| Regulation of microRNA miR-197-3p/CDC28 protein kinase regulatory subunit 1B (CKS1B) axis by Circular RNA hsa_circ_0000285 promotes glioma progression. | Regulation of microRNA miR-197-3p/CDC28 protein kinase regulatory subunit 1B (CKS1B) axis by Circular RNA hsa_circ_0000285 promotes glioma progression.
Deng T, Liu Y, Yang Y, Yuan L, Liu F, Wang X, Zhang Q, Xie M., Free PMC Article | 04/16/2022 |
| Establishment of high-throughput screening HTRF assay for identification small molecule inhibitors of Skp2-Cks1. | Establishment of high-throughput screening HTRF assay for identification small molecule inhibitors of Skp2-Cks1.
Hu K, Li XJ, Asmamaw MD, Shi XJ, Liu HM., Free PMC Article | 01/29/2022 |
| A Pan-Cancer Analysis of Clinical Prognosis and Immune Infiltration of CKS1B in Human Tumors. | A Pan-Cancer Analysis of Clinical Prognosis and Immune Infiltration of CKS1B in Human Tumors.
Jia Y, Tian Q, Yang K, Liu Y, Liu Y., Free PMC Article | 01/22/2022 |
| CKS1B promotes cell proliferation and invasion by activating STAT3/PD-L1 and phosphorylation of Akt signaling in papillary thyroid carcinoma. | CKS1B promotes cell proliferation and invasion by activating STAT3/PD-L1 and phosphorylation of Akt signaling in papillary thyroid carcinoma.
Wang H, Zhang Z, Yan Z, Ma S., Free PMC Article | 10/23/2021 |
| The survival impact of CKS1B gains or amplification is dependent on the background karyotype and TP53 deletion status in patients with myeloma. | The survival impact of CKS1B gains or amplification is dependent on the background karyotype and TP53 deletion status in patients with myeloma.
Hao S, Lu X, Gong Z, Bassett RL, Hu S, Konoplev SN, Tang G, Li S, Xu J, Khanlari M, Lee HC, Manasanch EE, Weber DM, Orlowski RZ, Medeiros LJ, Lin P. | 10/23/2021 |
| Circular RNA NOX4 promotes the development of colorectal cancer via the microRNA4855p/CKS1B axis. | Circular RNA NOX4 promotes the development of colorectal cancer via the microRNA‑485‑5p/CKS1B axis.
Wang X, Tao G, Huang D, Liang S, Zheng D., Free PMC Article | 07/24/2021 |
| High Cks1 expression predicted poorer prognosis and worse clinicopathological parameters in various cancers. Increased Cks1 could be a significant prognostic biomarker for poor survival in patients with various cancers. Meta-analysis. | Prognostic and clinicopathological significance of Cks1 in cancer: Evidence from a meta-analysis.
Zhang Y, Chen Y, You F, Li W, Lang Z, Zou Z. | 05/30/2020 |
| Considering the highly increased levels of CKS1B and decreased expression of miR-1258 in tumors from CRC patients, these findings suggest that miR-1258 may play tumor-suppressive roles by targeting CKS1B expression in CRC. | MicroRNA-1258 Inhibits the Proliferation and Migration of Human Colorectal Cancer Cells through Suppressing CKS1B Expression.
Hwang JS, Jeong EJ, Choi J, Lee YJ, Jung E, Kim SK, Min JK, Han TS, Kim JS., Free PMC Article | 05/16/2020 |
| the data propose a novel function for Cks1 as a tumor promoter through the expression of the strongly oncogenic protein osteopontin (OPN) in human hepatocellular carcinoma (HCC). | Cks1 regulates human hepatocellular carcinoma cell progression through osteopontin expression.
Kang YS, Jeong EJ, Seok HJ, Kim SK, Hwang JS, Choi ML, Jo DG, Kim Y, Choi J, Lee YJ, Jung E, Min JK, Han TS, Kim JS. | 06/15/2019 |
| miR-204 inhibits cell proliferation in gastric cancer by targeting CKS1B, CXCL1 and GPRC5A. | Integrated MicroRNA-mRNA Analysis Reveals miR-204 Inhibits Cell Proliferation in Gastric Cancer by Targeting CKS1B, CXCL1 and GPRC5A.
Shrestha S, Yang CD, Hong HC, Chou CH, Tai CS, Chiew MY, Chen WL, Weng SL, Chen CC, Chang YA, Lee ML, Huang WY, Hsu SD, Chen YC, Huang HD., Free PMC Article | 07/28/2018 |
| Multiple myeloma patients with CKS1B amplification are more likely to have additional high-risk cytogenetic abnormalities and a shorter PFS and OS after an auto-HCT. | Outcome of Patients with Multiple Myeloma and CKS1B Gene Amplification after Autologous Hematopoietic Stem Cell Transplantation.
Bock F, Lu G, Srour SA, Gaballa S, Lin HY, Baladandayuthapani V, Honhar M, Stich M, Shah ND, Bashir Q, Patel K, Popat U, Hosing C, Korbling M, Delgado R, Rondon G, Shah JJ, Thomas SK, Manasanch EE, Isermann B, Orlowski RZ, Champlin RE, Qazilbash MH., Free PMC Article | 01/27/2018 |
| Loss of miR-1258 contributes to carcinogenesis and progression of liver cancer through targeting CKS1B. | Loss of miR-1258 contributes to carcinogenesis and progression of liver cancer through targeting CDC28 protein kinase regulatory subunit 1B.
Hu M, Wang M, Lu H, Wang X, Fang X, Wang J, Ma C, Chen X, Xia H., Free PMC Article | 12/30/2017 |
| High CKS1B gene expression correlates with disease onset and progression of Multiple Myeloma and associated with more extra copies of 1q21. | [Prognostic value of 1q21 amplification in multiple myeloma].
