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    CKM creatine kinase, M-type [ Homo sapiens (human) ]

    Gene ID: 1158, updated on 5-May-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The role of serum creatine kinase levels in anterior cervical spinal surgery: Change trends and risk factors.

    The role of serum creatine kinase levels in anterior cervical spinal surgery: Change trends and risk factors.
    Sang P, Ma Y, Chen B, Zhang M., Free PMC Article

    02/19/2022
    CKM Gene rs8111989 Polymorphism and Power Athlete Status.

    CKM Gene rs8111989 Polymorphism and Power Athlete Status.
    Ginevičienė V, Jakaitienė A, Utkus A, Hall ECR, Semenova EA, Andryushchenko LB, Larin AK, Moreland E, Generozov EV, Ahmetov II., Free PMC Article

    02/12/2022
    Ancestral contribution of the muscle-specific creatine kinase (CKM) polymorphism rs4884 in the knee osteoarthritis risk: a preliminary study.

    Ancestral contribution of the muscle-specific creatine kinase (CKM) polymorphism rs4884 in the knee osteoarthritis risk: a preliminary study.
    Fernández-Torres J, Martínez-Nava GA, Zamudio-Cuevas Y, Barbier OC, Narváez-Morales J, Martínez-Flores K.

    06/26/2021
    Acetylation of muscle creatine kinase negatively impacts high-energy phosphotransfer in heart failure.

    Acetylation of muscle creatine kinase negatively impacts high-energy phosphotransfer in heart failure.
    Walker MA, Chavez J, Villet O, Tang X, Keller A, Bruce JE, Tian R., Free PMC Article

    05/29/2021
    Population-Wide Duchenne Muscular Dystrophy Carrier Detection by CK and Molecular Testing.

    Population-Wide Duchenne Muscular Dystrophy Carrier Detection by CK and Molecular Testing.
    Han S, Xu H, Zheng J, Sun J, Feng X, Wang Y, Ye W, Ke Q, Ren Y, Yao S, Zhang S, Chen J, Griggs RC, Zhao Z, Qi M, Gatheridge MA., Free PMC Article

    05/1/2021
    Serological risk factors for concomitant interstitial lung disease in patients with idiopathic inflammatory myopathy.

    Serological risk factors for concomitant interstitial lung disease in patients with idiopathic inflammatory myopathy.
    Huang HL, Lin WC, Yeh CC, Sun YT.

    09/12/2020
    BMI and CK-MB were independent markers of SAMS

    Biochemical markers of muscle damage and high serum concentration of creatine kinase in patients on statin therapy.
    Nogueira AA, Strunz CM, Takada JY, Mansur AP.

    05/23/2020
    This method allows absolute quantitative measurement when conventional calibration curve fails to provide accurate estimation of cardiac biomarkers, especially at low and high concentration ranges. Under an optimised condition, the LOD of our SERS-based muPAD was identified at 8, 10, and 1pgmL(-1), for GPBB, CK-MB and cTnT, respectively, which is well below the clinical cutoff values.

    Using SERS-based microfluidic paper-based device (μPAD) for calibration-free quantitative measurement of AMI cardiac biomarkers.
    Lim WY, Goh CH, Thevarajah TM, Goh BT, Khor SM.

    04/4/2020
    This study aims to measure CK kinetics during pharmacological stress at 3 T, with measurement in the supine position.

    Localized rest and stress human cardiac creatine kinase reaction kinetics at 3 T.
    Clarke WT, Peterzan MA, Rayner JJ, Sayeed RA, Petrou M, Krasopoulos G, Lake HA, Raman B, Watson WD, Cox P, Hundertmark MJ, Apps AP, Lygate CA, Neubauer S, Rider OJ, Rodgers CT., Free PMC Article

    12/7/2019
    This study suggests that the ACE and CKMM polymorphisms influence the endurance performance phenotype in non-trained adolescent males.

    Do ACE and CKMM gene variations have potent effects on physical performance in inactive male adolescents?
    Zehsaz F, Safabakhsh AH, Farhangi N, Keynezhad N, Monfaredan A, Ghahramani M.

    09/14/2019
    elevated CK-MB value is a common finding in RV-infection and completely mediated by the severity of diarrhea. CK-MB monitoring may help to identify children with more severe viral infection.

    Interrelationship of rotavirus infection and Creatine Kinase-MB isoenzyme levels in children hospitalized with acute gastroenteritis in Guangzhou, China, 2012-2015.
    Zheng J, Zheng H, Gupta RK, Li H, Shi H, Pan L, Gong S, Liang H., Free PMC Article

    03/2/2019
    The formation of insoluble aggregates would decrease levels of active Creatine kinase (CK) which may provide clues in CK deficiency disease. Moreover, these results indicated that the degree of synergism had closely relationship to the conformational changes of CK

    Roles of amino acid residues H66 and D326 in the creatine kinase activity and structural stability.
    Wu QY, Wei F, Zhu YY, Tong YX, Cao J, Zhou P, Li ZY, Zeng LY, Li F, Wang XY, Xu KL.

    07/28/2018
    Low CK-MB expression is associated with ST-Segment Elevation Myocardial Infarction.

