| Lnc-PSMA8-1 activated by GEFT promotes rhabdomyosarcoma progression via upregulation of mTOR expression by sponging miR-144-3p. | Lnc-PSMA8-1 activated by GEFT promotes rhabdomyosarcoma progression via upregulation of mTOR expression by sponging miR-144-3p.
Meng L, Shang H, Liu Q, Li Z, Wang X, Li Q, Li F, Zhao Z, Liu C., Free PMC Article | 02/16/2024 |
| Guanine nucleotide exchange factor T exerts the cancer-promoting function in cholangiocarcinoma by enhancing the Wnt-GSK-3beta-beta-catenin cascade via regulation of Rac1/Cdc42. | Guanine nucleotide exchange factor T exerts the cancer-promoting function in cholangiocarcinoma by enhancing the Wnt-GSK-3β-β-catenin cascade via regulation of Rac1/Cdc42.
Wang X, Zhang X, Sun J, Sun Y, Zhang Y, He L, Wang P, Li F, Sun C. | 08/10/2023 |
| p63RhoGEF(619) relocates to the plasma membrane upon activation of Galphaq coupled GPCRs, resembling the well-known activation mechanism of RhoGEFs activated by Galpha12/13. | Kinetics of recruitment and allosteric activation of ARHGEF25 isoforms by the heterotrimeric G-protein Gαq.
van Unen J, Yin T, Wu YI, Mastop M, Gadella TW Jr, Goedhart J., Free PMC Article | 05/26/2018 |
| p63RhoGEF can rapidly activate RhoA through endogenous G-protein coupled receptors. | Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization.
van Unen J, Reinhard NR, Yin T, Wu YI, Postma M, Gadella TW, Goedhart J., Free PMC Article | 08/20/2016 |
| assessed p63RhoGEF gene and protein expression and RhoA/Rho kinase activity in essential hypertensive and Bartter's and Gitelman's syndrome patients, a model opposite to hypertension | Increased level of p63RhoGEF and RhoA/Rho kinase activity in hypertensive patients.
Calò LA, Davis PA, Pagnin E, Dal Maso L, Maiolino G, Seccia TM, Pessina AC, Rossi GP. | 09/27/2014 |
| Signaling efficiency of Galphaq through its effectors p63RhoGEF and GEFT depends on their subcellular location. | Signaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular location.
Goedhart J, van Unen J, Adjobo-Hermans MJ, Gadella TW Jr., Free PMC Article | 02/22/2014 |
| p63RhoGEF-mediated formation of a single polarized lamellipodium is required for chemotactic migration in breast carcinoma cells. | p63RhoGEF-mediated formation of a single polarized lamellipodium is required for chemotactic migration in breast carcinoma cells.
Hayashi A, Hiatari R, Tsuji T, Ohashi K, Mizuno K. | 05/4/2013 |
| Signaling through p63RhoGEF provides a novel mechanism for selective regulation of blood pressure. | p63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility.
Momotani K, Artamonov MV, Utepbergenov D, Derewenda U, Derewenda ZS, Somlyo AV., Free PMC Article | 12/17/2011 |
| p63RhoGEF is regulated chiefly through allosteric control by Galpha(q), as opposed to other known Galpha-regulated RhoGEFs, which are instead sequestered in the cytoplasm, perhaps because of their high basal activity. | Plasma membrane association of p63 Rho guanine nucleotide exchange factor (p63RhoGEF) is mediated by palmitoylation and is required for basal activity in cells.
Aittaleb M, Nishimura A, Linder ME, Tesmer JJ., Free PMC Article | 11/26/2011 |
| Specifically mediates angiotensin II- Gq/11-dependent RhoA activation and downstream signaling and processes in vascular smooth muscle cells | p63RhoGEF--a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells.
Wuertz CM, Lorincz A, Vettel C, Thomas MA, Wieland T, Lutz S. | 09/30/2010 |
| MLK3 functions in a regulated way to limit levels of the activated GTPase Rho by binding to the Rho activator, p63RhoGEF/GEFT, which, in turn, prevents its activation by Galphaq. | MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF.
Swenson-Fields KI, Sandquist JC, Rossol-Allison J, Blat IC, Wennerberg K, Burridge K, Means AR., Free PMC Article | 01/21/2010 |
| the crystal structure of the Galphaq-p63RhoGEF-RhoA complex, detailing the interactions of Galphaq with the Dbl and pleckstrin homology (DH and PH) domains of p63RhoGEF was determined | Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.
Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ. | 01/21/2010 |
| Results show that p63RhoGEF is a RhoA-specific GEF that may play a key role in actin cytoskeleton reorganization in different tissues, especially in heart cellular morphology. | Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere.
Souchet M, Portales-Casamar E, Mazurais D, Schmidt S, Léger I, Javré JL, Robert P, Berrebi-Bertrand I, Bril A, Gout B, Debant A, Calmels TP. | 01/21/2010 |
| GEFT enhances dendritic spine formation and neurite outgrowth in primary neurons and neuroblastoma cells, respectively, through the activation of Rac/Cdc42-PAK signaling pathways. | GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation.
Bryan B, Kumar V, Stafford LJ, Cai Y, Wu G, Liu M. | 01/21/2010 |
| Endogenous GEFT is transcriptionally upregulated during myogenic differentiation and downregulated during adipogenic differentiation. | Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT.
Bryan BA, Mitchell DC, Zhao L, Ma W, Stafford LJ, Teng BB, Liu M., Free PMC Article | 01/21/2010 |
| Together, our data provide new evidence suggesting that GEFT is an important regulator of multiple processes involved in axon and dendrite formation. | The Rho-family guanine nucleotide exchange factor GEFT enhances retinoic acid- and cAMP-induced neurite outgrowth.
Bryan BA, Cai Y, Liu M. | 01/21/2010 |
| a new signaling pathway by which G alpha(q/11)-coupled receptors specifically induce Rho signaling through a direct interaction of activated G alpha(q/11) subunits with p63RhoGEF. | The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA.
Lutz S, Freichel-Blomquist A, Yang Y, Rümenapp U, Jakobs KH, Schmidt M, Wieland T. | 01/21/2010 |