Abramova TV, Obukhova TN, Mendeleeva LP, Pokrovskaya OS, Gribanova EO, Ryzhko VV, Grebenyuk LA, Nareyko MV, Solovyev MV, Votyakova OM, Kulikov SM, Rusinov MA, Savchenko VG. | 12/2/2017 |
| we overexpressed CKS1B in multiple cell lines and found increased sensitivity to PLK1 knockdown and PLK1 drug inhibition. Finally, combined inhibition of WEE1 and PLK1 results in less apoptosis than predicted based on an additive model of the individual inhibitors, showing an epistatic interaction and confirming a prediction of the yeast data. | A Synthetic Dosage Lethal Genetic Interaction Between CKS1B and PLK1 Is Conserved in Yeast and Human Cancer Cells.
Reid RJ, Du X, Sunjevaric I, Rayannavar V, Dittmar J, Bryant E, Maurer M, Rothstein R., Free PMC Article | 05/27/2017 |
| High expression of Cks1 was significantly associated with lymph node metastasis and survival status in nasopharyngeal carcinoma | Increased expression of Cks1 protein is associated with lymph node metastasis and poor prognosis in nasopharyngeal carcinoma.
Xu L, Fan S, Zhao J, Zhou P, Chu S, Luo J, Wen Q, Chen L, Wen S, Wang L, Shi L., Free PMC Article | 02/18/2017 |
| Results show that Cks1 and Cks2 promoted proliferation and prevented apoptosis of hepatocellular carcinoma HepG2 cells. | Depletion of Cks1 and Cks2 expression compromises cell proliferation and enhance chemotherapy-induced apoptosis in HepG2 cells.
Lin L, Fang Z, Lin H, You H, Wang J, Su Y, Wang F, Zhang ZY., Free PMC Article | 10/22/2016 |
| Specifically, CKS1B and MAP2K5 significantly inhibited hepatitis C viral RNA replication. PACSIN1, by contrast, inhibited hepatitis C virus infection by decreasing the level of viral protein p7. | Identification of novel human kinases that suppress hepatitis C virus infection.
Lee A, Liu S, Wang T., Free PMC Article | 10/17/2015 |
| Regulation of Cks1 protein stability is crucially dependent on specific tyrosine and lysine residues which are potential sites for post-translational modifications. | Cks1 proteasomal turnover is a predominant mode of regulation in breast cancer cells: role of key tyrosines and lysines.
Khattar V, Thottassery JV. | 08/15/2015 |
| We conclude that perturbing the Hsp90 pathway could provide a useful therapeutic strategy in tumors driven by Cks1 overexpression | Cks1 proteasomal degradation is induced by inhibiting Hsp90-mediated chaperoning in cancer cells.
Khattar V, Fried J, Xu B, Thottassery JV. | 04/4/2015 |
| Our results suggest a role for CKS1B in the multiple step process of progression of MGUS to MM and show that CKS1B copy gain has a more significant prognostic value than its overexpression. | Quantitative analysis of CKS1B mRNA expression and copy number gain in patients with plasma cell disorders.
Stella F, Pedrazzini E, Baialardo E, Fantl DB, Schutz N, Slavutsky I. | 04/4/2015 |
| EGF upregulates the mRNA and protein levels of Skp2/Cks1 and p27(kip1) via the PI3K/Akt pathway and direct binding of E2F1 transcription factor with the Skp2 promoter in extrahepatic cholangiocarcinoma cells. | Epidermal growth factor upregulates Skp2/Cks1 and p27(kip1) in human extrahepatic cholangiocarcinoma cells.
Kim JY, Kim HJ, Park JH, Park DI, Cho YK, Sohn CI, Jeon WK, Kim BI, Kim DH, Chae SW, Sohn JH., Free PMC Article | 11/22/2014 |
| CKS1 mRNA and protein expression were increased in esophageal carcinoma. Overexpression of CKS1 was associated with higher grad, regional lymph node invasion, and neoplastic embolus. CKS1 was negatively associated with the p27(kip1) level in the tumor. | Clinical significance of overexpressed cyclin-dependent kinase subunits 1 and 2 in esophageal carcinoma.
Wang JJ, Fang ZX, Ye HM, You P, Cai MJ, Duan HB, Wang F, Zhang ZY., Free PMC Article | 09/20/2014 |
| We demonstrated that high expression of CKS1B immunostaining can be one potent prognostic factor for disease-specific survival, metastasis-free survival, and local recurrence-free survival in patients with nasopharyngeal carcinoma. | Overexpression of CDC28 protein kinase regulatory subunit 1B confers an independent prognostic factor in nasopharyngeal carcinoma.
Lee SW, Lin CY, Tian YF, Sun DP, Lin LC, Chen LT, Hsing CH, Huang CT, Hsu HP, Huang HY, Wu LC, Li CF, Shiue YL. | 04/12/2014 |
| Anaplastic multiple myeloma was associated with significantly higher prevalence of CKS1B amplification than non-anaplastic multiple myeloma. | Genomic aberrations in anaplastic multiple myeloma: high frequency of 1q21(CKS1B) amplifications.
Bahmanyar M, Qi X, Chang H. | 02/22/2014 |
| CKS1B analysis predicts 1q21 amplification and adverse outcome for risk stratification of patients with multiple myeloma. | CKS1B nuclear expression is inversely correlated with p27Kip1 expression and is predictive of an adverse survival in patients with multiple myeloma.
Chang H, Jiang N, Jiang H, Saha MN, Qi C, Xu W, Reece D., Free PMC Article | 11/17/2012 |