| Dynamic localization of the Na+-HCO3- co-transporter NBCn1 to the plasma membrane, centrosomes, spindle and primary cilia. | Dynamic localization of the Na+-HCO3- co-transporter NBCn1 to the plasma membrane, centrosomes, spindle and primary cilia.
Severin M, Pedersen EL, Borre MT, Axholm I, Christiansen FB, Ponniah M, Czaplinska D, Larsen T, Pardo LA, Pedersen SF. | 04/12/2023 |
| Trafficking, localization and degradation of the Na(+),HCO3(-) co-transporter NBCn1 in kidney and breast epithelial cells | Trafficking, localization and degradation of the Na(+),HCO(3)(-) co-transporter NBCn1 in kidney and breast epithelial cells.
Olesen CW, Vogensen J, Axholm I, Severin M, Schnipper J, Pedersen IS, von Stemann JH, Schrøder JM, Christensen DP, Pedersen SF., Free PMC Article | 10/12/2019 |
| The finding of a genotypic influence on SLC4A7 expression and pHi regulation in vascular smooth muscle cells provides an insight into the molecular mechanism underlying the association of variation at the SLC4A7 locus with blood pressure | Increased NBCn1 expression, Na+/HCO3- co-transport and intracellular pH in human vascular smooth muscle cells with a risk allele for hypertension.
Ng FL, Boedtkjer E, Witkowska K, Ren M, Zhang R, Tucker A, Aalkjær C, Caulfield MJ, Ye S., Free PMC Article | 05/20/2017 |
| PSD-95 interacts with NBCn1 and increases its channel-like activity while negligibly affecting Na/HCO(3) cotransport. | PSD-95 interacts with NBCn1 and enhances channel-like activity without affecting Na/HCO(3) cotransport.
Lee S, Yang HS, Kim E, Ju EJ, Kwon MH, Dudley RK, Smith Y, Yun CC, Choi I., Free PMC Article | 06/1/2013 |
| A binding site for calcineurin A beta was found to reside within splice cassette II of NBCn1. | Splice cassette II of Na+,HCO3(-) cotransporter NBCn1 (slc4a7) interacts with calcineurin A: implications for transporter activity and intracellular pH control during rat artery contractions.
Danielsen AA, Parker MD, Lee S, Boron WF, Aalkjaer C, Boedtkjer E., Free PMC Article | 05/18/2013 |
| Current-voltage relationships showed a positive and nearly linear relationship between NH(4)Cl-mediated current and voltage, which was markedly reduced by NBCn1. | Sodium-bicarbonate cotransporter NBCn1/Slc4a7 inhibits NH4Cl-mediated inward current in Xenopus oocytes.
Lee S, Choi I., Free PMC Article | 01/21/2012 |
| The electroneutral sodium bicarbonate co-transporter SLC4A7 localizes in mitochondria and suppresses the ischaemia-induced activation of the mitochondrial pathway of apoptosis in coronary endothelial cells. | SLC4A7 sodium bicarbonate co-transporter controls mitochondrial apoptosis in ischaemic coronary endothelial cells.
Kumar S, Flacke JP, Kostin S, Appukuttan A, Reusch HP, Ladilov Y. | 04/23/2011 |
| In acidic conditions, kidney medullary thick ascending DIDS-sensitive bicarbonate extrusion is inactivated, while NBCn1 is upregulated to stimulate ammonium transport. | Sodium-bicarbonate cotransporter NBCn1 in the kidney medullary thick ascending limb cell line is upregulated under acidic conditions and enhances ammonium transport.
Lee S, Lee HJ, Yang HS, Thornell IM, Bevensee MO, Choi I., Free PMC Article | 12/4/2010 |
| It was concluded that NBCn1 in neurons is upregulated by chronic acid loads, and this upregulation is associated with glutamate excitotoxicity. | Neuronal expression of sodium/bicarbonate cotransporter NBCn1 (SLC4A7) and its response to chronic metabolic acidosis.
Park HJ, Rajbhandari I, Yang HS, Lee S, Cucoranu D, Cooper DS, Klein JD, Sands JM, Choi I., Free PMC Article | 05/31/2010 |
| We conclude that the primary function of cassette II is to reduce NBCn1 protein expression | Inhibition of rat Na+(-)HCO3(-) cotransporter (NBCn1) function and expression by the alternative splice domain.
Yang HS, Cooper DS, Rajbhandari I, Park HJ, Lee S, Choi I. | 01/21/2010 |
| We conclude that NBCn1 has a dynamic upregulation in low pH(o) and Mg(2+) depletion. NBCn1 is not required for acidic protection, but increases cytotoxicity in Mg(2+)-free conditions. | Sodium/bicarbonate cotransporter NBCn1/slc4a7 increases cytotoxicity in magnesium depletion in primary cultures of hippocampal neurons.
Cooper DS, Yang HS, He P, Kim E, Rajbhandari I, Yun CC, Choi I., Free PMC Article | 01/21/2010 |
| Electrogenic NBCe1 (SLC4A4), but not electroneutral NBCn1 (SLC4A7), cotransporter undergoes cholinergic-stimulated endocytosis in salivary ParC5 cells. | Electrogenic NBCe1 (SLC4A4), but not electroneutral NBCn1 (SLC4A7), cotransporter undergoes cholinergic-stimulated endocytosis in salivary ParC5 cells.
Perry C, Quissell DO, Reyland ME, Grichtchenko II., Free PMC Article | 01/21/2010 |
| Bilateral ureteral obstruction caused a significant reduction in the expression of NHE3, NBC1, NKCC2, NBCn1, and pendrin. | Ureter obstruction alters expression of renal acid-base transport proteins in rat kidney.
Wang G, Li C, Kim SW, Ring T, Wen J, Djurhuus JC, Wang W, Nielsen S, Frøkiaer J. | 01/21/2010 |
| Slc4a7 activity is enhanced during development of cardiac hypertrophy. | Enhanced activity of ventricular Na+-HCO3- cotransport in pressure overload hypertrophy.
Yamamoto T, Shirayama T, Sakatani T, Takahashi T, Tanaka H, Takamatsu T, Spitzer KW, Matsubara H. | 01/21/2010 |
| NBCn1 is a basolateral Na(+)-HCO(3)(-) cotransporter of inner medullulary collecting duct cells and is differentially regulated in these and medullary thick ascending limb. | NBCn1 is a basolateral Na+-HCO3- cotransporter in rat kidney inner medullary collecting ducts.
Praetorius J, Kim YH, Bouzinova EV, Frische S, Rojek A, Aalkjaer C, Nielsen S. | 01/21/2010 |
| Molecular mechanism by which CSF-1-dependent alkalinization increases osteoclast survival may be associated with inhibition of caspase-8 and -3. NBCn1 may be novel therapeutic target for preventing pathological bone loss. | Colony-stimulating factor-1 increases osteoclast intracellular pH and promotes survival via the electroneutral Na/HCO3 cotransporter NBCn1.
Bouyer P, Sakai H, Itokawa T, Kawano T, Fulton CM, Boron WF, Insogna KL. | 01/21/2010 |
| NBCn1 in hippocampal neurons may affect neuronal activity by regulating local pH as well as steady-state inward currents at synapses. | Molecular and functional characterization of the electroneutral Na/HCO3 cotransporter NBCn1 in rat hippocampal neurons.
Cooper DS, Saxena NC, Yang HS, Lee HJ, Moring AG, Lee A, Choi I. | 01/21/2010 |