| MiR-196a promotes the proliferation and migration of esophageal cancer via the UHRF2/TET2 axis. | MiR-196a promotes the proliferation and migration of esophageal cancer via the UHRF2/TET2 axis.
Hu CM, Peng J, Lv L, Wang XH, Huo JR, Liu DL. | 03/26/2022 |
| UHRF2 promotes Hepatocellular Carcinoma Progression by Upregulating ErbB3/Ras/Raf Signaling Pathway. | UHRF2 promotes Hepatocellular Carcinoma Progression by Upregulating ErbB3/Ras/Raf Signaling Pathway.
Sun J, Wu K, Chen S, Jiang S, Chen Y, Duan C., Free PMC Article | 01/15/2022 |
| IGF2BP1/UHRF2 Axis Mediated by miR-98-5p to Promote the Proliferation of and Inhibit the Apoptosis of Esophageal Squamous Cell Carcinoma. | IGF2BP1/UHRF2 Axis Mediated by miR-98-5p to Promote the Proliferation of and Inhibit the Apoptosis of Esophageal Squamous Cell Carcinoma.
Fang XY, Sun JJ, Chen SY, Wu KJ, Yu Y, Zhang C, Duan CZ. | 12/18/2021 |
| HBx promotes hepatocarcinogenesis by enhancing phosphorylation and blocking ubiquitinylation of UHRF2. | HBx promotes hepatocarcinogenesis by enhancing phosphorylation and blocking ubiquitinylation of UHRF2.
Cheng F, Qian G, Fang X, Sun J, Chen S, Chen R, Liu S, Li Z, Wu K, Jiang S, Chen Y, Tang N, Chen J, Duan C. | 10/30/2021 |
| UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1. | UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1.
Liu X, Xu B, Yang J, He L, Zhang Z, Cheng X, Yu H, Liu X, Jin T, Peng Y, Huang Y, Xia L, Wang Y, Wu J, Wu X, Liu S, Shan L, Yang X, Sun L, Liang J, Zhang Y, Shang Y. | 07/31/2021 |
| UV-induced activation of ATR is mediated by UHRF2. | UV-induced activation of ATR is mediated by UHRF2.
Hanaki S, Habara M, Shimada M. | 07/17/2021 |
| UHRF2 promotes intestinal tumorigenesis through stabilization of TCF4 mediated Wnt/beta-catenin signaling. | UHRF2 promotes intestinal tumorigenesis through stabilization of TCF4 mediated Wnt/β-catenin signaling.
Li L, Duan Q, Zeng Z, Zhao J, Lu J, Sun J, Zhang J, Siwko S, Wong J, Shi T, Zhang X, Liu M, Chen J, Li D. | 04/17/2021 |
| Uncoupling of UHRF2 from the DNA methylation maintenance program is linked to differences in the molecular readout of chromatin signatures that connect UHRF1 to ubiquitination of histone H3. | Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance.
Vaughan RM, Dickson BM, Cornett EM, Harrison JS, Kuhlman B, Rothbart SB., Free PMC Article | 07/27/2019 |
| Immunoprecipitation and immunofluorescence staining reveled that UHRF2 combined with p21 in the nucleus. In addition, UHRF2 degraded p21 through ubiquitination and shortened the half-life of p21. | UHRF2 promotes DNA damage response by decreasing p21 via RING finger domain.
Wang Y, Yan X, Zeng S, Zhang T, Cheng F, Chen R, Duan C. | 07/6/2019 |
| UHRF2 may be a negative regulator of EMT and a novel prognostic biomarker for ESCC. | Identification of UHRF2 as a Negative Regulator of Epithelial-Mesenchymal Transition and Its Clinical Significance in Esophageal Squamous Cell Carcinoma.
Iguchi T, Ueda M, Masuda T, Nambara S, Kidogami S, Komatsu H, Sato K, Tobo T, Ogawa Y, Hu Q, Saito T, Hirata H, Sakimura S, Uchi R, Hayashi N, Ito S, Eguchi H, Sugimachi K, Maehara Y, Mimori K. | 09/8/2018 |
| UHRF2 expression is reduced in some leukemia cell lines, this correlates with promoter hypermethylation, and similar UHRF2 methylation profiles are seen in primary human leukemia samples. Thus, UHRF2 and 5hmC are widely present in differentiated human tissues, and UHRF2 protein is poorly expressed or mislocalized in diverse human cancers. | Loss of UHRF2 expression is associated with human neoplasia, promoter hypermethylation, decreased 5-hydroxymethylcytosine, and high proliferative activity.
