| At an experimental level mouse APOBEC1 is remarkable among 12 mammalian A1 enzymes in that it represents a source of somatic mutations in mouse genome, potentially fueling oncogenesis. | Mouse APOBEC1 cytidine deaminase can induce somatic mutations in chromosomal DNA.
Caval V, Jiao W, Berry N, Khalfi P, Pitré E, Thiers V, Vartanian JP, Wain-Hobson S, Suspène R., Free PMC Article | 04/4/2020 |
| APOBEC1-mediated RNA editing occurs within brain microglia cells and is key to maintaining their resting status. Apobec1-/- mice display age-related signs of CNS neurodegeneration. | Loss of APOBEC1 RNA-editing function in microglia exacerbates age-related CNS pathophysiology.
Cole DC, Chung Y, Gagnidze K, Hajdarovic KH, Rayon-Estrada V, Harjanto D, Bigio B, Gal-Toth J, Milner TA, McEwen BS, Papavasiliou FN, Bulloch K., Free PMC Article | 07/7/2018 |
| Here, we show that partial loss of either APOBEC1 complementation factor (A1CF), the RNA-binding cofactor of APOBEC1 in RNA editing, or Argonaute 2 (AGO2), a key factor in the biogenesis of certain noncoding RNAs, modulates risk for TGCTs and testicular abnormalities in both parent-of-origin and conventional genetic manners. | Parent-of-origin effects of A1CF and AGO2 on testicular germ-cell tumors, testicular abnormalities, and fertilization bias.
Carouge D, Blanc V, Knoblaugh SE, Hunter RJ, Davidson NO, Nadeau JH., Free PMC Article | 01/27/2018 |
| substantial rearrangement/duplication of transgene elements is present, and transgene integration was accompanied by the deletion of a 19,500 bp fragment of genomic DNA that contains the promoter, exon 1 and part of intron 1 of the APOBEC1 complementation factor (A1cf) gene, as well as several elements that are predicted to regulate chromosomal architecture | Chromosomal mapping of the αMHC-MerCreMer transgene in mice reveals a large genomic deletion.
Harkins S, Whitton JL., Free PMC Article | 01/6/2018 |
| The observations demonstrate that A1CF does not act as the APOBEC1 complementation factor in vivo under normal physiological conditions and suggest new roles for A1CF, specifically within the male adult kidney. | APOBEC1 complementation factor (A1CF) is dispensable for C-to-U RNA editing in vivo.
Snyder EM, McCarty C, Mehalow A, Svenson KL, Murray SA, Korstanje R, Braun RE., Free PMC Article | 09/9/2017 |
| Apobec-1-dependent C-to-U RNA editing exerts broad functional effects in a tissue-specific manner. | Genome-wide identification and functional analysis of Apobec-1-mediated C-to-U RNA editing in mouse small intestine and liver.
Blanc V, Park E, Schaefer S, Miller M, Lin Y, Kennedy S, Billing AM, Ben Hamidane H, Graumann J, Mortazavi A, Nadeau JH, Davidson NO., Free PMC Article | 04/4/2015 |
| RBM47 and APOBEC1 constitute the basic machinery for C to U RNA editing. | C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47.
Fossat N, Tourle K, Radziewic T, Barratt K, Liebhold D, Studdert JB, Power M, Jones V, Loebel DA, Tam PP., Free PMC Article | 04/4/2015 |
| In contrast to in vitro results, APOBEC1 neither inhibited nor significantly drove the molecular evolution of Friend retrovirus in wild type or APOBEC1 knockout mice. | Reassessment of murine APOBEC1 as a retrovirus restriction factor in vivo.
Barrett BS, Guo K, Harper MS, Li SX, Heilman KJ, Davidson NO, Santiago ML., Free PMC Article | 02/21/2015 |
| Individual genetic variability at the Apobec1 locus results in differential rates of C-to-U(T) editing in murine macrophages; with mouse strains expressing mostly a truncated alternative transcript isoform of Apobec1 exhibiting lower rates of editing. | The genetic basis for individual differences in mRNA splicing and APOBEC1 editing activity in murine macrophages.