    Significant Association of Serum Adiponectin and Creatine Kinase-MB Levels in ST-Segment Elevation Myocardial Infarction.
    Natsukawa T, Maeda N, Fukuda S, Yamaoka M, Fujishima Y, Nagao H, Sato F, Nishizawa H, Sawano H, Hayashi Y, Funahashi T, Kai T, Shimomura I., Free PMC Article

    05/26/2018
    On admission, high-sensitivity troponin T/creatine kinase-MB ratio was significantly higher in takotsubo syndrome patients compared to myocardial infarction patients.

    Ratio of high-sensitivity troponin to creatine kinase-MB in takotsubo syndrome.
    Pirlet C, Pierard L, Legrand V, Gach O.

    04/28/2018
    A genetic factor known to be associated with constitutive creatine kinase levels is also associated with creatine kinase variability and inducibility and the variant has an impact on inducibility of creatine kinase by trauma through a homozygous carrier.

    CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia.
    Siddiqui MK, Veluchamy A, Maroteau C, Tavendale R, Carr F, Pearson E, Colhoun H, Morris AD, George J, Doney A, Pirmohamed M, Alfirevic A, Wadelius M, Maitland van der Zee AH, Ridker PM, Chasman DI, Palmer CNA, PREDICTION-ADR Consortium.

    01/13/2018
    These findings support increased CK activity as protection against ischaemia-reperfusion injury, in particular, protection via CKMT2 in a cardiac-relevant cell line, which merits further investigation in vivo.

    Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro.
    Zervou S, Whittington HJ, Ostrowski PJ, Cao F, Tyler J, Lake HA, Neubauer S, Lygate CA., Free PMC Article

    10/14/2017
    Marathoners with a lower CKMM response after the race had a more favorable polygenic profile than runners with high serum CKMM concentrations. This might suggest a significant role of genetic polymorphisms in the levels of exertional muscle damage and rhabdomyolysis.

    Optimum polygenic profile to resist exertional rhabdomyolysis during a marathon.
    Del Coso J, Valero M, Salinero JJ, Lara B, Gallo-Salazar C, Areces F., Free PMC Article

    09/2/2017
    Myocardial Creatine Kinase is a significant independent predictor of 6-month left ventricle remodeling in myocardial infarction patients.

    Predictors of Left Ventricle Remodeling: Combined Plasma B-type Natriuretic Peptide Decreasing Ratio and Peak Creatine Kinase-MB.
    Hsu JT, Chung CM, Chu CM, Lin YS, Pan KL, Chang JJ, Wang PC, Chang ST, Yang TY, Jang SJ, Yang TH, Hsiao JF., Free PMC Article

    05/27/2017
    A positive association was found between PANSS-total and sCK [serum creatine kinase] in SzA [schizoaffective disorder] and BP-I; however, PANSS-positive scores correlated with sCK only in SzA. Serum CK may serve as a biomarker for affective exacerbation rather than psychosis.

    The association between serum creatine kinase, mood and psychosis in inpatients with schizophrenia, bipolar and schizoaffective disorders.
    Hollander S, Hochman E, Shoval G, Taler M, Trommer S, Hermesh H, Weizman A, Krivoy A.

    01/14/2017
    These results demonstrate an association between physical performance measures and genetic variation in the muscle-specific creatine kinase gene (rs8111989).

    CK-MM Polymorphism is Associated With Physical Fitness Test Scores in Military Recruits.
    Sprouse C, Tosi LL, Gordish-Dressman H, Abdel-Ghani MS, Panchapakesan K, Niederberger B, Devaney JM, Kelly KR.

    12/17/2016
    Muscle pain induced by simvastatin resulted in increased levels of creatine kinase compared to non-treated patients.

    Increased creatine kinase with statin treatment may identify statin-associated muscle symptoms.
    Taylor BA, Panza G, Thompson PD., Free PMC Article

    12/17/2016
    Data show that a low serum creatine kinase activity is more common in female than male, and is associated with older age.

    Low serum creatine kinase activity in hospital patients.
    Cobbold L, Curd R, Crook MA.

    04/16/2016
    CK-MB mass is more significant criteria of myocardial injury.

    Study of CK-MB activity in patients with acute myocardial infarction after percutaneous coronary intervention.
    Emukhvari NM, Tsetsekhladze ED, Khijakadze KhA, Mamatsashvili IO, Napetvaridze RG.

    02/13/2016
    troponin T and creatinine kinase isoenzyme (CK-MB) have roles in combined renal and myocardial injuries in asphyxiated infants

    The diagnostic value of both troponin T and creatinine kinase isoenzyme (CK-MB) in detecting combined renal and myocardial injuries in asphyxiated infants.
    Sadoh WE, Eregie CO, Nwaneri DU, Sadoh AE., Free PMC Article

    01/30/2016
    CK-MB levels were higher after ERCP in non-ischemic patients compared with a myocardial ischemia group. Creatine phosphokinase levels did not differ significantly between groups.

    Role of serum myeloperoxidase, CPK, CK-MB, and cTnI tests in early diagnosis of myocardial ischemia during ERCP.
    Yıldız K, Ince AT, Sarbay Kemik A, Sert S, Isen HC, Tozlu M, Baysal B, Akyüz U, Kocaman O, Danalıoğlu A.

    09/10/2015
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