| The CCL2-CCR4 axis promotes Regulatory T cell trafficking to canine glioma tissues. | The CCL2-CCR4 axis promotes Regulatory T cell trafficking to canine glioma tissues.
Panek WK, Toedebusch RG, Mclaughlin BE, Dickinson PJ, Van Dyke JE, Woolard KD, Berens ME, Lesniak MS, Sturges BK, Vernau KM, Li C, Miska J, Toedebusch CM., Free PMC Article | 10/28/2024 |
| CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection. | CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection.
Burgess HM, Grande R, Riccio S, Dinesh I, Winkler GS, Depledge DP, Mohr I., Free PMC Article | 12/18/2023 |
| Blockade of CCR4 breaks immune tolerance in chronic hepatitis B patients by modulating regulatory pathways. | Blockade of CCR4 breaks immune tolerance in chronic hepatitis B patients by modulating regulatory pathways.
Khanam A, Ghosh A, Chua JV, Kottilil S., Free PMC Article | 05/5/2023 |
| Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction. | Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction.
Knowles CM, Goich D, Bloom ALM, Kalem MC, Panepinto JC., Free PMC Article | 04/28/2023 |
| FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor Microenvironment by Inducing CCR4 Expression in Breast Cancer. | FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor Microenvironment by Inducing CCR4 Expression in Breast Cancer.
Sarkar T, Dhar S, Chakraborty D, Pati S, Bose S, Panda AK, Basak U, Chakraborty S, Mukherjee S, Guin A, Jana K, Sarkar DK, Sa G., Free PMC Article | 04/16/2022 |
| Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma. | Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma.
Ling Z, Li W, Hu J, Li Y, Deng M, Zhang S, Ren X, Wu T, Xia J, Cheng B, Tao X., Free PMC Article | 04/16/2022 |
| RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation. | RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation.
Poetz F, Corbo J, Levdansky Y, Spiegelhalter A, Lindner D, Magg V, Lebedeva S, Schweiggert J, Schott J, Valkov E, Stoecklin G., Free PMC Article | 01/22/2022 |
| Immune signature of CCR7(+) central memory T cells associates with disease severity and Immunoglobulin E in bronchial asthma. | Immune signature of CCR7(+) central memory T cells associates with disease severity and Immunoglobulin E in bronchial asthma.
Moaaz M, Youssry S, Baess A, Abed A, Moaaz M. | 12/18/2021 |
| Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4. | Tumors establish resistance to immunotherapy by regulating T(reg) recruitment via CCR4.
Marshall LA, Marubayashi S, Jorapur A, Jacobson S, Zibinsky M, Robles O, Hu DX, Jackson JJ, Pookot D, Sanchez J, Brovarney M, Wadsworth A, Chian D, Wustrow D, Kassner PD, Cutler G, Wong B, Brockstedt DG, Talay O., Free PMC Article | 09/18/2021 |
| Identification of Phosphorylated Amino Acids in Human TNRC6A C-Terminal Region and Their Effects on the Interaction with the CCR4-NOT Complex. | Identification of Phosphorylated Amino Acids in Human TNRC6A C-Terminal Region and Their Effects on the Interaction with the CCR4-NOT Complex.
Munakata F, Suzawa M, Ui-Tei K., Free PMC Article | 07/31/2021 |
| MiR-532-5p Suppresses Migration and Invasion of Lung Cancer Cells Through Inhibiting CCR4. | MiR-532-5p Suppresses Migration and Invasion of Lung Cancer Cells Through Inhibiting CCR4.
Hu J, Wang L, Guan C. | 07/17/2021 |
| Serum CCL22 levels decreased in parallel with disease activity in CCR4-positive mycosis fungoides treated with mogamulizumab. | Serum CCL22 levels decreased in parallel with disease activity in CCR4-positive mycosis fungoides treated with mogamulizumab.
Ohuchi K, Fujimura T, Lyu C, Amagai R, Muto Y, Aiba S. | 07/10/2021 |
| Upregulation of CCR4 in activated CD8(+) T cells indicates enhanced lung homing in patients with severe acute SARS-CoV-2 infection. | Upregulation of CCR4 in activated CD8(+) T cells indicates enhanced lung homing in patients with severe acute SARS-CoV-2 infection.
Spoerl S, Kremer AN, Aigner M, Eisenhauer N, Koch P, Meretuk L, Löffler P, Tenbusch M, Maier C, Überla K, Heinzerling L, Frey B, Lutzny-Geier G, Winkler TH, Krönke G, Vetter M, Bruns H, Neurath MF, Mackensen A, Kremer AE, Völkl S., Free PMC Article | 06/19/2021 |
| Anti-HMGCR Antibody-Positive Myopathy Shows Bcl-2-Positive Inflammation and Lymphocytic Accumulations. | Anti-HMGCR Antibody-Positive Myopathy Shows Bcl-2-Positive Inflammation and Lymphocytic Accumulations.
Kurashige T, Murao T, Mine N, Sugiura T, Inazuka Y, Kuraoka K, Takahashi T, Maruyama H, Torii T., Free PMC Article | 11/21/2020 |
| De Novo Variants in CNOT1, a Central Component of the CCR4-NOT Complex Involved in Gene Expression and RNA and Protein Stability, Cause Neurodevelopmental Delay. | De Novo Variants in CNOT1, a Central Component of the CCR4-NOT Complex Involved in Gene Expression and RNA and Protein Stability, Cause Neurodevelopmental Delay.