Hassan MA, Butty V, Jensen KD, Saeij JP., Free PMC Article | 11/8/2014 |
| The transgenic rescue of intestinal apobec-1 expression restores C-to-U RNA editing of apoB mRNA in vivo, including the canonical site at position 6666 and also at approximately 20 other newly identified downstream sites present in WT mice. | Intestine-specific expression of Apobec-1 rescues apolipoprotein B RNA editing and alters chylomicron production in Apobec1 -/- mice.
Blanc V, Xie Y, Luo J, Kennedy S, Davidson NO., Free PMC Article | 04/27/2013 |
| Results suggest that apo B mRNA editing protein (Apobec1 cytidine deaminase) plays a central role in controlling testicular germ cell tumors susceptibility in both a conventional and a transgenerational manner. | Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability.
Nelson VR, Heaney JD, Tesar PJ, Davidson NO, Nadeau JH., Free PMC Article | 01/12/2013 |
| The transcriptomics approach to RNA editing presented in this study dramatically expands the list of APOBEC1 mRNA editing targets and reveals a novel cellular mechanism for the modification of transcript 3' UTRs. | Transcriptome-wide sequencing reveals numerous APOBEC1 mRNA-editing targets in transcript 3' UTRs.
Rosenberg BR, Hamilton CE, Mwangi MM, Dewell S, Papavasiliou FN., Free PMC Article | 04/2/2011 |
| LDL receptor and the apolipoprotein B mRNA editing enzyme Apobec1 are regulated via calcium signaling in mechanistic response to genetic, mechanical, and environmental insults that trigger an imbalance of intracellular calcium homeostasis | Differential expression of genes in the calcium-signaling pathway underlies lesion development in the LDb mouse model of atherosclerosis.
Mak S, Sun H, Acevedo F, Shimmin LC, Zhao L, Teng BB, Hixson JE., Free PMC Article | 03/12/2011 |
| the AU-rich RNA binding-protein Apobec-1 mediates post-transcriptional regulation of Cyp7a1 expression and influences susceptibility to diet-induced gallstone formation | Decreased expression of cholesterol 7alpha-hydroxylase and altered bile acid metabolism in Apobec-1-/- mice lead to increased gallstone susceptibility.
Xie Y, Blanc V, Kerr TA, Kennedy S, Luo J, Newberry EP, Davidson NO., Free PMC Article | 01/21/2010 |
| Murine APOBEC1 is a hypermutator of both RNA and single-stranded DNA in vivo, which could exert occasional side effects upon overexpression. | Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo.
Petit V, Guétard D, Renard M, Keriel A, Sitbon M, Wain-Hobson S, Vartanian JP. | 01/21/2010 |
| Deletion of apobec-1, by modulating expression of AU-rich RNA targets, provides an important mechanism for attenuating a dominant genetic restriction point in intestinal adenoma formation. | Deletion of the AU-rich RNA binding protein Apobec-1 reduces intestinal tumor burden in Apc(min) mice.
Blanc V, Henderson JO, Newberry RD, Xie Y, Cho SJ, Newberry EP, Kennedy S, Rubin DC, Wang HL, Luo J, Davidson NO. | 01/21/2010 |
| apobec-1-mediated apoB mRNA editing is regulated by BAG-4 | Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing.
Lau PP, Chan L. | 01/21/2010 |
| Lipopolysaccharide increases intestinal stem cell survival through apobec-1-mediated regulation of cyclooxygenase-2 messenger RNA stability. | Apobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression.
Anant S, Murmu N, Houchen CW, Mukhopadhyay D, Riehl TE, Young SG, Morrison AR, Stenson WF, Davidson NO. | 01/21/2010 |
| studies establish the existence of preferential degradation of intestinal apolipoprotein B-100 and subtle defects in triglyceride secretion in apolipoprotein B editing complex 1-/- mice | Intestinal lipoprotein assembly in apobec-1-/- mice reveals subtle alterations in triglyceride secretion coupled with a shift to larger lipoproteins.
Xie Y, Nassir F, Luo J, Buhman K, Davidson NO. | 01/21/2010 |
| RNA editing of this protein is unable to induce somatic hypermutation in mammalian cells. | RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells.
Eto T, Kinoshita K, Yoshikawa K, Muramatsu M, Honjo T., Free PMC Article | 01/21/2010 |
| apobec-1 complementation factor has a role in regulating nucleocytoplasmic import and shuttling | A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling.
Blanc V, Kennedy S, Davidson NO. | 01/21/2010 |