| Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE. | Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE.
Pernet E, Sun S, Sarden N, Gona S, Nguyen A, Khan N, Mawhinney M, Tran KA, Chronopoulos J, Amberkar D, Sadeghi M, Grant A, Wali S, Prevel R, Ding J, Martin JG, Thanabalasuriar A, Yipp BG, Barreiro LB, Divangahi M., Free PMC Article | 06/24/2023 |
| Key Role of 12-Lipoxygenase and Its Metabolite 12-Hydroxyeicosatetraenoic Acid (12-HETE) in Diabetic Retinopathy. | Key Role of 12-Lipoxygenase and Its Metabolite 12-Hydroxyeicosatetraenoic Acid (12-HETE) in Diabetic Retinopathy.
Chen S, Zou H. | 04/23/2022 |
| Hydrogen sulfide guards myoblasts from ferroptosis by inhibiting ALOX12 acetylation. | Hydrogen sulfide guards myoblasts from ferroptosis by inhibiting ALOX12 acetylation.
Wang Y, Yu R, Wu L, Yang G. | 12/11/2021 |
| Alox12/15 Deficiency Exacerbates, While Lipoxin A4 Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis. | Alox12/15 Deficiency Exacerbates, While Lipoxin A(4) Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis.
Queck A, Fink AF, Sirait-Fischer E, Rüschenbaum S, Thomas D, Snodgrass RG, Geisslinger G, Baba HA, Trebicka J, Zeuzem S, Weigert A, Lange CM, Brüne B., Free PMC Article | 04/17/2021 |
| Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice. | Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice.
Mori Y, Kawakami Y, Kanzaki K, Otsuki A, Kimura Y, Kanji H, Tanaka R, Tsukayama I, Hojo N, Suzuki-Yamamoto T, Kawakami T, Takahashi Y. | 03/6/2021 |
| Knockout of ALOX12 protects against spinal cord injury-mediated nerve injury by inhibition of inflammation and apoptosis. | Knockout of ALOX12 protects against spinal cord injury-mediated nerve injury by inhibition of inflammation and apoptosis.
Li JL, Liang YL, Wang YJ. | 07/11/2020 |
| these results indicate that Alox12 loss activates a compensatory increase in Alox15 that sensitizes mouse beta cells to oxidative stress. | Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in mouse islet β cells.
Conteh AM, Reissaus CA, Hernandez-Perez M, Nakshatri S, Anderson RM, Mirmira RG, Tersey SA, Linnemann AK., Free PMC Article | 10/19/2019 |
| 12(S)-HETrE, a 12-lipoxygenase oxylipin of dihomo-gamma-linolenic acid, inhibits thrombosis via Galphas signaling in platelets. | 12(S)-HETrE, a 12-Lipoxygenase Oxylipin of Dihomo-γ-Linolenic Acid, Inhibits Thrombosis via Gαs Signaling in Platelets.
Yeung J, Tourdot BE, Adili R, Green AR, Freedman CJ, Fernandez-Perez P, Yu J, Holman TR, Holinstat M., Free PMC Article | 06/24/2017 |
| the amount of LPL expressed in muscle and heart governed both the binding of chylomicron particles and the assimilation of chylomicron lipids in the tissue. | A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase.
Ibrahim AS, Elshafey S, Sellak H, Hussein KA, El-Sherbiny M, Abdelsaid M, Rizk N, Beasley S, Tawfik AM, Smith SB, Al-Shabrawey M., Free PMC Article | 11/21/2015 |
| Data show that the coordinated action of phospholipase A2 IIA (sPLA2-IIA) and 12-lipoxygenase (12-LO) promotes inflammatory arthritis. | Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA.
Duchez AC, Boudreau LH, Naika GS, Bollinger J, Belleannée C, Cloutier N, Laffont B, Mendoza-Villarroel RE, Lévesque T, Rollet-Labelle E, Rousseau M, Allaeys I, Tremblay JJ, Poubelle PE, Lambeau G, Pouliot M, Provost P, Soulet D, Gelb MH, Boilard E., Free PMC Article | 10/31/2015 |
| IGF-1 reduces lipid oxidation and foam cell formation via downregulation of 12/15-LOX to prevent atherosclerosis. | Insulin-like growth factor I reduces lipid oxidation and foam cell formation via downregulation of 12/15-lipoxygenase.
Sukhanov S, Snarski P, Vaughn C, Lobelle-Rich P, Kim C, Higashi Y, Shai SY, Delafontaine P., Free PMC Article | 09/26/2015 |
| Data indicate that 12/15-LO knockout (KO) mice were protected from high fat (HF) diet with high dietary omega6/omega3 ratio (11ratio1, HFH)-induced fatty liver. | Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis.
Lazic M, Inzaugarat ME, Povero D, Zhao IC, Chen M, Nalbandian M, Miller YI, Cherñavsky AC, Feldstein AE, Sears DD., Free PMC Article | 06/27/2015 |
| These results suggest that cardiac 12/15-LOX-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy and that inhibition of 12/15-LOX could be a novel treatment for this condition. | Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy.
