| YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis. | YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis.
Su W, Guo Y, Wang Q, Ma L, Zhang Q, Zhang Y, Geng Y, Jin T, Guo J, Yang R, Niu Z, Ren L, Wang Y, Ning Z, Li W, He W, Sun J, Li T, Li Z, Shan H, Liang H., Free PMC Article | 09/12/2024 |
| Peroxiredoxin 3 has a crucial role in the macrophage polarization by regulating mitochondrial homeostasis. | Peroxiredoxin 3 has a crucial role in the macrophage polarization by regulating mitochondrial homeostasis.
Huang W, Wang L, Huang Z, Sun Z, Zheng B., Free PMC Article | 03/11/2024 |
| Circular RNA circPRDX3 mediates neuronal survival apoptosis in ischemic stroke by targeting miR-641 and NPR3. | Circular RNA circPRDX3 mediates neuronal survival apoptosis in ischemic stroke by targeting miR-641 and NPR3.
Chen W, Zhang Y, Yin M, Cheng Z, Li D, Luo X, Liu X, Tu J. | 11/15/2023 |
| Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases. | Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases.
Cui S, Ghai A, Deng Y, Li S, Zhang R, Egbulefu C, Liang G, Achilefu S, Ye J., Free PMC Article | 11/10/2023 |
| The m6A reader YTHDF3-mediated PRDX3 translation alleviates liver fibrosis. | The m6A reader YTHDF3-mediated PRDX3 translation alleviates liver fibrosis.
Sun R, Tian X, Li Y, Zhao Y, Wang Z, Hu Y, Zhang L, Wang Y, Gao D, Zheng S, Yao J., Free PMC Article | 07/16/2022 |
| Peroxiredoxin 3 deficiency induces cardiac hypertrophy and dysfunction by impaired mitochondrial quality control. | Peroxiredoxin 3 deficiency induces cardiac hypertrophy and dysfunction by impaired mitochondrial quality control.
Sonn SK, Song EJ, Seo S, Kim YY, Um JH, Yeo FJ, Lee DS, Jeon S, Lee MN, Jin J, Kweon HY, Kim TK, Kim S, Moon SH, Rhee SG, Chung J, Yang J, Han J, Choi EY, Lee SB, Yun J, Oh GT., Free PMC Article | 04/23/2022 |
| Peroxiredoxin 3 Inhibits Acetaminophen-Induced Liver Pyroptosis Through the Regulation of Mitochondrial ROS. | Peroxiredoxin 3 Inhibits Acetaminophen-Induced Liver Pyroptosis Through the Regulation of Mitochondrial ROS.
Wang Y, Zhao Y, Wang Z, Sun R, Zou B, Li R, Liu D, Lin M, Zhou J, Ning S, Tian X, Yao J., Free PMC Article | 10/2/2021 |
| This body of evidence sheds light on the capability of neurons to activate neuroprotective pathways and points the attention to peroxiredoxin 3, an antioxidant enzyme that might be critical for neuronal survival also in other disorders affecting mitochondria. | Upregulation of Peroxiredoxin 3 Protects Afg3l2-KO Cortical Neurons In Vitro from Oxidative Stress: A Paradigm for Neuronal Cell Survival under Neurodegenerative Conditions.
Bettegazzi B, Pelizzoni I, Salerno Scarzella F, Restelli LM, Zacchetti D, Maltecca F, Casari G, Grohovaz F, Codazzi F., Free PMC Article | 04/25/2020 |
| Prx3 deficiency accelerates chronic kidney injury in mice through interactions between macrophages and tubular epithelial cells. | Peroxiredoxin 3 deficiency accelerates chronic kidney injury in mice through interactions between macrophages and tubular epithelial cells.
Hwang I, Uddin MJ, Lee G, Jiang S, Pak ES, Ha H. | 01/25/2020 |
| The importance of mitochondrial Prdx3 in regulating the oxidative stress environment in adipocytes.Loss of Prdx3 leads to decreased pS473 Akt and insulin-stimulated glucose transport. | Down regulation of Peroxiredoxin-3 in 3T3-L1 adipocytes leads to oxidation of Rictor in the mammalian-target of rapamycin complex 2 (mTORC2).
Olson DH, Burrill JS, Kuzmicic J, Hahn WS, Park JM, Kim DH, Bernlohr DA. | 10/28/2017 |
| Oxidative stress promotes PRX2 and PRX3 hyperoxidation and attenuates pro-survival signaling in aging chondrocytes. | Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes.
Collins JA, Wood ST, Nelson KJ, Rowe MA, Carlson CS, Chubinskaya S, Poole LB, Furdui CM, Loeser RF., Free PMC Article | 08/6/2016 |
| This study showed that from E10.5,Prdx3 showed strong ventral lateral expression. This increased ventral immunotaining persisted until E18.5 but became relatively less striking at later stages. | Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development.
Pirson M, Knoops B. | 07/16/2016 |
| Prx3 plays a crucial role in mitochondrial homeostasis and thereby controls the contractile functions of skeletal muscle. | Peroxiredoxin 3 has a crucial role in the contractile function of skeletal muscle by regulating mitochondrial homeostasis.
