| Role of Na/K-ATPase alpha1 caveolin-binding motif in adipogenesis. | Role of Na/K-ATPase α1 caveolin-binding motif in adipogenesis.
Huang M, Wang X, Chen Y, Pessoa MT, Terrell KC, Zhang J, Tian J, Xie Z, Pierre SV, Cai L. | 07/10/2024 |
| Involvement of the Na[+], K[+]-ATPase alpha1 Isoform and Endogenous Cardiac Steroids in Depression- and Manic-like Behaviors. | Involvement of the Na(+), K(+)-ATPase α1 Isoform and Endogenous Cardiac Steroids in Depression- and Manic-like Behaviors.
Horesh N, Pelov I, Pogodin I, Zannadeh H, Rosen H, Mikhrina AL, Dvela-Levitt M, Sampath VP, Lichtstein D., Free PMC Article | 06/24/2024 |
| ATP1A1-linked diseases require a malfunctioning protein product from one allele. | ATP1A1-linked diseases require a malfunctioning protein product from one allele.
Spontarelli K, Young VC, Sweazey R, Padro A, Lee J, Bueso T, Hernandez RM, Kim J, Katz A, Rossignol F, Turner C, Wilczewski CM, Maxwell GL, Holmgren M, Bailoo JD, Yano ST, Artigas P. | 12/15/2023 |
| Normalization of the ATP1A1 Signalosome Rescinds Epigenetic Modifications and Induces Cell Autophagy in Hepatocellular Carcinoma. | Normalization of the ATP1A1 Signalosome Rescinds Epigenetic Modifications and Induces Cell Autophagy in Hepatocellular Carcinoma.
Rajan PK, Udoh US, Nakafuku Y, Pierre SV, Sanabria J., Free PMC Article | 11/28/2023 |
| PPAR-alpha knockout leads to elevated blood pressure response to angiotensin II infusion associated with an increase in renal alpha-1 Na(+)/K(+) ATPase protein expression and activity. | PPAR-α knockout leads to elevated blood pressure response to angiotensin II infusion associated with an increase in renal α-1 Na(+)/K(+) ATPase protein expression and activity.
Khundmiri SJ, Ecelbarger CM, Amponsem J, Ji H, Sandberg K, Lee DL., Free PMC Article | 03/26/2022 |
| The cellular prion protein interacts with and promotes the activity of Na,K-ATPases. | The cellular prion protein interacts with and promotes the activity of Na,K-ATPases.
Williams D, Mehrabian M, Arshad H, Eid S, Sackmann C, Zhao W, Wang X, Ghodrati F, Verkuyl CE, Watts JC, Schmitt-Ulms G., Free PMC Article | 12/25/2021 |
| The Na/K-ATPase alpha1/Src interaction regulates metabolic reserve and Western diet intolerance. | The Na/K-ATPase α1/Src interaction regulates metabolic reserve and Western diet intolerance.
Kutz LC, Cui X, Xie JX, Mukherji ST, Terrell KC, Huang M, Wang X, Wang J, Martin AJ, Pessoa MT, Cai L, Zhu H, Heiny JA, Shapiro JI, Blanco G, Xie Z, Pierre SV., Free PMC Article | 08/28/2021 |
| A Na,K-ATPase-Fodrin-Actin Membrane Cytoskeleton Complex is Required for Endothelial Fenestra Biogenesis. | A Na,K-ATPase-Fodrin-Actin Membrane Cytoskeleton Complex is Required for Endothelial Fenestra Biogenesis.
Ju M, Ioannidou S, Munro P, Rämö O, Vihinen H, Jokitalo E, Shima DT., Free PMC Article | 03/6/2021 |
| this study examines the function of alpha1- and alpha2-Na,K-ATPase isozymes in respiratory diaphragm and postural soleus muscles from mdx and Bla/J mice compared with control capital ES, Cyrillic57Bl/6 mice. | Isoform-specific Na,K-ATPase and membrane cholesterol remodeling in motor endplates in distinct mouse models of myodystrophy.
Kravtsova VV, Bouzinova EV, Chibalin AV, Matchkov VV, Krivoi II. | 08/13/2020 |
| Data suggest that G protein-coupled receptor 35 (GPR35 ) acts as a central signaling and metabolic pacesetter, which reveals an unexpected role of sodium potassium pump (Na/K-ATPase) in macrophage and intestinal epithelial cells (IECs) biology. | GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump.
Schneditz G, Elias JE, Pagano E, Zaeem Cader M, Saveljeva S, Long K, Mukhopadhyay S, Arasteh M, Lawley TD, Dougan G, Bassett A, Karlsen TH, Kaser A, Kaneider NC., Free PMC Article | 03/21/2020 |
| Our results show that cytosolic Na(+) in mouse cortical astrocytes can vary considerably and depends greatly on the concentrations of HCO3 (-) and K(+) , attributable to the activity of the Na(+) -K(+) -ATPase, of NBCe1 and NKCC1 | Cytosolic sodium regulation in mouse cortical astrocytes and its dependence on potassium and bicarbonate.
Noor ZN, Deitmer JW, Theparambil SM. | 10/5/2019 |
| Functional selection and assembly of NKA subunit isoforms occurs in the cochlear stria vascularis lateral wall, which is disrupted and dysregulated with age. | Age-related changes in Na, K-ATPase expression, subunit isoform selection and assembly in the stria vascularis lateral wall of mouse cochlea.
