| Single-cell transcriptomics in MI identify Slc25a4 as a new modulator of mitochondrial malfunction and apoptosis-associated cardiomyocyte subcluster. | Single-cell transcriptomics in MI identify Slc25a4 as a new modulator of mitochondrial malfunction and apoptosis-associated cardiomyocyte subcluster.
Zhou T, Pan J, Xu K, Yan C, Yuan J, Song H, Han Y., Free PMC Article | 05/14/2024 |
| The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT). | The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT).
Pharaoh G, Kamat V, Kannan S, Stuppard RS, Whitson J, Martín-Pérez M, Qian WJ, MacCoss MJ, Villén J, Rabinovitch P, Campbell MD, Sweet IR, Marcinek DJ., Free PMC Article | 11/15/2023 |
| Mitochondrial GSNOR Alleviates Cardiac Dysfunction via ANT1 Denitrosylation. | Mitochondrial GSNOR Alleviates Cardiac Dysfunction via ANT1 Denitrosylation.
Tang X, Zhao S, Liu J, Liu X, Sha X, Huang C, Hu L, Sun S, Gao Y, Chen H, Zhang Z, Wang D, Gu Y, Chen S, Wang L, Gu A, Chen F, Pu J, Chen X, Yu B, Xie L, Huang Z, Han Y, Ji Y. | 10/26/2023 |
| Identification of ADP/ATP Translocase 1 as a Novel Glycoprotein and Its Association with Parkinson's Disease. | Identification of ADP/ATP Translocase 1 as a Novel Glycoprotein and Its Association with Parkinson's Disease.
Zhang W, Liu J, Chen Q, Ding W, Li S, Ma L. | 10/15/2022 |
| Nicotinamide riboside alleviates exercise intolerance in ANT1-deficient mice. | Nicotinamide riboside alleviates exercise intolerance in ANT1-deficient mice.
Schaefer PM, Huang J, Butic A, Perry C, Yardeni T, Tan W, Morrow R, Baur JA, Wallace DC., Free PMC Article | 09/24/2022 |
| Mice that lack ANT1 show blunted mitophagy and consequent profound accumulation of aberrant mitochondria | The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.
Hoshino A, Wang WJ, Wada S, McDermott-Roe C, Evans CS, Gosis B, Morley MP, Rathi KS, Li J, Li K, Yang S, McManus MJ, Bowman C, Potluri P, Levin M, Damrauer S, Wallace DC, Holzbaur ELF, Arany Z., Free PMC Article | 04/11/2020 |
| By mediating two distinct transport modes, ADP/ATP exchange and H(+) leak, ADP/ATP carrier connects coupled (ATP production) and uncoupled (thermogenesis) energy conversion in mitochondria. | H(+) transport is an integral function of the mitochondrial ADP/ATP carrier.
Bertholet AM, Chouchani ET, Kazak L, Angelin A, Fedorenko A, Long JZ, Vidoni S, Garrity R, Cho J, Terada N, Wallace DC, Spiegelman BM, Kirichok Y., Free PMC Article | 09/14/2019 |
| Results suggest that adenine nucleotide translocator 1 (ANT1) modulates interleukin-6 (IL-6) expression through JNK signal pathway in macrophages. | The inner mitochondrial membrane protein ANT1 modulates IL-6 expression via the JNK pathway in macrophages.
Nakahara K, Tanaka T, Okuda H, Isonishi A, Morita-Takemura S, Tatsumi K, Wanaka A. | 06/15/2019 |
| The ANT1-deficient muscle mitochondria produce excess reactive oxygen species (ROS) and are partially uncoupled. Hence, the muscle respiration under nonphosphorylating conditions is increased. Muscle transcriptome analysis revealed the induction of mitochondrial biogenesis, down-regulation of diabetes-related genes, and increased expression of the genes encoding the myokines FGF21 and GDF15. | Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity.
Morrow RM, Picard M, Derbeneva O, Leipzig J, McManus MJ, Gouspillou G, Barbat-Artigas S, Dos Santos C, Hepple RT, Murdock DG, Wallace DC., Free PMC Article | 04/21/2018 |
| ANT1 can induce autoimmune myocarditis in A/J mice by generating autoreactive T cells. | Identification of an Epitope from Adenine Nucleotide Translocator 1 That Induces Inflammation in Heart in A/J Mice.
Basavalingappa RH, Massilamany C, Krishnan B, Gangaplara A, Kang G, Khalilzad-Sharghi V, Han Z, Othman S, Li Q, Riethoven JJ, Sobel RA, Steffen D, Reddy J., Free PMC Article | 09/23/2017 |
| miR-2861 and ANT1 are regulators of cardiomyocyte necrosis and myocardial infarction. | MicroRNA-2861 regulates programmed necrosis in cardiomyocyte by impairing adenine nucleotide translocase 1 expression.
Wang K, Long B, Li N, Li L, Liu CY, Dong YH, Gao JN, Zhou LY, Wang CQ, Li PF. | 12/17/2016 |
| These results suggest that follicular helper T cells cells and IL-21 might be involved in the pathogenesis of viral myocarditis and play an important role in anti-ANT autoantibody production. | Increased frequency of follicular helper T cells in mice viral myocarditis is relevant with anti-ANT antoantibody.