Lu H, Bhoopatiraju S, Wang H, Schmitz NP, Wang X, Freeman MJ, Forster CL, Verneris MR, Linden MA, Hallstrom TC., Free PMC Article | 02/10/2018 |
| Here, we report the complex structure of PCNA and the peptide ((784)NEILQTLLDLFFPGYSK(800)) derived from UHRF2 that contains a PIP box. Structural analysis combined with mutagenesis experiments provide the molecular basis for the recognition of UHRF2 by PCNA via PIP-box. | Structure insights into the molecular mechanism of the interaction between UHRF2 and PCNA.
Chen W, Wu M, Hang T, Wang C, Zhang X, Zang J. | 11/25/2017 |
| Results show that UHRF2 down-regulates a number of epithelial-mesenchymal transition markers and up-regulates the expression of transcription factors. The study also suggests that UHRF2 play a role in tumor metastasis. | Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).
Lai M, Liang L, Chen J, Qiu N, Ge S, Ji S, Shi T, Zhen B, Liu M, Ding C, Wang Y, Qin J., Free PMC Article | 06/24/2017 |
| TIP60 acted downstream of UHRF2 to regulate H3K9ac and H3K14ac expression. | E3 ligase UHRF2 stabilizes the acetyltransferase TIP60 and regulates H3K9ac and H3K14ac via RING finger domain.
Zeng S, Wang Y, Zhang T, Bai L, Wang Y, Duan C., Free PMC Article | 06/10/2017 |
| The overexpression of UHRF2 increased the expression of H3K9ac in L02 normal cells (P<0.01), but decreased the expression of histone H3 lysine 9 acetylation in HepG2 cancer cells. | UHRF2 decreases H3K9ac expression by interacting with it through the PHD and SRA/YDG domain in HepG2 hepatocellular carcinoma cells.
Zhang T, Zhao L, Zeng S, Bai L, Chen J, Zhang Z, Wang Y, Duan C., Free PMC Article | 03/11/2017 |
| study suggests that ZNF618 is a key protein that regulates UHRF2 function as a specific 5hmC reader in vivo. | Zinc Finger Protein 618 Regulates the Function of UHRF2 (Ubiquitin-like with PHD and Ring Finger Domains 2) as a Specific 5-Hydroxymethylcytosine Reader.
Liu Y, Zhang B, Kuang H, Korakavi G, Lu LY, Yu X., Free PMC Article | 12/17/2016 |
| UHRF2 may contribute to the progression of colon carcinogenesis and function as a novel prognostic indicator after curative operation | Ubiquitin-like with PHD and ring finger domains 2 is a predictor of survival and a potential therapeutic target in colon cancer.
Lu S, Yan D, Wu Z, Jiang T, Chen J, Yuan L, Lin J, Peng Z, Tang H. | 11/8/2014 |
| A hydrogen bond between the hydroxyl group of 5hmC and UHRF2-SRA is critical for their preferential binding. | Structural basis for hydroxymethylcytosine recognition by the SRA domain of UHRF2.
Zhou T, Xiong J, Wang M, Yang N, Wong J, Zhu B, Xu RM. | 08/9/2014 |
| UHRF2 is a transcriptional target of E2F, that it directly interacts with E2F1. | The nuclear protein UHRF2 is a direct target of the transcription factor E2F1 in the induction of apoptosis.
Lu H, Hallstrom TC., Free PMC Article | 11/30/2013 |
| UHRF2, the homolog of UHRF1, interacts with N-methylpurine DNA glycosylase (MPG) in cancer cells. | Identification of UHRF1/2 as new N-methylpurine DNA glycosylase-interacting proteins.
Liang C, Zhang X, Song S, Tian C, Yin Y, Xing G, He F, Zhang L. | 06/15/2013 |
| Low UHRF2 mRNA expression is associated with malignant glioma. | UHRF2 mRNA expression is low in malignant glioma but silencing inhibits the growth of U251 glioma cells in vitro.
Wu TF, Zhang W, Su ZP, Chen SS, Chen GL, Wei YX, Sun T, Xie XS, Li B, Zhou YX, Du ZW. | 06/8/2013 |
| UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131 | UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131.
Oh Y, Chung KC., Free PMC Article | 06/1/2013 |
| NIRF may contribute to the coupling between the cell cycle network and the epigenetic landscape | NIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscape.
Mori T, Ikeda DD, Yamaguchi Y, Unoki M, NIRF Project. | 08/11/2012 |
| In the present study, ubiquitin ligase, NIRF, binds to hepatitis B virus core protein and leads to the proteasome-mediated degradation of hepatitis B virus core protein in vivo. | NIRF, a novel ubiquitin ligase, interacts with hepatitis B virus core protein and promotes its degradation.
Qian G, Jin F, Chang L, Yang Y, Peng H, Duan C. | 03/31/2012 |
| NIRF is immediately adjacent to the single nucleotide polymorphism rs719725, which is reportedly associated with the risk of colorectal cancer. | NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.
Mori T, Ikeda DD, Fukushima T, Takenoshita S, Kochi H., Free PMC Article | 03/24/2012 |