Ding B, Walton JP, Zhu X, Frisina RD., Free PMC Article | 09/21/2019 |
| The impact of alpha1 content on soleus muscle mass is consistent with a Na/K-ATPase alpha1-specific role in skeletal muscle growth that cannot be fulfilled by alpha2. The preserved running capacity in alpha1(+/-) is in sharp contrast with previously reported consequences of genetic manipulation of alpha2. These results lend further support to the concept of distinct isoform-specific functions of Na/K-ATPase alpha1 and ... | Isoform-specific role of Na/K-ATPase α1 in skeletal muscle.
Kutz LC, Mukherji ST, Wang X, Bryant A, Larre I, Heiny JA, Lingrel JB, Pierre SV, Xie Z., Free PMC Article | 02/23/2019 |
| These results suggested the involvement of the actin binding site, but not tail regions, of class II non-muscle myosins in their interaction with Na(+)/K(+)-ATPase alpha1 subunits. | Multiple myosin motors interact with sodium/potassium-ATPase alpha 1 subunits.
Dash B, Dib-Hajj SD, Waxman SG., Free PMC Article | 01/12/2019 |
| An antibody against the extracellular DR region (897-911) of Na(+)-K(+)-ATPase subunit alpha 1 disrupted the Na+-K+-ATPase/ROS amplifier and protected embryonic hearts in organ culture from ROS-induced injury and apoptosis. | Activation of Na(+)-K(+)-ATPase with DRm217 attenuates oxidative stress-induced myocardial cell injury via closing Na(+)-K(+)-ATPase/Src/Ros amplifier.
Yan X, Xun M, Dou X, Wu L, Zhang F, Zheng J. | 03/10/2018 |
| Cardiotonic steroids activate NF-kappaB leading to proinflammatory cytokine production in primary macrophages through a signaling complex, including CD36, TLR4, and Na/K-ATPase. | Cardiotonic Steroids Stimulate Macrophage Inflammatory Responses Through a Pathway Involving CD36, TLR4, and Na/K-ATPase.
Chen Y, Huang W, Yang M, Xin G, Cui W, Xie Z, Silverstein RL., Free PMC Article | 08/12/2017 |
| Study identified the Na+/K+-ATPase alpha 1 and 3 subunits as receptors for the extracellular fragment of GPNMB that mediates activation of cellular signaling pathways and subsequent neuroprotective effects. | Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na+/K+-ATPase.
Ono Y, Tsuruma K, Takata M, Shimazawa M, Hara H., Free PMC Article | 01/28/2017 |
| effects of endogenous acetylcholine on alveolar fluid clearance are likely mediated by Na,K-ATPase function through activation of muscarinic acetylcholine receptors on alveolar epithelia | Endogenous acetylcholine increases alveolar epithelial fluid transport via activation of alveolar epithelial Na,K-ATPase in mice.
Li X, Yan XX, Li HL, Li RQ. | 07/16/2016 |
| Oxidized LDL-bound CD36 recruits an Na/K-ATPase-Lyn complex in macrophages that promotes atherosclerosis. | Oxidized LDL-bound CD36 recruits an Na⁺/K⁺-ATPase-Lyn complex in macrophages that promotes atherosclerosis.
Chen Y, Kennedy DJ, Ramakrishnan DP, Yang M, Huang W, Li Z, Xie Z, Chadwick AC, Sahoo D, Silverstein RL., Free PMC Article | 06/11/2016 |
| TGFbeta1 is a powerful regulator of megakaryocytic Na+/K+ ATPase activity. | Effect of TGFβ on Na+/K+ ATPase activity in megakaryocytes.
Hosseinzadeh Z, Schmid E, Shumilina E, Laufer S, Borst O, Gawaz M, Lang F. | 02/28/2015 |
| Inhibition of the Na+/K+-ATPase pathway in astrocytes leads to rearrangement of cytoskeleton. | Links between L-glutamate transporters, Na+/K+-ATPase and cytoskeleton in astrocytes: evidence following inhibition with rottlerin.
Sheean RK, Lau CL, Shin YS, O'Shea RD, Beart PM. | 02/28/2015 |
| Reduction of Na/K-ATPase affects cardiac remodeling and increases c-kit cell abundance in partial nephrectomized mice. | Reduction of Na/K-ATPase affects cardiac remodeling and increases c-kit cell abundance in partial nephrectomized mice.
Drummond CA, Sayed M, Evans KL, Shi H, Wang X, Haller ST, Liu J, Cooper CJ, Xie Z, Shapiro JI, Tian J., Free PMC Article | 10/4/2014 |
| Enhanced Na+ entry did not alter Na,K-ATPase a1 mRNA level in tranfected mCDD cells. Post-transcriptional control of Na,K-ATPase abundance is effected by lysosomal degradation. | Sodium transport is modulated by p38 kinase-dependent cross-talk between ENaC and Na,K-ATPase in collecting duct principal cells.
Wang YB, Leroy V, Maunsbach AB, Doucet A, Hasler U, Dizin E, Ernandez T, de Seigneux S, Martin PY, Féraille E., Free PMC Article | 04/19/2014 |
| This coupling of astrocytic A2ARs to the regulation of glutamate transport through modulation of NKA-alpha2 activity provides a novel mechanism linking neuronal activity to ion homeostasis controlling glutamatergic activity. | Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-α2 controlling glutamate uptake in astrocytes.
Matos M, Augusto E, Agostinho P, Cunha RA, Chen JF., Free PMC Article | 01/25/2014 |
| Concurrent impairment of Na(+)+K(+)-ATPase function in multi-organ may serve as one of the molecular pathways participating in and contributing to the mechanism of type-1 diabetes-induced complications in NOD mice. | Concurrent impairment of (Na++K+)-ATPase activity in multi-organ of type-1 diabetic NOD mice.
Shi Q, Zeng J, Dong Y, Xu KY. | 12/28/2013 |