Suzuki H, Kayama Y, Sakamoto M, Iuchi H, Shimizu I, Yoshino T, Katoh D, Nagoshi T, Tojo K, Minamino T, Yoshimura M, Utsunomiya K. | 04/4/2015 |
| EET-heme oxygenase-1 crosstalk as an important cytoprotective mechanism in the amelioration of vascular and adipocyte dysfunction resulting from diet-induced obesity. | CYP2J2 targeting to endothelial cells attenuates adiposity and vascular dysfunction in mice fed a high-fat diet by reprogramming adipocyte phenotype.
Abraham NG, Sodhi K, Silvis AM, Vanella L, Favero G, Rezzani R, Lee C, Zeldin DC, Schwartzman ML., Free PMC Article | 01/24/2015 |
| Overexpression of 15-lipoxygenase increases anxiety behavior in female mice. | Overexpression of 12/15-lipoxygenase increases anxiety behavior in female mice.
Joshi YB, Di Meco A, Praticò D. | 10/11/2014 |
| Findings suggest 12/15-LOX expressed in non-epithelial cells such as macrophages and fibroblasts leads to bronchial epithelial injury. | 12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma.
Mabalirajan U, Rehman R, Ahmad T, Kumar S, Leishangthem GD, Singh S, Dinda AK, Biswal S, Agrawal A, Ghosh B., Free PMC Article | 09/21/2013 |
| Data indicate that intravenous injection of B16F10 melanoma cells caused lung nodule formation, which was markedly attenuated in 12/15-Lipoxygenase (12/15-LOX) null mice. | Enhancement role of host 12/15-lipoxygenase in melanoma progression.
Kang KH, Ling TY, Liou HH, Huang YK, Hour MJ, Liou HC, Fu WM. | 09/21/2013 |
| Following middle cerebral artery occlusion to induce stroke, immunohistochemistry shows both Sema3A and 12/15-LOX are increased in the cortex up to 2 wk. | Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling.
Pekcec A, Yigitkanli K, Jung JE, Pallast S, Xing C, Antipenko A, Minchenko M, Nikolov DB, Holman TR, Lo EH, van Leyen K., Free PMC Article | 03/30/2013 |
| ALOX12 may have a role in growth of breast cancer, and its inhibition may be a strategy for inhibiting tumor growth | Structure based design and synthesis of peptide inhibitor of human LOX-12: in vitro and in vivo analysis of a novel therapeutic agent for breast cancer.
Singh AK, Singh R, Naz F, Chauhan SS, Dinda A, Shukla AA, Gill K, Kapoor V, Dey S., Free PMC Article | 09/1/2012 |
| IT delivery of 12-LOX metabolites of arachidonic acid 12(S)-HpETE, 12(S)-HETE, HXA(3), or HXB(3) evoked profound, persistent tactile allodynia, but 12(S)-HpETE and HXA(3) produced relatively modest, transient heat hyperalgesia | Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors.
Gregus AM, Doolen S, Dumlao DS, Buczynski MW, Takasusuki T, Fitzsimmons BL, Hua XY, Taylor BK, Dennis EA, Yaksh TL., Free PMC Article | 07/14/2012 |
| These data indicate that 12/15-LO and its metabolites have a prominent antifibrotic role during dermal fibrosis. | The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis.
Krönke G, Reich N, Scholtysek C, Akhmetshina A, Uderhardt S, Zerr P, Palumbo K, Lang V, Dees C, Distler O, Schett G, Distler JH. | 07/7/2012 |
| reduction of alox12 activity or expression could provide a new therapeutic target to reduce ER stress and | 12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response.
Cole BK, Kuhn NS, Green-Mitchell SM, Leone KA, Raab RM, Nadler JL, Chakrabarti SK., Free PMC Article | 05/5/2012 |
| Arachidonic acid epoxygenase and 12(S)-lipoxygenase jointly produce a hitherto uncharacterized compound acting as oxygen messenger in the ductus arteriosus. | Arachidonic acid epoxygenase and 12(S)-lipoxygenase: evidence of their concerted involvement in ductus arteriosus constriction to oxygen.
Baragatti B, Coceani F. | 12/10/2011 |
| Increased expression of 12/15LO in the vessel wall enhances Id3-dependent cell proliferation, fibronectin deposition, and neointimal formation in response to carotid artery injury. | Increased 12/15-lipoxygenase enhances cell growth, fibronectin deposition, and neointimal formation in response to carotid injury.
Deliri H, Meller N, Kadakkal A, Malhotra R, Brewster J, Doran AC, Pei H, Oldham SN, Skaflen MD, Garmey JC, McNamara CA., Free PMC Article | 01/22/2011 |
| 12/15-LOX and AIF are sequential actors in a common cell death pathway that may contribute to stroke-induced brain damage. | Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway.
Pallast S, Arai K, Pekcec A, Yigitkanli K, Yu Z, Wang X, Lo EH, van Leyen K., Free PMC Article | 06/28/2010 |