Yang F, Mo WH, Tan BP, Wei XM, Wang H., Free PMC Article | 12/26/2015 |
| Data indicate that palmitoyl-carnitine (PC) increases the type 2 ryanodine receptor (RyR2) oxidation and reduces the ATP/ADP translocase (ANT) activity. | Palmitoyl-carnitine increases RyR2 oxidation and sarcoplasmic reticulum Ca2+ leak in cardiomyocytes: Role of adenine nucleotide translocase.
Roussel J, Thireau J, Brenner C, Saint N, Scheuermann V, Lacampagne A, Le Guennec JY, Fauconnier J. | 10/3/2015 |
| Downregulation of adenine nucleotide translocator 1 exacerbates tumor necrosis factor-alpha-mediated cardiac inflammatory responses. | Downregulation of adenine nucleotide translocator 1 exacerbates tumor necrosis factor-α-mediated cardiac inflammatory responses.
Pan S, Wang N, Bisetto S, Yi B, Sheu SS., Free PMC Article | 03/7/2015 |
| Its mutation causes some inherited Parkinson disease. | Mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice.
Martin LJ, Semenkow S, Hanaford A, Wong M., Free PMC Article | 10/11/2014 |
| Plasma membrane-localized ANT1 and ANT2 regulate L1-mediated neurite outgrowth in conjunction with MMP14. | The interaction between cell adhesion molecule L1, matrix metalloproteinase 14, and adenine nucleotide translocator at the plasma membrane regulates L1-mediated neurite outgrowth of murine cerebellar neurons.
Loers G, Makhina T, Bork U, Dörner A, Schachner M, Kleene R., Free PMC Article | 05/5/2012 |
| Although the molecular mechanism linking ANT1-Cys(57) nitroalkylation and uncoupling is not yet known, these data suggest that ANT1-mediated uncoupling may be a mechanism for nitroalkene-induced cardioprotection. | Nitroalkenes confer acute cardioprotection via adenine nucleotide translocase 1.
Nadtochiy SM, Zhu QM, Urciuoli W, Rafikov R, Black SM, Brookes PS., Free PMC Article | 03/24/2012 |
| The attenuation of ANT-1 in the presence of PGC-1alpha overexpression preserves the mitochondrial membrane potential in response to hydrogen-peroxide stress. | Transient upregulation of PGC-1alpha diminishes cardiac ischemia tolerance via upregulation of ANT1.
Lynn EG, Stevens MV, Wong RP, Carabenciov D, Jacobson J, Murphy E, Sack MN., Free PMC Article | 01/1/2011 |
| Data demonstrate that ANT1 protein levels are upregulated in Mecp2-null mice. | The MeCP2/YY1 interaction regulates ANT1 expression at 4q35: novel hints for Rett syndrome pathogenesis.
Forlani G, Giarda E, Ala U, Di Cunto F, Salani M, Tupler R, Kilstrup-Nielsen C, Landsberger N., Free PMC Article | 10/30/2010 |
| uncoupling protein-3 can minimize the induction of the adenine nucleotide translocase-mediated 'energy-wasting' process during Calorie restriction (CR). | Absence of uncoupling protein-3 leads to greater activation of an adenine nucleotide translocase-mediated proton conductance in skeletal muscle mitochondria from calorie restricted mice.
Bevilacqua L, Seifert EL, Estey C, Gerrits MF, Harper ME. | 08/23/2010 |
| Inhibition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury | Inhibition of the mitochondrial permeability transition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury in mice.
Zhuge J, Cederbaum AI., Free PMC Article | 01/21/2010 |
| Data indicate that ANT mediates cell death, not through the MPT pore, but rather via a ROS-dependent upregulation and activation of Bax. | Adenine nucleotide translocase-1 induces cardiomyocyte death through upregulation of the pro-apoptotic protein Bax.
Baines CP, Molkentin JD., Free PMC Article | 01/21/2010 |
| The mitochondrial membrane potential of Ant1-deficient brain mitochondria is increased and the permeability transition pore is more resistant to calcium induced permeability transition. | Adenine nucleotide translocator 1 deficiency increases resistance of mouse brain and neurons to excitotoxic insults.
Lee J, Schriner SE, Wallace DC., Free PMC Article | 01/21/2010 |
| Cardiomyocyte-restricted overexpression of ANT1 prevents the development of diabetic cardiomyopathy; therefore, accelerated ADP/ATP exchange could be a new promising target to treat diabetic cardiomyopathy. | Myocardial overexpression of adenine nucleotide translocase 1 ameliorates diabetic cardiomyopathy in mice.
Wang Y, Ebermann L, Sterner-Kock A, Wika S, Schultheiss HP, Dörner A, Walther T. | 01/21/2010 |
| The Ant1 deficient mouse skeletal muscle demonstrates that energy metabolism, antioxidant defenses, and apoptosis form an integrated metabolic network. | MITOCHIP assessment of differential gene expression in the skeletal muscle of Ant1 knockout mice: coordinate regulation of OXPHOS, antioxidant, and apoptotic genes.
Subramaniam V, Golik P, Murdock DG, Levy S, Kerstann KW, Coskun PE, Melkonian GA, Wallace DC., Free PMC Article | 01/21/2010 |