPR/Cas9 enhances human primary natural killer cell functions against allogeneic glioblastoma.
Nakazawa T, Morimoto T, Maeoka R, Matsuda R, Nakamura M, Nishimura F, Ouji N, Yamada S, Nakagawa I, Park YS, Ito T, Nakase H, Tsujimura T., Free PMC Article | 08/16/2023 |
| CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging. | CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging.
Jin J, Mu Y, Zhang H, Sturmlechner I, Wang C, Jadhav RR, Xia Q, Weyand CM, Goronzy JJ., Free PMC Article | 05/28/2023 |
| MiR-944/CISH mediated inflammation via STAT3 is involved in oral cancer malignance by cigarette smoking. | MiR-944/CISH mediated inflammation via STAT3 is involved in oral cancer malignance by cigarette smoking.
Peng HY, Hsiao JR, Chou ST, Hsu YM, Wu GH, Shieh YS, Shiah SG., Free PMC Article | 07/31/2021 |
| Genetic Predisposition to the Mortality in Septic Shock Patients: From GWAS to the Identification of a Regulatory Variant Modulating the Activity of a CISH Enhancer. | Genetic Predisposition to the Mortality in Septic Shock Patients: From GWAS to the Identification of a Regulatory Variant Modulating the Activity of a CISH Enhancer.
Rosier F, Brisebarre A, Dupuis C, Baaklini S, Puthier D, Brun C, Pradel LC, Rihet P, Payen D., Free PMC Article | 06/19/2021 |
| NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS. | NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS.
Louis C, Souza-Fonseca-Guimaraes F, Yang Y, D'Silva D, Kratina T, Dagley L, Hediyeh-Zadeh S, Rautela J, Masters SL, Davis MJ, Babon JJ, Ciric B, Vivier E, Alexander WS, Huntington ND, Wicks IP., Free PMC Article | 12/26/2020 |
| We conclude that the Cish-SH2 domain is essential for PLC-gamma1 regulation in TCR-stimulated CD8(+) T cells. | The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8(+) T cells.
Guittard G, Dios-Esponera A, Palmer DC, Akpan I, Barr VA, Manna A, Restifo NP, Samelson LE., Free PMC Article | 10/5/2019 |
| The CISH rs414171 polymorphism is associated significantly with susceptibility to sepsis and multiple organ dysfunction syndrome in traumatic patients, which might prove to be a novel biomarker for indicating risk of infectious outcomes in critically injured patients. | Genetic contribution of suppressor of cytokine signalling polymorphisms to the susceptibility to infection after traumatic injury.
Zhang A, Gu W, Lu H, Zeng L, Zhang L, Du D, Hao J, Wen D, Wang X, Jiang J., Free PMC Article | 08/17/2019 |
| These findings suggest that CISH plays a key role in the eosinophilic inflammation associated with bronchial asthma by regulating IL-13-induced CCL26 production. | CISH is a negative regulator of IL-13-induced CCL26 production in lung fibroblasts.
Takeshima H, Horie M, Mikami Y, Makita K, Miyashita N, Matsuzaki H, Noguchi S, Urushiyama H, Hiraishi Y, Mitani A, Borok Z, Nagase T, Yamauchi Y. | 04/6/2019 |
| identified P2RX2, KCNQ5, ERBB3 and SOCS3 to be associated with the progression of age-related hearing impairment | Down-expression of P2RX2, KCNQ5, ERBB3 and SOCS3 through DNA hypermethylation in elderly women with presbycusis.
Bouzid A, Smeti I, Dhouib L, Roche M, Achour I, Khalfallah A, Gibriel AA, Charfeddine I, Ayadi H, Lachuer J, Ghorbel A, Petit C, Masmoudi S. | 09/22/2018 |
| CIS interacted with phosphorylated EpoR at Y401, which was critical for the activation of STAT5 and ERK. | Phosphorylated CIS suppresses the Epo or JAK2 V617F mutant-triggered cell proliferation through binding to EpoR.
Funakoshi-Tago M, Moriwaki T, Ueda F, Tamura H, Kasahara T, Tago K. | 12/2/2017 |
| Studies indicate that suppressors of cytokine signaling (SOCS) proteins CIS, SOCS1, and SOCS3 can be considered the third immunocheckpoint molecules since they regulate cytokine signals that control the polarization of CD4(+) T cells and the maturation of CD8(+) T cells. | Suppressors of cytokine signaling: Potential immune checkpoint molecules for cancer immunotherapy.
Chikuma S, Kanamori M, Mise-Omata S, Yoshimura A., Free PMC Article | 09/30/2017 |
| CISH rs414171 and rs6768300 variants might be associated with protection from pulmonary tuberculosis in Zahedan, Southeast Iran. | Association of genetic polymorphisms of CISH with the risk of pulmonary tuberculosis in Zahedan, Southeast Iran.
Naderi M, Hashemi M, Safdari A, Bahari G, Taheri M., Free PMC Article | 03/4/2017 |
| This study showed that there was significantly increased levels of CIS mRNA in elderly and Alzheimer's disease brains. | Expression of suppressor of cytokine signaling genes in human elderly and Alzheimer's disease brains and human microglia.