Vissers LELM, Kalvakuri S, de Boer E, Geuer S, Oud M, van Outersterp I, Kwint M, Witmond M, Kersten S, Polla DL, Weijers D, Begtrup A, McWalter K, Ruiz A, Gabau E, Morton JEV, Griffith C, Weiss K, Gamble C, Bartley J, Vernon HJ, Brunet K, Ruivenkamp C, Kant SG, Kruszka P, Larson A, Afenjar A, Billette de Villemeur T, Nugent K, DDD Study, Raymond FL, Venselaar H, Demurger F, Soler-Alfonso C, Li D, Bhoj E, Hayes I, Hamilton NP, Ahmad A, Fisher R, van den Born M, Willems M, Sorlin A, Delanne J, Moutton S, Christophe P, Mau-Them FT, Vitobello A, Goel H, Massingham L, Phornphutkul C, Schwab J, Keren B, Charles P, Vreeburg M, De Simone L, Hoganson G, Iascone M, Milani D, Evenepoel L, Revencu N, Ward DI, Burns K, Krantz I, Raible SE, Murrell JR, Wood K, Cho MT, van Bokhoven H, Muenke M, Kleefstra T, Bodmer R, de Brouwer APM., Free PMC Article | 10/24/2020 |
| A degradatory fate for CCR4 suggests a primary role in Th2 inflammation. | A degradatory fate for CCR4 suggests a primary role in Th2 inflammation.
Anderson CA, Patel P, Viney JM, Phillips RM, Solari R, Pease JE., Free PMC Article | 08/15/2020 |
| Potential roles of the CCL17-CCR4 axis in immunopathogenesis of oral lichen planus. | Potential roles of the CCL17-CCR4 axis in immunopathogenesis of oral lichen planus.
Shan J, Shen C, Fang J, Li S, Fan Y. | 08/13/2020 |
| CCR4 immunohistochemistry may be an adjunct in distinguishing advanced CD8+ mycosis fungoides (MF) from other CD8+ cutaneous T-cell lymphomas (CTCLs)/lymphoproliferative disorders (LPDs). | C-C chemokine receptor 4 expression in CD8+ cutaneous T-cell lymphomas and lymphoproliferative disorders, and its implications for diagnosis and treatment.
Geller S, Hollmann TJ, Horwitz SM, Myskowski PL, Pulitzer M., Free PMC Article | 07/4/2020 |
| Study demonstrates that PAL cell lines express and secrete CCL17 and/or CCL22 chemokines, the ligands of C-C motif chemokine receptor 4 (CCR4), in contrast to EBV-negative DLBCL cell lines | Epstein-Barr virus-positive pyothorax-associated lymphoma expresses CCL17 and CCL22 chemokines that attract CCR4-expressing regulatory T cells.
Higuchi T, Matsuo K, Hashida Y, Kitahata K, Ujihara T, Taniguchi A, Yoshie O, Nakayama T, Daibata M. | 03/28/2020 |
| Through its interaction with the Ccr4-Not complex, eIF4A2 represses mRNAs at translation initiation. | eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5'UTR.
Wilczynska A, Gillen SL, Schmidt T, Meijer HA, Jukes-Jones R, Langlais C, Kopra K, Lu WT, Godfrey JD, Hawley BR, Hodge K, Zanivan S, Cain K, Le Quesne J, Bushell M., Free PMC Article | 03/21/2020 |
| Mycosis fungoides/Sezary syndrome patients with high CCR3 or CCR4 expression had a poor survival prognosis. | Expression of CCR3 and CCR4 Suggests a Poor Prognosis in Mycosis Fungoides and Sézary Syndrome.
Shono Y, Suga H, Kamijo H, Fujii H, Oka T, Miyagaki T, Shishido-Takahashi N, Sugaya M, Sato S. | 02/1/2020 |
| identified CCR4 as a potential prognostic biomarker for recurrence and survival of patients with pN0 oral tongue cancer | CCR4 Expression Is Associated With Poor Prognosis in Patients With Early Stage (pN0) Oral Tongue Cancer.
Wang L, Zhang M, Zhu Y, Zhang X, Yang Y, Wang C. | 01/11/2020 |
| Another decapping activator PatL1 directly interacts with CIR and alleviates the CIR-mediated inhibition of CCR4-NOT activity in vitro. Ribosome profiling revealed that XRN1 loss impacts not only on mRNA levels but also on the translational efficiency of many cellular transcripts likely as a consequence of incomplete decay | A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5'-3' messenger RNA decay.
Chang CT, Muthukumar S, Weber R, Levdansky Y, Chen Y, Bhandari D, Igreja C, Wohlbold L, Valkov E, Izaurralde E., Free PMC Article | 12/14/2019 |
| The frequency of CC genotypes at both SNPs rs4359426 and rs2228428 in C-C motif chemokine 22 (CCL22) and chemokine (C-C motif) receptor 4 protein (CCR4) genes was significantly higher in myocardial infarction (MI) patients compared to other genotypes. | CCL22 and CCR4 Gene Polymorphisms in Myocardial Infarction: Risk Assessment of rs4359426 and rs2228428 in Iranian Population.
Noori F, Naeimi S, Zibaeenezhad MJ, Gharemirshamlu FR. | 09/21/2019 |
| CCR4(+) rather than CLA(+) is the predominant phenotype in peanut-allergic subjects. | Circulating allergen-specific T(H)2 lymphocytes: CCR4(+) rather than CLA(+) is the predominant phenotype in peanut-allergic subjects.
Blom LH, Juel-Berg N, Larsen LF, Hansen KS, Poulsen LK. | 08/3/2019 |