Lee KP, Shin YJ, Cho SC, Lee SM, Bahn YJ, Kim JY, Kwon ES, Jeong DY, Park SC, Rhee SG, Woo HA, Kwon KS. | 08/15/2015 |
| The SirT1 regulates the expression of several antioxidant genes in bovine aortic endothelial cells, including Mn superoxide dismutase, catalase, peroxiredoxins 3 and 5, thioredoxin 2, thioredoxin reductase 2, and uncoupling protein 2. | SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex.
Olmos Y, Sánchez-Gómez FJ, Wild B, García-Quintans N, Cabezudo S, Lamas S, Monsalve M., Free PMC Article | 12/6/2014 |
| Prx3 is up-regulated in response to oxidative stress; the maintenance of Prx3 levels in hair cells is a critical factor in their susceptibility to acquired hearing loss. | Mitochondrial peroxiredoxin 3 regulates sensory cell survival in the cochlea.
Chen FQ, Zheng HW, Schacht J, Sha SH., Free PMC Article | 11/30/2013 |
| The concerted action of PrxIII and Srx is important for protection against pyrazole-induced oxidative stress arising from the convergent induction of CYP2E1-derived and ER stress-derived ROS in mitochondria. | Peroxiredoxin III and sulfiredoxin together protect mice from pyrazole-induced oxidative liver injury.
Bae SH, Sung SH, Lee HE, Kang HT, Lee SK, Oh SY, Woo HA, Kil IS, Rhee SG., Free PMC Article | 02/9/2013 |
| PrxIII in mouse adrenal cortex is inactivated by H(2)O(2) produced by cytochrome P450 enzymes during corticosterone production stimulated by adrenocorticotropic hormone. | Feedback control of adrenal steroidogenesis via H2O2-dependent, reversible inactivation of peroxiredoxin III in mitochondria.
Kil IS, Lee SK, Ryu KW, Woo HA, Hu MC, Bae SH, Rhee SG. | 09/1/2012 |
| endogenous Prx3 may play an essential role in maintaining normal characteristics of adipocytes and that defect in Prx3 alters mitochondrial redox state and function. | Peroxiredoxin 3 is a key molecule regulating adipocyte oxidative stress, mitochondrial biogenesis, and adipokine expression.
Huh JY, Kim Y, Jeong J, Park J, Kim I, Huh KH, Kim YS, Woo HA, Rhee SG, Lee KJ, Ha H., Free PMC Article | 05/19/2012 |
| Immunohistochemical analysis revealed segment-specific alterations induced by the ischemic insult. Grx2, Prx3, and Prx6 were highly expressed in proximal tubule cells | Segment-specific overexpression of redoxins after renal ischemia and reperfusion: protective roles of glutaredoxin 2, peroxiredoxin 3, and peroxiredoxin 6.
Godoy JR, Oesteritz S, Hanschmann EM, Ockenga W, Ackermann W, Lillig CH. | 10/29/2011 |
| Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys peroxiredoxin Prx3. | Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys peroxiredoxin Prx3.
Hanschmann EM, Lönn ME, Schütte LD, Funke M, Godoy JR, Eitner S, Hudemann C, Lillig CH., Free PMC Article | 01/29/2011 |
| Results indicate that PrxIII is not involved in pre-eclamptic development. Instead, PrxIII is an indispensable antioxidant in placentas where oxidative stress exists. | Role of peroxiredoxin III in the pathogenesis of pre-eclampsia as evidenced in mice.
Li L, Obinata M, Hori K., Free PMC Article | 01/1/2011 |
| This study showed that peroxiredoxin 3 protects pancreatic beta cells from cell stress induced by accumulation of hydrogen peroxide, or the induction of inducible nitric oxide synthase or caspase-9 and -3 by pro-inflammatory cytokines or streptozotocin. | Peroxiredoxin III protects pancreatic ß cells from apoptosis.
Wolf G, Aumann N, Michalska M, Bast A, Sonnemann J, Beck JF, Lendeckel U, Newsholme P, Walther R. | 11/27/2010 |
| Hyperoxia induced the degradation of Prx III in Nrf2-deficient mice but not in wild-type animals, suggesting that, in the absence of a sufficient amount of Srx | Induction of sulfiredoxin via an Nrf2-dependent pathway and hyperoxidation of peroxiredoxin III in the lungs of mice exposed to hyperoxia.
Bae SH, Woo HA, Sung SH, Lee HE, Lee SK, Kil IS, Rhee SG. | 03/8/2010 |
| PrxIII is necessary for macrophages to protect against lipopolysaccharide-induced oxidative stress. | Peroxiredoxin III-deficiency sensitizes macrophages to oxidative stress.
Li L, Kaifu T, Obinata M, Takai T. | 01/21/2010 |
| Local antioxidant activity of peroxiredoxin 3 may have a role in maintaining cardiac function. | Reversible oxidation of mitochondrial peroxiredoxin 3 in mouse heart subjected to ischemia and reperfusion.
Kumar V, Kitaeff N, Hampton MB, Cannell MB, Winterbourn CC. | 01/21/2010 |