Walker DG, Whetzel AM, Lue LF., Free PMC Article | 04/30/2016 |
| Data indicate that CIS protein stability is regulated through multiple mechanisms, including ubiquitination and interaction with Elongin B/C proteins, whereas CIS functional inhibition of PRLR signaling is dependent on the Elongin B/C interaction. | Regulation of cytokine-inducible SH2-containing protein (CIS) by ubiquitination and Elongin B/C interaction.
Jensik PJ, Arbogast LA., Free PMC Article | 10/17/2015 |
| SOCS single nucleotide polymorphism is associated with breast cancer. | Genetic variation in the JAK/STAT/SOCS signaling pathway influences breast cancer-specific mortality through interaction with cigarette smoking and use of aspirin/NSAIDs: the Breast Cancer Health Disparities Study.
Slattery ML, Lundgreen A, Hines LM, Torres-Mejia G, Wolff RK, Stern MC, John EM., Free PMC Article | 09/26/2015 |
| Study in Chinese Han population confirms that previously identified variants of CISH are associated with susceptibility to pulmonary tuberculosis. | Polymorphisms in the CISH gene are associated with susceptibility to tuberculosis in the Chinese Han population.
Ji LD, Xu WN, Chai PF, Zheng W, Qian HX, Xu J. | 07/25/2015 |
| CISH gene polymorphisms at -292 (rs414171) are associated with HBV clearance in HBeAg-positive CHB patients in the immune active phase, and AA is a favorable genotype for this effect. | Association between CISH polymorphisms and spontaneous clearance of hepatitis B virus in hepatitis B extracellular antigen-positive patients during immune active phase.
Song G, Rao H, Feng B, Wei L. | 04/11/2015 |
| Two SNPs (rs414171 and rs2239751) in the CISH gene were associated with persistent HBV infection in Han Chinese population | Polymorphisms in CISH gene are associated with persistent hepatitis B virus infection in Han Chinese population.
Hu Z, Yang J, Wu Y, Xiong G, Wang Y, Yang J, Deng L., Free PMC Article | 02/14/2015 |
| two genetic variants in CISH gene appear to increase susceptibility to TB in Chinese Han population | Association between single-nucleotide polymorphism in CISH gene and susceptibility to tuberculosis in Chinese Han population.
Zhao L, Chu H, Xu X, Yue J, Li H, Wang M. | 11/22/2014 |
| CISH promoter rs414171 and rs809451 polymorphisms may play a vital role in mediating individual susceptibility to tuberculosis | Genetic contribution of CISH promoter polymorphisms to susceptibility to tuberculosis in Chinese children.
Sun L, Jin YQ, Shen C, Qi H, Chu P, Yin QQ, Li JQ, Tian JL, Jiao WW, Xiao J, Shen AD., Free PMC Article | 11/22/2014 |
| methylation of SOCS1, SOCS2, SOCS3 and CISH is infrequent in Ph-ve MPN. | Methylation profiling of SOCS1, SOCS2, SOCS3, CISH and SHP1 in Philadelphia-negative myeloproliferative neoplasm.
Zhang MY, Fung TK, Chen FY, Chim CS., Free PMC Article | 05/31/2014 |
| data suggest FXR-mediated upregulation of cytokine inducible SH2-containing protein (CISH) may play an important role in the homeostasis of cytokine signal networks and be beneficial to control cytokine-associated inflammatory diseases | Activation of farnesoid X receptor increases the expression of cytokine inducible SH2-containing protein in HepG2 cells.
Xu Z, Huang G, Gong W, Zhao Y, Zhou P, Zeng Y, He F. | 05/18/2013 |
| In GH transduction defect, abnormal GH signalling may be caused by over-expression of CIS, which may increase degradation of GHR | Increased growth hormone receptor (GHR) degradation due to over-expression of cytokine inducible SH2 domain-containing protein (CIS) as a cause of GH transduction defect (GHTD).
Gil AP, Kostopoulou E, Karageorgou I, Kamzelas K, Spiliotis BE. | 04/27/2013 |
| Suppressors of both cytokine signaling SOCS7 and cytokine-inducible SH2 protein (CIS) are expressed constitutively at higher levels in LNCaP-S17 (prostate cancer) cells than in LNCaP-C3 cells. | LNCaP prostate cancer cells with autocrine interleukin-6 expression are resistant to IL-6-induced neuroendocrine differentiation due to increased expression of suppressors of cytokine signaling.
Ge D, Gao AC, Zhang Q, Liu S, Xue Y, You Z., Free PMC Article | 10/6/2012 |
| Study indicates the vital role of CISH single nucleotide polymorphism (SNP)-292A>T variant to hepatitis B virus infection in a Vietnamese population. | Association of CISH -292A/T genetic variant with hepatitis B virus infection.
Tong HV, Toan NL, Song le H, Kremsner PG, Kun JF, Tp V. | 05/12/2012 |